Mentoring. Linking student interests to science curricula     

Denofrio LA  Russell B  Lopatto D  Lu Y 《Science (New York, N.Y.)》2007,318(5858):1872-1873

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Paleoindian seafaring, maritime technologies, and coastal foraging on California's Channel Islands     

Erlandson JM  Rick TC  Braje TJ  Casperson M  Culleton B  Fulfrost B  Garcia T  Guthrie DA  Jew N  Kennett DJ  Moss ML  Reeder L  Skinner C  Watts J  Willis L 《Science (New York, N.Y.)》2011,331(6021):1181-1185

Three archaeological sites on California's Channel Islands show that Paleoindians relied heavily on marine resources. The Paleocoastal sites, dated between ~12,200 and 11,200 years ago, contain numerous stemmed projectile points and crescents associated with a variety of marine and aquatic faunal remains. At site CA-SRI-512 on Santa Rosa Island, Paleocoastal peoples used such tools to capture geese, cormorants, and other birds, along with marine mammals and finfish. At Cardwell Bluffs on San Miguel Island, Paleocoastal peoples collected local chert cobbles, worked them into bifaces and projectile points, and discarded thousands of marine shells. With bifacial technologies similar to those seen in Western Pluvial Lakes Tradition assemblages of western North America, the sites provide evidence for seafaring and island colonization by Paleoindians with a diversified maritime economy.  相似文献   

CO2-forced climate and vegetation instability during Late Paleozoic deglaciation     

Montañez IP  Tabor NJ  Niemeier D  Dimichele WA  Frank TD  Fielding CR  Isbell JL  Birgenheier LP  Rygel MC 《Science (New York, N.Y.)》2007,315(5808):87-91

The late Paleozoic deglaciation is the vegetated Earth's only recorded icehouse-to-greenhouse transition, yet the climate dynamics remain enigmatic. By using the stable isotopic compositions of soil-formed minerals, fossil-plant matter, and shallow-water brachiopods, we estimated atmospheric partial pressure of carbon dioxide (pCO2) and tropical marine surface temperatures during this climate transition. Comparison to southern Gondwanan glacial records documents covariance between inferred shifts in pCO2, temperature, and ice volume consistent with greenhouse gas forcing of climate. Major restructuring of paleotropical flora in western Euramerica occurred in step with climate and pCO2 shifts, illustrating the biotic impact associated with past CO2-forced turnover to a permanent ice-free world.  相似文献   

Resolution of lung inflammation by CD44     

Teder P  Vandivier RW  Jiang D  Liang J  Cohn L  Puré E  Henson PM  Noble PW 《Science (New York, N.Y.)》2002,296(5565):155-158

Successful repair after tissue injury and inflammation requires resolution of the inflammatory response and removal of extracellular matrix breakdown products. We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation. CD44-deficient mice succumb to unremitting inflammation following noninfectious lung injury, characterized by impaired clearance of apoptotic neutrophils, persistent accumulation of hyaluronan fragments at the site of tissue injury, and impaired activation of transforming growth factor-beta1. This phenotype was partially reversed by reconstitution with CD44+ cells, thus demonstrating a critical role for this receptor in resolving lung inflammation.  相似文献   

Very high energy gamma-ray binary stars     

Lamb RC  Weekes TC 《Science (New York, N.Y.)》1987,238(4833):1528-1534

One of the major astronomical discoveries of the last two decades was the detection of luminous x-ray binary star systems in which gravitational energy from accretion is released by the emission of x-ray photons, which have energies in the range of 0.1 to 10 kiloelectron volts. Recent observations have shown that some of these binary sources also emit photons in the energy range of 10(12) electron volts and above. Such sources contain a rotating neutron star that is accreting matter from a companion. Techniques to detect such radiation are ground-based, simple, and inexpensive. Four binary sources (Hercules X-1, 4U0115+63, Vela X-1, and Cygnus X-3) have been observed by at least two independent groups. Although the discovery of such very high energy "gamma-ray binaries" was not theoretically anticipated, models have now been proposed that attempt to explain the behavior of one or more of the sources. The implications of these observations is that a significant portion of the more energetic cosmic rays observed on Earth may arise from the action of similar sources within the galaxy during the past few million years.  相似文献   

Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes     

Seshadri R  Adrian L  Fouts DE  Eisen JA  Phillippy AM  Methe BA  Ward NL  Nelson WC  Deboy RT  Khouri HM  Kolonay JF  Dodson RJ  Daugherty SC  Brinkac LM  Sullivan SA  Madupu R  Nelson KE  Kang KH  Impraim M  Tran K  Robinson JM  Forberger HA  Fraser CM  Zinder SH  Heidelberg JF 《Science (New York, N.Y.)》2005,307(5706):105-108

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Assisted colonization: Integrating conservation strategies in the face of climate change     

Scott R. Loss  Lauren A. Terwilliger  Anna C. Peterson 《Biological conservation》2011,(1):92-100

Global climate change poses an immense challenge for conservation biologists seeking to mitigate impacts to species and ecosystems. Species persistence will depend on geographic range shifts or adaptation in response to warming patterns as novel climates and community assemblages arise. Assisted colonization has been proposed as a method for addressing these challenges. This technique, which consists of transporting species to a new range that is predicted to be favorable for persistence under future climate scenarios, has become the subject of controversy and discussion in the conservation community due to its highly manipulative nature, questions about widespread feasibility, and uncertainty associated with the likelihood of translocated species becoming invasive. We reviewed the discussion and criticism associated with assisted colonization and sought to identify other conservation techniques that also display potential to promote the colonization and adaptation of species in response to climate change. We propose an integrated conservation strategy that includes management for habitat connectivity, conservation genetics, and when necessary, assisted colonization of species that are still unable to shift their ranges even given implementation of the above standard conservation approaches. We argue that this integrated approach will facilitate persistence for a larger proportion of species than is possible by solely using assisted colonization. Furthermore, a multi-faceted approach will likely reduce the uncertainty of conservation outcomes and will become increasingly necessary for conservation of biodiversity in a changing climate.  相似文献   

Pteroside A2--a new illudane-type sesquiterpene glucoside from pteridium caudatum L. Maxon,and the spectrometric characterization of caudatodienone     

Castillo UF  Wilkins AL  Lauren DR  Smith BL  Alonso-Amelot M 《Journal of agricultural and food chemistry》2003,51(9):2559-2564

Fractionation of an extract of Pteridium caudatum L. Maxon. (syn P. aquilinum L. Kuhn var. caudatum) which had earlier yielded the illudane-type sesquiterpene glucosides, ptaquiloside (1a), isoptaquiloside (1b), and caudatoside (1c) afforded a mixture containing 1a and two minor components. Preparative HPLC afforded ptaquiloside Z (1d) and a new pteroside glucoside (pteroside A2) (3e), which was identified using a combination of mass spectral and one- and two-dimensional NMR analyses. The (1)H and (13)C NMR and mass spectrometric characterization of caudatodienone (2b), an unstable dienone derived from the degradation of caudatoside (1c) in pyridine solution, and the GC-MS characterization of some pterosin-type degradation products produced by reacting this solution with cosolvents is also reported.  相似文献   

Simultaneous analysis of nivalenol and deoxynivalenol in cereals by liquid chromatography   总被引：1，自引：0，他引：1  

D R Lauren  R Greenhalgh 《Journal of the Association of Official Analytical Chemists》1987,70(3):479-483

A sensitive method is described for determination of nivalenol (NIV) and deoxynivalenol (DON) in cereals by using reverse phase liquid chromatography and UV detection at 222 nm. The sample is extracted with acetonitrile-water (85 + 15) and an aliquot is purified by passage through a combined column of cation exchange resin and alumina-carbon (20 + 1). Analysis at this stage is possible with some samples but the method recommends passing an aliquot through a carbon minicolumn after evaporation and solubilization in methanol. Interference from coextracted compounds at this point is negligible. Recoveries of both NIV and DON from spiked extracts taken through the full method were in the range 83-94%. The relative standard deviation, based on 5 replicate determinations from each of 2 corn samples, was approximately 5% for both NIV and DON. With a 10 microL injection, the minimum contamination (3 X signal/noise ratio) able to be detected in cereal samples was about 0.015 micrograms NIV/g and 0.05 micrograms DON/g. The cleaned up extracts are also suitable for analysis by gas chromatography.  相似文献   

Ultrasound- guided catheter biopsy of the lower urinary tract: technique and results in 12 dogs   总被引：1，自引：0，他引：1  

C. R. Lamb  N. D. Trower  S. P. Gregory 《The Journal of small animal practice》1996,37(9):413-416

Ultrasound-guided catheter biopsy of lesions affecting the lower urinary tract was attempted in 12 dogs with mucosal lesions affecting the bladder [nine] or urethra (three). Histological biopsies were obtained by catheter biopsy in 10 dogs, enabling diagnosis of transitional cell carcinoma in five, papilloma in two, prostatic carcinoma in two and chronic cystitis in one. Cytological samples alone were obtained in two dogs, one of which enabled a diagnosis of transitional cell carcinoma; the other contained evidence of haemorrhage and inflammation, but squamous cell carcinoma was found in a subsequent exci-sional biopsy. Intravesicular haemorrhage after biopsy was observed ultrasonographically in two dogs. Ultrasound guidance enables accurate determination of biopsy catheter position. The size of biopsies obtained by this method may limit the accuracy of histological diagnosis.  相似文献