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Clinical Trial Design: Veterinary Perspectives 总被引：2，自引：1，他引：1
Elizabeth M. Lund DVM MPH Katherine M. James James D. Neaton 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1994,8(5):317-322
Tremendous potential exists for the use of the randomized clinical trial (RCT) in veterinary clinical research. Understanding the fundamentals of RCT design not only benefits clinical researchers, but it can enhance the ability of practitioners to interpret published RCT reports. In this article, the essential components of RCT design and implementation are described using examples from clinical veterinary medicine. 相似文献
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Jana L. Jones DVM D.J. Krahwinkel Jr. DVM MS B.W. Rorhbach VMD MPH 《Journal of Veterinary Emergency and Critical Care》1999,9(4):195-202
Alterations in nitric oxide (NO)production may play a role in critical illness. Total serum nitrate/nitrite concentrations [SNN (uM/L)], the stable metabolites of NO, have been used as an indirect measure of NO in people, with increased concentrations reported in cases of critical illness. The relationship of nitric oxide (NO) to criticalillness in dgos is unknown. We tested the hypothesis that critically ill intensive care unit (ICU) canine illness in dogs is unknown. We tested the hypothesis that critically ill intesive care unit (ICU) canine patients would have increased SNN as compared to healthy dogs and non-critically ill dogs. An organ failure index score (OFI) was assigned to dogs admitted to the ICU to evaluate trends between disease severtiy and SNN. Critically ill dogs had significantly (p < 0.05) higher SNN (median 10.53) as compared to non-critically ill dogs (median 2.3) and healthy dogs (median 1.92). Critically ill dogs with the most severe disease (as based on OFI) had higher SNN concentrations. Survival of critically ill dogs with SNN of > 15 upon ICU admission (12% survival) was significantly less than survival of critically ill dogs with SNN ≤ 15 (91%) survival).l (Vet. Emerg. & Crit. Care, 9: 195–202, 1999) 相似文献
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Thomas L. Seahorn DVM MS Janyce L. Cornick DVM MS Noah D. Cohen VMD MPH PhD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1992,6(6):307-311
The medical records of 75 horses with duodenitis-proximal jejunitis (DPJ) were reviewed. Ages, physical parameters, laboratory values, and treatment data were compared between horses surviving DPJ and horses not surviving DPJ (Table 1). Fifty of 75 horses (66.6%) survived. Sixty-six horses (88.0%) were managed with medical treatment alone and nine horses (12.0%) were managed with medical treatment plus surgical intervention. Using a logistic regression model, the association of each of the 19 physical and laboratory parameters with death was evaluated retrospectively in the 75 horses. Three parameters (anion gap, abdominal fluid total protein concentration, and volume of gastric fluid for the first 24 hours of hospitalization) were significantly associated with death by univariate analysis. Using a stepwise multiple logistic regression, two parameters remained significantly associated with death (P < 0.05), anion gap and abdominal fluid total protein concentration. 相似文献
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Keaton R. S. Morgan BVSc Ameet Singh DVM DVSc DACVS-SA Michelle A. Giuffrida VMD MSCE DACVS Ingrid M. Balsa DVM DACVS-SA Galina Hayes PhD DACVECC DACVS Margaret L. Chu DVM Christopher B. Thomson DVM Shiori Arai DVM PhD DACVS-SA Daniel D. Smeak DVM MS DACVS Eric Monnet DVM PhD DACVS DECVS Laura E. Selmic BVetMed MPH DACVS-SA DECVS Megan Cray VMD Janet A. Grimes DVM MS DACVS-SA Taylor Morris HBSc J. Brad Case DVM MS DACVS-SA Jeffrey J. Biskup DVM DACVS Jason Haas DVM Kelley Thieman-Mankin DVM MS DACVS-SA Milan Milovancev DVM DACVS-SA Mathieu Gatineau DVM MS DACVS-SA 《Veterinary surgery : VS》2020,49(1):138-145
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Jessica A. Ogden DVM DACVS-SA Laura E. Selmic BVetMed MPH DACVS-SA Julius M. Liptak BVSc MVetClinStud FACVSc DACVS-SA DECVS Michelle L. Oblak DVM DVSc DACVS-SA William T. N. Culp VMD DACVS Carlos H. de Mello Souza DVM MS DACVIM DACVS Janet A. Grimes DVM MS DACVS-SA Marine Traverson DVM MS DACVS-SA Megan Cray VMD Brittany E. Abrams DVM Vincent A. Wavreille DVM MS MRCVS DACVS-SA 《Veterinary surgery : VS》2020,49(6):1132-1143