Transendoscopic Laser Surgery to Correct Nasopharyngeal Obstruction Caused by Head Flexion in Horses     

Ann Kristin Barton DVM  Diplomate ECEIM  Anja Cehak DVM  Diplomate ECEIM  Karl Rohn DVM  Bernhard Ohnesorge Prof.  DVM  Diplomate ECEIM 《Veterinary surgery : VS》2014,43(4):418-424

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Additional Local Therapy With Primary Re‐Excision or Radiation Therapy Improves Survival and Local Control After Incomplete or Close Surgical Excision of Mast Cell Tumors in Dogs     

Kristin L. Kry DVM  MSc  Sarah E. Boston DVM  DVSc  Diplomate ACVS 《Veterinary surgery : VS》2014,43(2):182-189

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Can Flush and Lock Solutions Used in Human Medicine Be Applied to Large Animal IV Therapy: A Systematic Review     

James Leonard  Tracy L. SkaerMark W. Garrison  PharmD 《Journal of Equine Veterinary Science》2014

A recent shortage of prepackaged heparinized saline (HS) syringes has led to the question of whether or not normal saline (NS) can be used to both flush and lock IV catheters in large animal medicine (LAM). Moreover, several known medication incompatibilities exist with IV heparin administration. This is of particular concern in veterinary medicine where limited to no compatibility data exists between “veterinary only” (non-Food and Drug Administration approved) medications and heparin. Most of the literature on this subject is in human medicine where flushing of peripheral IV lines (PIVL) is done safely and effectively with NS. The jugular lines inserted in LAM have characteristics that are more similar to PIVLs versus most central venous access devices used in human patients. In addition, LAM catheters are of larger diameter than those typically used in human medicine thereby reducing the risk of occlusion. Based on the data evaluated, flushing and locking all LAM catheters with of NS is a reasonable alternative method for maintaining IV patency and eliminating problems associated with medication-related incompatibilities or shortages of prepackaged HS syringes.  相似文献   

Mutations in the pericentrin (PCNT) gene cause primordial dwarfism     

Rauch A  Thiel CT  Schindler D  Wick U  Crow YJ  Ekici AB  van Essen AJ  Goecke TO  Al-Gazali L  Chrzanowska KH  Zweier C  Brunner HG  Becker K  Curry CJ  Dallapiccola B  Devriendt K  Dörfler A  Kinning E  Megarbane A  Meinecke P  Semple RK  Spranger S  Toutain A  Trembath RC  Voss E  Wilson L  Hennekam R  de Zegher F  Dörr HG  Reis A 《Science (New York, N.Y.)》2008,319(5864):816-819

Fundamental processes influencing human growth can be revealed by studying extreme short stature. Using genetic linkage analysis, we find that biallelic loss-of-function mutations in the centrosomal pericentrin (PCNT) gene on chromosome 21q22.3 cause microcephalic osteodysplastic primordial dwarfism type II (MOPD II) in 25 patients. Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence. Absence of PCNT results in disorganized mitotic spindles and missegregation of chromosomes. Mutations in related genes are known to cause primary microcephaly (MCPH1, CDK5RAP2, ASPM, and CENPJ).  相似文献   

Book reviews     

John Lyon  Jan Wojcik  Sara Ebenreck Ph.D.  Kristin Shrader-Frechette  Nicholas Ellig  Lawrence Busch  Larry K. Laird  Marcie Brewster  Donald E. Voth  John H. Perkins 《Agriculture and Human Values》1985,2(4):54-75

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The mutational landscape of head and neck squamous cell carcinoma     

Stransky N  Egloff AM  Tward AD  Kostic AD  Cibulskis K  Sivachenko A  Kryukov GV  Lawrence MS  Sougnez C  McKenna A  Shefler E  Ramos AH  Stojanov P  Carter SL  Voet D  Cortés ML  Auclair D  Berger MF  Saksena G  Guiducci C  Onofrio RC  Parkin M  Romkes M  Weissfeld JL  Seethala RR  Wang L  Rangel-Escareño C  Fernandez-Lopez JC  Hidalgo-Miranda A  Melendez-Zajgla J  Winckler W  Ardlie K  Gabriel SB  Meyerson M  Lander ES  Getz G  Golub TR  Garraway LA  Grandis JR 《Science (New York, N.Y.)》2011,333(6046):1157-1160

Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs. The majority exhibited a mutational profile consistent with tobacco exposure; human papillomavirus was detectable by sequencing DNA from infected tumors. In addition to identifying previously known HNSCC genes (TP53, CDKN2A, PTEN, PIK3CA, and HRAS), our analysis revealed many genes not previously implicated in this malignancy. At least 30% of cases harbored mutations in genes that regulate squamous differentiation (for example, NOTCH1, IRF6, and TP63), implicating its dysregulation as a major driver of HNSCC carcinogenesis. More generally, the results indicate the ability of large-scale sequencing to reveal fundamental tumorigenic mechanisms.  相似文献   

Recommendations for rehabilitation after surgical treatment of cranial cruciate ligament disease in dogs: A 2017 survey of veterinary practitioners     

Jennifer Eiermann BVSc  Kristin Kirkby-Shaw DVM  MS  PhD  DACVS-SA  DACVSMR  CCRT  Richard B. Evans PhD  Sebastian C. Knell Dr med vet  DECVS  Michael P. Kowaleski DVM  DACVS  DECVS  Philipp A. Schmierer Dr med vet  DECVS  Mary S. Bergh DVM  DACVS  DACVSMR  Jason Bleedorn DVM  MS  DACVS  Laura C. Cuddy MVB  MS  DACVS-SA  DECVS  DACVSMR  DECVSMR  MRCVS  Nina R. Kieves DVM  DACVS-SA  DACVSMR  CCRT  Peter Lotsikas DVM  DACVS  DACVSMR  Antonio Pozzi DVM  MS  DACVS  DECVS  DACVSMR 《Veterinary surgery : VS》2020,49(1):80-87

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Retrospective evaluation of the induction of emesis with apomorphine as treatment for gastric foreign bodies in dogs (2010‐2014): 61 cases     

Kristin M. Zersen  Nathan Peterson  Philip J. Bergman 《Journal of Veterinary Emergency and Critical Care》2020,30(2):209-212

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Decreased concentration of hemoglobin,accumulation of lipid oxidation products and unchanged skeletal muscle in Atlantic salmon (Salmo salar) fed low dietary vitamin E     

Kristin Hamre  Brit Hjeltnes  Harald Kryvi  Sverre Sandberg  Mette Lorentzen  Øyvind Lie 《Fish physiology and biochemistry》1994,12(5):421-429

Atlantic salmon (Salmo salar) fry, initial weight 0.16 g, were fed a semipurified diet with 0, 15, 30, 60 or 120 mg dl-α-tocopheryl acetate/kg. After 24 weeks, the first two of these groups were extinct, and the fish receiving 30 mg/kg were clearly vitamin E deficient. Vitamin E deficient fish had low hemoglobin levels, characterized by a combination of reduced cellular hemoglobin concentration, red cell volume and red cell number, and an increased number and fraction of immature red blood cells. The hemoglobin concentration decreased over the decreasing range of experimental dl-ga-tocopheryl acetate levels. Therefore, even if 60 mg dl-α-tocopheryl acetate/kg gave good survival, this level was clearly physiologically suboptimal. Ceroid accumulated in the liver of fish fed 30 mg vitamin E/kg, and autofluorescent inclusions were found in the red blood cells of fish fed 30 and 60 mg vitamin E/kg. Degeneration of skeletal muscle was not observed in the present study.  相似文献   

Tissue lipid peroxidative responses in Atlantic salmon (Salmo salar L.) parr fed high levels of dietary copper and cadmium     

Marc H.G. Berntssen  Anne-Katrine Lundebye  Kristin Hamre 《Fish physiology and biochemistry》2000,23(1):35-48

Atlantic salmon (Salmo salar L.) parr were fed for one month on fish meal based diets supplemented with Cd (0, 0.7, or 204 mg Cd kg^–1 DW) or Cu (0, 34, or 691 mg Cu kg^–1 DW) to assess the effects of non-essential (Cd) and essential (Cu) dietary metals on lipid peroxidation and the oxidative defence system. Cadmium accumulated significantly in the liver, intestine, and kidney of 204 mg Cd kg^–1exposed fish compared to controls. Copper accumulated significantly in the intestine, kidney, and liver of fish exposed to 691 mg Cu kg^–1, and in the intestine of 34 mg Cu kg^–1 exposed fish. Tissue Cu accumulation significantly increased intestinal and hepatic lipid peroxidation (as seen from thiobarbituric acid reactive substances, TBARS, levels) and subsequently decreased intestinal -tocopherol levels and increased intestinal and hepatic selenium dependent glutathione peroxidase (SeGSH-Px) activity. Dietary Cd significantly reduced SeGSH-Px activity in the intestine and liver of 204 mg Cd kg^–1 exposed fish compared to controls. No significant increase in tissue TBARS or reduction of -tocopherol levels was observed in the intestine of fish exposed to dietary Cd, with exception of the highest exposure group (204 mg Cd kg^–1). Dietary Cu caused depletion of tissue Se and glutathione levels, however the reduced availability of GSH and Se did not seem to explain the differences in SeGSH-Px activity. Dietary Cu had a direct effect on lipid peroxidation at a relatively low concentration (34 mg Cu kg^–1). Cadmium indirectly affected tissue lipid peroxidation by damaging the oxidative defence system at the highest dietary concentration (204 mg Cd kg^–1).  相似文献