DETECTION OF A LIVER TUMOR IN A BEAGLE DOG USING SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY     

Ronald K.  Wolff  PhD  Wayne F.  Beierman  P. ENG  Margaret J.  Mason  DVM  Jack R.  Harkema  DVM  PhD  Bruce A.  Muggenburg  DVM  PhD 《Veterinary radiology & ultrasound》1988,29(4):179-183

This case report describes the detection of a liver tumor in an 11–year-old female Beagle dog using single photon-emission computed tomography (SPECT). A mass was palpated in the cranial abdomen during removal of recurrent mammary tumors. A conventional nuclear medicine liver scan, following injection of ^99mTc-sulfur colloid, was equivocal. SPECT was then performed in a second procedure, using a simple system that rotated the dog before a gamma camera. Transverse plane images clearly showed a spheric space-occupying lesion, found at gross necropsy and confirmed histologically as a hepatoma. Discrete liver tumors may be detected more readily and their size determined more accurately using SPECT than with conventional nuclear medicine approaches.  相似文献   

Veterinary Tomography     

Jack C.  Geary  D.V.M. 《Veterinary radiology & ultrasound》1967,8(1):32-38

  相似文献   

Possible hexachlorophane poisoning in calves     

E J Jack 《The Veterinary record》1972,90(7):198-199

  相似文献   

The possible role of weed races in the evolution of cultivated plants   总被引：1，自引：0，他引：1  

Jack R. Harlan 《Euphytica》1965,14(2):173-176

Most of our cultivated plants have companion weed races. This phenomenon is so common that it must have some biological significance. In some cases the weeds are the progenitors of the crops, but in many cases we must look for something that could give rise to both the weed forms and the cultivated form together.The weed races have served as reservoirs of reserve germ plasm, periodically injecting portions of it into the crop under conditions that would most favor increase in variability, heterozygosity and heterosis.Presented at a symposium entitled The Origin and Evolution of Cultivated Plants held during the Tenth International Botanical Congress, 1964. Submitted by J. B. Hutchinson and J. G. Hawkes.  相似文献   

"Good samaritans": a legislative solution for mandatory reporting of suspected animal abuse     

Jack DC 《The Canadian veterinary journal. La revue veterinaire canadienne》2005,46(6):539-540

  相似文献   

Physiologic assessment of blood glucose homeostasis via combined intravenous glucose and insulin testing in horses     

Eiler H  Frank N  Andrews FM  Oliver JW  Fecteau KA 《American journal of veterinary research》2005,66(9):1598-1604

OBJECTIVE: To characterize the physiologic response to i.v. bolus injection of glucose and insulin for development of a combined glucose-insulin test (CGIT) in horses. ANIMALS: 6 healthy mares and 1 mare each with pituitary adenoma and urolithiasis. PROCEDURE: Horses were given a CGIT (glucose, 150 mg/kg; insulin, 0.1 U/kg); results were compared with a singular i.v. glucose tolerance test (GTT; 150 mg/kg) and a singular i.v. insulin sensitivity test (IST; 0.1 U/kg). Healthy horses were also given a CGIT after receiving xylazine and undergoing stress. RESULTS: Physiologically, the CGIT resulted in a 2-phase curve with positive (hyperglycemic) and negative (hypoglycemic) portions; the positive phase came first (250% of baseline at 1 minute). The descending segment declined linearly to baseline by approximately 30 minutes and to a nadir at 58% of baseline by 75 minutes. After a 35-minute valley, a linear ascent to baseline began. Addition of insulin in the CGIT increased glucose utilization by approximately 4.5 times during the positive phase but not during the negative phase. The diseases' effects and experimental inhibition of insulin secretion with xylazine and stress were detectable by use of the 2 phases of the CGIT. Only a single positive phase resulted from the GTT and a single negative phase from the IST CONCLUSIONS AND CLINICAL RELEVANCE: The CGIT resulted in a consistent, well-defined glycemia profile, which can be disrupted experimentally or by a disease process. The CGIT has clinical potential because it provides integrated information and more information than either the singular GTT or IST.  相似文献   

In vitro investigation of the effects of nonsteroidal anti-inflammatory drugs, prostaglandin E2, and prostaglandin F2alpha on contractile activity of the third compartment of the stomach of llamas     

Van Hoogmoed LM  Drake CM  Snyder JR 《American journal of veterinary research》2004,65(2):220-224

OBJECTIVE: To determine the in vitro effect of prostaglandin (PG) E2, PGF2alpha, and the nonsteroidal anti-inflammatory drugs (NSAIDs) indomethacin, ketoprofen, and nabumetone on the contractile strength of the circular smooth muscle layer of the third compartment of the stomach of llamas. SAMPLE POPULATION: Specimens of the third compartment obtained from 5 healthy adult llamas. PROCEDURE: Full-thickness tissue samples were collected from the third compartment immediately after euthanasia. Specimens were cut into strips oriented along the circular muscle layer and mounted in a tissue bath system. Incremental amounts of ketoprofen, nabumetone, indomethacin, PGE2, and PGF2alpha were added, and contractile strength (amplitude of contractions) was recorded. RESULTS: Generally, PGE2 reduced contractile strength of the circular smooth layer of the third compartment, whereas PGF2alpha, increased the strength of contractions. The activity of the NSAIDs was generally excitatory in a concentration-dependent manner, although significant changes were induced only by administration of indomethacin. CONCLUSIONS AND CLINICAL RELEVANCE: On isolated smooth muscle strips of the third compartment of llamas, exogenous PGE2 and PGF2alpha had a variable effect on contractile strength. Administration of the NSAIDs did not inhibit contractility and would not be likely to induce stasis of the third compartment in the absence of an underlying disease process.  相似文献   

Effect of glomerular filtration rate on clearance and myelotoxicity of carboplatin in cats with tumors     

Bailey DB  Rassnick KM  Erb HN  Dykes NL  Hoopes PJ  Page RL 《American journal of veterinary research》2004,65(11):1502-1507

  相似文献   

Surfactant protein D expression in normal and pneumonic ovine lung     

Grubor B  Gallup JM  Ramírez-Romero R  Bailey TB  Crouch EC  Brogden KA  Ackermann MR 《Veterinary immunology and immunopathology》2004,101(3-4):235-242

  相似文献   

Cell-based cancer gene therapy: breaking tolerance or inducing autoimmunity?   总被引：2，自引：0，他引：2  

Rodriguez-Lecompte JC  Kruth S  Gyorffy S  Wan YH  Gauldie J 《Animal health research reviews / Conference of Research Workers in Animal Diseases》2004,5(2):227-234

This review examines the mechanisms involved in anti-tumor immunity and how peptides present in many tumor types (tumor-associated antigens) are recognized by T cells from tumor-bearing cancer patients. Tumor-associated antigens are derived from proteins that are also expressed in normal cells. It is predicted that immune responses to such peptides will be compromised by self-tolerance or that stimulation of effective immune responses will be accompanied by autoimmunity. We also consider that the immunity induced against two autoantigens, which are highly conserved in vertebrates, involve qualitatively different mechanisms, such as the production of antibodies and cell-mediated immune responses. However, both pathways lead to tumor immunity and identical phenotypic manifestations of autoimmunity. Appropriate selection of the optimal tumor antigen is critical for the induction of an anti-tumor immune response. Thus, we stress that the methods for antigen presentation using dendritic cells play a critical role in the development of tumor vaccines, to break immune tolerance and induce a strong immune response against them. The viability and feasibility of expansion of canine dendritic cells from bone marrow and peripheral blood ex vivo for the treatment of spontaneous cancers in dogs is also discussed.  相似文献