Trace metal concentrations in marine organisms from St. Vincent Gulf,South Australia     

W. A. Maher 《Water, air, and soil pollution》1986,29(1):77-84

Trace metal concentrations were measured in the tissues of fish, molluscs, crustaceans and macrophytes from St. Vincent Gulf, South Australia. The concentrations of the measured metals (Cd < 0.025 to 2.1 μg g^?1; Cu 0.51 to 9l μg g^?1 5 Pb 0.02 to 3.6 ?g g^?1; Zn l5 to 110 μg g^?1)are similar to those from unpolluted areas and thus give no indication of pollution.  相似文献   

Response     

Corr M  Slanetz AE  Boyd LF  Jelonek MT  Khilko S  Al-Ramadi BK  Kim YS  Maher SE  Bothwell AL  Margulies DH 《Science (New York, N.Y.)》1995,268(5207):117

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Complement factor H variant increases the risk of age-related macular degeneration   总被引：1，自引：0，他引：1  

Haines JL  Hauser MA  Schmidt S  Scott WK  Olson LM  Gallins P  Spencer KL  Kwan SY  Noureddine M  Gilbert JR  Schnetz-Boutaud N  Agarwal A  Postel EA  Pericak-Vance MA 《Science (New York, N.Y.)》2005,308(5720):419-421

Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as harboring a susceptibility locus for AMD. We used single-nucleotide polymorphisms to interrogate this region and identified a strongly associated haplotype in two independent data sets. DNA resequencing of the complement factor H gene within this haplotype revealed a common coding variant, Y402H, that significantly increases the risk for AMD with odds ratios between 2.45 and 5.57. This common variant likely explains approximately 43% of AMD in older adults.  相似文献   

Pore Fluid Constraints on the Temperature and Oxygen Isotopic Composition of the Glacial Ocean     

DP Schrag  G Hampt  DW Murray 《Science (New York, N.Y.)》1996,272(5270):1930-1932

Pore fluids from the upper 60 meters of sediment 3000 meters below the surface of the tropical Atlantic indicate that the oxygen isotopic composition (delta18O) of seawater at this site during the last glacial maximum was 0.8 ± 0.1 per mil higher than it is today. Combined with the delta18O change in benthic foraminifera from this region, the elevated ratio indicates that the temperature of deep water in the tropical Atlantic Ocean was 4°C colder during the last glacial maximum. Extrapolation from this site to a global average suggests that the ice volume contribution to the change in delta18O of foraminifera is 1.0 per mil, which partially reconciles the foraminiferal oxygen isotope record of tropical sea surface temperatures with estimates from Barbados corals and terrestrial climate proxies.  相似文献   

Inner-shell electron spectroscopy for microanalysis     

Joy DC  Maher DM 《Science (New York, N.Y.)》1979,206(4415):162-168

The transmission electron energy-loss spectrum shows characteristic "edges" corresponding to the excitation of inner-shell electrons of atoms in a thin sample. Analysis of these edges provides detailed chemical, structural, and electronic data from the radiated volume. By combining electron spectroscopy and electron microscopy, this microanalytical technique can be performed in conjunction with highresolution imaging of the sample. It is shown that this approach has advantages of sensitivity, spatial resolution, and convenience over other comparable techniques.  相似文献   

Nonstationary Phase of the Plio-Pleistocene Asian Monsoon     

SC Clemens  DW Murray  WL Prell 《Science (New York, N.Y.)》1996,274(5289):943-948

Paleoclimate records indicate that the strength of the Asian summer monsoon is sensitive to orbital forcing at the obliquity and precession periods (41,000 and 23,000 years, respectively) and the extent of Northern Hemisphere glaciation. Over the past 2.6 million years, the timing (phase) of strong monsoons has changed by approximately 83 degrees in the precession and approximately 124 degrees in the obliquity bands relative to the phase of maximum global ice volume (inferred from the marine oxygen isotope record). These results suggest that one or both of these systems is nonstationary relative to orbital forcing.  相似文献   

An Investigation of Uterine Nitric Oxide Production in Mares Susceptible and Resistant to Persistent Breeding‐Induced Endometritis and the Effects of Immunomodulation     

EM Woodward  M Christoffersen  J Campos  DW Horohov  KE Scoggin  E Squires  MHT Troedsson 《Reproduction in domestic animals》2013,48(4):554-561

The first objective of this study was to evaluate intrauterine nitric oxide (NO) and endometrial inducible NO synthase (iNOS) in mares susceptible or resistant to persistent breeding‐induced endometritis (PBIE) within 24 h after breeding. Mares susceptible (n = 6) or resistant (n = 6) to PBIE were inseminated over five cycles, and uterine secretions and endometrial biopsies were collected before and 2, 6, 12 and 24 h after insemination. Uterine secretions were analysed for NO and biopsies were analyzed for iNOS expression. A second experiment evaluated the effect of treatment with dexamethasone or mycobacterial cell wall extract (MCWE) on uterine NO production and endometrial iNOS mRNA expression. Six susceptible mares were inseminated over three cycles with (i) killed spermatozoa without treatment (control), (ii) killed spermatozoa with 50 mg of dexamethasone IV or (iii) MCWE IV 24 h prior to insemination with killed spermatozoa. Six resistant mares were inseminated with killed spermatozoa as a control. Six hours after breeding, uterine biopsies and secretions were collected and evaluated for NO and iNOS mRNA. In Experiment 1, resistant mares had an increase in iNOS mRNA expression 2 h post‐breeding compared to baseline (p = 0.045), 12 h (p = 0.014) and 24 h (p = 0.001). Susceptible mares had higher expression 2 h compared to 6 h (p = 0.046). No differences were observed in mRNA or protein expression of iNOS between resistant and susceptible mares. Resistant mares had a relatively steady amount of total intrauterine NO over 24 h, while susceptible mares had an increase over time, with a significantly higher increase in total NO than resistant mares at 6 (p = 0.04) and 12 h (p = 0.032). In Experiment 2, no differences were observed for iNOS mRNA expression. Susceptible mares had increased NO when compared to resistant mares (p = 0.008) and MCWE decreased NO (p = 0.047).  相似文献   

Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells     

Esther Guzmán  Michael Maher  Alexis Temkin  Tara Pitts  Amy Wright 《Marine drugs》2013,11(4):1140-1151

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Bioactivity Potential of Marine Natural Products from Scleractinia-Associated Microbes and In Silico Anti-SARS-COV-2 Evaluation     

Eman Maher Zahran  Amgad Albohy  Amira Khalil  Alyaa Hatem Ibrahim  Heba Ali Ahmed  Ebaa M. El-Hossary  Gerhard Bringmann  Usama Ramadan Abdelmohsen 《Marine drugs》2020,18(12)

Marine organisms and their associated microbes are rich in diverse chemical leads. With the development of marine biotechnology, a considerable number of research activities are focused on marine bacteria and fungi-derived bioactive compounds. Marine bacteria and fungi are ranked on the top of the hierarchy of all organisms, as they are responsible for producing a wide range of bioactive secondary metabolites with possible pharmaceutical applications. Thus, they have the potential to provide future drugs against challenging diseases, such as cancer, a range of viral diseases, malaria, and inflammation. This review aims at describing the literature on secondary metabolites that have been obtained from Scleractinian-associated organisms including bacteria, fungi, and zooxanthellae, with full coverage of the period from 1982 to 2020, as well as illustrating their biological activities and structure activity relationship (SAR). Moreover, all these compounds were filtered based on ADME analysis to determine their physicochemical properties, and 15 compounds were selected. The selected compounds were virtually investigated for potential inhibition for SARS-CoV-2 targets using molecular docking studies. Promising potential results against SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and methyltransferase (nsp16) are presented.  相似文献   

Antioxidant and Anti-Protease Activities of Diazepinomicin from the Sponge-Associated Micromonospora Strain RV115     

Usama Ramadan Abdelmohsen  Matthias Szesny  Eman Maher Othman  Tanja Schirmeister  Stephanie Grond  Helga Stopper  Ute Hentschel 《Marine drugs》2012,10(10):2208-2221

Diazepinomicin is a dibenzodiazepine alkaloid with an unusual structure among the known microbial metabolites discovered so far. Diazepinomicin was isolated from the marine sponge-associated strain Micromonospora sp. RV115 and was identified by spectroscopic analysis and by comparison to literature data. In addition to its interesting preclinical broad-spectrum antitumor potential, we report here new antioxidant and anti-protease activities for this compound. Using the ferric reducing antioxidant power (FRAP) assay, a strong antioxidant potential of diazepinomicin was demonstrated. Moreover, diazepinomicin showed a significant antioxidant and protective capacity from genomic damage induced by the reactive oxygen species hydrogen peroxide in human kidney (HK-2) and human promyelocytic (HL-60) cell lines. Additionally, diazepinomicin inhibited the proteases rhodesain and cathepsin L at an IC₅₀ of 70–90 µM. It also showed antiparasitic activity against trypomastigote forms of Trypanosoma brucei with an IC₅₀ of 13.5 µM. These results showed unprecedented antioxidant and anti-protease activities of diazepinomicin, thus further highlighting its potential as a future drug candidate.  相似文献