Gunshot wounds in military working dogs in Operation Enduring Freedom and Operation Iraqi Freedom: 29 cases (2003–2009)     

Janice L. Baker DVM  Karyn A. Havas DVM  Laura A. Miller LVT  Ward. A. Lacy EMT‐P  RVT  Justin Schlanser DVM 《Journal of Veterinary Emergency and Critical Care》2013,23(1):47-52

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A Review of the Efficacy of Tiludronate in the Horse     

Lacy Kamm DVM  Wayne McIlwraith BVSc  DACVS  PhD  Chris Kawcak DVM  PhD  DACVS   《Journal of Equine Veterinary Science》2008,28(4):209-214

Tiludronate is a compound in the bisphosphonate class of drugs. The main pharmacologic action of bisphosphonates is to inhibit bone resorption; they cause osteoclast apoptosis and disrupt intercellular trafficking of pro-inflammatory mediators. Bisphosphonates are used to treat humans with diseases such as osteoporosis and Paget's disease. Recently tiludronate has been studied as a treatment for bone resorptive diseases in horses. Tildren, an injectable form of tiludronate made for the horse, has been licensed to treat navicular disease and distal tarsal osteoarthritis in Europe. Some clinical studies have been completed to assess the efficacy of tiludronate in the horse. Many of the studies are reviewed here, and their standards of research are evaluated individually. Tiludronate may be beneficial in managing lameness isolated to the navicular bone and distal tarsal osteoarthritis by decreasing bone resorption and inflammation.  相似文献   

A descriptive study of the equine proximal interphalangeal joint using magnetic resonance imaging, contrast arthrography, and arthroscopy     

JL Kamm  LR Goodrich  NM Werpy  CW McIlwraith 《Veterinary surgery : VS》2012,41(6):677-684

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Clients' Perspectives on the Effects of Laparoscopic Ovariectomy on Equine Behavior and Medical Problems     

J. Lacy Kamm DVM  Dean A. Hendrickson DVM  MS  DACVS   《Journal of Equine Veterinary Science》2007,27(10):435-438

Because laparoscopic surgery eliminates the side effects of general anesthesia, the success and therefore the use of laparoscopic surgery continues to broaden. Laparoscopic ovariectomy, once only used to treat medical problems such as granulosa cell tumors, is now being expanded to treat behavioral problems in mares. Thirty-five mares with behavioral or medical problems were treated with ovariectomies, and their owners were later contacted and questioned concerning the effect of ovariectomy on their mares.Behavioral improvement was seen in 83% (19/23) of mares treated for behavior-related problems. Aggression problems improved in 86% (12/14) of cases, general disagreeable demeanor improved in 81% (17/21), and excitability improved in 75% (12/16) of cases in which these behaviors were previously observed. Kicking and biting improved in 73% (8/11), problems in training improved in 72% (13/18), and frequent urination and problems with other horses improved in 64% (7/11 and 9/14, respectively) of cases.Owners with nonovariectomized mares also were contacted to compare the normal progression of mare behavior over time with the behavioral change in ovariectomized mares. A statistically significant change in behavior of ovariectomized mares over nonovariectomized mares was seen in the categories of decreased aggression (P < .01), decreased training problems (P < .025), decreased frequency of problem behaviors (P < .001), and improved overall behavior (P < .01).In cases in which medical problems such as granulosa cell tumors, ovarian cysts, and cycle-related colic were treated with ovariectomy, all of the clients were very satisfied with the treatment, whereas clients attempting to treat cycle-related laminitis were dissatisfied.  相似文献   

Evaluation of proposed amended names of several pseudomonads and xanthomonads and recommendations     

Schaad NW  Vidaver AK  Lacy GH  Rudolph K  Jones JB 《Phytopathology》2000,90(3):208-213

ABSTRACT In 1980, over 90% of all plant-pathogenic pseudomonads and xanthomonads were lumped into Pseudomonas syringae and Xanthomonas campestris, respectively, as pathovars. The term "pathovar" was created to preserve the name of plant pathogens, but has no official standing in nomenclature. Proposals to elevate and rename several pathovars of the genera Pseudomonas and Xanthomonas to the rank of species has caused great confusion in the literature. We believe the following changes have merit and expect to adopt them for publication in a future American Phytopathological Society Laboratory Guide for Identification of Plant Pathogenic Bacteria. Upon review of published data and the Rules of The International Code of Nomenclature of Bacteria, we make the following recommendations. We reject the proposal to change the name of P. syringae pvs. phaseolicola and glycinea to P. savastanoi pvs. phaseolicola and glycinea, respectively, because both pathogens are easily differentiated phenotypically from pv. savastanoi and convincing genetic data to support such a change are lacking. We accept the elevation of P. syringae pv. savastanoi to the rank of species. We accept the reinstatement of X. oryzae to the rank of species with the inclusion of X. oryzicola as a pathovar of X. oryzae and we accept the species X. populi. We agree with the elevation of the pvs. cassavae, cucurbitae, hyacinthi, pisi, and translucens to the rank of species but not pvs. melonis, theicola, and vesicatoria type B. We recommend that all type A X. vesicatoria be retained as X. campestris pv. vesicatoria and all type B X. vesicatoria be named X. exitiosa. We reject the newly proposed epithets arboricola, bromi, codiaei (poinsettiicola type B), hortorum, sacchari, and vasicola and the transfer of many pathovars of X. campestris to X. axonopodis. The proposed pathovars of X. axonopodis should be retained as pathovars of X. campestris.  相似文献   

Identification of volatiles generated by potato tubers (Solanum tuberosum CV: Maris Piper) infected by Erwinia carotovora, Bacillus polymyxa and Arthrobacter sp.     

de Lacy Costello  Evans  Ewen  Gunson  Ratcliffe  & Spencer-Phillips 《Plant pathology》1999,48(3):345-351

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Comparative Effectiveness of Tillandsia Usneoides L. and Parmotrema Praesorediosum (Nyl.) Hale as Bio-Indicators of Atmospheric Pollution in Louisiana (U.S.A.)     

Pyatt  F. B.  Grattan  J. P.  Lacy  D.  Pyatt  A. J.  Seaward  M. R. D. 《Water, air, and soil pollution》1999,111(1-4):317-326

Samples of the epiphytic bromeliad Tillandsia usneoides L. (Bromeliaceae) and the lichen Parmotrema praesorediosum (Nyl.) Hale, growing on bald cypress trees in southern Louisiana, were chemically examined by means of X-ray micro-probe analysis to determine their comparative elemental content. The plants were found to effectively bio-accumulate heavy metals and sulfur from the atmosphere; the accumulatory capacities and implications are discussed. Partitioning occurs within the plants of T. usneoides and consequently any analytical procedure should standardise on precisely which parts are to be analysed. The bio- accumulation of certain heavy metals such as manganese, nickel and cadmium increases with age of the T. usneoides.  相似文献   

Biodiversity. Confronting amphibian declines and extinctions     

Mendelson JR  Lips KR  Gagliardo RW  Rabb GB  Collins JP  Diffendorfer JE  Daszak P  Ibáñez D R  Zippel KC  Lawson DP  Wright KM  Stuart SN  Gascon C  da Silva HR  Burrowes PA  Joglar RL  La Marca E  Lötters S  du Preez LH  Weldon C  Hyatt A  Rodriguez-Mahecha JV  Hunt S  Robertson H  Lock B  Raxworthy CJ  Frost DR  Lacy RC  Alford RA  Campbell JA  Parra-Olea G  Bolaños F  Domingo JJ  Halliday T  Murphy JB  Wake MH  Coloma LA  Kuzmin SL  Price MS  Howell KM  Lau M  Pethiyagoda R  Boone M  Lannoo MJ  Blaustein AR  Dobson A  Griffiths RA 《Science (New York, N.Y.)》2006,313(5783):48

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A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore     

Krantz BA  Melnyk RA  Zhang S  Juris SJ  Lacy DB  Wu Z  Finkelstein A  Collier RJ 《Science (New York, N.Y.)》2005,309(5735):777-781

The protective antigen component of anthrax toxin forms a homoheptameric pore in the endosomal membrane, creating a narrow passageway for the enzymatic components of the toxin to enter the cytosol. We found that, during conversion of the heptameric precursor to the pore, the seven phenylalanine-427 residues converged within the lumen, generating a radially symmetric heptad of solvent-exposed aromatic rings. This "phi-clamp" structure was required for protein translocation and comprised the major conductance-blocking site for hydrophobic drugs and model cations. We conclude that the phi clamp serves a chaperone-like function, interacting with hydrophobic sequences presented by the protein substrate as it unfolds during translocation.  相似文献   

Hybridization between pascal celery and parsley   总被引：1，自引：0，他引：1  

S. Honma  M. L. Lacy 《Euphytica》1980,29(3):801-805

Summary Pascal celery cv. Golden Spartan was hybridized with parsley which is immune to celery blight (Septoria apiicola). Three F₁ hybrids were obtained from over a thousand seedlings grown from the pascal celery parent. The F₁ plants were intermediate for most characters. Segregation for petiole color in the F₂ generation demonstrated that a hybrid actually occurred. Segregation for late blight resistance occurred independently from petiole color.Received for publication 6 December 1979. Michigan Agricultural Experiment Station Journal Article No. 9222.Department of Botany and Plant Pathology, Michigan State University.  相似文献