Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats   总被引：3，自引：0，他引：3  

Le Bon AM  Vernevaut MF  Guenot L  Kahane R  Auger J  Arnault I  Haffner T  Siess MH 《Journal of agricultural and food chemistry》2003,51(26):7617-7623

The anticarcinogenic effect of garlic has been demonstrated in both epidemiologic and experimental studies. In this study, possible mechanisms involved in the anticarcinogenic effect of garlic consumption were assessed by determining its capacity to alter drug metabolizing enzymes, in relation with its alliin content. Rats were fed a diet for 2 weeks containing 5% garlic powders produced from bulbs grown on soils with different levels of sulfate fertilization and therefore containing differing amounts of alliin. Activities of several hepatic enzymes, which are important in carcinogen metabolism such cytochromes P450 (CYP) and phase II enzymes, were determined. Garlic consumption slightly increased ethoxyresorufin O-deethylase and CYP 1A2 levels. In contrast, garlic consumption decreased CYP 2E1 activity and the level of the corresponding isoform. UDP glucuronosyl transferase and glutathion S-transferase activities were increased by garlic powders. The alliin content of the garlic powders was positively correlated with UGT activity although not with other activities. Effects produced by garlic consumption were qualitatively similar to that of diallyl disulfide, a sulfur compound that has been extensively studied. These data could partially explain the chemoprotective effect of garlic.  相似文献   

Misinterpretation     

Goodman N 《Science (New York, N.Y.)》1969,164(3886):1043

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Determination of energy source utilized by the light horse     

H M Goodman  G W Vander Noot  J R Trout  R L Squibb 《Journal of animal science》1973,37(1):56-62

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Nine simultaneous primary tumors in a Boxer dog.     

W A Priester  D G Goodman  G H Theilen 《Journal of the American Veterinary Medical Association》1977,170(8):823-826

An aged Boxer dog had 9 distinct primary tumors: chemodectoma, osteosarcoma, bronchiolo-alveolar adenocarcinoma, interstitial cell tumor, seminoma, basal cell tumor, fibropapilloma, adrenal cortical adenoma, and pancreatic adenoma. From this report, as well as from other studies, it is clear that Boxers have special susceptibilities to a variety of tumors. Analysis of clinical data on canine tumors indicated that the risk of Boxers for multiple tumors is only slightly higher than all tumors, indicating little or no specific predisposition for multiple tumors. In Boxers, however, certain tumor types occurred more frequently as multiple primary tumors than would be expected by chance.  相似文献   

Tumor necrosis factor-alpha, interleukin-6, serum amyloid A, haptoglobin, and cortisol concentrations in sows following intramammary inoculation of Escherichia coli     

Zhu Y  Osterlundh I  Hultén F  Magnusson U 《American journal of veterinary research》2004,65(10):1434-1439

OBJECTIVE: To determine whether concentrations of proinflammatory cytokines, acute-phase proteins, and cortisol differ at parturition among 3 categories of sows (noninoculated, clinically affected and nonaffected following intramammary inoculation with Escherichia coll). ANIMALS: 16 sows. PROCEDURE: Sows were allocated to inoculated (n = 12) or noninoculated (4) groups. Inoculated sows received intramammary administration of E coli (serotype O127) during the 24-hour period preceding parturition. Blood samples were collected from noninoculated and inoculated sows for 3 consecutive days within 3 to 11 days before farrowing and inoculation. Samples were also collected 0, 24, 48, 72, and 96 hours after farrowing and inoculation. Inoculated sows were further categorized as affected (4 sows) or nonaffected (8 sows) based on clinical signs of disease. Serum tumor necrosis factor (TNF)-alpha, plasma interleukin (IL)-6, and serum amyloid A (SAA) concentrations were measured by use of ELISA; serum haptoglobin concentration was assayed by use of a hemoglobin-binding method; and plasma cortisol concentration was determined by use of radioimmunoassay. RESULTS: Plasma or serum concentrations of TNF-alpha, IL-6, and SAA of both categories of inoculated sows were significantly increased by 24 hours after intramammary inoculation of E coli, compared with concentrations in noninoculated sows. Concentrations of serum TNF-alpha and plasma IL-6 were significantly higher in inoculated sows that developed clinical mastitis than in nonaffected inoculated sows. CONCLUSIONS AND CLINICAL RELEVANCE: Concentrations of TNF-alpha and IL-6 are promising markers for the identification of periparturient sows with subclinical coliform mastitis. Identification of such sows should help improve the health and survival of piglets.  相似文献   

Biogeographic evolution of Madagascar's microendemic biota     

Wilmé L  Goodman SM  Ganzhorn JU 《Science (New York, N.Y.)》2006,312(5776):1063-1065

The endemic species richness on Madagascar, relative to landmass area, is unparalleled in the world. Many organisms on the island have restricted geographical ranges. A comprehensive hypothesis explaining the evolution of this microendemism has yet to be developed. Using an analysis of watersheds in the context of Quaternary climatic shifts, we provide a new mechanistic model to explain the process of explosive speciation on the island. River catchments with sources at relatively low elevations were zones of isolation and hence led to the speciation of locally endemic taxa, whereas those at higher elevations were zones of retreat and dispersion and hence contain proportionately lower levels of microendemism. These results provide a framework for biogeographic and phylogeographic studies, as well as a basis for prioritizing conservation actions of the remaining natural forest habitats on the island.  相似文献   

Building capacity     

Keller I 《Public health nutrition》2006,9(1):94

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Immunology. Mouse studies question importance of toll-like receptors to vaccines     

Wickelgren I 《Science (New York, N.Y.)》2006,314(5807):1859-1860

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The structure of mating type,virulence, metalaxyl resistance of Phytophthora infestans in a long-term phenotypic study in distinct location in Eastern Estonia     

Runno-Paurson  Eve  Hannukkala  Asko  Trdan  Stanislav  Williams  Ingrid  Koppel  Mati  Mänd  Marika 《植物病害和植物保护杂志》2012,119(2):45-52

Journal of Plant Diseases and Protection - The potato late blight pathogen Phytophthora infestans was collected from a region of Eastern Estonia during a period of seven years (2001–07). In...  相似文献   

Computed tomography findings in 32 joints affected with severe elbow incongruity and fragmented medial coronoid process     

Samoy Y  Gielen I  Van Caelenberg A  van Bree H  Duchateau L  Van Ryssen B 《Veterinary surgery : VS》2012,41(4):486-494

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