A double‐blind,placebo‐controlled,randomized study to evaluate the weight gain drug,mirtazapine transdermal ointment,in cats with unintended weight loss     

Melinda Poole  Jessica M. Quimby  Tianhua Hu  Daizie Labelle  William Buhles 《Journal of veterinary pharmacology and therapeutics》2019,42(2):179-188

Mirtazapine is classified as a weight gain drug in cats, and the purpose of this study was to evaluate its efficacy in cats experiencing unintended weight loss. This was a multi‐center, double‐blind, placebo‐controlled, randomized clinical study in client‐owned cats ≥1 year of age, weighing ≥2 kg, with a documented loss (≥5%) in body weight. Cats were treated once daily with either 2 mg/cat mirtazapine transdermal ointment (n = 83) or placebo (n = 94) (Per Protocol population) applied to the inner surface of the pinna for 14 ± 3 days. Physical examination, body weight, complete blood count, serum chemistry, and urinalysis were performed prior to treatment and on Day 14. Changes in body weight between the mirtazapine and placebo groups were evaluated from Day 1 to Day 14 and compared using a two‐sample t test. The mean percent change in body weight was +3.9% (standard deviation ±5.4%) in the mirtazapine group and +0.4% (±3.3%) in the placebo group (p < 0.0001). The most common adverse event was mild erythema at the application site in 17.4% of placebo and 10.4% of mirtazapine‐treated cats. Application of mirtazapine transdermal ointment was well tolerated both topically and systemically and resulted in significant weight gain in cats experiencing unintended weight loss associated with various underlying diseases.  相似文献   

Induction of tetraploidy in meristematically active seeds of Japanese barberry (Berberis thunbergii var. atropurpurea) through exposure to colchicine and oryzalin     

Jonathan M. Lehrer  Mark H. Brand  Jessica D. Lubell 《Scientia Horticulturae》2008

Japanese barberry (Berberis thunbergii DC) is an invasive shrub, widely naturalized across the United States, whose numerous cultivars remain an important horticultural commodity. Maintaining this crop for the future necessitates the development of sterile clones. Exposure to the mitotic inhibitors colchicine and oryzalin is a traditional method for inducing tetraploidy in breeding lines as a precursor to creating sterile genotypes. Treatments utilized pre-germinated B. t. var. atropurpurea seeds with emerged radicles. Seeds were immersed in aqueous solutions of colchicine (.02%, .05%, .1% and .2%) and oryzalin (.002%, .005%, .01% and .02%) dissolved in 1% DMSO for 6, 12 and 24 h durations. Seedling ploidy level was determined via flow cytometry following 6 and 52 weeks of growth in the greenhouse. Both anti-mitotic chemicals proved effective at inducing tetraploidy and produced comparable efficiency rates. The survival rate of treated seeds decreased in response to both increased mitotic inhibitor concentration and longer exposure duration. While exposure to oryzalin produced greater seed mortality than colchicine, most seedlings that survived had altered ploidy levels. The most efficient oryzalin concentration was 0.002% with a rating of 28%, while the most efficient colchicine concentrations were in the range from 0.05% to 0.2%. Duration of exposure to mitotic inhibitor was not a significant factor over the range from 6 to 24 h. Reversion of tetraploid plants to the diploid state occurred at a low frequency following a dormancy period. Some tetraploid seedlings derived from exposure to both chemicals displayed foliar abnormalities including irregular leaf margins and mottled lamina. The primary advantage of colchicine was low seedling toxicity, while oryzalin was notable for its ability to induce tetraploidy at low concentrations.  相似文献   

Retinal detachment and glaucoma in the Boston Terrier and Shih Tzu following phacoemulsification (135 patients): 2000–2014          下载免费PDF全文

Braidee C. Foote  Samantha L. Pederson  Anja Welihozkiy  Jessica M. Stine  Susan M. Carastro  Stacy E. Andrew  Tammy M. Michau 《Veterinary ophthalmology》2018,21(3):240-248

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Distribution of alveolar‐interstitial syndrome in dogs and cats with respiratory distress as assessed by lung ultrasound versus thoracic radiographs          下载免费PDF全文

Jessica L. Ward DVM  DACVIM  Gregory R. Lisciandro DVM  DACVECC  Teresa C. DeFrancesco DVM  DACVIM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2018,28(5):415-428

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Application of unmanned aerial systems for high throughput phenotyping of large wheat breeding nurseries     

Atena?Haghighattalab  Lorena?González Pérez  Suchismita?Mondal  Daljit?Singh  Dale?Schinstock  Jessica?Rutkoski  Ivan?Ortiz-Monasterio  Ravi?Prakash?Singh  Douglas?Goodin  Jesse?PolandEmail author 《Plant methods》2016,12(1):35

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Substitution of fish meal by soybean meal in diets for juvenile marbled spinefoot,Siganus rivulatus     

Samer Monzer  Nivin Nasser  Jessica Babikian 《Journal Of Applied Aquaculture》2017,29(2):101-116

The present work was performed to assess whether soybean meal (SBM) could replace fish meal (FM) as a source of dietary protein in diets of the marine herbivore Siganus rivulatus. Five iso-nitrogenous (40% protein) and iso-energetic (14 MJ/Kg) diets were prepared with SBM replacing fish meal at 0%, 25%, 50%, 75%, and 100% dietary protein. A 60-day feeding trial was conducted with 240 juvenile S. rivulatus (initial body mass 1.74 ± 0.03 g). Survival, growth, feed, and protein efficiency and hematological parameters were assessed. Growth correlated negatively with increase in dietary SBM. All production parameters measured were negatively affected at all levels of SBM inclusion. There were no effects on total or differential blood counts, hemoglobin, or plasma protein, but hematocrit values were negatively correlated with SBM addition. Results suggest that total replacement of FM by SBM without adding other supplements is not recommended, even for an herbivorous marine fish such as S. rivulatus.  相似文献   

Osmoregulatory and immunological status of the pond-raised striped catfish (<Emphasis Type="Italic">Pangasianodon hypophthalmus</Emphasis> S.) as affected by seasonal runoff and salinity changes in the Mekong Delta,Vietnam     

Mélodie Schmitz  Sébastien Baekelandt  Lam Khoa Tran Thi  Syaghalirwa N. M. Mandiki  Jessica Douxfils  Thinh Quoc Nguyen  Huong Do Thi Thanh  Patrick Kestemont 《Fish physiology and biochemistry》2017,43(1):39-49

In Vietnam, the production of striped catfish Pangasianodon hypophthalmus S. reached more than 1.2 millions of tons in 2014 and is mainly gathered in the Mekong Delta (South Vietnam). A survey was carried out during the dry season 2013 (March–April) and rainy season 2014 (July–August) in 12 fish farms of the lower (Tra Vinh Province) and higher (Can Tho Province) Mekong River Delta. This study allowed drawing up current key osmoregulatory and innate immune parameters of striped catfish in aquaculture depending on the geographical location, particularly the proximity to the River Mekong Estuary and the seasonal surface runoff. In the dry season, plasma osmolality was positively correlated with salinity. Gill Na⁺K⁺ ATPase dropped in the rainy season, while kidney Na⁺K⁺ ATPase remained stable. Abundance of immune blood cells, especially thrombocytes and monocytes, tended to increase in farms located in tidal area. Production of reactive oxygen species in the spleen, kidney lysozyme activity and plasma complement activity did not vary whatever the season or the proximity to the estuary. Plasma lysozyme activity was 50-fold higher than in kidney and increased in the rainy season as well as in tidal sites. Kidney complement activity decreased in the dry season, especially in tidal sites. In conclusion, regarding key osmoregulatory and immune factors, striped catfish farms located in the Mekong Delta may be affected by seasonal and regional salinity and runoff fluctuations.  相似文献   

Survival and respiration of marbled rabbitfish (Siganus rivulatus) fingerlings at various oxygen tensions          下载免费PDF全文

Jessica Babikian  Nivin Nasser  Samer Monzer  Imad Patrick Saoud 《Aquaculture Research》2017,48(8):4219-4227

Marbled rabbitfish, Siganus rivulatus, is an economically valuable herbivorous fish and a potential candidate for warmwater aquaculture. This study was carried out to: (1) assess the effect of various oxygen concentrations on survival and behaviour of S. rivulatus fingerlings and (2) investigate the response of S. rivulatus to hypoxia and determine its critical oxygen tension (P_crit). In the first experiment, groups of rabbitfish (15 fish per group) were maintained for 1 h in waters of various oxygen concentrations. They were then transferred to well‐aerated tanks and observed for 72 h. Survival was recorded, fish behaviour at low oxygen concentrations observed, and LC₅₀ after 1‐h hypoxia and 72‐h recovery evaluated. In the second experiment, a series of stop‐flow respirometry experiments were performed during which dissolved oxygen was allowed to drop to 0.5 mg L^?1 and respiration rate recorded at various oxygen concentrations. In the first experiment, all fish survived for 1 h at oxygen concentration of 1.44 mg L^?1 and greater, but started dying at oxygen concentrations below 0.65 mg L^?1 (16% survival). The LC₅₀ of S. rivulatus fingerlings was 0.6 mg L^?1. Results of the second experiment showed that S. rivulatus is an oxyregulator until P_crit (1.7 mg L^?1 O₂) is reached, becoming an oxyconformer below this concentration. Findings allow for a better understanding of environmental oxygen tolerances and minimum acceptable oxygen concentration in rabbitfish aquaculture.  相似文献   

Bonamia in Ostrea angasi: Diagnostic performance,field prevalence and intensity     

Jessica J. Buss  Kathryn H. Wiltshire  Thomas A. A. Prowse  James O. Harris  Marty R. Deveney 《Journal of fish diseases》2019,42(1):63-74

Bonamia spp. parasites threaten flat oyster (Ostrea spp.) farming worldwide. Understanding test performance is important for designing surveillance and interpreting diagnostic results. Following a pilot survey which found low Bonamia sp. intensity in farmed Ostrea angasi, we tested further oysters (n = 100–150) from each of three farms for Bonamia sp. using heart smear, histology and qPCR. We used a Bayesian Latent Class Model to assess diagnostic sensitivity (DSe) and specificity (DSp) of these tests individually or in combination, and to assess prevalence. Histology was the best individual test (DSe 0.76, DSp 0.93) compared to quantitative polymerase chain reaction (qPCR) (DSe 0.69, DSp 0.93) and heart smear (DSe 0.61, DSp 0.60). Histology combined with qPCR and defining a positive from either test as an infected case maximized test performance (DSe 0.91, DSp 0.88). Prevalence was higher at two farms in a high‐density oyster growing region than at a farm cultivating oysters at lower density. Parasite intensities were lower than in New Zealand and European studies, and this is probably contributed to differences in the performance of test when compared to other studies. Understanding diagnostic test performance in different populations can support the development of improved Bonamia surveillance programs.  相似文献   

Back Cover     

Jessica J. Buss  Kathryn H. Wiltshire  Thomas A. A. Prowse  James O. Harris  Marty R. Deveney 《Journal of fish diseases》2019,42(1):ii-ii

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