Gastric squamous cell carcinoma in three horses     

EC McKENZIE  JN MILLS  JR BOLTON 《Australian veterinary journal》1997,75(7):480-483

Gastric squamous cell carcinoma was diagnosed in three horses. Clinical signs observed in all cases were weight loss, anorexia and lethargy. Respiratory signs were prominent in one case. All three horses had depressed albumin and elevated globulin and fibrinogen concentrations. Two horses were mildly anaemic. Inflammatory exudates were present in peritoneal cavities in all cases, and cytological evaluation provided a positive diagnosis of squamous cell carcinoma in two cases. Pleural fluid samples taken from two cases were also classified as inflammatory exudates, but no neoplastic cells were detected on initial examination. In all cases the neoplasms had arisen from the oesophageal region of the stomach, and had metastised throughout the abdomen. Two cases had metastatic lesions within the pleural cavity.  相似文献   

Radiological,vascular osteochondrosis occurs in the distal tarsus,and may cause osteoarthritis     

Sigurdur F. Sigurdsson  Kristin Olstad  Charles J. Ley  Sigriður Björnsdóttir  David J. Griffiths  Cathrine T. Fjordbakk 《Equine veterinary journal》2022,54(1):82-96

  相似文献   

Interleukin-6 and tumour necrosis factor in synovial fluid from horses with carpal joint pathology   总被引：1，自引：0，他引：1  

Ley C  Ekman S  Elmén A  Nilsson G  Eloranta ML 《Journal of veterinary medicine. A, Physiology, pathology, clinical medicine》2007,54(7):346-351

The carpal joints are common sites of traumatic arthritis and osteoarthritis (OA) in athletic horses. The pro-inflammatory cytokines interleukin (IL)-6 and tumour necrosis factor (TNF) may be of great importance in the development of intra-articular lesions. The aim of the present study was to investigate possible associations between synovial fluid levels of bioactive IL-6 and TNF and different types of joint lesions seen in traumatic arthritis and OA. Synovial fluid was collected from horses with carpal lameness immediately before arthroscopic surgery. Articular cartilage, synovial membranes and intra-articular ligaments were assessed macroscopically at arthroscopy. Synovial fluid levels of IL-6 and TNF were determined by bioassays, and the cytokine levels between different grades of morphologic changes in each type of assessed tissue were compared. The highest levels of IL-6 were detected in joints with chip fractures. All joints with chip fractures also showed some degree of synovitis. Tumour necrosis factor bioactivity was low and not associated with any joint lesion. Hence, TNF is not useful as a biomarker indicating a specific joint lesion in equine traumatic arthritis or OA. We conclude that a dramatic increase of IL-6 in synovial fluid indicates the presence of osteochondral fragmentation, although low or undetectable levels of IL-6 do not exclude chip fractures. The role of IL-6 in the disease process of osteochondral fragmentation needs further investigation.  相似文献   

Discrepancy between the composition of some commercial cat foods and their package labelling and suitability for meeting nutritional requirements          下载免费PDF全文

EC Gosper  D Raubenheimer  GE Machovsky‐Capuska  AV Chaves 《Australian veterinary journal》2016,94(1-2):12-17

  相似文献   

Caroline Hopkins (nee Perrin) 1972–2016          下载免费PDF全文

Kersti Seksel  Jacqui Ley 《Australian veterinary journal》2016,94(12):437-437

  相似文献   

Falciform fat:femur length ratio provides a novel method for objective postmortem estimation of total body fat in overweight and obese cats     

Cecilia Ley  Alexandra T. Leijon  Tora E. Nyberg  Lisa M. Lindstrm  Charles J. Ley 《Journal of veterinary diagnostic investigation》2022,34(2):237

Determination of the nutritional condition, including estimation of amounts of total body fat (tBF), at routine postmortem examination of cats is typically based on subjective visual assessment. Subjective assessment may result in uncertainties regarding degree of overweight, and objective methods that provide a numerical value reflecting the tBF could be valuable to accurately judge excess body fat. We investigated if the falciform fat pad weight (FFPW) was correlated to tBF and could be used to detect overweight and obesity in cats. The FFPW and the femur length (FL) were recorded at postmortem examination in 54 cats and the FFPW:FL ratio (FFR) calculated. Each cat was additionally assigned to a fat category (FC) according to subjective assessment. Computed tomography was used to determine tBF as the body fat percentage (%BF), the body fat volume (BFV), and BFV normalized to animal size (nBFV) in 39 cats. There was strong correlation between the FFPW and the BFV (r = 0.888) and between the FFR and the nBFV (r = 0.897). The correlation between the nBFV and %BF was very strong (r = 0.974). Using a lower FFR cutoff value of 3.5 for obesity and 1.6 for overweight, there was a discrepancy in FC between using the FFR and subjective assessment in 6 of 54 cats (11%). We conclude that the FFPW increases proportionally with tBF and that the FFR provides a method for objective tBF estimation. We suggest introducing the FFR to feline postmortem examination protocols as an objective estimate of tBF.  相似文献   

Bodyweights and growth rates of spring- and autumn-born Thoroughbred horses raised on pasture     

CG Brown-Douglas  TJ Parkinson  EC Firth  PF Fennessy 《New Zealand veterinary journal》2013,61(5):326-331

AIM: To examine the growth of spring- and autumn-born Thoroughbred foals raised on pasture.

METHODS: Bodyweight and growth rates were measured in pasture-raised Thoroughbred horses, born in either spring (n=56) or autumn (n=7), from birth to approximately 13 and 17 months of age.

RESULTS: Birthweight tended to be lower in autumn- than spring-born foals (54.4, SD 7.92 kg vs 57.3, SD 5.90 kg; p=0.08). Between birth and 6 months of age, there was no difference in growth rate at equivalent ages between horses born in spring and autumn. Spring-born horses, which were weaned in the autumn, had lower post-weaning growth rates than autumn-born horses that were weaned in the spring. At time of the late yearling sales (March–April) in the Southern Hemisphere, unadjusted mean bodyweights of autumn-born horses (379.3, SD 24.8 kg) were lower (p=0.017) than those of the spring-born horses (437.2, SD 35.3 kg), although values in the autumn-born horses were all within two standard deviations (SD) of the mean of the spring-born animals. When adjusted for the covariates of birthweight and gender, the difference between spring- and autumn-born horses at that time was not significant (p=0.25).

CONCLUSIONS AND CLINICAL RELEVANCE: Some autumn-born foals could be marketed for late yearling sales in the Southern Hemisphere, on the basis of bodyweight. Furthermore, they might also be competitive in the Northern Hemisphere industry (sales or racing), as they would be competing against horses of the same official age.  相似文献   

Musculoskeletal responses of 2-year-old Thoroughbred horses to early training. Conclusions     

EC Firth  CW Rogers 《New Zealand veterinary journal》2013,61(6):377-383

This paper summarises and presents in context the main findings of an extensive series of studies of early training lasting 13 weeks in which the tissue responses of 2-year-old Thoroughbred horses were assessed using a combination of methods. Negligible clinical injury was detected and thus the study fulfilled the intention of investigating adaptive change rather than injury. Cancellous and cortical bone, some digital tendons, and articular cartilage responded to early training exercise to a greater or lesser degree. Clinical examination and ancillary diagnostic aids currently in veterinary clinical use are not sufficient to detect early abnormalities in metacarpo-phalangeal joint (MCPJ) cartilage found in both trained and untrained horses. Future work should centre on detection of such changes, on the precise registration of training workload, and on the manipulation of the responses of musculoskeletal tissues by careful investigation of the effects of introducing conditioning exercise at a young age.  相似文献   

More about Nomenclature     

Ley W 《Science (New York, N.Y.)》1960,131(3412):1566

  相似文献   

EFFECTS OF HYDRATION ON SCINTIGRAPHIC GLOMERULAR FILTRATION RATE MEASURED USING INTEGRAL AND PLASMA VOLUME METHODS IN DOGS WITH SUSPECTED RENAL DISEASE     

Frida Westgren  Charles J. Ley  Naruepon Kampa  Peter Lord 《Veterinary radiology & ultrasound》2014,55(6):632-637

The current standard scintigraphic method for estimating glomerular filtration rate (GFR) in dogs is the integral method, which normalizes renal GFR to body weight. The plasma volume method, that is normalizing GFR to plasma volume, has been reported to be more physiologically correct. The aim of this prospective study was to test the effect of hydration status on GFR measured by these two methods in a group of dogs with suspected renal disease. Eleven dogs were recruited. All dogs underwent standardized scintigraphic examinations before and after 15 ml/kg of fluid was administered intravenously at 5–7 ml/kg/min. Individual kidney GFR estimates (n = 22) were calculated using both methods and a consensus of two observers who were unaware of clinical findings. Individual kidney GFR increased significantly (P = 0.0008) after fluid administration using the integral method and individual kidney GFR using the plasma volume method remained constant. Percentage differences for individual kidney GFR before and after fluid administration were 31.4 ± 58.1% (change ± 95% CI) for the integral method and 0.1 ± 70% (change ± 95% CI) for the plasma volume method. Intravenously administered fluid increased individual kidney GFR from low to normal in 10 of 22 kidneys using the integral method and in 1 of 22 kidneys using the plasma volume method. Findings supported the use of the plasma volume method for scintigraphic calculation of GFR in dogs with suspected renal disease and indicated that errors of kidney status classification may more likely occur when the integral method is used.  相似文献