SnakeMap: four years of experience with a national small animal snake envenomation registry     

M Boller  K Kelers  MA Stevenson  KD Winkel  S Hardjo  J Heller  PR Judge  HM Ong  AM Padula  C Reddrop  LCP Santos  CR Sharp  L Smart  KL Swindells  D Tabrett  JR Wierenga 《Australian veterinary journal》2020,98(9):442-448

SnakeMap is a national cloud-based, veterinary snakebite registry. It was designed to prospectively collect data of the clinical circumstances and temporospatial information on cases of snake envenomation in dogs and cats. We herein introduce the project and summarise the data from the first 4 years of SnakeMap. The registry is a veterinary community-based online database allowing case entry from veterinary hospitals across Australia. Registry data comprise hospital characteristics, patient characteristics, envenoming snake type, treatment and outcome variables, including time and geolocation of the snake bite. We present summative information on select key variables from the SnakeMap registry (1 July 2015 to 30 June 2019). Twenty-eight hospitals from 6 states/territories entered 624 cases into the registry, including 419 dogs (67%) and 205 cats (33%). Bite time was available in 216 animals of which 90 (42%) were reported to be bitten in the 3 hours between 03:00 pm and 05:59 pm; median bite to presentation interval was 60 (interquartile range [IQR] 30, 211) minutes in dogs and 95 (IQR 41, 238) minutes in cats. Bites occurred in the owner's yard in 356 dogs (85%) and 53 cats (26%). A snake venom detection kit was used in 172 cases (28%) and antivenom was administered in 523 cases (85%). Most animals (n = 534, 88%) survived to discharge (median hospitalisation of 25 [IQR 16, 62] hours). SnakeMap effectively collects relevant clinical data from dogs and cats with presumed snake bite and provides locally specific information on the epidemiology of snake envenomation in small animals.  相似文献   

Dynamic surface water distributions influence wetland connectivity within a highly modified interior landscape     

Blake A. Barbaree  Matthew E. Reiter  Catherine M. Hickey  Nathan K. Elliott  Danica Schaffer-Smith  Mark D. Reynolds  Gary W. Page 《Landscape Ecology》2018,33(5):829-844

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Students’, colleagues’ and research partners’ experience about work and accomplishments from collaborating with Robin Thompson     

John Hickey  William G. Hill  Agustin Blasco  Neil Cameron  Brian Cullis  Brian McGuirk  Esa Mntysaari  John Ruane  Geoff Simm  Roel Veerkamp  Peter M. Visscher  Naomi R. Wray 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2019,136(4):301-309

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In vitro antimicrobial activity of seven adjuvants against common pathogens associated with canine otitis externa     

Wei Yee Chan  Manouchehr Khazandi  Elizabeth E. Hickey  Stephen W. Page  Darren J. Trott  Peter B. Hill 《Veterinary dermatology》2019,30(2):133-e38

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Repurposing Ionophores as novel antimicrobial agents for the treatment of bovine mastitis caused by Gram‐positive pathogens          下载免费PDF全文

Elizabeth E. Hickey  Hui San Wong  Manouchehr Khazandi  Abiodun D. Ogunniyi  Kiro R. Petrovski  Sanjay Garg  Stephen W. Page  Ryan O'Handley  Darren J. Trott 《Journal of veterinary pharmacology and therapeutics》2018,41(5):746-754

Increasing reports of multidrug‐resistant bacterial infections in animals has created a need for novel antimicrobial agents that do not promote cross‐resistance to critically important antimicrobial classes used in human medicine. In response to the recent emergence of antimicrobial resistance in several bovine mastitis pathogens, in vitro antimicrobial susceptibility was determined for four polyether ionophores (lasalocid, monensin, narasin and salinomycin) against Staphylococcus spp. and Streptococcus spp. isolated from clinical cases. In addition, erythrocyte haemolysis and WST ‐1 cell proliferation assays were used to assess in vitro mammalian cell cytotoxicity and biofilm susceptibility testing was performed using the minimum biofilm eradication concentration (MBEC ?) biofilm assay. Lasalocid, monensin, narasin and salinomycin exhibited bacteriostatic antimicrobial activity against all pathogens tested, including methicillin‐resistant staphylococci, with MIC ₉₀ values <16 μg/ml. Narasin and monensin displayed the least toxicity against mammalian cell lines and all compounds significantly reduced viable cell numbers in a Staphylococcus aureus biofilm. Based on in vitro characterization, all four ionophores offer potentially novel treatments against bovine mastitis but in vivo studies will be essential to determine whether acceptable safety and efficacy is present following intramammary administration.  相似文献   

IN VITRO EVIDENCE OF REGENERATION OF ACTIVE PENICILLIN FROM PENICILLIN ESTERS     

Hickey RJ 《Science (New York, N.Y.)》1945,101(2627):462-463

It has been found that methyl and ethyl esters of penicillin may be hydrolyzed in vitro to yield 26 and 16 per cent. respectively of the theoretical bacteriostatically active penicillin.  相似文献   

Rapid phenotyping for adult‐plant resistance to stripe rust in wheat     

Lee T. Hickey  Peter M. Wilkinson  Cheridan R. Knight  Ian D. Godwin  Olena Y. Kravchuk  Elizabeth A. B. Aitken  Urmil K. Bansal  Harbans S. Bariana  Ian H. De Lacy  Mark J. Dieters 《Plant Breeding》2012,131(1):54-61

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Regulation of Insulin Action by Diet and Exercise     

Stacy L. Schmidt  Matthew S. Hickey 《Journal of Equine Veterinary Science》2009

The regulation of the cellular actions of the hormone insulin is essential to the maintenance of macronutrient metabolism, body weight regulation, and a surprisingly diverse range of other integrative physiologic functions. Because of the diverse targets of insulin action, any dysfunction in insulin is likely to have systemic consequences. Although type 1 and type 2 diabetes are the most obvious clinical consequences of impaired insulin synthesis and insulin action, respectively, there are also subclinical disorders that attend defects in the function of insulin. In humans and horses, the “metabolic syndrome” is characterized by a cluster of metabolic sequelae that arise as a result of insulin resistance. Importantly, both diet and exercise can regulate insulin action and can thus be leveraged as treatment tools to prevent and treat the metabolic syndrome. The aim of this review is to characterize the integrative biology of insulin action and to describe the role of diet and exercise in regulating tissue responsiveness to insulin.  相似文献   

Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction     

Lavoie JP  Léguillette R  Pasloske K  Charette L  Sawyer N  Guay D  Murphy T  Hickey GJ 《American journal of veterinary research》2002,63(4):579-585

OBJECTIVE: To evaluate whether the leukotriene (LT) D4 receptor antagonist L-708,738 is therapeutically beneficial in treating horses with recurrent airway obstruction (heaves). ANIMALS: 12 adult horses with heaves and healthy lung lobes from 20 slaughtered horses. PROCEDURE: Lung lobes were used for smooth muscle tension and radioligand binding studies. Horses with heaves were given a placebo for 14 days and administered L-708,738 (n = 6; 2.5 mg/kg PO, q 12 h) or dexamethasone (6; 0.04 mg/kg, IV, q 24 h) from days 14 to 28. Pulmonary function was measured weekly for 36 days, and bronchoalveolar cells were collected on days 0,14, and 29 for cytologic examination. RESULTS: Nanomolar concentrations of L-708,738 were effective at antagonizing LTD4-induced bronchoconstriction and LTD4-receptor binding in lung lobes. Mean peak and trough L708,738 plasma concentrations during the treatment period were 1.54 and 0.28 microM, respectively. On days 21 and 29, lung mechanics were significantly improved in the dexamethasone-treated horses but not in the L-708,738-treated horses. Neither dexamethasone nor L-708,738 had a significant effect on cytologic findings. CONCLUSIONS AND CLINICAL RELEVANCE: L-708,738 was bioavailable after oral administration and sustained concentrations in plasma during the dosing period that exceeded in vitro efficacy values. However, airway function did not improve, suggesting that either drug concentrations in the lungs were subtherapeutic or that cysteinyl LT may not be important mediators of airway inflammation in heaves. Results provide the first evidence of cysteinyl LT1 receptors in airways of horses.  相似文献   

Malignant Sertoli Cell Tumour in a Young Simmenthal Bull – Clinical and Pathological Observations     

KL Jensen  L Krag  GB Boe‐Hansen  HE Jensen  H Lehn‐Jensen 《Reproduction in domestic animals》2008,43(6):760-763

Tumours are rare in the bovine testicle. A case of malignant Sertoli cell tumour in a 29‐month‐old Simmenthal bull that was hospitalized with a history of severe unilateral scrotal swelling is reported. On inspection and palpation, the scrotal sac was found enlarged with fluctuant content in the right side. The right testicle was enlarged, hard and indolent. Also the right plexus pampiniformis and funiculus spermaticus were enlarged. Sonograms revealed severe changes in the right testicle with a loss of homogeneity and multiple hyperechogenic areas. After slaughter, the scrotum with testicles were removed and evaluated pathologically. On section, the right testicle contained areas of necrosis, haemorrhage, and mineralization. Histology showed Sertoli cells in tubular structures surrounded by dense fibrous stroma replacing normal testicular tissue. Both lymphatic and blood vessels were infiltrated by neoplastic cells. Immunohistochemically, the neoplastic cells stained positive for vimentin and negative for cytokeratin and S‐100. Based on the pathological observations a diagnosis of right‐sided malignant Sertoli cell tumour with vascular invasion and hydrocele was established.  相似文献