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41.
A full ophthalmic examination was performed on 40 Siberian husky dogs using direct and indirect ophthalmoscopy, gonloscopy and nasolacrimal cannulation. Eight (20%) of the dogs were found to have distichia, 10 (25%) had excessive medial caruncular hairs, 8 (20%) had absence, displacement, or narrowing of the nasolacrimal puncta, 2 (5%) had bilateral corneal crystalline opacities, and 2 (5%) had unilateral areas of lateral corneal lipidosis. Fifty percent of the dogs had some abnormality of the iridocorneal (drainage) angle. However, in only one of these was the deformity severe enough to require glaucoma prophylaxis. An association between blue iris colour and malformation of the iridocorneal angle was noted.  相似文献   
42.
A diagnosis of dicoumarol toxicity in a herd of Friesian cattle was made following investigation of the deaths of three mature cows and eleven yearling heifers. Affected stock had been fed wrapped, bailed silage containing approximately 90% sweet vernal grass ( Anthoxanthum odoratum ). Sweet vernal grass contains coumarin, which can be converted to dicoumarol, a vitamin K antagonist, through the action of moulds. Most deaths were preceded by lethargy, severe anaemia and subcutaneous and internal haemorrhage. Dicoumarol toxicosis was suspected based on clinical signs, necropsy findings and prolonged prothrombin and activated partial thromboplastin times. Dicoumarol analysis of blood from affected animals and silage confirmed the diagnosis.  相似文献   
43.
Endothelial expression of cell adhesion molecules (CAM) including VCAM-1, E-selectin, and PECAM-1 plays a leading role in atherosclerosis. Phenolic flavones have been shown to have an anti-inflammatory property. This study examines whether 3',4'-dimethoxy-7-hydroxyflavone (methoxyflavone) and 2',3',7-trihydroxyflavone (hydroxyflavone) inhibited monocyte adhesion to TNF-alpha-activated endothelium via reduction of CAM expression in human umbilical vein endothelial cells (HUVEC). In stimulated HUVEC the expression of VCAM-1 and E-selectin was enhanced with increasing mRNA levels. Methoxyflavone markedly interfered with the THP-1 monocyte adhesion to TNF-alpha-stimulated HUVEC. At concentrations of > or =25 microM, methoxyflavone blocked the induction of VCAM-1 but not that of E-selectin on the activated HUVEC. Immunocytochemical staining showed that methoxyflavone modestly inhibited PECAM-1 expression induced by TNF-alpha. In contrast, hydroxyflavone minimally inhibited TNF-alpha-stimulated E-selectin expression without affecting VCAM-1 level. The inhibitory effect of methoxyflavone on THP-1 adhesion to HUVEC appears to be greater than that of hydroxyflavone, most likely due to a greater inhibition of CAM expression. Thus, some flavone derivatives containing methoxy groups may have therapeutic potential attenuating inflammatory response-related atherosclerosis.  相似文献   
44.
After far-infrared (FIR) radiation onto rice hull, a methanolic extract was prepared for the determination of antioxidant ability. After 30 min of FIR treatment, the radical scavenging activity and total phenol contents of rice hull extracts increased from 47.74 to 79.63% and from 0.12 to 0.19 mM, respectively, compared to control. Inhibition of lipid peroxidation in extracts was also increased from 41.07 to 47.96%. According to the GC-MS analysis, more phenolic compounds (p-coumaric acid, 3-vinyl-1-oxybenzene, p-hydroxybenzaldehyde, vanillin, p-hydroxybenzoic acid, and 4,7-dihydroxyvanillic acid) were detected in FIR-irradiated rice hull extract. These results indicated that FIR radiation onto rice hull could liberate and activate covalently bound phenolic compounds that have antioxidant activities.  相似文献   
45.
In order to investigate the regional background concentration levels of mercury (Hg), measurements were routinely recorded on An-Myun Island off the coast of Korea (December 2004 to April 2006). The mean concentration of Hg computed from the entire measurement period was 4.61?±?2.21 ng m?3 with a range of 0.10–25.4 ng m?3 (N?=?10,485). Using these data, we inspected various aspects of Hg behavior from the relatively remote island of An-Myun in Korea. Inspection of the seasonal patterns of Hg indicated that its concentration levels generally peaked in spring, while reached a minimum in summer. The summertime deficiency of Hg along with the lack of diurnal variation suggests that the environmental behavior of Hg at the study site was strongly suppressed by heavy precipitation during specific period. The diurnal variations of Hg, typically characterized by a relative daytime dominance, are distinguishable between seasons so that such patterns disappear during the summer. The results of our analysis, when inspected in terms of long-range transport of airborne pollutants, imply that Hg concentration levels can be affected intensively by trans-boundary input processes over certain period of time. Its springtime dominance hence suggests the combined effects of various local source processes and the meteorological conditions favorable for the massive air mass transport phenomenon (such as Asian Dust storms) during that time period.  相似文献   
46.
A gene responsible for the chlorothalonil biotransformation was cloned from the chromosomal DNA of Ochrobactrum anthropi SH35B, capable of efficiently dissipating the chlorothalonil. The gene encoding glutathione S-transferase (GST) of O. anthropi SH35B was expressed in Escherichia coli, and the GST was subsequently purified by affinity chromatography. The fungicide chlorothalonil was rapidly transformed by the GST in the presence of glutathione. LC-MS analysis supported the formation of mono-, di-, and triglutathione conjugates of chlorothalonil by the GST. The monoglutathione conjugate was observed as an intermediate in the enzymatic reaction. The triglutathione conjugate has not been previously reported and seems to be the final metabolite in the biotransformation of chlorothalonil. The glutathione-dependent biotransformation of chlorothalonil catalyzed by the bacterial GST is reported.  相似文献   
47.
The effect of heat treatment on the antioxidant activity of extracts from Citrus unshiu peels was evaluated. Citrus peels (CP) (5 g) were placed in Pyrex Petri dishes (8.0 cm diameter) and heat-treated at 50, 100, or 150 degrees C for 10, 20, 30, 40, 50, and 60 min in an electric muffle furnace. After heat treatment, 70% ethanol extract (EE) and water extract (WE) (0.1 g/10 mL) of CP were prepared, and total phenol contents (TPC), radical scavenging activity (RSA), and reducing power of the extracts were determined. The antioxidant activities of CP extracts increased as heating temperature increased. For example, heat treatment of CP at 150 degrees C for 60 min increased the TPC, RSA, and reducing power of EE from 71.8 to 171.0 microM, from 29.64 to 64.25%, and from 0.45 to 0.82, respectively, compared to non-heat-treated control. In the case of WE from CP heat-treated at the same conditions (150 degrees C for 60 min), the TPC, RSA, and reducing power also increased from 84.4 to 204.9 microM, from 15.81 to 58.26%, and from 0.27 to 0.96, respectively. Several low molecular weight phenolic compounds such as 2,3-diacetyl-1-phenylnaphthalene, ferulic acid, p-hydroxybenzaldoxime, 5-hydroxyvaleric acid, 2,3-diacetyl-1-phenylnaphthalene, and vanillic acid were newly formed in the CP heated at 150 degrees C for 30 min. These results indicated that the antioxidant activity of CP extracts was significantly affected by heating temperature and duration of treatment on CP and that the heating process can be used as a tool for increasing the antioxidant activity of CP.  相似文献   
48.
49.
Spatial Variability of Turbulent Mixing in the Abyssal Ocean   总被引:3,自引:0,他引:3  
Ocean microstructure data show that turbulent mixing in the deep Brazil Basin of the South Atlantic Ocean is weak at all depths above smooth abyssal plains and the South American Continental Rise. The diapycnal diffusivity there was estimated to be less than or approximately equal to 0.1 x 10(-4) meters squared per second. In contrast, mixing rates are large throughout the water column above the rough Mid-Atlantic Ridge, and the diffusivity deduced for the bottom-most 150 meters exceeds 5 x 10(-4) meters squared per second. Such patterns in vertical mixing imply that abyssal circulations have complex spatial structures that are linked to the underlying bathymetry.  相似文献   
50.
Changes in the distribution of dry matter and nonstructural carbohydrates in various parts of young ‘Fuyu’ persimmon (Diospyros kaki) were examined with 3- and 4-year-old trees with (fruited) and without fruits (defruited). The effect of such changes was then monitored with regard to the magnitude of new growth the following year. From June 15 to November 1, fruiting significantly decreased the rate of dry weight accumulation in perennial parts of the tree. Dry matter was partitioned the most to fruits (68–72%) and the least to the roots. Of the total dry weight, root accounted for 8–27% in fruited and 58–62% in defruited trees. During this period, soluble sugars were three times more in fruited than in defruited trees, but more than 95% of sugars were in the fruits. Starch content increased in defruited trees, more than 93% of which being distributed to the perennial parts. Compared with fruited trees, defruiting in the previous year increased new shoot growth and the number of fruits the following year, with a 20–58% greater increase in dry matter. During the new growth from April 10 to June 10 the following year, root dry weight decreased by 30–32% in defruited trees, whereas it increased by 20–80% in the fruited ones. Soluble sugars in roots decreased by 8.8–19.7 g in defruited trees but increased by 9.7–12.3 g in fruited ones. Starch in roots decreased by 68–75.1 g in defruited trees but increased by 10.2–13.3 g in fruited ones. However, there were no significant differences in soluble sugars and starch in the newly grown parts. It was estimated that a 1-g difference in dry matter accumulated in the previous season resulted in a 116-mg and 256-mg difference in dry weight of newly grown parts, and a 6.5-mm and 17.5-mm new shoot in the following season for 3- and 4-year-old trees, respectively.  相似文献   
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