Correlation of serum and synovial leptin concentrations with body condition scores in healthy and osteoarthritic dogs     

Stephanie A. Kleine  Sherry L. Sanderson  Clinton George  Ira Roth  Robert M. Gogal  Mary Ann Thaliath  Steven C. Budsberg 《Veterinary surgery : VS》2019,48(5):780-785

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Lower fumonisin mycotoxin levels in the grain of Bt corn grown in the United States in 2000-2002     

Hammond BG  Campbell KW  Pilcher CD  Degooyer TA  Robinson AE  McMillen BL  Spangler SM  Riordan SG  Rice LG  Richard JL 《Journal of agricultural and food chemistry》2004,52(5):1390-1397

Fumonisins were monitored in corn grain collected from Bt hybrids grown in 107 locations across the United States in 2000-2002. Bt corn hybrids contain the Cry1Ab protein from Bacillus thuringiensis that controls European corn borers and other stalk-boring pests. Fumonisin levels were frequently lower in grain from Bt hybrids grown in field trials under conditions of natural (FACT trials) or manual insect infestation (university trials). Over three years of FACT trials, there were 126/210 comparisons when fumonisin levels in grain from control hybrids were >2 ppm, exceeding U.S. FDA guidance levels of 2 ppm for human food. Grain from Bt hybrids was at or below 2 ppm of fumonisins for 58 of the 126 comparisons. The use of Bt hybrids can increase the percentage of corn grain that would be suitable for use in food and feed.  相似文献   

Proteomics analysis of rat brain protein modulations by grape seed extract   总被引：6，自引：0，他引：6  

Deshane J  Chaves L  Sarikonda KV  Isbell S  Wilson L  Kirk M  Grubbs C  Barnes S  Meleth S  Kim H 《Journal of agricultural and food chemistry》2004,52(26):7872-7883

Dietary supplements such as grape seed extract (GSE) enriched in proanthocyanidins (PA) (oligomeric polyphenols) have been suggested to have multiple health benefits, due to antioxidant and other beneficial activities of the PA. However, a systematic analysis of the molecular basis of these benefits has not been demonstrated. Because the brain is vulnerable to age-related oxidative damage and other insults including inflammation, it was hypothesized that rats ingesting GSE would experience changes in expression or modifications of specific brain proteins that might protect against pathologic events. Normal adult female rats were fed diets supplemented with 5% GSE for 6 weeks. Proteomics analysis (2D electrophoresis and mass spectrometry) of brain homogenates from these animals identified 13 proteins that were altered in amount and/or charge. Because many of these changes were quantitatively in the opposite direction from previous findings for the same proteins in either Alzheimer disease or mouse models of neurodegeneration, the data suggest that these identified proteins may mediate the neuroprotective actions of GSE. This is the first identification and quantitation of specific proteins in mammalian tissues modulated by a dietary supplement, as well as the first to demonstrate links of such proteins with any disease.  相似文献   

Prevalence of calcium oxalate uroliths in miniature schnauzers.   总被引：2，自引：0，他引：2  

J P Lulich  C A Osborne  L K Unger  J Sanna  C W Clinton  M P Davenport 《American journal of veterinary research》1991,52(10):1579-1582

Epidemiologic data were evaluated from all dogs admitted to the University of Minnesota, Veterinary Teaching Hospital (UMVTH) between June 1981 and November 1989. Of 69,890 admissions, 2,077 were Miniature Schnauzers. Uroliths were retrieved from 63 of the 2,077 Miniature Schnauzers admitted. In 20 of the 63 urolith episodes, calcium oxalate was the predominant mineral identified. By comparison, calcium oxalate uroliths were identified in only 56 of the remaining 67,813 non-Miniature Schnauzer canine admissions. The odds that uroliths from Miniature Schnauzers were composed of calcium oxalate was 11.8 times greater than for other canine breeds evaluated at the UMVTH (95% confidence interval = 6.8 to 20.1). Data also were evaluated from files of uroliths retrieved from dogs and submitted to the Minnesota Urolith Center for quantitative mineral analysis, between June 1981 and November 1989. Of 3,930 uroliths analyzed, 615 (15.6%) uroliths were obtained from Miniature Schnauzers. of the 615 uroliths, 175 (28.4%) were calcium oxalate. By comparison, only 550 (16.6%) of the remaining 3,315 from dogs of breeds other than Miniature Schnauzers were calcium oxalate. The odds that uroliths submitted for analysis were composed of calcium oxalate was 2 times greater for Miniature Schnauzers than for dogs of other breeds (95% confidence interval = 1.6 to 2.4). Calcium oxalate uroliths were retrieved more frequently in males than females. The risk for males developing calcium oxalate uroliths was greater than 3 times the risk for females in both groups of data evaluated. The mean age of all Miniature Schnauzers admitted to the UMVTH with calcium oxalate uroliths was 9 years. Calcium oxalate uroliths were not detected in Miniature Schnauzers younger than 1.7 years.  相似文献   

Increased Serum Growth Hormone Concentration in Feline Hypertrophic Cardiomyopathy     

Mark D. Kittleson DVM  PhD    Paul D. Pion DVM    Laura A. DeLellis DVM    Yousry Mekhamer BVSc    Noel Dybdal DVM  PhD  Clinton D. Lothrop Jr.  DVM  PhD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1992,6(6):320-324

Serum growth hormone concentration was measured by radioimmunoassay in 31 cats with hypertrophic cardiomyopathy, 38 normal cats, and 35 cats with other cardiac disease. Cats with hypertrophic cardiomyopathy had a significantly increased serum growth hormone concentration when compared with normal cats and cats with other cardiac disease. The serum growth hormone concentration in cats with hypertrophic cardiomyopathy was less than that previously reported in cats with growth hormone secreting pituitary tumors. Pituitary tumors were not identified in eight of the cats with hypertrophic cardiomyopathy examined at necropsy. An increased serum growth hormone concentration may be measured in cats with hypertrophic cardiomyopathy but it is unclear if the increased serum growth hormone concentration is a cause or effect of hypertrophic cardiomyopathy.  相似文献   

Resistin concentrations in serum and stifle synovial fluid from normal and cruciate deficient dogs with osteoarthritis     

Stephanie A. Kleine DVM  DACVAA  PhD  Robert M. Gogal DVM  Thomas M. Krunkosky DVM  PhD  Sherry L. Sanderson DVM  PhD  DACVIM  DACVN  Clinton George DVM  Megan Norton MS  Steven C. Budsberg DVM  MS  DACVS 《Veterinary surgery : VS》2020,49(6):1164-1173

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Retraction     

Sebastiani P  Solovieff N  Puca A  Hartley SW  Melista E  Andersen S  Dworkis DA  Wilk JB  Myers RH  Steinberg MH  Montano M  Baldwin CT  Perls TT 《Science (New York, N.Y.)》2011,333(6041):404

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Effectiveness of sorting calves with high risk of developing bovine respiratory disease on the basis of serum haptoglobin concentration at the time of arrival at a feedlot     

Holland BP  Step DL  Burciaga-Robles LO  Fulton RW  Confer AW  Rose TK  Laidig LE  Richards CJ  Krehbiel CR 《American journal of veterinary research》2011,72(10):1349-1360

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Soil carbon pools, plant biomarkers and mean carbon residence time after afforestation of grassland with three tree species     

Zhiqun Huang  Murray R. Davis  Peter W. Clinton 《Soil biology & biochemistry》2011,43(6):1341-1349

Afforestation of grassland has been globally identified as being an important means for creating a sink for atmospheric carbon (C). However, the impact of afforestation on soil C is still poorly understood, due to the paucity of well designed long-term experiments and the lack of investigation into the response of different soil C fractions to afforestation. In addition, little is known about the origins of soil C and soil organic matter (SOM) stability after afforestation. In a retrospective study, we measured C mass in the soil light and heavy fractions in the first 10 years after afforestation of grassland with Eucalyptus nitens, Pinus radiata and Cupressus macrocarpa. The results suggest that C mass in the soil heavy fraction remained stable, but the C mass in the light fraction decreased at year 5 under three species. Soil δ¹³C analysis showed that the decrease in the light fraction may be due to reduced C inputs from grassland species litter and low inputs from the still young trees. After the initial reduction, the recovery of soil C in the light fraction depended on tree species. At year 10, an increase of 33% in light fraction soil C was observed at the 0-30 cm depth under E. nitens, compared to that under the original grassland (year 0). Planting P. radiata restored light fraction soil C to the original level under grassland, whereas planting C. macrocarpa led to a decrease of 33%. We concluded that the increase of light fraction soil C between year 5 and 10 is most likely due to C input from tree residues. Most of the increased C was derived from root turnover under pine and from both root and leaf turnover under E. nitens, as indicated by plant C biomarkers such as lignin-derived phenols and suberin and cutin-derived compounds in the 0-5 cm soil layer. Modelling of soil ?¹⁴C‰ suggested that SOM had a greater mean residence time at year 10 than year 0 and 5 due to increased relative abundance of recalcitrant plant biopolymers.  相似文献   

THE EFFECT OF 11-DESOXY-17-HYDROXYCORTICOSTERONE ON RENAL EXCRETION OF ELECTROLYTES     

Clinton M  Thorn GW 《Science (New York, N.Y.)》1942,96(2493):343-344

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