Chemotherapy of equine babesiosis     

E A Carbrey  R J Avery  R C Knowles  S C Sash 《Journal of the American Veterinary Medical Association》1971,159(11):1538-1545

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Vaccinia recombinant virus expressing the rabies virus glycoprotein: safety and efficacy trials in Canadian wildlife.   总被引：1，自引：0，他引：1       下载免费PDF全文

M Artois  K M Charlton  N D Tolson  G A Casey  M K Knowles    J B Campbell 《Canadian journal of veterinary research》1990,54(4):504-507

Twenty-six meadow voles (Microtus pennsylvanicus), ten woodchucks (Marmota monax), thirteen grey squirrels (Sciurus carolinensis), thirteen ring-billed gulls (Larus delawarensis), six red-tailed hawks (Buteo jamaicensis) and eight great horned owls (Bubo virginianus) received vaccinia virus recombinant expressing the rabies virus glycoprotein (V-RG) by direct instillation into the oral cavity. Each of ten coyotes (Canis latrans) received the virus in two vaccine-laden baits. Several voles and most of the gulls died from diseases unrelated to vaccination during the observation period, but all other animals remained healthy and survived. These deaths from causes other than vaccination and the absence of any lesions suggestive of vaccinia infection indicate that it is unlikely that any animal suffered or died as a result of V-RG administration. In addition several animals showed an unexpected high level of rabies neutralizing antibodies.  相似文献   

QUANTITATIVE TC-99m-MDP JOINT SCINTIGRAPHY IN A LENTIVIRUS-INDUCED ARTHRITIS OF GOATS     

Marc  Papageorges  DVM  PhD  Patrick R.  Gavin  DVM  PhD  David D.  Barbee  DVM  MS  Ronald D.  Sande  DVM  PhD  Donald P.  Knowles  DVM  PhD  William P.  Cheevers  PhD 《Veterinary radiology & ultrasound》1991,32(2):82-86

Caprine arthritis-encephalitis (CAE) is a lentivirus-induced disease of goats used as a model for the study of lentiviral infections. Tc-99m-MDP scintigraphy was investigated as a method to quantitate the severity of joint inflammation in CAE virus-induced arthritis in six goats (12 carpi). Carpal/metacarpal Tc-99m-MDP uptake ratio was compared to a clinical indicator of joint inflammation and histopathologic grading. Quantitative joint scintigraphy provided a better correlation (r = 0.75, p < 0.001) with histopathologic grading than the clinical indicator (r = 0.18, p > 0.10). Quantitative Tc-99m-MDP joint scintigraphy should be used when non-invasive quantitation of joint inflammation is needed for pathogenetic studies of CAE.  相似文献   

BIOASSAY OF CHLORPHENAMIDINE USING LARVAE OF THE CATTLE TICK BOOPHILUS MICROPLUS     

C. O. Knowles  M.Sc.  Ph.D.  J. T. Wilson  H. J. Schnitzerling  Dip. Ind. Chem. 《Australian veterinary journal》1973,49(4):205-206

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Mycobacterium bovis infections in wild ferrets     

de Lisle GW  Crews K  de Zwart J  Jackson R  Knowles GJ  Paterson KD  MacKenzie RW  Waldrup KA  Walker R 《New Zealand veterinary journal》1993,41(3):148-149

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Comparative study of the efficacy of eprinomectin versus ivermectin, and field efficacy of eprinomectin only, for the treatment of chorioptic mange in alpacas     

D'Alterio GL  Jackson AP  Knowles TG  Foster AP 《Veterinary parasitology》2005,130(3-4):267-275

The efficacy of eprinomectin versus ivermectin (Study 1: a single-centre, randomised, treatment-controlled, blinded field trial), and the field efficacy of eprinomectin (Study 2: a single-centre, open, un-controlled field trial) for the treatment of chorioptic infestation in naturally infested alpacas were assessed in two studies. Thirty alpacas, all positive for Chorioptes sp. mite, were randomly allocated to two treatment groups in Study 1. Group A received a single topical administration of a 0.5% formulation of eprinomectin at the dose rate of 500 μg/kg. Group B received three subcutaneous administrations at 14 days interval of a 1% formulation of ivermectin at the dose rate of 400 μg/kg. Response to treatment was assessed by periodic mite count, and skin lesions scored. In Study 2, one group of 19 alpacas received four administrations at weekly interval of topical eprinomectin at the dose rate of 500 μg/kg, and response to treatment was monitored by mite counts. No localised or systemic side effects were observed in either trial. There was a statistically significant decrease in mite counts on day 7 (P < 0.001) within treatment Groups A and B of Study 1, but mite counts increased again on day 14 and remained high for the duration of the trial in both treatment groups. On day 14 of Study 2, there was a statistically significant reduction in mite counts (P < 0.008) and the mite counts remained very low throughout the remainder of the study. The eprinomectin protocol employed in Study 2, consisting of four weekly topical administrations at the dose rate of 500 μg/kg of body weight, proved highly effective at reducing the Chorioptes mite burden in alpacas.  相似文献   

Accuracy of indirect measurement of blood pressure in neonatal foals     

Giguère S  Knowles HA  Valverde A  Bucki E  Young L 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(4):571-576

The objectives of this study were to assess, in anesthetized neonatal foals, the accuracy of 2 automated indirect oscillometric monitors for measurement of mean arterial pressure (MAP), to determine the optimal site of cuff placement for MAP monitoring, and to determine the relationship between arterial blood pressure and cardiac output. Ten neonatal foals were anesthetized and instrumented with a catheter in the metatarsal artery for direct MAP monitoring and measurement of cardiac output by lithium dilution. Concurrent MAP measurements were obtained with Cardell and Dinamap oscillometric monitors with cuffs placed at 3 different sites (coccygeal, metatarsal, and median arteries). Blood pressure was manipulated by varying the depth of anesthesia and by administration of dobutamine or phenylephrine. A statistically significant (P = .025) interaction was found between the type of monitor and cuff placement site. With the Cardell monitor, placement of the cuff over the coccygeal artery resulted in a significantly lower bias than placement over the median or dorsal metatarsal artery (P < .0001 and P = .0149, respectively). No significant difference in bias was found with cuff placement site when using the Dinamap monitor. The correlation coefficient (r) between MAP and cardiac output was 0.47. Indirect oscillometry with a cuff placed over the coccygeal artery or dorsal metatarsal artery is an acceptable method for measuring MAP in foals. Blood pressure does not correlate well with cardiac output in anesthetized foals.  相似文献   

Relationships between blood Se concentrations and milk somatic cell counts in dairy cows     

Grace ND  Knowles SO  Lee J 《New Zealand veterinary journal》1997,45(4):171-172

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Comparison of the pathogenic, antigenic and molecular characteristics of two encephalomyocarditis virus (EMCV) isolates from Belgium and Greece     

F Koenen  H Vanderhallen  O Papadopoulos  C Billinis  E Paschaleri-Papadopoulou  E Brocchi  F De Simone  E Carra  N.J Knowles 《Research in veterinary science》1997,62(3):239

The pathogenicity of two porcine encephalomyocarditis virus (EMCV) isolates for sows in gestation and young piglets was studied. One virus originated from a case of reproductive failure in pigs in Belgium and the other from a case of acute myocarditis in pigs in Greece. Sows in the mid-gestation period and one- to two-month old piglets were inoculated with each isolate. The molecular relationship between both isolates was studied by determining the nucleotide sequence located across the junction of the 1C and 1D capsid-coding genes. Antigenic analysis was performed using a panel of 35 monoclonal antibodies raised against an Italian field isolate of EMCV. All three approaches revealed differences between both isolates and also confirmed that there was no link between the two outbreaks of disease.  相似文献   

Effects of well-boat transportation on the muscle pH and onset of rigor mortis in Atlantic salmon     

Gatica MC  Monti G  Gallo C  Knowles TG  Warriss PD 《The Veterinary record》2008,163(4):111-116

During the transport of salmon (Salmo salar), in a well-boat, 10 fish were sampled at each of six stages: in cages after crowding at the farm (stage 1), in the well-boat after loading (stage 2), in the well-boat after eight hours transport and before unloading (stage 3), in the resting cages immediately after finishing unloading (stage 4), after 24 hours resting in cages, (stage 5) and in the processing plant after pumping from the resting cages (stage 6). The water in the well-boat was at ambient temperature with recirculation to the sea. At each stage the fish were stunned percussively and bled by gill cutting. Immediately after death, and then every three hours for 18 hours, the muscle pH and rigor index of the fish were measured. At successive stages the initial muscle pH of the fish decreased, except for a slight gain in stage 5, after they had been rested for 24 hours. The lowest initial muscle pH was observed at stage 6. The fishes' rigor index showed that rigor developed more quickly at each successive stage, except for a slight decrease in rate at stage 5, attributable to the recovery of muscle reserves.  相似文献