Endotoxin Concentrations Measured by a Chromogenic Assay in Portal and Peripheral Venous Blood in Ten Dogs With Portosystemic Shunts     

Steven L. Peterson DVM  MS    Philip D. Koblik DVM  MS    Pamela G. Whiting DVM  Eugene M. Breznock DVM  PhD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1991,5(2):71-74

A chromogenic Limulus amebocyte lysate assay was used to measure portal and peripheral venous endotoxin concentrations in ten medically managed dogs undergoing surgery for correction of a single extrahepatic portosystemic shunt. In all dogs, both peripheral and portal venous blood samples were obtained at the time of surgical manipulation of the anomalous vessel. In six dogs, peripheral venous samples were obtained an average of 8.0 months after surgery. Five physically normal dogs without biochemical or histologic evidence of liver disease served as controls. Data analysis failed to demonstrate significant differences in peripheral and portal venous endotoxin concentrations between the control and study groups. Postoperatively five of six dogs showed a measurable reduction in peripheral venous endotoxin concentration over intraoperatively obtained values, but the differences were not statistically significant (P = 0.06). Based on results of this study it was concluded that systemic endotoxemia was not present in dogs with a single extrahepatic portosystemic shunt that were medically stable prior to surgery.  相似文献   

Surgical reconstruction of chronic coronary band avulsions in three horses     

M D Markel  G L Richardson  P R Peterson  D M Meagher 《Journal of the American Veterinary Medical Association》1987,190(6):687-688

Three adult horses were admitted with chronic coronary band avulsions of 2-, 3-, and 46-month durations, respectively. The hoof had a typical appearance in all 3 horses, with a spur of coronary band and associated horn growing at right angles to the hoof wall. Each horse was anesthetized, and the coronary band was reconstructed. Follow-up evaluation of the 3 horses (12, 15, and 23 months after surgery, respectively), revealed healing of all 3 avulsed coronary bands. Mild roughening of the hoof wall distal to the previous avulsion site was observed.  相似文献   

Muscular dystrophy syndrome in the Cornish chicken   总被引：1，自引：0，他引：1  

W D Wagner  R A Peterson 《American journal of veterinary research》1970,31(2):331-338

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Relationship of blood serum selenium levels of pregnant cows to low dietary intake, and effect on tissue selenium levels of their calves     

T W Perry  R C Peterson  D D Griffin  W M Beeson 《Journal of animal science》1978,46(2):562-565

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Hypertropic cardiomyopathy and hyperthyroidism in the cat   总被引：2，自引：0，他引：2  

S K Liu  M E Peterson  P R Fox 《Journal of the American Veterinary Medical Association》1984,185(1):52-57

In a 21/2-year period, hypertrophic cardiomyopathy was found at necropsy of 23 cats that died (13 cats) or were euthanatized (10) because of problems associated with hyperthyroidism. Of these, 4 (17%) also had evidence of cardiac failure (pulmonary edema or pleural effusion). The mean body weight of the cats with hyperthyroidism and hypertrophic cardiomyopathy was significantly less (P less than 0.001) than that of clinically normal cats and cats with primary cardiomyopathy (congestive or restrictive) or excessive moderator band cardiomyopathy. In addition, the ratio of heart weight to body weight was significantly greater (P less than 0.001) in the 23 hyperthyroid cats than in the normal cats and cats with primary cardiomyopathy. Twenty (87%) of the cats had symmetric hypertrophy of the ventricular septum and left ventricular free wall, whereas the remaining 3 cats had disproportionate thickening of the ventricular septum, compared with the free wall, similar to what is found in cats with asymmetric hypertrophic cardiomyopathy. Histologic cardiac abnormalities included large, hyperchromatic nuclei, interstitial fibrosis, endocardial fibroplasia, fibrosis of the atrioventricular node, and marked disorganization of cardiac muscle cells. The study showed that hypertrophic cardiomyopathy develops in most hyperthyroid cats, some of which also develop congestive heart failure. Although the signs of heart disease in primary myocardial disease and thyrotoxic disease are similar, the characteristic signalment and clinical signs of hyperthyroidism should lead one to suspect the association of hypertrophic cardiomyopathy with the hyperthyroidism.  相似文献   

Hypoadrenocorticism     

E C Feldman  M E Peterson 《Veterinary Clinics of North America: Small Animal Practice》1984,14(4):751-766

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Clinico-pathologic diagnosis of guttural pouch mycosis in a horse   总被引：1，自引：0，他引：1  

F B Peterson  K Harmany  D C Dodd 《Journal of the American Veterinary Medical Association》1970,157(2):220-228

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Analgesic efficacy of preoperative administration of meloxicam or butorphanol in onychectomized cats     

Carroll GL  Howe LB  Peterson KD 《Journal of the American Veterinary Medical Association》2005,226(6):913-919

OBJECTIVE: To determine analgesic efficacy and adverse effects of preemptive administration of meloxicam or butorphanol in cats undergoing onychectomy or onychectomy and neutering. DESIGN: Randomized controlled study. ANIMALS: 64 female and 74 male cats that were 4 to 192 months old and weighed 1.09 to 705 kg (2.4 to 15.5 lb). PROCEDURE: Cats received meloxicam (0.3 mg/kg [0.14 mg/lb], s.c.) or butorphanol (0.4 mg/kg [0.18 mg/lb], s.c.) 15 minutes after premedication and prior to anesthesia. A single blinded observer measured physiologic variables, assigned analgesia and lameness scores, and withdrew blood samples for each cat at baseline and throughout the 24 hours after surgery. Rescue analgesia (butorphanol, 0.4 mg/kg, i.v. or s.c.) or administration of acepromazine (0.025 to 0.05 mg/kg [0.011 to 0.023 mg/lb], i.v.) was allowed. RESULTS: Meloxicam-treated cats were less lame and had lower pain scores. Cortisol concentration was higher at extubation and lower at 1, 5, and 12 hours in the meloxicam-treated cats. Fewer meloxicam-treated cats required rescue analgesia at 3, 5, 12, and 24 hours after extubation. General impression scores were excellent or good in 75% of meloxicam-treated cats and 44% of butorphanol-treated cats. There was no treatment effect on buccal bleeding time; PCV and BUN concentration decreased in both groups, and glucose concentration decreased in meloxicam-treated cats. CONCLUSIONS AND CLINICAL RELEVANCE: Preoperative administration of meloxicam improved analgesia for 24 hours without clinically relevant adverse effects in cats that underwent onychectomy or onychectomy and neutering and provided safe, extended analgesia, compared with butorphanol.  相似文献   

Entry of pesticides into the plant symplast as measured by their loss from an ambient solution     

Carol A. Peterson  Lloyd V. Edgington 《Pest management science》1976,7(5):483-491

A method was developed to determine the extent of penetration of substances into the plant symplast. The known apoplastic dye trisodium 3-hydroxy-5,8,10-pyrenetri-sulphonate (PTS) and various systemic pesticides were studied using potato tuber tissue. The dye penetrated only 5% of the volume of living tissue while those pesticides which display an apoplastic pattern of transport in plants penetrated the entire tissue volume. The pesticides diffused freely out of the tissue when it was transferred to fresh medium. It is proposed that the term euapoplastic be used to describe chemicals that behave like the dye, and that the term pseudoapoplastic be used to describe chemicals that behave like atrazine, carbendazim, carboxin and diuron. 2,4-D, which displays a symplastic transport pattern in the plant, was concentrated by the tissue and did not diffuse out freely. It appears that the property which allows a pesticide to be transported in the symplast is not its ability to penetrate the plasmalemma but rather its ability to be retained by the symplast after entry.  相似文献   

Propylthiouracil-associated hemolytic anemia, thrombocytopenia, and antinuclear antibodies in cats with hyperthyroidism   总被引：2，自引：0，他引：2  

M E Peterson  A I Hurvitz  M S Leib  P G Cavanagh  R E Dutton 《Journal of the American Veterinary Medical Association》1984,184(7):806-808

Nine of 105 cats with hyperthyroidism treated with propylthiouracil developed a serious immune-mediated drug reaction during treatment. Adverse clinical signs, which developed after 19 to 37 days (mean, 24.8 days) of propylthiouracil administration, included lethargy, weakness, anorexia, and bleeding diathesis. Physical examination revealed pale mucous membranes, and petechial hemorrhages of the skin and oral cavity. Results of hematologic testing revealed severe anemia and thrombocytopenia. The direct antiglobulin (Coombs') test was positive in all 7 cats evaluated, whereas the serum antinuclear antibody titer was greater than or equal to 1:10 in 5 of the 8 cats tested. In 4 of the cats, treatment included appropriate supportive therapy and cessation of propylthiouracil; in these cats, anemia and thrombocytopenia resolved and Coombs' and antinuclear antibody tests became negative within 2 weeks.  相似文献