Combined Therapeutic Effect of Dietary Selenium and Vitamin Ε on Manifested Vesd Syndrome in Weaned Pigs     

Juhani Hakkarainen  Paul Lindberg  Gsta Bengtsson  Lennart Jnsson 《Acta veterinaria Scandinavica》1978,19(2):285

By using a therapeutic dietary supplementation in pigs, which had developed the vitamin Ε and selenium deficiency (VESD) syndrome, the same amounts of α-tocopheryl acetate and selenium were found to be effective as under prophylactic conditions. The experiment thus supported the conclusions that the addition of 5 mg DL-α-tocopheryl acetate/kg and 135 μg selenium/kg to a diet, which contained only traces of vitamin Ε and selenium, represents a level of minimal requirement. Glutathione peroxidase activity in blood serum was used to evaluate the selenium status in pigs. A modified method for determination of tocopherol in fat tissue was described. The addition of 15 mg α-tocopheryl acetate/kg diet was demonstrated to be sufficient to maintain the tocopherol stores in body fat at an unchanged level.  相似文献   

Elution of glomerular bound antibodies in experimental streptococcal glomerulonephritis   总被引：1，自引：0，他引：1  

L H Lindberg  K L Vosti 《Science (New York, N.Y.)》1969,166(908):1032-1033

lmmnunoglobulin G, eluted from glomeruli of rats with streptococcal glomerulonephritis, reacts with type 12 M protein of the streptococcus but not with other streptococcal or renal antigens. Thtrefore, this disease may be madiated by fixation of antigen-antibody complexes consisting of streptococcal M protein and type-specific antibody.  相似文献   

Blood selenium in a beef hern affected with muscular degeneration     

S O Jacobsson  S Lidman  P Lindberg 《Acta veterinaria Scandinavica》1970,11(2):324-326

In a Hereford herd in the middle of Sweden high mortality occurred in the calves in 1967 and 1968. Most frequent symtoms were respiratory distress and weakness. The diagnosis M.D. was established by postmortem examination. For this reason a study was made of the selenium content in forage, in blood and milk from cows and in blood from their offspring. The Se analyses were made by the method of Lindberg (1968).  相似文献   

Histiocytic ulcerative colitis in a boxer. A case report   总被引：1，自引：0，他引：1  

R Lindberg  T Segall 《Nordisk veterinaermedicin》1977,29(12):552-555

A case of canine histiocytic ulcerative colitis, a disease of boxers, is here described. It appears that this disease has not been previously reported in Scandinavia. The diagnosis was established at necropsy of a 5-month-old boxer, which had shown bloody diarrhoea since the age of four weeks. Treatment with antibiotics had only given a temporary remission of the condition. Macroscopical findings included thickening of the wall of the descending colon and rectum, multiple ulcers in the rectocolonic mucosa and marked enlargement of the colonic lymph nodes. Microscopically the lesions were characterized by large accumulations of PAS-positive histiocytes, mixed with cells of the plasma cell type, in the mucosa and submucosa of the rectum and descending colon and in the colonic lymph nodes. The importance of using proctocolonoscopy and colon biopsy for the clinical diagnosis of this condition is stressed.  相似文献   

Relationship between selenium content of forage, blood and organs of sheep, and lamb mortality rate     

P Lindberg  S O Jacobsson 《Acta veterinaria Scandinavica》1970,11(1):49-58

The investigation comprised 12 herds, totalling 660 sheep, in the counties of Stockholm and Uppsala. The selenium content of specimens of forage, whole blood, muscle, liver, and kidney was determined by a fluorimetric method. Data on the number of born and dead lambs were collected 4—5 months after lambing. Dead and sick lambs were subjected to necropsy and to clinico-chemical analyses, respectively.The selenium content of hay and corn was lower than 60 ng per g, which some authors regard as the minimum level of Se requirement for protection against white muscle disease in sheep. The analyses of forage mixtures containing oil concentrates and beet pulp showed selenium levels that were about 2—5 times as high as this minimum level.In herds in which the animals had not been treated with selenium preparations prior to sampling, there was a significant positive correlation between the selenium content of the forage and that of whole blood. A relationship was also noted between the selenium content of forage and of organs.In 9 out of the 12 herds the selenium concentrations in whole blood were on the level that is considered to be representative of white muscle disease.A high mortality rate was recorded for lambs whose mothers had low selenium levels in their blood.Prophylactic and curative treatment with selenium plus vitamin E orally and/or parenterally probably reduced lamb mortality rate in the herds fed a low-selenium diet.  相似文献   

Experimental contagious caprine pleuropneumonia: a long term study on the course of infection and pathology in a flock of goats infected with Mycoplasma capricolum subsp. capripneumoniae     

Wesonga HO  Bölske G  Thiaucourt F  Wanjohi C  Lindberg R 《Acta veterinaria Scandinavica》2004,45(3-4):167-179

Contagious caprine pleuropneumonia (CCPP) is a major threat to goat farming in parts of Africa and Asia. It classically causes acute high morbidity and mortality early in infection, but little is known of its long term epizootiology and course. In this study, 10 goats were inoculated with Mycoplasma capricolum subsp. capripneumoniae (M. capripneumoniae) and then mixed with 15 goats for contact transmission. The disease course was monitored in each goat for 56-105 days, whereafter the goats were killed and necropsied. Varying features signifying infection occurred in altogether 17 goats (7 inoculated, 10 in-contact). Clinical signs were severe in 8 goats but no fatalities occurred. Only 6 goats had serum antibody titres against M. capripneumoniae in ELISA. Fourteen goats (5 inoculated, 9 in-contact) had chronic pleuropulmonary lesions compatible with CCPP at necropsy and 7 of those showed M. capripneumoniae antigen in the lung by immunohistochemistry. Neither cultivation nor PCR tests were positive for the agent in any goat. The results indicate that the clinical course of CCPP in a flock may be comparatively mild, M. capripneumoniae-associated lung lesions may be present at a late stage of infection, and chronic infection may occur without a significant serological response.  相似文献   

Lack of virus transmission from bovine viral diarrhoea virus infected calves to susceptible peers     

Niskanen R  Lindberg A  Larsson B  Alenius S 《Acta veterinaria Scandinavica》2000,41(1):93-99

None of 14 calves not previously exposed to BVDV became infected after being forced to have nose-to-nose contact with a group of 5 calves primarily infected with BVDV. These were 5 male calves primarily infected with a type I BVDV strain, after nose-to-nose contact with a persistently viraemic calf. All 5 became infected and were clinically affected. They were slightly depressed and pyretic at 8-9 days post-infection, with a body temperature of up to 41.6 degrees C, but no medical treatment was required. Seroconversions to BVDV were detected in these calves at 14 to 21 days post-infection. The 14 healthy calves, proved to be free from BVD virus--as well as antibodies, were introduced 2 by 2 into the group of 5 primarily infected calves on days 4, 7, 14, 21, 28, 35 and 42 after the 5 calves had been in contact with the persistently BVDV-infected calf. Each pair of calves stayed within the primarily infected group for 2 days. None of these 14 calves seroconverted to BVDV.  相似文献   

Parameters of the Reproductive Tract,Spermatogenesis, Daily Sperm Production and Major Seminal Plasma Proteins of Tropically Adapted Morada Nova Rams     

FML Sousa  CH Lobo  ESB Menezes  JPA Rego  RV Oliveira  AC Lima‐Souza  M Fioramonte  FC Gozzo  RCFF Pompeu  MJD Cândido  JT Oliveira  AA Moura 《Reproduction in domestic animals》2014,49(3):409-419

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Immunolocalization of the Cholesterol Transporters ABCA1 and ABCG1 in Canine Reproductive Tract Tissues and Spermatozoa     

N Palme  AC Becher  M Merkl  M Glösmann  C Aurich  S Schäfer‐Somi 《Reproduction in domestic animals》2014,49(3):441-447

The mammalian sperm membrane undergoes cholesterol efflux during maturation and fertilization. Although ATP‐binding cassette (ABC) transporters are known to transport cholesterol through cell membranes in other organs, their presence in canine testis, epididymis and sperm has not been proven to date. Hence, the aim of the present study was to localize the ABC transporters ABCA1 and ABCG1 in canine testicular and epididymidal tissue as well as in spermatozoa membranes. To this end, semen samples from 12 dogs as well as testicles and epididymides of four young and healthy dogs were prepared for immunohistochemistry, respectively. Capacitation and acrosome reaction (AR) were induced in aliquots of the semen samples before immunostaining to assess changes in the expression of ABCA1 and ABCG1. Evaluation by confocal microscopy revealed the presence of both ABCA1 and ABCG1 in canine testicles and of ABCA1 in the epididymides. In spermatozoa, only ABCA1 immunoreactivity was detected, mainly in the region of the acrosome and midpiece. After induction of capacitation, ABCA1 signal persisted in the acrosome but disappeared after AR, indicating a loss of ABCA1 with the loss of the acrosome. We conclude that ABCA1 and ABCG1 are expressed in canine testis, whereas only ABCA1 is expressed in epididymis and spermatozoa membrane, both transporters probably contributing to the regulation of membrane cholesterol content.  相似文献   

Role of CD47 as a marker of self on red blood cells     

Oldenborg PA  Zheleznyak A  Fang YF  Lagenaur CF  Gresham HD  Lindberg FP 《Science (New York, N.Y.)》2000,288(5473):2051-2054

The immune system recognizes invaders as foreign because they express determinants that are absent on host cells or because they lack "markers of self" that are normally present. Here we show that CD47 (integrin-associated protein) functions as a marker of self on murine red blood cells. Red blood cells that lacked CD47 were rapidly cleared from the bloodstream by splenic red pulp macrophages. CD47 on normal red blood cells prevented this elimination by binding to the inhibitory receptor signal regulatory protein alpha (SIRPalpha). Thus, macrophages may use a number of nonspecific activating receptors and rely on the presence or absence of CD47 to distinguish self from foreign. CD47-SIRPalpha may represent a potential pathway for the control of hemolytic anemia.  相似文献