Cerebral phaeohyphomycosis in a Birman kitten     

AF Julian 《New Zealand veterinary journal》2013,61(1)

Extract

A 6-month-old female Birman kitten was presented for long-lasting and repeated seizures. It initially had some response to treatment but deteriorated and was euthanised. At necropsy, the brain was swollen and some of the caudal cerebellum was compressed into the foramen magnum. The right cerebral hemisphere was enlarged and had a round, dark, 5 mm-diameter focus on the dorsal surface of the rostral sigmoid gyrus of the frontal cerebrum. There were smaller dark areas extending caudally into the endomarginal gyrus. When the fixed brain was sliced transversely, the lesions were grey-coloured or translucent and involved most of the rostral half of the right cerebral hemisphere. Histologically, there was severe, extensive pyogranulomatous inflammation with some interspersed areas of spongiosus and oedema. Within the granulomas were variable numbers of branching, pigmented, thin-walled, septate fungal hyphae. Cladosporium bantianum (trichoides) was isolated from the brain. This is the most frequent agent reported from cases of cerebral phaeohyphomycosis.  相似文献   

Integration of partial resistance,plant density and use of fungicide for management of white mould in common bean     

R. C. Lima  P. H. Teixeira  L. R. V. Sousa  L. B. Rodrigues  J. E. S. Carneiro  M. S. Lehner  T. J. Paula Júnior  R. F. Vieira 《Plant pathology》2019,68(3):481-491

In-row plant densities have not been studied for common beans with type II growth habit and contrasting reactions to white mould. Advanced breeding lines with partial resistance or susceptibility to white mould were combined with 4, 7, 10 or 13 plants m⁻¹ and with or without fungicide at a constant between-row spacing of 0.5 m in five sprinkler-irrigated field trials conducted during the autumn–winter season in Brazil. White mould pressures in the trials covered the whole range from zero to moderate/high (46–60% of white mould severity index). In all trials, means of white mould incidence, severity and yield did not vary significantly between 7 and 13 plants m⁻¹ for the partially resistant line, regardless of the fungicide levels. For the susceptible line, 13 plants m⁻¹ increased white mould incidence and severity under moderate disease, regardless of the fungicide levels, and decreased yield compared with 10 plants m⁻¹ when fungicide was applied twice under moderate/high disease pressure. For the susceptible line, 7 or 10 plants m⁻¹ maximized yield in all trials, with or without fungicide applications. The results suggest that the current recommendation of 11–13 plants m⁻¹ could be used for type II beans with partial resistance to white mould in either a conventional or organic system. For susceptible genotypes, 7–10 plants m⁻¹ seems to be the most appropriate in-row plant density. This study may improve the recommendation of in-row plant density for type II beans cultivated under white mould pressure.  相似文献   

A case of a canine pigmented plaque associated with the presence of a Chi-papillomavirus     

Lange CE  Tobler K  Lehner A  Vetsch E  Favrot C 《Veterinary dermatology》2012,23(1):76-80, e18-9

The seven fully described canine papillomaviruses (CPVs) have been allocated by sequence comparison and other genetic features into three phylogenetic clades. This largely reflects clinical findings, so each sequence of a newly discovered CPV in combination with clinical and pathological details is a valuable piece of evidence. We hypothesize that the genomic sequence of a new CPV can help to predict clinical features and progression, and that this can be tested in subsequent cases. In this case, a 2-year-old female dachshund-mix presented with papillomatosis clinically and histologically characterized as pigmented viral plaques. PCRs using primers evaluated for CPVs successfully amplified papillomavirus (PV) DNA. Sequencing of the products revealed an unknown PV putatively belonging to the PV genus Chi. Rolling circle amplification was used to amplify the entire viral genome. Sequencing revealed a novel PV, designated as CPV8, which was most closely related (63% homology) to the recently discovered CPV4. CPV4 is associated with benign pigmented plaques in pugs. Phylogenetic analysis based on the nucleotide sequences of four viral genes showed that the novel virus was closest to CPV3, CPV4 and CPV5. The presence of viral DNA was confirmed in the lesions by in situ hybridization using specific probes. CPV8 may consequently be regarded as the fourth member of the Chi-papillomavirus genus. All viruses belonging to this genus induce pigmented plaques in dogs. These findings support the hypothesis that genomic sequences can be useful in predicting the clinical features of CPV infection.  相似文献   

The Application of Reproductive Technologies to Natural Populations of Red Deer   总被引：1，自引：0，他引：1  

JJ Garde  F Martínez-Pastor  M Gomendio  AF Malo  AJ Soler  MR Fernández-Santos  MC Esteso  AJ García  L Anel  ERS Roldán 《Reproduction in domestic animals》2006,41(S2):93-102

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Occurrence of bovine babesiasis in Southern Bavaria     

H K Dennig  M Lehner  F Teubner 《Berliner und Münchener tier?rztliche Wochenschrift》1974,87(10):190-193

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Identification of lidocaine and its metabolites in post-administration equine urine by ELISA and MS/MS     

Dirikolu L  Lehner AF  Karpiesiuk W  Harkins JD  Woods WE  Carter WG  Boyles J  Fisher M  Tobin T 《Journal of veterinary pharmacology and therapeutics》2000,23(4):215-222

Lidocaine is a local anesthetic drug that is widely used in equine medicine. It has the advantage of giving good local anesthesia and a longer duration of action than procaine. Although approved for use in horses in training by the American Association of Equine Practitioners (AAEP), lidocaine is also an Association of Racing Commissioners International (ARCI) Class 2 drug and its detection in forensic samples can result in significant penalties. Lidocaine was observed as a monoprotonated ion at m/z 235 by ESI+ MS/MS (electrospray ionization-positive ion mode) analysis. The base peak ion at m/z 86, representing the postulated methylenediethylamino fragment [CH2N(CH2CH3)2]+, was characteristic of lidocaine and 3-hydroxylidocaine in both ESI+ and EI (electron impact-positive ion mode) mass spectrometry. In addition, we identified an ion at m/z 427 as the principal parent ion of the ion at m/z 86, consistent with the presence of a protonated analog of 3-hydroxylidocaine-glucuronide. We also sought to establish post-administration ELISA-based 'detection times' for lidocaine and lidocaine-related compounds in urine following single subcutaneous injections of various doses (10, 40, 400 mg). Our findings suggest relatively long ELISA based 'detection times' for lidocaine following higher doses of this drug.  相似文献   

Differences in wound-induced changes in cell-wall peroxidase activities and isoform patterns between seedlings of Prosopis tamarugo and Prosopis chilensis     

Lehner G  Cardemil L 《Tree physiology》2003,23(7):443-452

We determined changes in cell-wall peroxidase activities and isoform patterns in response to wounding in seedlings of Prosopis tamarugo Phil. (an endemic species of the Atacama Desert) and Prosopis chilensis (Mol.) Stuntz (a native species of central Chile), to assess tolerance to predation. In seedlings of both species, the maximal increase in peroxidase activity occurred 48 h after wounding, reaching three times the control value in P. tamarugo and twice the control value in P. chilensis. The activity of ionically bound cell-wall peroxidases increased only locally in wounded embryonic axes, whereas the activity of soluble peroxidases increased systemically in unwounded cotyledons. Analysis of ionic peroxidases by isoelectrofocusing revealed two groups of peroxidases in the cell walls of both species: four distinct acidic isoforms and a group of basic isoforms. In response to wounding, there was a large increase in activity of the acidic isoforms in P. tamarugo, whereas there was an increase in the activity of the basic isoforms in P. chilensis. In P. chilensis, the wound-induced increase in activity of the basic isoforms corresponded with one of the two isoforms detected in P. tamarugo prior to wounding. Experiments with protein and RNA synthesis inhibitors indicated that a preexisting basic peroxidase is activated in P. chilensis after wounding. Assays of ionically bound peroxidase activity with four different substrates corroborated the differences found in isoform patterns between species. In P. tamarugo, the largest increases in activity were found with ortho-phenylenediamine and ferulic acid as substrates, whereas in P. chilensis the largest increase in activity was found with guaiacol as substrate. Because the same basic cell-wall peroxidase that accumulated after wounding in P. chilensis was present in P. tamarugo prior to wounding, and the activity of acidic cell-wall peroxidases increased after wounding in P. tamarugo but not in P. chilensis, we conclude that P. tamarugo is more tolerant to wound stress than P. chilensis.  相似文献   

Trimetoquinol: bronchodilator effects in horses with heaves following aerosolised and oral administration     

Camargo FC  Robinson NE  Berney C  Eberhart S  Baker S  Detolve P  Derksen FJ  Lehner AF  Hughes C  Tobin T 《Equine veterinary journal》2007,39(3):215-220

REASON FOR PERFORMING STUDY: The bronchodilator effects of trimetoquinol (TMQ) have been studied when administered i.v. or intratracheally, but not in an aerosolised form. OBJECTIVES: To define the relationship between the therapeutic and adverse responses (therapeutic index) of TMQ when administered as an aerosol or by the oral route. METHODS: Increasing doses of TMQ were administered to horses with heaves as an aerosol and by the oral route. Dose ranged 100-1000 microg/horse for aerosolised TMQ and from 6-60 microg/kg bwt for the oral route. Airway and cardiac effects were assessed by measurement of maximal change in pleural pressure (deltaPplmax) and heart rate (HR), respectively. Side effects of sweating, agitation and muscle trembling were scored subjectively. Duration of action of aerosolised (1000 pg/horse) and oral (6-60 microg/kg bwt) TMQ was evaluated over 6 h. RESULTS: Aerosol administration of TMQ caused dose-dependent bronchodilation but did not change HR or cause other observable side effects. When 1000 microg/horse was administered via aerosol, TMQ produced a 2-phase bronchodilation; an immediate effect lasting up to 30 min and a second phase between 2 and 4 h. Oral TMQ was therapeutically ineffective. CONCLUSION: Aerosol administration of TMQ is a safe and effective method of producing bronchodilation in horses.  相似文献   

Impacts of pollutant inputs on forest canopy condition in the UK: possible role of P limitations   总被引：1，自引：0，他引：1  

Harrison  AF; Carreira  J; Poskitt  JM; Robertson  SMC; Smith  R; Hall  J; Hornung  M; Lindley  DK 《Forestry》1999,72(4):367-378

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Freshwater biodiversity conservation through source water protection: Quantifying the potential and addressing the challenges     

Robin Abell  Kari Vigerstol  Jonathan Higgins  Shiteng Kang  Nathan Karres  Bernhard Lehner  Aparna Sridhar  Emily Chapin 《水产资源保护:海洋与淡水生态系统》2019,29(7):1022-1038