Germany wants in on u.s. Space station     

Dickson D 《Science (New York, N.Y.)》1985,227(4686):499

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Britain Debates Science Education Reforms: School curricula are criticized for being excessively academic; all agree changes are needed, but reforms may prove elusive     

Dickson D 《Science (New York, N.Y.)》1983,222(4622):397-399

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Britain's Ivory Tower Goes High Tech: Cambridge University's scientific talent and relaxed attitude toward off-campus work is attracting high-technology development     

Dickson D 《Science (New York, N.Y.)》1985,227(4694):1560-1562

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Hopes are flying high for u.N. Space conference     

Dickson D 《Science (New York, N.Y.)》1982,217(4555):134-135

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Discovery and directed evolution of a glyphosate tolerance gene   总被引：2，自引：0，他引：2  

Castle LA  Siehl DL  Gorton R  Patten PA  Chen YH  Bertain S  Cho HJ  Duck N  Wong J  Liu D  Lassner MW 《Science (New York, N.Y.)》2004,304(5674):1151-1154

The herbicide glyphosate is effectively detoxified by N-acetylation. We screened a collection of microbial isolates and discovered enzymes exhibiting glyphosate N-acetyltransferase (GAT) activity. Kinetic properties of the discovered enzymes were insufficient to confer glyphosate tolerance to transgenic organisms. Eleven iterations of DNA shuffling improved enzyme efficiency by nearly four orders of magnitude from 0.87 mM-1 min-1 to 8320 mM-1 min-1. From the fifth iteration and beyond, GAT enzymes conferred increasing glyphosate tolerance to Escherichia coli, Arabidopsis, tobacco, and maize. Glyphosate acetylation provides an alternative strategy for supporting glyphosate use on crops.  相似文献   

NIH Molecular Libraries Initiative     

Austin CP  Brady LS  Insel TR  Collins FS 《Science (New York, N.Y.)》2004,306(5699):1138-1139

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CD46 in meningococcal disease     

Johansson L  Rytkonen A  Bergman P  Albiger B  Källström H  Hökfelt T  Agerberth B  Cattaneo R  Jonsson AB 《Science (New York, N.Y.)》2003,301(5631):373-375

The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against meningococcal disease.  相似文献   

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP   总被引：2，自引：0，他引：2  

Lewis J  Dickson DW  Lin WL  Chisholm L  Corral A  Jones G  Yen SH  Sahara N  Skipper L  Yager D  Eckman C  Hardy J  Hutton M  McGowan E 《Science (New York, N.Y.)》2001,293(5534):1487-1491

JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice expressing mutant beta-amyloid precursor protein (APP), thus modulating the APP-Abeta (beta-amyloid peptide) environment. The resulting double mutant (tau/APP) progeny and the Tg2576 parental strain developed Abeta deposits at the same age; however, relative to JNPL3 mice, the double mutants exhibited neurofibrillary tangle pathology that was substantially enhanced in the limbic system and olfactory cortex. These results indicate that either APP or Abeta influences the formation of neurofibrillary tangles. The interaction between Abeta and tau pathologies in these mice supports the hypothesis that a similar interaction occurs in Alzheimer's disease.  相似文献   

NIOSH and the CDC reorganization     

Key MM  Robbins A  Millar JD  Rosenstock L 《Science (New York, N.Y.)》2004,305(5684):607

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Britain's Scientific Decline     

Dickson D 《Science (New York, N.Y.)》1986,234(4776):538-539

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