Transdermal absorption of a liposome-encapsulated formulation of lidocaine following topical administration in cats     

Fransson BA  Peck KE  Smith JK  Anthony JA  Mealey KL 《American journal of veterinary research》2002,63(9):1309-1312

OBJECTIVE: To determine plasma disposition after dermal application of a liposome-encapsulated formulation of lidocaine in cats. ANIMALS: 6 healthy adult cats with a mean (+/- SD) body weight of 4.1 +/- 0.44 kg. PROCEDURE: CBC determination and biochemical analysis of blood samples were performed for all cats. Cats were anesthetized by use of isoflurane, and catheters were placed IV in a central vein. The next day, blood samples were obtained from the catheters before and 1, 2, 3, 4, 6, 8, 10, 12, and 24 hours after applying a 4% liposome-encapsulated lidocaine cream (15 mg/kg) to a clipped area over the cephalic vein. Plasma concentrations of lidocaine were analyzed with a high-performance liquid chromatography assay. Results-Two cats had minimal transdermal absorption of lidocaine, with lidocaine concentrations below the sensitivity of the assay at all but 1 or 2 time points. In the other 4 cats, the median maximum plasma concentration was 149.5 ng/ml, the median time to maximum plasma concentration was 2 hours, and the median area under the concentration versus time curve from zero to infinity was 1014.5 ng.h/ml. CONCLUSIONS AND CLINICAL RELEVANCE: Maximum plasma concentrations of lidocaine remained substantially below toxic plasma concentrations for cats. On the basis of these data, topical administration of a liposome-encapsulated lidocaine formulation at a dose of 15 mg/kg appears to be safe for use in healthy adult cats.  相似文献   

Evaluation of canine gastric motility with ultrasonography     

Choi M  Seo M  Jung J  Lee K  Yoon J  Chang D  Park RD 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2002,64(1):17-21

For the evaluation of canine gastric motility with ultrasonography, contraction number of pyloric antrum and gastric emptying time (GET) by area and volume method developed by Bolondi et al.'s method were studied in 14 dogs. All experimental dogs were administered with saline and soup solution (10 ml/kg, B.W.). The mean values of contraction number of pyloric antrum in saline and soup group were 4.19 +/- 1.30/min and 4.82 +/- 0.65/min before feeding, and overall mean values were 4.66 +/- 1.37/min and 5.13 +/- 1.71/min, respectively. The mean values of the GET by area and volume method were 36.73 +/- 11.27, 40.00 +/- 8.87 min in saline group and 61.35 +/- 17.58, 59.11 +/- 14.46 min in soup group. In the GET in saline and soup groups, there was no significant difference between the area and volume method (p>0.05). Therefore, Bolondi et al.'s method by ultrasound can be used to evaluate the antropyloric motility and gastric emptying time with area and volume methods. The area method is easier to determine the GET than the volume method, but the latter is more accurate.  相似文献   

Parameter estimates for direct and maternal genetic effects on yearling, eighteen-month, and slaughter weights of Korean native cattle     

Lee JW  Choi SB  Jung YH  Keown JF  Van Vleck LD 《Journal of animal science》2000,78(6):1414-1421

Data collected by the National Livestock Research Institute of the Rural Development Administration of Korea were used to estimate genetic parameters for yearling (YWT, n = 5,848), 18-mo (W18, n = 4,585), and slaughter (SWT, n = 2,279) weights for Korean Native cattle. Nine animal models were used to obtain REML estimates of genetic parameters: DP-2 included genetic, uncorrelated dam, and residual random effects; DQ-2 included genetic, sire x region x year-season interaction, and residual random effects; DPQ-2 was based on DQ-2 but included both interaction and dam effects; DMP-2 was based on DP-2 but with dam effect partitioned to include maternal genetic and permanent environmental effects; and DMPQ-2 was based on DMP-2 but also included sire interaction effects. Those five models included two fixed factors: region x year-season and age of dam x sex effects. Models DP-3, DQ-3, DPQ-3, and DMPQ-3 were based on DP-2, DQ-2, DPQ-2, and DMPQ-2 but included as a third fixed factor whether or not identification of the sire was known. Estimates of heritability with DMPQ-3 for YWT, with DPQ-3 for W18 and SWT when analyzed with single-trait analyses were .14, .11, and .17, respectively, and were nearly the same with bivariate analyses. Estimate of maternal heritability for YWT from single-trait analysis was .04, with estimates for other traits near zero. For bivariate analyses, the estimate for YWT was .01. With single trait analysis, estimate of the direct-maternal genetic correlation for YWT was negative (-.81). Estimates of direct genetic correlations between YWT and W18, YWT and SWT, and W18 and SWT were .99, 1.00, and .97, respectively. Estimates of environmental correlations varied from .60 to .81; the largest was between W18 and SWT. Including a fixed factor for whether sire identification was missing or not missing reduced the estimate of heritability for slaughter weight. The results suggest that the sire x region x year-season interaction is important for yearling weight and may be needed in a model for slaughter weight. Maternal effects may be of slight importance for yearling weight but of no importance for W18 and SWT. Models for national cattle evaluations for Korean Native cattle for YWT should be considered that include maternal genetic and permanent environmental as well as sire x region x year-season interaction effects, but those effects seem not to be needed for models for W18 and SWT. Not much reranking of sires occurred when ranked was based on the different models for W18 and SWT.  相似文献   

Pharmacogenetics.     

Katrina L Mealey 《Veterinary Clinics of North America: Small Animal Practice》2006,36(5):961-73, v

Pharmacogenetics, the study of genetic determinants of response to drug therapy, is likely the ultimate way to establish the right drug and dose for each patient, thereby optimizing efficacy and minimizing toxicity. Despite the fact that this branch of pharmacology is still in its infancy as a science, a number of important discoveries have already contributed to improved pharmacotherapy in human and veterinary patients.  相似文献   

Genetic characterization of canine rotavirus isolated from a puppy in Korea and experimental reproduction of disease.   总被引：3，自引：0，他引：3  

Bo Kyu Kang  Dae Sub Song  Kwon Il Jung  Chul Seung Lee  Sung Jun Park  Jin Sik Oh  Dong Jun An  Jeong Sun Yang  Hyoung Joon Moon  Sang Sun Lee  Young Dhuk Yoon  Bong Kyun Park 《Journal of veterinary diagnostic investigation》2007,19(1):78-83

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Effectiveness of 99mTc-tetrofosmin for assessment of heart functions in micropigs     

Min Young Lee  Sang Hun Lee  Jae Hong Park  Jung Sun Heo  Yu Jin Lee  Han Na Suh  Jung Jun Min  Young Soon Seo  Ho Jae Han 《Journal of veterinary science (Suw?n-si, Korea)》2007,8(3):223-227

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Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings     

Byeong-Teck Kang  Jong-Hwan Lee  Dong-In Jung  Chul Park  Su-Hyun Gu  Hyo-Won Jeon  Dong-Pyo Jang  Chae-Young Lim  Fu-Shi Quan  Young-Bo Kim  Zang-Hee Cho  Eung-Je Woo  Hee-Myung Park 《Journal of veterinary science (Suw?n-si, Korea)》2007,8(4):369-376

The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery occlusion in four healthy beagle dogs using silicone plugs. They showed neurological signs of forebrain dysfunction such as reduced responsiveness, head turning, circling, postural reaction deficits, perceptual deficits, and hemianopsia. These signs gradually regressed within 4 weeks without therapy. On magnetic resonance imaging, T2 hyperintensity and T1 hypointensity were found in the cerebral cortex and basal ganglia. These lesions were well-defined and sharply demarcated from adjacent brain parenchyma with a homogenous appearance. No abnormalities of the cerebrospinal fluid were observed. At necropsy, atrophic and necrotic lesions were observed in the cerebral cortex. The cerebral cortex, basal ganglia, and thalamus were partially unstained with triphenyl-tetrazolium chloride. Histopathologically, typical features of infarction were identified in cortical and thalamic lesions. This study demonstrates that our canine model resembles the conditions of real stroke patients.  相似文献   

Effect of mixed protein silage in feed on the digestive tract and metabolism parameters in swine     

G Bolduan  H Jung  B Wittek  H Klukas 《Archives of Animal Nutrition》1985,35(3):183-196

With a view to studying the effect of acid addition, weaned piglets and fattening pigs were fed graduated amounts of protein mixed silage (pH-value 3.15 by adding 20 g H2SO4/kg) in rations of equal energy and protein levels. On average, the fattening pigs were taking in 0.26 g H2SO4/kg, whilst the amounts for piglets were 0.60 and 0.72 g H2SO4/kg. Higher acid intakes had a negative effect of energy expenditure, weight gains and feed intake. The experimental animals had significantly longer small intestines, whilst the intestine's wall was found thinner and the amount of digesta reduced and with a higher water content. The microbial activity in the stomach proved significantly inhibited. However, it was higher in the caecum as compared to the control animals. Metabolic parameters suggest that water and mineral balances are under stress. The significance of acid addition for tract flora and its metabolites is discussed. Protein mixed silage is regarded a dietetically favourable feed when given at a maximum daily amount of 25 g/kg LW or 1 kg/animal. The recommendation for dosing the daily administration of inorganic acids is as follows: max. 0.5 g acid/kg LW or 20 g/animal.  相似文献   

III. Buchbesprechungen     

E. Rohmeder  Huber  Assmann  H. W. Gebhardt  W. Kroth  A. Bernhart  J. Jung  V. Aufsess  Ernst 《European Journal of Forest Research》1961,80(3-4):122-128

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Blatt- und nadelanalytische Auswertungen bei mehrjährigen Düngungsversuchen mit Forstpflanzen in Gefäßen     

J. Jung  G. Riehle 《European Journal of Forest Research》1966,85(9-10):295-305

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