Myocardial and pancreatic lesions induced by T-2 toxin, a trichothecene mycotoxin, in swine     

V F Pang  J H Adams  V R Beasley  W B Buck  W M Haschek 《Veterinary pathology》1986,23(3):310-319

Myocardial and pancreatic lesions induced by sublethal doses of T-2 toxin in swine were characterized by light and electron microscopy. Toxin was given intravenously to six 17- to 18-week-old pigs. Pigs were killed 24 or 48 hours after treatment. Grossly, subendocardial hemorrhages, multifocal pinpoint white foci in myocardium, and pancreatic edema occurred in one treated pig. Histologic changes in myocardium of treated pigs consisted of multifocal edema, mononuclear cell infiltration, myofiber hyalinization, vacuolation, and contraction bands with nuclear pyknosis. Ultrastructurally, there were areas of edema, myofibrillar disorganization, dilation of sarcoplasmic reticulum, and formation of hypercontraction bands. Myocardial mineralization was seen in the pig with gross lesions. Pancreatic changes in treated pigs consisted of multifocal acinar degeneration and necrosis. Ultrastructural changes included irregular dilation of rough endoplasmic reticulum and abnormal zymogen granules. Thus, in addition to radiomimetic lesions of the gastrointestinal tract and lymphoid organs, heart and pancreas are target organs of T-2 toxin in swine.  相似文献   

Afforestation trials with Prosopis chilensis (Mol.) Stuntz and Prosopis flexuosa D.C. in the Dry Chaco, Argentina     

Leonor Cataln  Carlos Carranza  Laura Gonzlez  Ulf Karlin  Marcela Ledesma 《Forest Ecology and Management》1994,70(1-3):113-119

In implantation trials carried out with Prosopis chilensis and Prosopis flexuosa, the following variables were considered: implantation time (December and March), implantation technique (direct seeding and seedling transplantation) and age of the seedlings at the time of transplantation (60, 105 and 150 days). Survival was evaluated for more than 9 months after implantation and trials were repeated in 3 consecutive years.

Results from both species were similar and they show that survival after transplantation was higher (60–80%) than from direct seeding (35–45%). Survival from transplantation was independent of the size and age of the seedlings and it was less affected by climatic conditions than direct field sowing. Survival from direct seeding was higher in March than in December. The best time for either implantation alternative would be the end of the summer or beginning of fall, when climatic conditions increase the probability of seedling survival.  相似文献   

Assessment of the gross primary production dynamics of a Mediterranean holm oak forest by remote sensing time series analysis     

Víctor Cicuéndez  Javier Litago  Margarita Huesca  Manuel Rodriguez-Rastrero  Laura Recuero  Silvia Merino-de-Miguel  Alicia Palacios-Orueta 《Agroforestry Systems》2015,89(3):491-510

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SUSCEPTIBILITY ARTIFACTS ON T2*‐WEIGHTED MAGNETIC RESONANCE IMAGING OF THE CANINE AND FELINE SPINE          下载免费PDF全文

Laura J. Hammond  Silke Hecht 《Veterinary radiology & ultrasound》2015,56(4):398-406

The T2*‐weighted gradient recalled echo sequence is a sensitive means to detect blood degradation products. While not a routine sequence in magnetic resonance imaging of the spine in small animals, it can provide additional valuable information in select cases. The goal of this retrospective, cross‐sectional study was to describe findings when acquiring this sequence during magnetic resonance imaging examination of the spine in small animals. The University of Tennessee's veterinary radiology database was searched for dogs and cats that underwent magnetic resonance imaging for suspect spinal disease in which a T2*‐weighted gradient recalled echo sequence was acquired and susceptibility artifact was identified. The following information was recorded: signalment, clinical signs, location and appearance of susceptibility artifact, and final diagnosis. Thirty‐nine cases were included in the study. Extradural susceptibility artifacts were observed in cases of intervertebral disc herniation with or without associated hemorrhage (n = 28), extradural hemorrhage associated with spinal trauma (n = 2), hemophilia (n = 1), and in a cystic extradural mass (n = 1). Remaining lesions displaying susceptibility artifact were intramedullary and included presumptive acute noncompressive nucleus pulposus extrusion (n = 2), hematoma (n = 1), hemangiosarcoma metastasis (n = 1), intramedullary disc extrusion (n = 1), presumptive meningomyelitis (n = 1), and a mass of undetermined etiology (n = 1). Inclusion of a T2*‐weighted gradient recalled echo sequence may be helpful in spinal magnetic resonance imaging when standard imaging sequences are ambiguous or intramedullary lesions are observed.  相似文献   

Versatility of the Angularis Oris Axial Pattern Flap for Facial Reconstruction          下载免费PDF全文

Sara L. Losinski  Bryden J. Stanley  Sandra P. Schallberger  Laura L. Nelson  Heather A.M. Towle Millard 《Veterinary surgery : VS》2015,44(8):930-938

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Comparison of Outcome After Use of Extra‐Luminal Rings and Intra‐Luminal Stents for Treatment of Tracheal Collapse in Dogs          下载免费PDF全文

Selena Tinga DVM  Kelley M. Thieman Mankin DVM  MS  Diplomate ACVS  Laura E. Peycke DVM  MS  Diplomate ACVS  Noah D. Cohen VMD  MPH  PhD  Diplomate ACVIM 《Veterinary surgery : VS》2015,44(7):858-865

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Pre-operative fibrous osteodystrophy and severe,refractory, post-operative hypocalcemia following parathyroidectomy in a dog     

Jennifer M. Reinhart  Ellie K. Nuth  Christopher G. Byers  Mike Thoesen  Laura J. Armbrust  David S. Biller  Kenneth R. Harkin 《The Canadian veterinary journal. La revue veterinaire canadienne》2015,56(8):867-871

A 13-year-old dog exhibited dramatic, radiographic osteopenia consistent with fibrous osteodystrophy secondary to primary hyperparathyroidism. Following parathyroidectomy, the dog developed severe, prolonged hypocalcemia, but was successfully treated and discharged 32 d after surgery. A variety of factors may have contributed to this dog’s hypocalcemia including hypoparathyroidism and hungry bone syndrome.  相似文献   

Responses to the Standard for Exchange of Nonclinical Data (SEND) in non-US countries     

Takayuki Anzai  Masamichi Kaminishi  Keizo Sato  Laura Kaufman  Hijiri Iwata  Dai Nakae 《Journal of toxicologic pathology》2015,28(2):57-64

The Standard for the Exchange of Nonclinical Data (SEND), adopted by the US FDA, is part of a set of regulations and guidances requiring the submission of standardized electronic study data for nonclinical and clinical data submissions. SEND is the nonclinical implementation of SDTM (Study Data Tabulation Model), the standard electronic format for clinical regulatory submissions to FDA. SEND, SDTM, and the associated Controlled Terminology have been developed by CDISC (Clinical Data Interchange Standards Consortium). In order to successfully implement SEND, interdisciplinary contributions between sponsors and CROs, need a model for task allocation. This is being undertaken by the Pharmaceutical Users Software Exchange (PhUSE). Because SEND is currently the preferred submission format of the US FDA only and will become required by it starting in December 2016, only American academic societies and companies are actively involved. An exception to this is the INHAND initiative, which leads the way in standardizing terminology for toxicological pathology. On the other hand, international globalization of other clinical and nonclinical practices is not feasible because there are substantial differences between the US and non-US countries in CRO involvement in drug development. Thus, non-US countries must consider and develop approaches to SEND that meet their needs. This paper summarizes the activities of the major organizations involved in SEND development and implementation, discusses the effective use of SEND, and details a compliance scheme (research material of the Showa University School of Medicine) illustrating how pharmaceutical companies can complete a large amount of work up to an FDA application with the effective utilization of CROs and solution providers.  相似文献   

Canine cutaneous melanocytic tumours: significance of β‐catenin and survivin immunohistochemical expression          下载免费PDF全文

Laura Bongiovanni  Alessandra D'Andrea  Ilaria Porcellato  Andrea Ciccarelli  Daniela Malatesta  Mariarita Romanucci  Leonardo Della Salda  Luca Mechelli  Chiara Brachelente 《Veterinary dermatology》2015,26(4):270-e59

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Edge type determines the intensity of forest edge effect on epiphytic communities     

Gregorio Aragón  Laura Abuja  Rocío Belinchón  Isabel Martínez 《European Journal of Forest Research》2015,134(3):443-451

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