Doxorubicin affects the cardiac muscarinic system in the rat.     

A Chugun  T Uchide  K Temma  R H Kennedy  S V Klimberg  Y Hara  T Sasaki  T Akera 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2001,63(12):1315-1322

During the study on the mechanism of doxorubicin-induced cardiotoxicity, we observed that a long incubation (4 hr) with doxorubicin reduced the maximal negative inotropic effects of a muscarinic receptor agonist, carbachol. The mechanism responsible for this doxorubicin-induced reduction of the efficacy of carbachol was examined in isolated guinea pig hearts. In isolated left atrial muscle preparations, 1 hr incubation with 100 microM doxorubicin caused a parallel right-ward shift of the concentration-response curves for carbachol, but a longer (4 hr) incubation with this agent (30, 100 or 200 microM), caused a significant reduction of the magnitude of the negative inotropic effect of carbachol in addition to the concentration-dependent parallel right-ward shift. The 4-hr incubation with these concentrations of doxorubicin also reduced the maximal negative inotropic effect of an adenosine A1 receptor agonist, R-phenylisopropyl adenosine (R-PIA), without affecting the potency of this agonist. Doxorubicin (1 to 100 microM) reduced [3H]quinuclidinyl benzilate (QNB) binding in a concentration dependent manner, but failed to alter [3HIR-PIA binding. The decrease in the magnitude of the maximal negative inotropic effect by doxorubicin was caused by changes in the muscarinic system at steps common to the transduction of muscarinic and adenosine A1 receptor mechanisms.  相似文献   

Acupuncture for general veterinary practice.     

W W Chan  K Y Chen  H Liu  L S Wu  J H Lin 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2001,63(10):1057-1062

Since the International Society of Veterinary Acupuncture (IVAS) was founded in 1974, acupuncture (AP) has received greater acceptance by veterinary professionals throughout the world. This article introduces some important animal diseases that respond well to AP therapy. These include resuscitation of small animals, treatment of anoestrous gilts and sows, bovine reproductive disease, canine vertebral problems and equine backpain, etc. Conventional medicine considers these to be difficult cases to treat. Veterinarians have become more aware of the benefits of AP especially for those diseases, thanks to the efforts of experienced practitioners and scientists, and the many published reports on veterinary AP that have introduced some good indications for AP therapy in veterinary practice. Possible mechanisms behind the effectiveness of AP are discussed. This article aims to introduce veterinarians to good indications for AP to initiate their interest in the practice of AP. Although this is a rapidly expanding field, a long march must begin with one step. We wish this article to be the shoes for such a march. For more information on veterinary AP, contact IVAS , P.O. Box 1478, Longmont, CO.. 80502, USA (http://www.ivas.org), or your national veterinary acupuncture society (http://www.komvet.at/ ivadkom/vapsocs.htm).  相似文献   

银川地区羊肝中阿苯达唑(丙硫苯咪唑)残留情况的调查   总被引：1，自引：0，他引：1  

倪泽成刘辛赟  武占银马立均夏国振  蒋安文张惠英李春和  沙涌波 《中国动物检疫》2004,21(9):29-30

阿苯达唑又称丙硫苯咪唑或丙硫咪唑，有时又称抗蠕敏，是目前国内常用的驱虫效果好、范围广、毒性较低的兽用驱虫药。随着家庭舍饲养羊规模的不断扩大，饲养者为了减少因寄生虫导致的死亡并增加育肥效果，常把阿苯达唑作为育肥前预防驱虫或寄生虫病治疗的首选药，出现了滥用或超剂量使用的现  相似文献   

播量对水稻生长发育及干物质积累的影响     

李忠杰  矫江  王连敏  王春艳  王立志  刘功  焦占力 《北方水稻》2004,(1):18-20

用盆栽方法进行播量对寒地水稻生长发育及干物质积累影响试验,结果表明:稀播的秧苗发根力强、分蘖多、茎基宽、充实度高。播量200g/m2的产量最高。  相似文献   

大白菜耐热性遗传效应研究   总被引：19，自引：2，他引：17  

吴国胜  王永健 《园艺学报》1997,24(2):141-144

以两组耐热和热敏感的大白菜对应亲本（１７７与２７６；１７６与２７９）及其杂交、回交世代（Ｆ１、Ｆ２、Ｂ１、Ｂ２）为材料进行耐热性遗传模型分析和遗传参数估算，得到一致的结果：大白菜的耐热性符合加性－显性－上位性模型，以加性遗传效应为主，兼有上位性效应，显性效应不显著。广义遗传力和狭义遗传力均较高。以耐热和热敏感的５个代表性亲本材料采用Ｇｒｉｆｉｎｇ的双列杂交方法Ⅱ配制杂交组合进行配合力分析，结果表明：加性遗传方差组分很高，而显性遗传方差组分很小，与上述结果一致。同时，耐热亲本材料１７６和１７７均有较高的一般配合力效应值，是耐热性选育的较好亲本材料。  相似文献   

Acid-induced autoagglutination found in chicken pathogenic Escherichia coli strain.     

T Sekizaki  Y Nakasato  I Nonomura 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》1992,54(3):493-499

Chicken pathogenic Escherichia coli strains were found to autoagglutinate in a static culture of trypticase soy broth (TSB). One strain, designated PDI-386, was further studied for its autoagglutinating property. Acidity in the cultured medium caused by glucose degradation induced the autoagglutination. The bacterial cells grown in a glucose-free L-broth could be aggregated by adding acid, which suggests a potentiality of autoagglutination of the strain grown in the L-broth. The autoagglutinating parent (Agg) formed small colonies with irregular edges like rough colonies on the TS agar, whereas its non-autoagglutinating variant (Nag) formed larger smooth colonies with a perfectly round edge. The Nag colony was easily generated from the Agg colony on the TS agar. The autoagglutinating property was very unstable when the bacteria was passed in the TSB, but rather stable in the L-broth. Under electron microscope, the Agg were found to possess pili of more than 20 microns in length. However, the phenotypic expression of autoagglutination did not correlate with that of mannose-sensitive hemagglutination against guinea pig erythrocytes. Incubation of the Nag in the L-broth at room temperature for more than 10 days provoked the reversion of the autoagglutination. There was no difference between the Agg and the Nag in terms of surface hydrophobicity, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) patterns of membrane proteins and LPS, and plasmid profiles. The virulence of the Agg was higher than that of the Nag. The autoagglutination property is, however, so unstable that the pathogenicity of E. coli isolates from chickens should be carefully evaluated.  相似文献   

Characterization of phosphate species in urban sewage sludges by high-resolution solid-state ³¹P NMR     

E. FROSSARD  P. TEKELY  J.Y. GRIMAL 《European Journal of Soil Science》1994,45(4):403-408

The mineral forms of phosphorus in three urban sewage sludges were characterized using high-resolution solid-state phosphorus-31 nuclear magnetic resonance (NMR) coupled to a sequential extraction. The sludges studied were an anaerobically-digested and heat-treated sludge (Paris-Achères), an activated sludge (Briare) and an anaerobically-digested sludge (Nancy). NMR observations were conducted using both single-pulse and cross-polarization sequences in order to distinguish between ³¹P nuclei far from ¹H nuclei, and ³¹P located within a fraction of a nanometre of ¹H. This approach showed that a complex mixture of P species was present in these sludges. A mixture of hydrogenated octocalcium phosphates and apatites was observed in the three samples. Monetite was present in the anaerobically-digested sludge and brushite in the activated sludge. Dehydrogenated condensed calcium phosphates (compounds with a Ca:P ratio higher than 1.0 such as fluorapatite or tricalcium phosphate) and dehydrogenated pyrophosphates were also probably present in the anaerobically-digested sludge. A poorly-ordered wavellite was observed in the three sludges after the HCl extraction. However, results were inconclusive as to whether this mineral was present in the three sludges, or had been precipitated during the sequential extraction.  相似文献   

活性炭吸附痕量银的研究   总被引：3，自引：0，他引：3  

蒋婷  施荫锐 《林产化学与工业》1996,16(2):49-53

在静态、动态吸附条件下，分别选用果壳类净水用活性炭和煤质净水用活性炭对胶片工业废水中的痕量银的吸附行为进行了研究．结果表明，废水中的银浓度可降至＜５０ｐｐｂ，活性炭对银的吸附量达到３～５ｍｇ／ｇ．微孔发达的活性炭更适于吸附废水中的痕量银．随着银液浓度的升高，银液量增大，活性炭吸附能力增加．银液的最佳吸附ｐＨ值是５．  相似文献   

恩肥对平菇菌丝生长,产量及品质的影响   总被引：1，自引：0，他引：1  

蒋冬花  张萍华 《食用菌学报》1997,4(1):25-30

本文报道了恩肥的施用浓度、施用时期对平菇菌丝生长、产量和品质的影响。试验结果表明,施用恩肥可促进平菇菌丝生长和子实体发育,有利于提高产量及改善品质。用肥量为每1000ml PDA或每公斤干培养料0.2～0.3ml时,菌丝生长速度显著加快,长满袋的时间可缩短4～5d,子实体产量可提高45.7％～55.9％,蛋白质、必需氨基酸和非必需氨基酸分别增加25.8％、14.94％和11.32％。在不同施肥时期中,又以现蕾期喷施效果最佳。  相似文献   

Comparative effects of mu and kappa opiate agonists on the cecocolic motility in the pony.          下载免费PDF全文

T Roger  T Bardon    Y Ruckebusch 《Canadian journal of veterinary research》1994,58(3):163-166

The electrical and mechanical activity of the large intestine and its response to administration of opiate mu and kappa agonists were assessed from electrodes and inductograph coils chronically implanted on the cecocolic segment in six ponies given a diet of hay and concentrates. Before the drugs were given, migrating complexes propagating from the cecum into the colon occurred at the rate of 1.5 to 16/hour. During this propulsive activity, the cecocolic sphincter opened and closed allowing the outflow of cecal contents and preventing the backflow of colic contents. Each pony was used as its own control and was given fentanyl (0.01 and 0.05 mg/kg of body weight, IV) and U50488H (0.1 and 0.5 mg/kg, IV) at weekly intervals. The mu agonist fentanyl elicited a marked phase of inhibition of the propulsive activity and a closure of the cecocolic sphincter that lasted one to two hours depending on the dose. The kappa agonist U50488H induced an inhibition of the short spiking activity, i.e. of the resting muscle tone. It did not disturb the occurrence of migrating complexes nor that of the openings of the cecocolic sphincter. These kappa compounds may be drugs of choice to alleviate visceral pain in colic stases without inducing delay of transit unlike mu compounds.  相似文献