The characteristics of short- and long-term surviving Shiba dogs with chronic enteropathies and the risk factors for poor outcome     

Hiroki Okanishi  Tadashi Sano  Yoshiki Yamaya  Yumiko Kagawa  Toshihiro Watari 《Acta veterinaria Scandinavica》2013,55(1):32

Background

The objectives of this study were to investigate the differences in the characteristics of short- and long-term surviving dogs, and the factors that predict poor outcome in Shiba dogs with chronic enteropathies (CE).

Methods

A total of 25 Shiba dogs were included in this study, and classified as either short-term (≤6 months) survivors (Ss; n=16) or long-term (>6 months) survivors (Ls; n=9). The clinical and clinicopathological variables, histopathology, response to therapy, and outcomes were investigated between groups. Furthermore, these factors were tested for their ability to predict poor outcome.

Results

All CE dogs were diagnosed as having inflammatory bowel disease (IBD) with lymphocytic-plasmacytic enteritis (LPE). Age and canine inflammatory bowel disease activity index (CIBDAI) were significantly higher in the Ss group than in the Ls group (age: p = 0.035, CIBDAI: p = 0.018), as determined via univariate logistic regression analysis. According to receiver operator characteristic (ROC) curve analysis, the best predictors of poor outcome were age and CIBDAI, with the cutoffs determined as 7 years and 9 points, respectively. The majority of the cases (84%) responded to initial treatment; in particular, 75% of dogs in Ss group responded to therapy. The time to response (days) to the initial treatment in the Ss group (median 42.5 days, range: 20-91 days) was significantly shorter than that of the Ls group (median 285 days, range: 196-1026 days). Approximately half (55.5%) of the dogs in the Ls group died due to relapse of CE.

Conclusions

This study suggested that there is a high risk of early mortality in Shiba dogs with CE, particularly if the dogs are older (>7 years) and have a high CIBDAI score (>9 points). There appears to be a possibility of early mortality even if the initial treatment was efficacious. Furthermore, Shiba dogs with CE that become less responsive to initial therapy in the short-term (approximately 3 months) are more likely to have an early mortality. Thus, it is necessary to follow-up Shiba dogs with CE in the long-term, as approximately half of the long-term survivors eventually died due to a relapse of the signs.  相似文献   

Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma     

Sato M  Kanemoto H  Kagawa Y  Kobayashi T  Goto-Koshino Y  Mochizuki H  Takahashi M  Fujino Y  Ohno K  Tsujimoto H 《Veterinary journal (London, England : 1997)》2012,191(1):108-114

The clinical usefulness of BCL6 gene expression was evaluated as a prognostic indicator in dogs with high-grade B-cell lymphoma. Forty-four dogs were diagnosed with centroblastic or B-cell immunoblastic type lymphoma according to the updated Kiel classification. BCL6 mRNA expression was measured by real-time PCR and its relationship with prognosis was analyzed. Progression-free and overall survival was not significantly different between the high BCL6 expression group (higher than the median) and the low BCL6 expression group (lower than the median) (P=0.99 and P=0.61, respectively). No correlation between BCL6 and prognosis was observed in this study, which is inconsistent with findings reported for human diffuse large B-cell lymphoma. BCL6 protein expression was not detected in the 11 dogs evaluated by immunohistochemistry. Furthermore, BCL6 protein expression was assessed in 13 archived paraffin-embedded high-grade canine lymphoma tissues and all were also negative. The results suggest that most canine high-grade B-cell lymphomas correspond to human diffuse large B-cell lymphoma with no immunohistochemical expression of BCL6.  相似文献   

Localized amyloidosis in canine mammary tumors   总被引：1，自引：0，他引：1  

Taniyama H  Kitamura A  Kagawa Y  Hirayama K  Yoshino T  Kamiya S 《Veterinary pathology》2000,37(1):104-107

Histopathologic and immunohistochemical examinations were performed on localized amyloidosis associated with mammary tumors in two dogs. These tumors were identified as adenoma and adenocarcinoma. An acellular, amorphous pale eosinophilic material (amyloid) was observed in the lumina of acini lined by neoplastic cells and in the stroma of the tumors. Concentrically laminated pale eosinophilic bodies (corpora amylacea) were also found in the lumina of the acini. Amyloid and corpora amylacea stained positively with Congo red with and without 5% potassium permanganate pretreatment and revealed a green birefringence under polarized light. Corpora amylacea showed an occasional Maltese-cross pattern. Immunohistochemically, amyloid and corpora amylacea usually stained positively with anti-bovine alpha-casein antibody but negatively with anti-human amyloid AA, anti-bovine kappa-light and lambda-light chains, anti-human lactoferrin, anti-human transferrin, anti-human secretory component, and anti-human polyglucosan antibodies. These findings suggested that the amyloid deposition in these canine mammary tumors was related to lactating casein.  相似文献   

Rabies and brucellosis immunization status and adverse reactions to rabies vaccines in veterinary students.     

K J Kagawa  B B Chomel  L Lery 《Comparative immunology, microbiology and infectious diseases》1992,15(2):79-87

Rabies pre-immunization has been recommended for high risk professions, including veterinarians. Cell-cultured rabies vaccines have considerably reduced the risk of post-vaccination neurological reactions found in earlier vaccines. However, some adverse reactions have been reported with Human Diploid Cell Vaccines. 329 French veterinary students were surveyed about their rabies and brucellosis vaccination status, the occurrence of adverse reactions to rabies vaccine, and their antibody titer monitoring practices. Questions also were asked to determine if mandatory rabies pre-exposure immunization upon entry to veterinary school motivated students to maintain their rabies pre-exposure vaccination. The overall vaccination rate was 98.5% for rabies and 17% for brucellosis. 19% of the rabies vaccinated students reported some form of adverse reaction, whatever the vaccine brand used, but not experienced systemic allergic reaction. Adverse reactions were twice more frequent in female than male students and were more frequent after primary series than revaccination series (Relative Risk = 1.76). Despite the mild reactions encountered, rabies pre-exposure vaccination has been well-accepted by French veterinary students. In contrast, vaccination against brucellosis was not as well-accepted for prophylaxis.  相似文献   

Tumor-associated antigen detected by complement-dependent antibody cytotoxicity test and immunofluorescence test in enzootic bovine lymphosarcoma   总被引：1，自引：0，他引：1  

K Okada  M Onuma  S Numakunai  Y Kagawa  K Minamino  T Ito  Y Kobayashi  N Morimoto  H Morita  K Ohshima 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1983,45(2):195-202

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Gallbladder Agenesis in 17 Dogs: 2006–2016          下载免费PDF全文

K. Sato  M. Sakai  S. Hayakawa  Y. Sakamoto  Y. Kagawa  K. Kutara  K. Teshima  K. Asano  T. Watari 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(1):188-194

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Preoperative Differential Diagnosis of Canine Adrenal Tumors Using Triple‐Phase Helical Computed Tomography          下载免费PDF全文

Orie Yoshida  Kenji Kutara  Mamiko Seki  Kumiko Ishigaki  Kenji Teshima  Chieko Ishikawa  Gentoku Iida  Kazuya Edamura  Yumiko Kagawa  Kazushi Asano 《Veterinary surgery : VS》2016,45(4):427-435

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Effects of rice feeding on growth performance and protein (amino acids) metabolism in weanling piglets     

Yusuke Tasaka  Kanako Tachihara  Ryutaro Kagawa  Ryozo Takada 《Animal Science Journal》2020,91(1)

We investigated the effects of rice feeding on growth performance and protein (amino acids) metabolism of weanling piglets. In all, 16 weanling piglets with an average initial weight of 7.5 kg were divided into two groups. One group was fed a corn‐soybean meal‐based diet, and the other was fed a rice‐soybean meal diet, containing around 46% of corn or rice, respectively. A two‐week growth trial was conducted. The average daily gain (p = .025) and feed efficiency (p = .011) in rice‐fed piglets were significantly higher than those in corn‐fed piglets. Liver lysine‐ketoglutarate reductase activity tended to be lower (p = .073) in rice‐fed piglets than in corn‐fed piglets. Plasma urea nitrogen concentration in rice‐fed piglets was significantly lower than that in corn‐fed piglets. Plasma glucose and insulin concentrations were significantly higher in rice‐fed piglets than in corn‐fed piglets. Plasma‐free valine, isoleucine, and tryptophan concentrations were significantly higher in rice‐fed piglets than in corn‐fed piglets. In contrast, plasma histidine concentration was significantly lower in rice‐fed piglets than in corn‐fed piglets. Overall, these results show that rice feeding improves the growth performance and affects the protein (amino acids) metabolism in weanling piglets.  相似文献   

NOD2 mRNA Expression and NFkappaB Activation in Dogs with Lymphocytic Plasmacytic Colitis     

H. Okanishi  K. Hayashi  Y. Sakamoto  T. Sano  H. Maruyama  Y. Kagawa  T. Watari 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2013,27(3):439-444

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Plasma amino acid profiles in dogs with inflammatory bowel disease     

Yu Tamura  Hiroshi Ohta  Yumiko Kagawa  Tatsuyuki Osuga  Keitaro Morishita  Noboru Sasaki  Mitsuyoshi Takiguchi 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(4):1602-1607

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