Comparison of Insulin-Induced Digital Vessel Ring Responses of Laminitic and Clinically Healthy Horses     

Changaram Venugopal  Earnestine Holmes  Ralph Beadle  Michael Kearney  Susan Eades 《Journal of Equine Veterinary Science》2014

Hyperinsulinemia leads to insulin resistance of blood vessels and interferes with circulation of laminae of the equine foot. The objective of the study was to compare the digital vessel responses of clinically healthy and laminitic horses with and without experimental induction of insulin resistance. Vessel segments (artery and vein) collected after euthanasia were cut into 3-mm wide rings and were prepared in tissue baths containing Tyrode solution for response studies. Two rings of each vessel type from each horse were used as nonresistant, and two were made insulin resistant. Insulin resistance was induced by incubating the rings with 10-μM bath concentration of insulin. Then, all rings were contracted with phenylephrine (5 μM). When the contraction reached a plateau, insulin (10 μM) was added, and the response monitored for 30 minutes. The response to insulin was calculated as a percentage of the phenylephrine response. The results showed that the responses of the nonresistant rings differed significantly between the groups. However, when all rings were made insulin resistant, the significance between the groups disappeared. In the laminitic group, responses of resistant and nonresistant rings did not differ, whereas in the healthy group, the vessel responses differed significantly. In all experiments, arterial and venous rings followed the same pattern, but the magnitudes were greater in arterial rings. The findings suggest that the vessel responses to insulin are altered in laminitis which could be due to insulin resistance.  相似文献   

Mandibular condylectomy in a standing horse for treatment for osteoarthritis of the temporomandibular joint     

R. E. Sanders  J. Schumacher  P. A. J. Brama  M. Zarelli  C. M. Kearney 《Equine Veterinary Education》2014,26(12):624-628

An Irish Sport Horse mare presented for evaluation and treatment of inability to masticate effectively with subsequent severe weight loss. A slowly expanding, firm, nonpainful mass was noted at the left temporomandibular joint. Radiographic examination revealed extensive osteoarthritic changes of this joint. Due to the age and debilitated condition of the horse, along with financial constraints on the owner's behalf, the decision was made to perform a mandibular condylectomy as a standing procedure using sedation and local and regional anaesthesia techniques. The mare tolerated the procedure very well and post operatively improved significantly.  相似文献   

NEAR's flyby of 253 mathilde: images of a C asteroid     

J Veverka  P Thomas  A Harch  B Clark  JF Bell  B Carcich  J Joseph  C Chapman  W Merline  M Robinson  M Malin  LA McFadden  S Murchie  SE Hawkins  R Farquhar  N Izenberg  A Cheng 《Science (New York, N.Y.)》1997,278(5346):2109-2114

On 27 June 1997, the Near Earth Asteroid Rendezvous (NEAR) spacecraft flew within 1212 kilometers of asteroid 253 Mathilde. Mathilde is an irregular, heavily cratered body measuring 66 kilometers by 48 kilometers by 46 kilometers. The asteroid's surface is dark (estimated albedo between 0.035 and 0.050) and similar in color to some CM carbonaceous chondrites. No albedo or color variations were detected. The volume derived from the images and the mass from Doppler tracking of the spacecraft yield a mean density of 1.3 +/- 0.2 grams per cubic centimeter, about half that of CM chondrites, indicating a porous interior structure.  相似文献   

THE LOWER AUSTRAL ELEMENT IN THE FLORA OF THE SOUTHERN APPALACHIAN REGION. A PRELIMINARY NOTE     

Kearney TH 《Science (New York, N.Y.)》1900,12(309):830-842

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Metabolism of propanil in soils   总被引：4，自引：0，他引：4  

H Chisaka  P C Kearney 《Journal of agricultural and food chemistry》1970,18(5):854-858

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Surgical treatment of a mandibular ameloblastic carcinoma with metastases to the mandibular lymph nodes in a pony     

A. M. Derham  A. Kushnir  S. Hoey  H. Jahns  A. R. Hollis  C. M. Kearney 《Equine Veterinary Education》2020,32(11):e203-e208

A 4-year-old Connemara filly was presented with a rapidly growing oral mass on the right rostrolateral mandible and a right mandibular lymphadenopathy. Radiographs of the rostral mandible revealed a lytic, infiltrative mass consistent with soft tissue and mineralised material, and displacement of tooth 403. A biopsy showed characteristic histopathological features of an ameloblastic carcinoma. Subsequent FNA of the right abnormally firm and enlarged mandibular lymph node confirmed the metastatic spread. Computed tomography of the head was performed for surgical planning, including sentinel lymph node mapping to rule out other lymph node involvement. An aggressive lesion, consistent with soft tissue of the rostral right mandible was identified with intralesional contrast injection showing drainage of contrast within the right mandibular lymph nodes (Sentinel node). Based on the infiltrative and destructive nature reported in ameloblastic carcinoma in humans, a rostral mandibulectomy was performed, along with complete mandibular lymphadenectomy. The horse recovered uneventfully from surgery. In the early post-operative period marked lymphoedema of the ventral mandibular region was observed, which resolved 4–5 days post-operatively. Optimal cosmesis was maintained post-operatively, and no recurrence has been observed to date – 12 months post-surgery.  相似文献   

A simple system to simultaneously measure volatilization and metabolism of pesticides from soils.     

P C Kearney  A Kontson 《Journal of agricultural and food chemistry》1976,24(2):424-426

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Professional burnout among female veterinarians in the United States.     

A D Elkins  M Kearney 《Journal of the American Veterinary Medical Association》1992,200(5):604-608

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Use of hair root as a source of DNA for the detection of heterozygotes for recessive defects in cattle     

PJ HEALY  JA DENNIS  JF MOULE 《Australian veterinary journal》1995,72(10):392-392

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National survey of clinical and subclinical mastitis in Jamaican dairy herds, 1985–1986     

J. Zingeser  Y. Daye  V. Lopez  G. Grant  L. Bryan  M. Kearney  M. E. Hugh-Jones 《Tropical animal health and production》1991,23(1):2-10

Summary Between April 1985 and August 1986, 89 Jamaican dairy herds with 10 or more cows were visited, 1, 645 lactating cows were examined using the CMT test and 254 composite milk samples collected for bacteriological examination. Widespread management faults were noted, especially of milking machine usage and maintenance and the abuse of antibiotics. Fifty-six per cent of all quarters were found to have CMT scores of one or higher, 0·8% showed clinical mastitis and 3·2% were blind. The most common bacterial pathogenStaphylococcus aureus, was recovered from 31% of sampled cows. The resultant milk loss from clinical and subclinical mastitis was estimated to be 20% of the potential national production.

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Resumen Se visitaron 89 hatos lecheros con 10 o más, vacas en Jamaica, entre abril 1985 y agosto 1986. Se examinaron un total ede 1·645 vacas lactantes, por medio de la prueba California para mastitis, colectando a la vez 254 muestras compuestas de leche, para exámenes, bacteriológicos. Se detectaron un sinnúmero de fallas en el manejo, especialmente relacionados con el uso y mantenimeiento de las máquinas de orde?o, y con el abuso de antibióticos. Cincuenta y seis por ciento de todos los cuartos tenían mastitis clínica y 3·2% estaban ciegos. El patógeno más común fue elStaphylococcus aureus, el cual se recuperó de 31% de las vacas examinadas. La pérdida de leche resultante de mastitis clínica o subclínica, se calculó en un 20% de la producción nacional potencial.

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Résumé Entre avril 1985 et ao?t 1986, 89 troupeaux laitiers jama?cains de 10 vaches et plus, ont fait l'objet d'une enquête. 1645 vaches en lactation ont été contr?lées à l'aide du test californien pour le dépistage de la mammite (CMT) et 254 prélèvements de lait de mélange ont été récoltés pour un examen bactériologique. Des erreurs fréquentes de conduite du troupeau ont été notées particulièrement dans l'emploid des machines à traire et dans leur entretien ainsi que dans l'abus des antibiotiques. 56 p. 100 des quartiers avaient un résultat égal ou supérieur à 1 ou plus au test californien (CMT), 0,8 p. 100 étaient atteints d'une mammite clinique et 3,2 p. 100 étaient “secs”. Le germe pathogène le plus fréquent,Staphylococcus aureus a été trouvé chez 31 p. 100 des vaches examinées. On estime a 20 p. 100 du potential national de production la perte de lait résultant de ces mammites cliniques et subcliniques.

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