von Willebrand's disease in Dobermann dogs in Australia     

T. STOKOL  BW PARRY  PD MANSELL 《Australian veterinary journal》1995,72(7):257-262

SUMMARY Over a 5-year period (1988–92), von Willebrand factor antigen (vWf:Ag) concentrations were determined on plasma samples from 614 Dobermanns. The vWf:Ag concentration was < 50 canine units (CU)/dL in 373 dogs (61%); these dogs were classified as carriers of the von Willebrand's disease (vWD) gene. In order to identify which dogs were at risk of haemorrhage due to vWD, we determined a cut-off vWf:Ag concentration below which dogs could be considered at risk. This cut-off was chosen in order to minimise the number of dogs genuinely at risk of haemorrhage, being wrongly classified as not at risk. This was done without sacrificing the specificity of the cut-off to any great extent. A vWf:Ag concentration of < 36 CU/dL was empirically chosen as the optimum cut-off concentration. In 282 dogs (76% of the carriers), the vWf:Ag concentration was below this cut-off and these dogs were, thus, classified as being at risk of haemorrhage due to vWD. Haemorrhage attributable to vWD was seen in 107 dogs (29% of the carriers, or 17% of all the dogs). Haemorrhage mostly followed trauma or surgery, but spontaneous genitourinary and gastrointestinal haemorrhages were also frequent. Of these dogs, 92 were of known age, with a median of 3 years, and 102 were of known sex, with 61% being female. In 89 dogs in which the severity of haemorrhage was subjectively assessed, mild and moderate bleeding occurred with similar frequency (48% and 43%, respectively). There were 8 cases of severe haemorrhage, with two deaths. The likelihood of haemorrhage was related to the vWf:Ag concentration: only 8% of 91 dogs with concentrations between 36 and 49 CU/dL had haemorrhage attributable to vWD, but 36% with concentrations < 36 CU/dL did so. Furthermore, dogs with haemorrhage attributable to vWD had significantly (P < 0.001) lower vWf:Ag concentrations (median 12 CU/dL, n = 107) than dogs with no such history (median 30 CU/dL, n = 132). The data indicate that vWD is a significant problem in the Dobermann breed in Australia and we accordingly recommend that steps be taken to reduce its prevalence, such as the establishment of a national testing scheme to determine the vWD status of all dogs used for breeding.  相似文献   

Antigenic comparisons of selected avian reoviruses by use of the plaque-reduction neutralization assay     

B N Nersessian  P D Lukert  M A Goodwin 《American journal of veterinary research》1989,50(9):1475-1480

The antigenic interrelatedness of 3 clone-purified turkey reoviruses (NG-Turkey, 82-88, and NC-TEV) to each other and to 4 clone-purified chicken reoviruses (S1133, Co8, Fahey-Crawley, and avian type 2) was determined in reciprocal cross-neutralization tests, using polyclonal antisera and the plaque-reduction technique. The morphologic features of plaques formed under agar were studied for all 7 reoviruses, and size comparisons for turkey vs chicken isolates were made. All 3 turkey reoviruses (with the exception of NG-Turkey vs Fahey-Crawley chicken reovirus) formed plaques significantly (P less than 0.05) smaller than plaques produced by their chicken counterparts. The 3 turkey reoviruses were closely related to each other and to chicken reovirus CO8. The antigenic differences between turkey reoviruses 82-88 and NC-TEV and chicken reovirus S1133 were slight (minor subtype); however, the latter and NG-Turkey were serotypically distinct. The NG-Turkey and 82-88 turkey reoviruses were more related (minor subtype) to the Fahey-Crawley and avian type 2 chicken reoviruses, than was NC-TEV turkey reovirus (major subtype).  相似文献   

Haemophilia A in a family of miniature poodles     

PD MANSELL  BW PARRY  PJ VAN  ORSOUW 《Australian veterinary journal》1990,67(11):420-421

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Pathogenicity and immunosuppressive properties of infectious bursal disease "intermediate" strains   总被引：4，自引：0，他引：4  

L A Mazariegos  P D Lukert  J Brown 《Avian diseases》1990,34(1):203-208

This study was conducted to test the pathogenicity and immunosuppressive effects of seven commercially available infectious bursal disease (IBD) vaccines. These vaccine strains are intermediate in their pathogenicity in susceptible specific-pathogen-free (SPF) chickens. One-day-old and 3-week-old SPF chickens were vaccinated with these vaccines. Two weeks after IBD vaccination, they were vaccinated with Newcastle disease virus (NDV). The pathogenic and immunosuppressive effects of the IBD vaccines were evaluated by the antibody response to NDV vaccination, the bursa: body weight index, and histopathological lesions of the bursa. It was found that these strains were highly variable in their virulence and immunosuppressive properties. Three of the strains tested were found to be highly virulent and immunosuppressive; two others were moderate; and two could be classified as mild.  相似文献   

Cryptosporidiosis in four cockatoos with psittacine beak and feather disease.     

K S Latimer  W L Steffens  P M Rakich  B W Ritchie  F D Niagro  I M Kircher  P D Lukert 《Journal of the American Veterinary Medical Association》1992,200(5):707-710

Cryptosporidiosis was diagnosed in 4 cockatoos with psittacine beak and feather disease. Three of the birds had cryptosporidiosis confined to the epithelium covering the bursa of Fabricius. One bird had generalized parasitism of the small intestine, large intestine, and bursal epithelium. All of the birds had intermittent to protracted diarrhea before death. Presumably, acquired immunodeficiency from psittacine beak and feather disease promoted establishment of cryptosporidiosis and other secondary diseases including septicemia, peritonitis, chlamydiosis, and mycotic ventriculitis.  相似文献   

A survey of northern Victorian dairy farmers to investigate dairy calf management: calf‐rearing practices          下载免费PDF全文

AJ Phipps  DS Beggs  AJ Murray  PD Mansell  MF Pyman 《Australian veterinary journal》2018,96(4):107-110

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First detection of bovine noroviruses and detection of bovine coronavirus in Australian dairy cattle          下载免费PDF全文

SJ Symes  JL Allen  PD Mansell  KL Woodward  KE Bailey  JR Gilkerson  GF Browning 《Australian veterinary journal》2018,96(6):203-208

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Patrick John Wright 1942–2015          下载免费PDF全文

BW Parry  DB Galloway  PD Mansell  JR Watts 《Australian veterinary journal》2016,94(11):399-399

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Generation of Airborne Particles from Different Bedding Materials Used for Horse Keeping     

K. Fleming MSc  E.F. Hessel PD Dr  H.F.A. Van den Weghe Prof Dr Ir 《Journal of Equine Veterinary Science》2008,28(7):408-418

Among other factors (eg, feed), bedding material has an important effect on stable air quality with respect to airborne particle formation. This study was designed to establish which material is suited to create an improved stable environment for horses. First, the following materials were analyzed under standardized conditions in a laboratory experiment: wheat straw, dry wood shavings, hemp shives, linen shives, wheat straw pellets, paper cuttings (unprinted newspaper). The second investigation was carried out under in situ conditions in which three of these bedding materials (wheat straw, wood shavings, and straw pellets) were analyzed under practical conditions. In both experiments, airborne particle concentrations were detected online with the gravimetrically measuring analyzer TEOM 1400a (Rupprecht & Patashnick Co., Franklin, MA). In the laboratory experiment, the TEOM was equipped successively with different inlets to measure the particle fractions PM₁, PM_2.5, PM₁₀, and PM₂₀. During the in situ experiment, only the fraction PM₁₀ was detected. In the laboratory experiment, hemp and linen had the highest generation of airborne particles in all fractions. The lowest particle generation was detected with straw pellets. Results of the in situ investigation supported results of the laboratory experiment with respect to mean particle generation of straw pellets. With an average of 111.2 ± 149.2 μg/m³, it was significantly lower than the mean particle generation of wheat straw with 227.5 ± 280.8 μg/m³. The particle generation of wood shavings had an average of 140.9 ± 141.9 μg/m³ and also was significantly lower than the generation by wheat straw. An activity-correlated variation of particle concentrations was found. In conclusion, taking both experiments into consideration, straw pellets seemed to be suitable for horse stables, to promote an improvement in the stable climate in relation to airborne particle formation.  相似文献   

PALLIATIVE IRRADIATION OF SCOTTISH FOLD OSTEOCHONDRODYSPLASIA     

Madeleine Hubler  Dr. Med. Vet.    Mathias Volkert  Dr. Med. Vet.    Barbara Kaser-Hotz  Prof. Dr. Med. Vet.    Susi Arnold  PD Dr. Med. Vet. 《Veterinary radiology & ultrasound》2004,45(6):582-585

This report describes palliative irradiation as treatment for Scottish Fold osteochondrodysplasia. A 3-year-old female spayed Scottish Fold cat suffering from osteochondrodysplasia was referred to the Veterinary Teaching Hospital, University of Zurich. Based on the breed, history, clinical signs, radiographic findings, and the histologic diagnosis of a biopsy specimen, Scottish Fold osteochondrodysplasia was confirmed. To control the exostoses leading to inflammatory processes and pain, radiotherapy was initiated as palliative treatment. This was successful in relieving the clinical signs within a few weeks. The short- and long-term results after radiotherapy are presented and discussed with a comparable human disease, the plantar heel spur, which also responds well to radiotherapy.  相似文献