Equine idiopathic hemorrhagic cystitis: Clinical features and comparison with bladder neoplasia          下载免费PDF全文

Fauna L. Smith  K. Gary Magdesian  Adam O. Michel  Betsy Vaughan  Christopher M. Reilly 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(3):1202-1209

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Immune-mediated haemolytic anaemia and thrombocytopenia in 25 adult equids: 1997-2016     

Charlotte A. Easton-Jones  Krista E. Estell  K. Gary Magdesian 《Equine veterinary journal》2021,53(5):964-971

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Retrospective evaluation of acute kidney injury in horses treated with nonnitrogenous bisphosphonates (2013–2020): 8 cases     

Lisa Edwards DVM  DACVIM  DACVECC  K. Gary Magdesian DVM  DACVIM  DACVECC  DACVCP 《Journal of Veterinary Emergency and Critical Care》2023,33(6):685-695

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Neonatal isoerythrolysis in horse foals and a mule foal: 18 cases (1988-2003)     

Boyle AG  Magdesian KG  Ruby RE 《Journal of the American Veterinary Medical Association》2005,227(8):1276-1283

OBJECTIVE: To assess data regarding clinical features, clinicopathologic and blood gas variables, and outcome from horse and mule foals with confirmed neonatal isoerythrolysis (NI). DESIGN: Retrospective case series. ANIMALS: 17 horse and 1 mule foals. PROCEDURE: Medical records of foals (< 14 days old) with NI were reviewed. Information collected included signalment; clinical examination findings; results of hematologic, serum and plasma biochemical, and venous blood gas analyses and urinalysis; treatments; and outcome. RESULTS: Data from 17 horse foals and 1 mule foal with NI (mean age, 71 hours) were evaluated. Many foals had high serum indirect and direct bilirubin concentrations and sorbitol dehydrogenase activity. Whole blood immunoglobulin concentrations were < 400 mg/dL in 4 of 15 foals. Fresh whole blood transfusions were administered to 10 of 18 foals. Among the blood factors implicated in 11 foals, one (Dg) had not previously been associated with NI. Of 10 foals that received blood transfusions, 7 had significant improvements in Hct and hemoglobin concentration and 2 had significant improvements in central venous oxygen tension. Fifteen foals survived to discharge. CONCLUSIONS AND CLINICAL RELEVANCE: Data suggest that blood factor Dg may be associated with NI in foals. Liver disease may be concurrent with NI in foals, and NI can develop in foals with inadequate passive transfer of colostral antibodies. Whole blood transfusions were successful at increasing oxygen-carrying capacity and improving peripheral tissue oxygenation in NI-affected foals. With appropriate treatment, the prognosis for foals with NI is good.  相似文献   

Antemortem diagnosis of equine mesothelioma by pleural biopsy     

Fry MM  Magdesian KG  Judy CE  Pusterla N  Vidal JD  Pesavento RA  Zinkl JG 《Equine veterinary journal》2003,35(7):723-727

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Pharmacokinetics and clinical utility of sodium bromide (NaBr) as an estimator of extracellular fluid volume in horses     

Fielding CL  Magdesian KG  Elliott DA  Craigmill AL  Wilson WD  Carlson GP 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2003,17(2):213-217

The purpose of this study was to describe the pharmacokinetics of bromide in horses and to evaluate the corrected bromide space as an indicator of extracellular fluid volume (ECFV) in horses after the administration of a single dose of bromide by intravenous infusion. Sodium bromide (30 mg/kg of body weight, IV) was administered to 6 clinically healthy mares over a period of 3 minutes. Blood samples were collected before infusion and at intervals between 0.5 hours and 53 days after infusion. Mean elimination half-life (harmonic mean) was 126 hours (5.2 days), clearance was 1.4 +/- 0.09 mL/(kg x h), area under the curve was 17,520 +/- 1,100 microg x h/mL. and volume of distribution (steady state) was 0.255 +/- 0.015 L/kg. The mean corrected bromide space was determined from the volume of distribution (steady state) and the serum concentrations of bromide at equilibration. Corrected bromide space, an estimate of ECFV, was 0.218 +/- 0.01 L/kg. The conclusion was made that ECFV of horses can be estimated by measuring bromide concentrations in a preinfusion serum sample and a sample obtained 5 hours after the administration of bromide.  相似文献   

Measurement of plasma colloid osmotic pressure in neonatal foals under intensive care: comparison of direct and indirect methods and the association of COP with selected clinical and clinicopathologic variables     

K. Gary Magdesian  DVM  DACVIM  DACVECC    C. Langdon Fielding  DVM    John E. Madigan  MS  DVM  DACVIM 《Journal of Veterinary Emergency and Critical Care》2004,14(2):108-114

Objectives: To describe and compare admission colloid osmotic pressure (COP) measurement using both direct and indirect methods in neonatal foals under intensive care, and to evaluate for associations between COP and clinical/clinicopathologic parameters. Design: Prospective study. Setting: Intensive care unit at a veterinary medical teaching hospital. Animals: Twenty‐six critically ill neonatal foals were studied. A control group consisted of 9 clinically healthy neonatal foals. Interventions: Clinicopathologic data were collected at the time of admission. COP was measured directly using a colloid osmometer. Indirect COP was calculated using equations by both Landis–Pappenheimer (L–P) and Thomas and Brown. Measurements and main results: Measured admission COP values were 17.1±4.3 and 17.7±2.4 mmHg in critically ill and control foals, respectively, and these values were not significantly different. Critically ill foals with blood lactate concentrations >3 mmol/L had lower COP values than those with lactate ≤3 mmol/L. There was close agreement between indirect COP values calculated using the L–P equation and direct COP values measured in control foals (mean error=0.0±1.3 mmHg; R²=0.87). However, indirect values were not as predictive of direct COP in critically ill foals (mean error=0.8±3.8 mmHg; R²=0.64). As COP values increased, the indirect method tended to overestimate COP, whereas at lower values it slightly underestimated COP. Conclusion: While the L–P equation was a close approximation of direct COP in healthy foals, direct measurements of oncotic pressure cannot be replaced for monitoring of critically ill foals. Critically ill foals with higher lactate concentrations had lower COP values, suggesting a possible relationship between COP and lactate.  相似文献   

Clinical and scintigraphic findings in horses with a bone fragility disorder: 16 cases (1980-2006)     

Anderson JD  Galuppo LD  Barr BC  Puchalski SM  Macdonald MM  Whitcomb MB  Magdesian KG  Stover SM 《Journal of the American Veterinary Medical Association》2008,232(11):1694-1699

OBJECTIVE: To describe clinical and scintigraphic abnormalities in horses with a bone fragility disorder. DESIGN: Retrospective case series. ANIMALS: 16 horses with scintigraphic evidence of multiple sites of increased radiopharmaceutical uptake (IRU). Procedures-Medical records were reviewed for information on signalment; history; clinical, clinicopathologic, and diagnostic imaging findings; and treatment. Follow-up information was obtained through telephone interviews with owners. RESULTS: Horses ranged from 4 to 22 years old; there were 8 castrated males and 8 females. Foci of IRU most commonly involved the scapulae, ribs, sternebrae, sacral tubers, ilia, and cervical vertebrae. Most horses were examined because of chronic intermittent (n = 10) or acute (6) lameness involving a single (10) or multiple (6) limbs that could not be localized by means of regional anesthesia. Cervical stiffness (n = 3), scapular bowing (3), swayback (3), and ataxia (1) were also seen in more advanced cases. Signs of respiratory tract disease and exercise intolerance were evident in 4 horses. Ultrasonographic or radiographic evidence of bone remodeling or degeneration was seen in 19 of 33 affected bones. Histologic examination of bone biopsy specimens revealed reactive bone. Improvement was initially seen with conservative treatment in some horses, but the condition worsened in all horses, and 11 horses were euthanized within 7 years. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that horses may develop a bone fragility disorder characterized clinically by an unlocalizable lameness and scintigraphically by multiple sites of IRU involving the axial skeleton and proximal portion of the appendicular skeleton.  相似文献   

Temporal trends in prevalence of bacteria isolated from foals with sepsis: 1979–2010     

M. J. P. Theelen  W. D. Wilson  J. M. Edman  K. G. Magdesian  P. H. Kass 《Equine veterinary journal》2014,46(2):169-173

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Bacterial meningitis after dental extraction in a 17-year-old horse     

Stefanie Arndt  Isabelle Kilcoyne  Colleen M. Heney  Talia S. Wong  K. Gary Magdesian 《The Canadian veterinary journal. La revue veterinaire canadienne》2021,62(4):403

Dental extractions in horses may result in bacteremia, which can lead to systemic complications. Bacterial meningitis following oral cheek tooth extractions in a 17-year-old Thoroughbred gelding is described in this report. The bacterial meningitis was confirmed by histopathology. The gelding was presented for evaluation of intermittent fever, loose feces, and mild colic signs which started 5 days after cheek tooth extraction. This case illustrates a rare complication associated with oral tooth extraction in a horse and highlights the unusual presenting features of meningitis.Key clinical message:Bacterial meningitis secondary to oral cheek tooth extraction should be considered as differential diagnosis; particularly in cases with the development of pyrexia a few days after the procedure.  相似文献