Compartmental and noncompartmental pharmacokinetic analyses of minocycline hydrochloride in the dog   总被引：1，自引：0，他引：1  

R C Wilson  J V Kitzman  D T Kemp  D D Goetsch 《American journal of veterinary research》1985,46(6):1316-1318

Six adult dogs were given 5 mg of minocycline hydrochloride/kg of body weight IV. Pharmacokinetic evaluation of the serum drug concentration versus time data was performed, using the 2-compartment open model, the 3-compartment open model, and a noncompartmental model involving use of the statistical moment theory. All pharmacokinetic values except clearance were model independent. Minocycline half-life ranged between 6.48 and 7.24 hours; volume of distribution at steady state, between 1.859 +/- 0.368 and 2.001 +/- 0.468 L/kg; and clearance, between 3.195 +/- 0.618 and 3.424 +/- 0.684 ml/min/kg. These data are similar to those reported for oxytetracycline and indicate that the frequency of administration of the 2 tetracyclines should be the same. Three of the 6 dogs developed an adverse response to the IV injection of minocycline. Dog 1 developed urticaria and had initial serum drug concentrations of approximately 2 times the mean concentrations for the other dogs; values were not included in the pharmacokinetic analysis. Two other dogs had transient signs indicating cardiovascular depression or hypotension; their data were included. Due to the frequency of the unexpected reactions found in this study, it was concluded that dogs should not be given minocycline rapidly IV.  相似文献   

Treatment of Tumor-Bearing Dogs With Actinomycin D   总被引：2，自引：1，他引：1  

Alan S. Hammer  C. Guillermo Couto  Rodney D. Ayl  Karen A. Shank 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1994,8(3):236-239

Fifty dogs with advanced malignancies were treated with actinomycin D at doses ranging from 0.5 to 1.1 mg/m² every 3 weeks. The greatest number of responses was noted in dogs with lymphoma, including dogs that had received prior chemotherapy. Other responding tumor types included anal sac adenocarcinoma, perianal adenocarcinoma, squamous cell carcinoma, thyroid carcinoma, and transitional cell carcinoma. The median time to maximum response for dogs with lymphoma was 7 days, with a median duration of 42 days. Gastrointestinal toxicity was the most frequently observed side effect. A dose of 0.6 to 0.7 mg/m² appears to be appropriate for treating various malignancies in dogs.  相似文献   

Farrowing Rate and Litter Size after Transcervical Embryo Transfer in Sows     

W. Hazeleger  B. Kemp 《Reproduction in domestic animals》1994,29(6):481-487

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Transmission of Histomonas meleagridis to domestic fowl by means of earthworms recovered from pheasant yard soil.     

R L Kemp  J C Franson 《Avian diseases》1975,19(4):741-744

Four cockerels and two poults were fed ground earthworms recovered from soil where ring-necked pheasants (Phasianus colchicus) were raised. All 4 cockerels showed mild signs of histomoniasis, and numerous Heterakis were recovered at necropsy. One of the 2 poults died, with typical gross and microscopic lesions of histomoniasis. Heterakis eggs recovered from the 4 cockerels were used to infect an additional 12 cockerels and 11 poults.  相似文献   

Effect of rate of gain and slaughter weight on lamb carcass composition   总被引：2，自引：0，他引：2  

T R Lambuth  J D Kemp  H A Glimp 《Journal of animal science》1970,30(1):27-35

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Results on the use of dog appeasement phreromone (DAP) collars in a selection of australian dogs with anxiety disorders     

Jacqui Ley  Karen Kerr  Kersti Seksel 《Journal of Veterinary Behavior: Clinical Applications and Research》2010,5(1):45-46

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Biodiversity. Confronting amphibian declines and extinctions     

Mendelson JR  Lips KR  Gagliardo RW  Rabb GB  Collins JP  Diffendorfer JE  Daszak P  Ibáñez D R  Zippel KC  Lawson DP  Wright KM  Stuart SN  Gascon C  da Silva HR  Burrowes PA  Joglar RL  La Marca E  Lötters S  du Preez LH  Weldon C  Hyatt A  Rodriguez-Mahecha JV  Hunt S  Robertson H  Lock B  Raxworthy CJ  Frost DR  Lacy RC  Alford RA  Campbell JA  Parra-Olea G  Bolaños F  Domingo JJ  Halliday T  Murphy JB  Wake MH  Coloma LA  Kuzmin SL  Price MS  Howell KM  Lau M  Pethiyagoda R  Boone M  Lannoo MJ  Blaustein AR  Dobson A  Griffiths RA 《Science (New York, N.Y.)》2006,313(5783):48

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Sociology. Looking for patterns     

Heyman K 《Science (New York, N.Y.)》2006,313(5787):606

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Association of argyrophilic nucleolar organizing regions, Ki-67, and proliferating cell nuclear antigen scores with histologic grade and survival in dogs with soft tissue sarcomas: 60 cases (1996-2002)     

Ettinger SN  Scase TJ  Oberthaler KT  Craft DM  McKnight JA  Leibman NF  Charney SC  Bergman PJ 《Journal of the American Veterinary Medical Association》2006,228(7):1053-1062

OBJECTIVE: To determine whether argyrophilic nucleolar organizing regions (AgNORs), Ki-67, and proliferating cell nuclear antigen (PCNA) scores were associated with histologic grade and survival in dogs with soft tissue sarcomas (STSs). DESIGN: Retrospective study. ANIMALS: 60 dogs with STSs. PROCEDURE: Medical records were examined and histologic specimens were reviewed. Tissue specimens obtained from archival materials were used to prepare sections for histologic staining for AgNOR and immunohistochemical staining for Ki-67 and PCNA labeling. Follow-up monitoring was obtained by reevaluation or telephone conversations with referring veterinarians or owners. RESULTS: 27 (45%) STSs were grade 1, 23 (38%) were grade 2, and 10 (17%) were grade 3. The mean and median AgNOR, Ki-67, and PCNA scores were determined, and significant positive associations among AgNOR and Ki-67 scores with histologic grade and mitotic score were detected. Fifty-four dogs had adequate follow-up examinations and were included in survival analysis and evaluation of prognostic factors. Overall median survival time was > 1,306 days. Twelve of 54 (22%) dogs died of tumor-related causes. Metastatic disease developed in 8 of 54 (15%) dogs. Results of univariate analysis indicated that increased mitotic score, increased AgNOR score, increased Ki-67 score, incomplete surgical margins, noncurative intent surgery, Ki-67 score greater than the median Ki-67 score, and AgNOR score greater than the median AgNOR score were prognostic factors for decreased survival time. Results of multivariate analysis indicated that increased AgNOR score was the only prognostic factor for decreased survival time. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that AgNORs and possibly Ki-67 should be routinely evaluated with histologic grading for STSs in dogs.  相似文献   

World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of acaricides against ticks (Ixodidae) on ruminants     

Holdsworth PA  Kemp D  Green P  Peter RJ  De Bruin C  Jonsson NN  Letonja T  Rehbein S  Vercruysse J;World Association for the Advancement of Veterinary Parasitology 《Veterinary parasitology》2006,136(1):29-43

These guidelines have been prepared to assist in the planning, conduct and interpretation of studies for the assessment of the efficacy of acaricides (excluding vaccines and other bio-control agents) against single and multi-host ticks (Ixodidae) on ruminants. Information is provided on the selection of animals, dose determination, dose confirmation and field studies, record keeping and result interpretation. The use of pen facilities is advocated for dose determination and confirmation studies for defining therapeutic and persistent efficacy. A minimum of two studies per tick species for which claims are sought is recommended for each dose determination and dose confirmation investigation. If dose confirmation studies demonstrate greater than 95% efficacy the sponsor may proceed to field studies, where a minimum of two studies per geographical location is preferred to confirm the therapeutic and persistent efficacy under field conditions. If dose confirmation studies demonstrate less than 95% efficacy then longer-term field studies can be conducted over two tick seasons with a minimum of two studies per geographical location. These studies can incorporate other control methods such as tick vaccines, to demonstrate stable long-term tick management. Specific advice is also given on conducting studies with paralysis ticks. These guidelines are also intended to assist investigators on how to conduct specific experiments, to provide specific information for registration authorities involved in the decision-making process, to assist in the approval and registration of new acaricides, and to facilitate the worldwide adoption of standard procedures.  相似文献