Canine von Willebrand's disease. A heterogeneous group of bleeding disorders     

G S Johnson  M A Turrentine  K H Kraus 《Veterinary Clinics of North America: Small Animal Practice》1988,18(1):195-229

The term "von Willebrand's disease," refers to a group of inherited bleeding disorders, all of which are caused by a deficiency of the multimeric plasma glycoprotein, von Willebrand factor. The various forms of canine von Willebrand's disease can be categorized into one of three major types: in type I canine von Willebrand's disease, all sizes of von Willebrand factor multimers can be detected in the plasma; in type II canine von Willebrand's disease, only the smaller von Willebrand factor multimers are found in the plasma (larger multimers are absent); and in type III canine von Willebrand's disease, von Willebrand factor is completely absent from the plasma or present in only trace amounts. Von Willebrand's disease is common in dogs, but some forms of the disease are so mild that they are of questionable clinical significance.  相似文献   

Purchasing a Computer System: Check-off Sheets          下载免费PDF全文

Stowe JD 《The Canadian veterinary journal. La revue veterinaire canadienne》1988,29(3):259-264

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Ontario. Streptococcus pneumoniae Type 3 in an Ontario racehorse          下载免费PDF全文

Huber L  Willoughby R  Lynch J 《The Canadian veterinary journal. La revue veterinaire canadienne》1988,29(8):665-666

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An Unusual Necrotizing cholangiohepatitis in Broiler Chickens          下载免费PDF全文

Shapiro JL  Julian RJ  Hampson RJ  Trenton RG  Yo IH 《The Canadian veterinary journal. La revue veterinaire canadienne》1988,29(8):636-639

A diagnosis of toxic necrotizing cholangiohepatitis was made in approximately 35% of a flock of 23,000 commercial broiler chickens. Affected chickens were small, and had discrete green foci throughout the liver. Seven to twelve days prior to shipping the flock to slaughter, premixes containing oxytetracycline, monensin, and 3-nitro-4-hydroxyphenylarsonic acid had been added to the ration because the birds had wet droppings and were growing slowly. The 3-nitro-4-hydroxyphenylarsonic acid had been inadvertently incorporated at ten times the recommended level. Liver and kidney of affected birds had elevated levels of total arsenic, and special strains demonstrated arsenic in necrotic foci in liver. Histologically there was marked dilation of intrahepatic bile ducts, and patchy necrosis and hyperplasia of the bile duct epithelium. Damage to bile ducts may have been a toxic manifestation of altered metabolism and excretion of the three drugs being fed to birds suffering from intercurrent diarrhea and/or undefined interactions among the drugs.  相似文献   

Pay Cap for Grantees Has Up Side for NSF     

W J 《Science (New York, N.Y.)》1988,241(4870):1159

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Volcanic rocks: mantle xenoliths     

Shervais JW 《Science (New York, N.Y.)》1988,241(4863):366-367

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Neutrinos: physics of massive neutrinos     

Witherell MS 《Science (New York, N.Y.)》1988,241(4869):1108

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Tried and True Prokaryotes: Escherichia coli and Salmonella typhimurium     

Friesen JD 《Science (New York, N.Y.)》1988,240(4859):1678-1680

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NSF Appoints Two Assistant Directors     

W J 《Science (New York, N.Y.)》1988,240(4855):980

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The Natural History of Nautilus. Peter Douglas Ward. Allen and Unwin, Winchester, MA, 1987. xiv, 267 pp., illus. $34.95; Nautilus. The Biology and Paleobiology of a Living Fossil. W. Bruce Saunders and Neil H. Landman, Eds. Plenum, New York, 1988. xxviii, 632 pp., illus., + plates. $95. Topics in Geobiology, vol. 6     

Vermeij GJ 《Science (New York, N.Y.)》1988,240(4855):1074-1075

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