Transformation of a star into a planet in a millisecond pulsar binary     

Bailes M  Bates SD  Bhalerao V  Bhat ND  Burgay M  Burke-Spolaor S  D'Amico N  Johnston S  Keith MJ  Kramer M  Kulkarni SR  Levin L  Lyne AG  Milia S  Possenti A  Spitler L  Stappers B  van Straten W 《Science (New York, N.Y.)》2011,333(6050):1717-1720

Millisecond pulsars are thought to be neutron stars that have been spun-up by accretion of matter from a binary companion. Although most are in binary systems, some 30% are solitary, and their origin is therefore mysterious. PSR J1719-1438, a 5.7-millisecond pulsar, was detected in a recent survey with the Parkes 64-meter radio telescope. We show that this pulsar is in a binary system with an orbital period of 2.2 hours. The mass of its companion is near that of Jupiter, but its minimum density of 23 grams per cubic centimeter suggests that it may be an ultralow-mass carbon white dwarf. This system may thus have once been an ultracompact low-mass x-ray binary, where the companion narrowly avoided complete destruction.  相似文献   

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver     

Du K  Herzig S  Kulkarni RN  Montminy M 《Science (New York, N.Y.)》2003,300(5625):1574-1577

Insulin resistance is a major hallmark in the development of type II diabetes, which is characterized by the failure of insulin to promote glucose uptake in muscle and to suppress glucose production in liver. The serine-threonine kinase Akt (PKB) is a principal target of insulin signaling that inhibits hepatic glucose output when glucose is available from food. Here we show that TRB3, a mammalian homolog of Drosophila tribbles, functions as a negative modulator of Akt. TRB3 expression is induced in liver under fasting conditions, and TRB3 disrupts insulin signaling by binding directly to Akt and blocking activation of the kinase. Amounts of TRB3 RNA and protein were increased in livers of db/db diabetic mice compared with those in wild-type mice. Hepatic overexpression of TRB3 in amounts comparable to those in db/db mice promoted hyperglycemia and glucose intolerance. Our results suggest that, by interfering with Akt activation, TRB3 contributes to insulin resistance in individuals with susceptibility to type II diabetes.  相似文献   

Interim report on virus diseases of pawpaw in East Africa     

H. Y. Kulkarni  F. M. L. Sheffield 《国际虫害防治杂志》2013,59(2):184-185

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Ovine herpesvirus type 2 infection in captive bison in India     

Sood R  Kumar M  Bhatia S  Pateriya AK  Khandia R  Siddiqui A  Kulkarni DD  Kumar S  Venkatesha MD 《The Veterinary record》2012,170(25):654

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Characterization of an EMS-induced soybean mutant with an increased content of Af saponin and a new component Ab-δ in the seed hypocotyl     

Cheol Woo Park  Krishnanand P. Kulkarni  Minsu Kim  Kyosuke Mukaiyama  Chigen Tsukamoto  Gyuhwa Chung  Jong Tae Song  Jeong-Dong Lee 《Euphytica》2018,214(9):163

Saponins are one of the components present in the soybean seeds that have various functional properties. The chemical structures and concentration of soyasaponins affect the taste of the processed soyfood, thereby limiting its industrial applications. Therefore, it is important to understand saponin biosynthesis to explore natural and artificial variation in the saponin components, which can be modified to suit its application. The objective of the present study was to identify and characterize an EMS-induced soybean mutant with an altered saponin composition from a pool of 892 M4 lines. The mutant PE1905 showed an increased content of saponin Af (336.0%). The content of saponin Ab, DDMP-αg, and DDMP-βg was decreased in the mutant PE1905 by 89.3, 24.8, and 63.1%, respectively compared to the wild-type Pungsannamul. Additionally, four new components were detected in the mutant PE1905 that were absent in the wild type. Of these, the compound 4 (designated as Ab-δ) had the highest concentration, and therefore it was further characterized by HPLC and LC-PDA/MS/MS analysis to know the chemical structure, and molecular weight and formula. Considering these details, along with the alterations in the saponin Af and Ab concentrations, it was presumed that the Ab-δ acts as a precursor for the synthesis of saponin Af and Ab. Thus, we predicted a biosynthetic pathway from the Ab-δ to Ab saponin. The inheritance analysis showed that the concentration of saponin Ab-δ is controlled by a single recessive gene in the mutant PE1905. The results from the present study would be helpful in understanding the mechanisms behind altered seed saponin composition in soybeans.  相似文献   

Intraoperative use of a transarticular circular fixator construct to facilitate reduction and stabilisation of a proximal tibial physeal fracture in a dog          下载免费PDF全文

MD Johnson  DD Lewis  MD Winter 《Australian veterinary journal》2017,95(5):161-166

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Genotyping of newly isolated infectious bronchitis virus isolates from northeastern Georgia     

Kulkarni AB  Resurreccion RS 《Avian diseases》2010,54(4):1144-1151

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Efficacy of Head and Torso Rewarming Using a Human Model for Severe Hypothermia     

Kartik Kulkarni  Erik Hildahl  Ramesh Dutta  Sandra C. Webber  Steven Passmore  Gerren K. McDonald  Gordon G. Giesbrecht 《The Forestry Chronicle》2019,30(1):35-43

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Mobilization of organic reserves during ovarian development in a marine penaeid prawn,Parapenaeopsis hardwickii (Miers) (Crustacea,Decapoda, Penaeidae)     

G.K. Kulkarni  R. Nagabhushanam 《Aquaculture (Amsterdam, Netherlands)》1979,18(4):373-377

The present study furnishes data concerning changes in biochemical constituents of midgut gland and ovary of Parapenaeopsis hardwickii associated with ovarian development. The ovarian index (0I) increased as the ovary developed from stage I (0I = 2.80 ± 0.32) to stage IV (0I = 5.85 ± 0.38) and then decreased suddenly in stage V (0I = 1.20 ± 0.45) following spawning. Associated biochemical parameters (protein, glycogen and fat) show remarkable variation. There was a continuous decline in these parameters in the midgut gland during ovarian development and a similar increase in their concentration in the ovary. The physiological significance of these findings is discussed briefly.  相似文献   

A note on the growth rate of chicks fed with additional antibiotic to a commercial chick starter mash     

M V Kulkarni  D M Khare  W G Paranjape 《The Indian veterinary journal》1965,42(10):778-782

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