Maritime Halophyte Species from Southern Portugal as Sources of Bioactive Molecules     

Maria Jo?o Rodrigues  Katkam N. Gangadhar  Catarina Vizetto-Duarte  Sileshi G. Wubshet  Nils T. Nyberg  Luísa Barreira  Jo?o Varela  Luísa Custódio 《Marine drugs》2014,12(4):2228-2244

Extracts of five halophytes from southern Portugal (Arthrocnemum macrostachyum, Mesembryanthemum edule, Juncus acutus, Plantago coronopus and Halimione portulacoides), were studied for antioxidant, anti-inflammatory and in vitro antitumor properties. The most active extracts towards the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical were the methanol extracts of M. edule (IC₅₀ = 0.1 mg/mL) and J. acutus (IC₅₀ = 0.4 mg/mL), and the ether extracts of J. acutus (IC₅₀ = 0.2 mg/mL) and A. macrostachyum (IC₅₀ = 0.3 mg/mL). The highest radical scavenging activity (RSA) against the 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical was obtained in the ether extract of J. acutus (IC₅₀ = 0.4 mg/mL) and H. portulacoides (IC₅₀ = 0.9 mg/mL). The maximum total phenolic content (TPC) was found in the methanol extract of M. edule (147 mg gallic acid equivalents (GAE)/g) and in the ether extract of J. acutus (94 mg GAE/g). Significant decreases in nitric oxide (NO) production were observed after incubation of macrophages with lipopolysaccharide (LPS) and the chloroform extract of H. portulacoides (IC₅₀ = 109 µg/mL) and the hexane extract of P. coronopus (IC₅₀ = 98.0 µg/mL). High in vitro cytotoxic activity and selectivity was obtained with the ether extract of J. acutus. Juncunol was identified as the active compound and for the first time was shown to display selective in vitro cytotoxicity towards various human cancer cells.  相似文献   

Diazaquinomycins E–G,Novel Diaza-Anthracene Analogs from a Marine-Derived Streptomyces sp.     

Michael W. Mullowney  Eoghainín ó hAinmhire  Anam Shaikh  Xiaomei Wei  Urszula Tanouye  Bernard D. Santarsiero  Joanna E. Burdette  Brian T. Murphy 《Marine drugs》2014,12(6):3574-3586

As part of our program to identify novel secondary metabolites that target drug-resistant ovarian cancers, a screening of our aquatic-derived actinomycete fraction library against a cisplatin-resistant ovarian cancer cell line (OVCAR5) led to the isolation of novel diaza-anthracene antibiotic diazaquinomycin E (DAQE; 1), the isomeric mixture of diazaquinomycin F (DAQF; 2) and diazaquinomycin G (DAQG; 3), and known analog diazaquinomycin A (DAQA; 4). The structures of DAQF and DAQG were solved through deconvolution of X-Ray diffraction data of their corresponding co-crystal. DAQE and DAQA exhibited moderate LC₅₀ values against OVCAR5 of 9.0 and 8.8 μM, respectively. At lethal concentrations of DAQA, evidence of DNA damage was observed via induction of apoptosis through cleaved-PARP. Herein, we will discuss the isolation, structure elucidation, and biological activity of these secondary metabolites.  相似文献   

Cytogenetic and marker assisted identification of a wheat–Psathyrostachys huashanica Keng f. ex P.C.Kuo alien substitution line conferring processing quality and resistance to stripe rust     

Qu  Xiaojian  Zhang  Deshi  Zhang  Xiangyu  Wang  SiWen  Wang  Changyou  Wang  Yanzhen  Wang  Yajuan  Chen  Chunhuan  Zhang  Hong  Ji  Wanquan 《Genetic Resources and Crop Evolution》2022,69(2):687-698

Genetic Resources and Crop Evolution - Psathyrostachys huashanica Keng f. ex P.C.Kuo (2n?=?2x?=?14, NsNs) harbor numerous useful genes and exhibit application prospects as a...  相似文献   

Chronosequence of Technosols at the Peña Colorada mine in Colima,Mexico: a short-term remediation alternative     

Ortega  Jaime Díaz  Sedov  Sergey  Romero  Francisco  Jardines  Luis Gerardo Martínez  Rebolledo  Elizabeth Solleiro 《Journal of Soils and Sediments》2022,22(3):942-956

Journal of Soils and Sediments - The objective of this study was to examine the pedogenetic evolution occurring in technic hard materials from an iron mine through the characterization of a...  相似文献   

The impact of initial concentration of selected pharmaceuticals on their early stage of dissipation in soils     

Menacherry  Sunil Paul M.  Kočárek  Martin  Kacerova  Tereza  Kotíková  Zora  Kačer  Petr  Kodešová  Radka 《Journal of Soils and Sediments》2022,22(2):522-535

Journal of Soils and Sediments - Dissipation of pharmaceutical compounds entered into the natural environment is an important process minimizing the adverse effects on the living organisms. The aim...  相似文献   

Phosphorus fractionation and adsorption characteristics in drinking water reservoir inlet river sediments under human disturbance     

Fu  Zihao  Hong  Zijin  Wei  Junling  Liao  Yukai  You  Songlin  Wang  Yifan  Lv  Jianjing  Feng  Huan  Kolenčík  Marek  Chang  Xuexiu  Qian  Yu 《Journal of Soils and Sediments》2022,22(9):2530-2547

Journal of Soils and Sediments - Sediment phosphorus fractionation, adsorption kinetics, and adsorption isotherm characteristics were studied in two rivers, Muyang River and Lengshui River in...  相似文献   

Impacts of tillage and nutrient management on soil porosity trends in dryland agriculture     

Noemí Mateo-Marín  Àngela D. Bosch-Serra  Maria G. Molina  Rosa M. Poch 《European Journal of Soil Science》2022,73(1):e13139

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In Vitro Anti-Inflammatory Activity of Three Peptides Derived from the Byproduct of Rice Processing     

Qu  Tingmin  He  Shuwen  Ni  Ce  Wu  Ying  Xu  Zhou  Chen  Mao-Long  Li  Honghui  Cheng  Yunhui  Wen  Li 《Plant foods for human nutrition (Dordrecht, Netherlands)》2022,77(2):172-180

Plant Foods for Human Nutrition - Inflammation is a contributing factor to the initiation and progression of many diseases, and some food-derived biofunctional peptides show high anti-inflammatory...  相似文献   

Phaseolus vulgaris L. Leaves Increase Short-Chain Fatty Acid (SCFA) Production,Ameliorating Early Metabolic Alterations     

Becerril-Campos  Adriana Araceli  Ocampo-Anguiano  Perla Viridiana  Mondragón-Jacobo  Candelario  Escobar-García  Konisgmar  Camacho-Barrón  Mariela  Anaya-Loyola  Miriam Aracely  Feregrino-Perez  Ana Angélica  García-Gasca  Teresa  Ahumada-Solórzano  Santiaga Marisela 《Plant foods for human nutrition (Dordrecht, Netherlands)》2022,77(3):421-426

Plant Foods for Human Nutrition - High-fat/high-fructose diets promote early metabolic disorders in weight and lipid and glucose metabolism. Bioactive compounds such as polyphenols and fiber...  相似文献   

Starch Digestion in Infants: An Update of Available In Vitro Methods—A Mini Review     

Rodríguez  Marianela Desireé  León  Alberto Edel  Bustos  Mariela Cecilia 《Plant foods for human nutrition (Dordrecht, Netherlands)》2022,77(3):345-352

Plant Foods for Human Nutrition - Complementary feeding starts at around six months of age because neither breast milk nor formula assure the proper nutrition of infants. Therefore, along...  相似文献