Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis   总被引：33，自引：0，他引：33  

C Q Doe  Y Hiromi  W J Gehring  C S Goodman 《Science (New York, N.Y.)》1988,239(4836):170-175

Segmentation genes control cell identities during early pattern formation in Drosophila. One of these genes, fushi tarazu (ftz), is now shown also to control cell fate during neurogenesis. Early in development, ftz is expressed in a striped pattern at the blastoderm stage. Later, it is transiently expressed in a specific subset of neuronal precursor cells, neurons (such as aCC, pCC, RP1, and RP2), and glia in the developing central nervous system (CNS). The function of ftz in the CNS was determined by creating ftz mutant embryos that express ftz in the blastoderm stripes but not in the CNS. In the absence of ftz CNS expression, some neurons appear normal (for example, the aCC, pCC, and RP1), whereas the RP2 neuron extends its growth cone along an abnormal pathway, mimicking its sibling (RP1), suggesting a transformation in neuronal identity.  相似文献   

Undergraduate research. Genomics Education Partnership     

Lopatto D  Alvarez C  Barnard D  Chandrasekaran C  Chung HM  Du C  Eckdahl T  Goodman AL  Hauser C  Jones CJ  Kopp OR  Kuleck GA  McNeil G  Morris R  Myka JL  Nagengast A  Overvoorde PJ  Poet JL  Reed K  Regisford G  Revie D  Rosenwald A  Saville K  Shaw M  Skuse GR  Smith C  Smith M  Spratt M  Stamm J  Thompson JS  Wilson BA  Witkowski C  Youngblom J  Leung W  Shaffer CD  Buhler J  Mardis E  Elgin SC 《Science (New York, N.Y.)》2008,322(5902):684-685

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Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice   总被引：4，自引：0，他引：4  

M J Low  R M Lechan  R E Hammer  R L Brinster  J F Habener  G Mandel  R H Goodman 《Science (New York, N.Y.)》1986,231(4741):1002-1004

Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.  相似文献   

Immunogenicity of glucagon: determinants responsible for antibody binding and lymphocyte stimulation   总被引：4，自引：0，他引：4  

G Senyk  D Nitecki  J W Goodman 《Science (New York, N.Y.)》1971,171(969):407-408

Bovine glucagon, a polypeptide of 29 amino acids, is immunogenic in rabbits and guinea pigs. The antigenic determinants of glucagon were investigated with isolated tryptic peptides of the hormone. Antibodies from virtually all of more than a dozen animals tested had specificity primarily for the aminoterminal heptadecapeptide. However, only intact glucagon and its carboxy-terminal dodecapeptide stimulated spleen or lymph node cells to synthesize DNA. It thus appears that glucagon was cleaved along functional lines into two parts, one of which contained the major antigenic determinant for serum antibody and the other of which was "recognized" by antigen-reactive cells.  相似文献   

Eppendorf essay winner. Deconstructing C. elegans sensory mechanotransduction     

Goodman MB 《Science (New York, N.Y.)》2004,306(5695):427-428

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Coherin: a new peptide of the bovine neurohypophysis with activity on gastrointestinal motility   总被引：1，自引：0，他引：1  

I Goodman  R B Hiatt 《Science (New York, N.Y.)》1972,178(59):419-421

A factor with potent activity in the regulation of mammalian gastrointestinal motor function has been isolated from the bovine posterior pituitary gland by a process allowing minimal dissociation of neurophysin-bound complexes and the separation of free unbound peptides. This substance alters the frequency, amplitude, rhythm, and duration of peristaltic contraction.  相似文献   

Immunotherapy. Can worms tame the immune system?     

Wickelgren I 《Science (New York, N.Y.)》2004,305(5681):170-171

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NINDS delves into drug development     

Wickelgren I 《Science (New York, N.Y.)》2002,297(5579):180

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Federal land releases     

Goodman GL 《Science (New York, N.Y.)》1971,172(3988):1085

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Standardized Pain Stimulation as Controlled Stress in Physiological Studies of Psychoneurosis     

Malmo RB  Shagass C  Davis JF  Cleghorn RA  Graham BF  Goodman AJ 《Science (New York, N.Y.)》1948,108(2810):509-511

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