Pain-related cerebral potentials in response to acute painful electrical stimulation in sheep     

JP MORRIS  RM ONG  JK O'DWYER  JL BARNETT  PH HEMSWORTH  IJ CLARKE  EC JONGMAN 《Australian veterinary journal》1997,75(12):883-886

Objective To examine associations between late event-related cerebral potential amplitudes and behavioural responses to noxious electrical stimulation as an indicator of acute pain in sheep.
Design Analysis of variance for the effects of stimulus intensity on the behaviour and event-related cerebral potential variables.
Procedure Ninety-six brief constant current electrical pulse trains were presented to the front left leg of eight sheep at four intensities (2.5 to 10 mA) in a randomised order. An event-related cerebral potential and a graded flinch response were recorded for each stimulus and the 24 event-related cerebral potentials at each intensity were averaged to produce a mean waveform. Various components of this waveform were analysed and changes in these measures and the sheep's flinch response, as stimulus intensity increased, were determined.
Results Both the flinch response and some event-related cerebral potential components, that is, peak amplitudes 114 {N1}, 187 {P1}, 318 {P2} and 230 {Pm} ms after stimulus onset, were significantly affected as stimulus intensity increased.
Conclusion These corresponding behavioural and event-related cerebral potential changes indicate the usefulness of using changes in the event-related cerebral potential to measure acute pain in sheep.  相似文献   

Extramedullary plasmacytoma of the gastrointestinal tract in two dogs     

E G MacEwen  A K Patnaik  G F Johnson  A I Hurvitz  R A Erlandson  P H Lieberman 《Journal of the American Veterinary Medical Association》1984,184(11):1396-1398

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Gross, histologic, cytochemical, and immunocytochemical study of medullary thyroid carcinoma in sixteen dogs     

A K Patnaik  P H Lieberman 《Veterinary pathology》1991,28(3):223-233

The gross, histomorphologic, cytochemical, and immunocytochemical findings in 16 dogs with medullary thyroid carcinoma were evaluated. Grossly, the neoplasms were encapsulated, firm, lobulated, and grey-white to tan. The typical histologic pattern was groups or sheets of round to polygonal cells with fibrovascular stroma, which was thickened and hyalinized in places. Variants of clear cell (two dogs), giant cell (one dog), and oxyphil cell (one dog) types were also seen. In all 16 dogs, Grimelius-stained sections of the neoplasms revealed intracytoplasmic silver granules; ten tumors contained amyloid and four contained mucin. Immunohistochemically, the neoplasms reacted to AE1/AE3 (n = 13), S-100 protein (n = 5), neuron specific enolase (n = 14), synaptophysin (n = 11), calcitonin (n = 16), somatostatin (n = 4), gastrin (n = 7), and serotonin (n = 6). Only one neoplasm was positive for vimentin. None of the neoplasms reacted to antibodies for neurofilaments, thyroglobulin, insulin, glucagon, or adrenocorticotrophic hormone. Eleven neoplasms contained multiple (two to four) peptides, in various combinations. It was concluded that in dogs, gross and histologic features can be used to distinguish medullary thyroid carcinoma from other thyroid malignancies. Cytochemical and immunocytochemical studies with neuron specific enolase, synaptophysin, and calcitonin can be used to establish the diagnosis of medullary thyroid carcinoma in dogs.  相似文献   

Histopathology in a Case of Feline Urolithiasis          下载免费PDF全文

R. M. McCully  L. L. Lieberman 《The Canadian veterinary journal. La revue veterinaire canadienne》1961,2(2):52-61

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LESIONS IN SHEEP AND GUINEA PIGS PEN FED PARASITISED ANNUAL RYEGRASS (LOLIUM RIGIDUM)     

P. H. BERRY B.V.Sc.  R. D. COOK B.Sc.  Ph.D.    J. McHOWELL B.V.Sc.  Ph.D.  D.V.Sc.  M.R.C.V.S.  M.R.C.Path  M.A.C.V.S.    R. R. WHITE B.Sc.  Ph.D.  D. A. PURCELL M.V.B.  M.A.  PH.D.  M.R.C.V.S. 《Australian veterinary journal》1976,52(11):540-541

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SENSITIVITY OF RADIOGRAPHIC DETECTION OF LUNG METASTASES IN THE DOG     

JOHANN  LANG  DR MED VET    JEFFREY A. WORTMAN  VMD  PHD    LARRY T. GLICKMAN  VMD  DR PH    DARRYL N. BIERY  DVM    W. HARKER RHODES  VMD M MED SCI 《Veterinary radiology & ultrasound》1986,27(3):74-78

Thoracic radiographs were taken in right lateral recumbent (RLR), left lateral recumbent (LLR), and ventrodorsal (VD) projections in 80 dogs with known or suspected malignant tumors. Radiographs in each projection were interpreted, independently of those in the other two projections, by four veterinary radiologists, and classified as positive or negative for one or more lung metastases. The four radiologists then met, to agree on a diagnosis for each patient by simultaneously reviewing all three views. This panel diagnosis became the standard for subsequently classifying individual views as either true positive or true negative. As determined by a consensus of the panel, 25 dogs had at least one positive thoracic radiograph.
The three radiographic projections differed in sensitivity for the detection of lung metastases. In this study, the RLR view was the most sensitive, and the VD view the least sensitive. The sensitivity of detection improved significantly with multiple readers. From these data we recommend that, for detection of lung metastases in the dog, the RLR view be included in any diagnostic protocol; a minimum of two readers be used; and a three-view protocol be used if only one reader is available.  相似文献   

Interferon administered orally: protection of neonatal mice from lethal virus challenge   总被引：1，自引：0，他引：1  

T W Schafer  M Lieberman  M Cohen  P E Came 《Science (New York, N.Y.)》1972,176(41):1326-1327

Interferon was identified in the milk of mice injected with an interferon inducer. The kinetics of interferon appearance in serum and in milk were similar, but maximum concentrations in milk were 10 to 20 percent of those in serum. Interferon administered orally to neonatal mice was detected in their serums. Significantly more newborns survived an oral challenge with vesicular stomatitis virus when interferon had been induced in the lactating mothers.  相似文献   

Bioelectric phenomena related to protein-fixed charge in a crab nerve fiber     

E M Lieberman  M S Perkins  T Tomita  E B Wright 《Science (New York, N.Y.)》1967,156(772):240-242

The bioelectrical characteristics of a crab nerve fiber subjected to solutions containing the impermeant anions ferrocyanide, glutamate, or ethanolsulfate substituted for chloride include prolonged slow depolarizations that elicit prolonged trains of impulses sulperimposed on the plateau portion. Propionate and nitrate depress repetitive firing while thiocyancite has only a slighit effect. Nerves treated with ferrocyanide lose potassium and gain sodium, which fact may account for their depolarization. On the other hand, studies with interference microscopy reveal shift by ferrocyanide in the interference fringe pattern of the sheath material; this suggests a reorientation of fixed charges in the protein layers by direct action of the anion on these layers. This may also account for the electrical manifestations observed.  相似文献   

Identification of host proteins required for HIV infection through a functional genomic screen     

Brass AL  Dykxhoorn DM  Benita Y  Yan N  Engelman A  Xavier RJ  Lieberman J  Elledge SJ 《Science (New York, N.Y.)》2008,319(5865):921-926

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Rotation and Magnetism of Earth's Inner Core   总被引：1，自引：0，他引：1  

GA Glatzmaier  PH Roberts 《Science (New York, N.Y.)》1996,274(5294):1887-1891

Three-dimensional numerical simulations of the geodynamo suggest that a super- rotation of Earth's solid inner core relative to the mantle is maintained by magnetic coupling between the inner core and an eastward thermal wind in the fluid outer core. This mechanism, which is analogous to a synchronous motor, also plays a fundamental role in the generation of Earth's magnetic field.  相似文献