Improving the health of the global poor     

Jha P  Mills A  Hanson K  Kumaranayake L  Conteh L  Kurowski C  Nguyen SN  Cruz VO  Ranson K  Vaz LM  Yu S  Morton O  Sachs JD 《Science (New York, N.Y.)》2002,295(5562):2036-2039

We analyzed the technical basis for a major global program to reduce disease among the poor. Effective interventions exist against the few diseases which most account for excess mortality among the poor. Achieving high coverage of effective interventions requires a well-functioning health system, as well as overcoming a set of financial and nonfinancial constraints. The annual incremental cost would be between $40 billion and $52 billion by 2015 in 83 low-income and sub-Saharan African countries. Such a program is feasible and would avoid millions of child, maternal, and adult deaths annually in poor countries.  相似文献   

Device Applications of Side-Chain Ferroelectric Liquid Crystalline Polymer Films     

KM Blackwood 《Science (New York, N.Y.)》1996,273(5277):909-912

Side-chain ferroelectric liquid crystalline polymers are currently used in a number of applications, including displays and electrical sensors. Comparisons with existing technologies and materials indicate that relative to ceramics, such polymers have lower figures of merit but offer greater durability in sensor applications.  相似文献   

Education. Funding roller coaster for public higher education     

McPherson MS  Schapiro MO 《Science (New York, N.Y.)》2003,302(5648):1157

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Leaching of 2,4-D and dicamba from home lawns     

A. J. Gold  T. G. Morton  W. M. Sullivan  J. McClory 《Water, air, and soil pollution》1988,37(1-2):121-129

Leaching of the broadleaf herbicides 2,4-D and dicamba from home lawns was monitored with ceramic extraction plates placed at a 0.2 m depth beneath undisturbed sod. The site was located on a Merrimac sandy loam. Four treatments, consisting of two rates of herbicide applications coupled with two irrigation regimes. were evaluated on 12 plots. The low herbicide rate consisted of 1.1 and 0.1 kg ha^?1 yr^?1 of 2,4-D and dicamba, respectively. The high rate used was 3.3 and 0.33 kg ha^?1 yr^?1 of 2,4-D and dicamba applied in three equal applications. Irrigation treatments were (1) minimal irrigation to avoid drought stress and percolation from the root zone and (2) overwatering at 37.5 mm week^?1. Geometric mean concentra tions of 2,4-D ranged from 0.55 to 0.87 μg L^?1 compared to 0.26 to 0.55 μg L^?1 for dicamba. The low application-minimum irrigation treatment generated significantly higher concentrations than the other treatments for both herbicides. The low concentrations observed for both herbicides suggest that excellent degradation conditions exist in the root zone of turfgrass during the summer months when application occurs.  相似文献   

Cerebellar cortical atrophy in a baboon   总被引：1，自引：0，他引：1  

D A Sadoff  W E Giddens  W R Morton 《Veterinary pathology》1986,23(3):335-336

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The in vitro degradation of [¹⁴C]malathion by enzymatic extracts from resistant and susceptible strains of Drosophila melanogaster     

B.C. Holwerda  R.A. Morton 《Pesticide biochemistry and physiology》1983,20(2):151-160

Enzyme preparations from Drosophila melanogaster flies degraded [¹⁴C]malathion to α- and β-malathion monoacids and, hence, were considered to contain malathion carboxylesterase (ME) activity. Although ME- activity was stable during preincubation in the absence of malathion, it decreased dramatically during the course of the reaction, and could not be completely recovered by Sephadex G-25 chromatography. Furthermore, the protein fraction after chromatography still contained ¹⁴C, suggesting that the enzyme had become inhibited by a bound, ¹⁴C-labeled derivative. Extracts from a resistant (malathion-selected), an intermediate control, and the susceptible Canton S strains of D. melanogaster differed in the lability of ME activity during the reaction. This difference was partly attributed to the production of small amounts of malaoxon (2–8%) by the extracts from the more resistant strains. No consistent strain differences were found when the rate of malathion degradation was measured during the first minute of reaction, either with or without a microsomal oxidase inhibitor (metyrapone) present. These results, together with the cross-resistance of the malathion-selected strain to other insecticides and the lack of a synergistic effect of two carboxylesterase inhibitors (triphenyl phosphate and S,S,S-tributylphosphorotrithioate) suggested that malathion carboxylesterase does not contribute significantly to the observed differences in malathion resistance between strains.  相似文献   

Effects of some clinically significant mycotoxins on the incorporation of DNA, RNA and protein precursors in cultured mammalian cells     

F H Jeffery  J G Morton  J K Miller 《Research in veterinary science》1984,37(1):30-38

The effects of zearalenone (F-2), ochratoxin A and T-2 toxins on the synthesis of DNA, RNA and proteins in mouse L cells were studied. F-2 toxin inhibited protein synthesis to a lesser extent than DNA and RNA synthesis, whereas ochratoxin A inhibited the synthesis of each equally. Exposure to the toxins for 24 hours relatively reduced the synthetic ability of the cells. T-2 toxin inhibited protein and DNA synthesis in parallel but RNA synthesis to a lesser extent. Enhanced incorporation of tritiated thymidine was found when L cells were exposed to 0.4 to 0.016 ng of T-2 toxin ml-1 for 24 hours.  相似文献   

Hemodynamics in the guinea pig after anesthetization with ketamine/xylazine   总被引：2，自引：0，他引：2  

M V Hart  J R Rowles  A R Hohimer  M J Morton  J D Hosenpud 《American journal of veterinary research》1984,45(11):2328-2330

The resting hemodynamics were determined in 8 guinea pigs after they were anesthetized with ketamine/xylazine. Measurements were made of blood pressure, heart rate, cardiac output, arterial blood gases, and pH. These measurements were obtained initially at 4 to 5 hours after an injection (IM) of ketamine HCl (25 mg) and xylazine (0.15 mg) was given to anesthetize the animals for catheterization (period 1), again 5 days after the operation (period 2), and finally 4 to 5 hours after a 2nd injection of ketamine/xylazine (period 3). There were no differences in heart rates, respiratory rates, or cardiac outputs among the 3 study periods. However, arterial blood pressure was slightly, but significantly, lowered after, and presumably due to, instrumentation (62 +/- 4 mm of Hg, P less than 0.05) when compared with the 5-day postoperative period (67 +/- 7 mm of Hg) or after the readministration of anesthetics (66 +/- 7 mm of Hg). The partial pressure of carbon dioxide in the arterial blood was slightly lower (4 mm of Hg, P less than 0.05) in both acutely postanesthetic periods (period 1 and period 3) than in the same animals at postoperative day 5 (period 2). This study has demonstrated that resting hemodynamics measured shortly after this anesthesia with ketamine/xylazine are not largely different from those in chronically instrumented animals.  相似文献   

Use of DNA fingerprint analysis in identification of the sire     

D B Morton  R E Yaxley  I Patel  A J Jeffreys  S J Howes  P G Debenham 《The Veterinary record》1987,121(25-26):592-594

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Application of a scaling model to establish and validate an interval level pain scale for assessment of acute pain in dogs     

Morton CM  Reid J  Scott EM  Holton LL  Nolan AM 《American journal of veterinary research》2005,66(12):2154-2166

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