Influence of inflammation on serum concentration, molecular heterogeneity and drug binding properties of canine alpha–1–acid glycoprotein     

C. P. DELLO  F. M. BELPAIRE  A. DE RICK†  N. H. FRAEYMAN 《Journal of veterinary pharmacology and therapeutics》1988,11(1):71-76

The concentration and the heterogeneity of alpha-1-acid glycoprotein (alpha-1-AGP) and oxprenolol binding were determined in serum of healthy dogs and dogs with inflammatory disease. In inflammation, an increase in the mean alpha-1-AGP concentration from 0.47 to 2.85 g/l was accompanied by a reduction in the mean free oxprenolol fraction from 25% to 6%. alpha-1-AGP concentration and oxprenolol binding were inversely correlated. The heterogeneity of canine alpha-1-AGP remained essentially unchanged in dogs with inflammation and, in both these dogs and the controls, between five and seven forms with different isoelectric points and one single concanavalin A-reactive form were detected. It is concluded that in dogs, as in humans, oxprenolol binds to serum alpha-1-AGP. Changes in serum binding of oxprenolol during inflammation result from a change in the serum concentration of alpha-1-AGP rather than a change of molecular heterogeneity.  相似文献   

Einfluss von Pflanzenschutzmitteln einer Zuckerrüben-Spritzfolge auf biologische Aktivitäten und auf den Abbau von Chloridazon im Boden. II. Gefäss-und Laborversuche     

FAN DE  FANG  W. PESTEMER  H.-P. MALKOMES 《Weed Research》1983,23(5):293-304

Effect of carious pesticides of a sugar-fact spray programme on biological activities and chloridazon degradation in soil. II Pot trials and laboratory experiments In pot trials and laboratory experiments degradation and plant availability of Chloridazon (Pyramin) in soil, applied alone and in combination with other pesticides of a sugar-beet spray programme were investigated and also the influence of these treatments on soil dehydrogenusc activity and straw decomposition. After an initial lag-period chloridazon degradation was rapid, and obviously was unaffected by plant growth and other pesticides. The average lime for 50% decrease of the initial concentration was 10 days. The water-extractable portion of chloridazon in soil was not affected by the presence of other pesticides and was about 43% 1 week after application and decreased to 0% during the following week. Pyramin alone did not influence straw decomposition, and the spray programme was slightly stimulatory. In pot trials with and without plains, dehydrogenase activity was not significantly inhibited by Pyramin, whereas with the spray programme and bare soil, slightly reduced enzyme activities were observed. Under laboratory conditions the spray programme was more inhibitory than Pyramin alone. There was no correlation between biological soil activities and chloridazon degradation.  相似文献   

Comparison of the effects of etomidate and its fluoro analogue, R 8110, on plasma Cortisol, 11β-deoxycortisol, 17α-hydroxyprogesterone and testosterone concentrations in dogs     

R. DE COSTER  A.-D. A. Y. DEGRYSE  P. VAN DIJK  L. A. A. OOMS  E. LAGERWEIJ 《Journal of veterinary pharmacology and therapeutics》1987,10(3):227-232

R 8110, an imidazole derivative, was shown to be clinically superior to etomidate for induction and maintenance of anaesthesia in dogs. The present study compared the effects of intravenous (i.v.) R 8110, etomidate and Ringer solution on cortisol biosynthesis by the adrenal gland in seven male labradors. A tetracosactide challenge was carried out 30 min after the i.v. injection of 3 mg/kg of both drugs and after i.v. Ringer solution (1 ml/kg). Etomidate and R 8110 both suppressed the cortisol response to tetracosactide almost completely and increased the plasma 11 beta-deoxycortisol levels more than 20 fold. Maximal 11 beta-deoxycortisol values were reached 120 min after R 8110, and not less than 300 min after etomidate. Plasma 17 alpha-hydroxyprogesterone and testosterone concentrations did not differ between placebo and R 8110 treatment, but they decreased after etomidate. These results indicate that the effects of R 8110 on steroid biosynthesis in dogs are less pronounced than those of etomidate and are largely limited to a temporary inhibition of the 11 beta-hydroxylase in the adrenal gland.  相似文献   

Bovine renal tumors,incidence and histopathology     

DE MENEZES Z 《Journal of the American Veterinary Medical Association》1948,112(855):466-470

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Assessment of tetracycline and Babesia culture supernatant as prophylactics for moderating reactions in cattle to live Babesia and Anaplasma vaccines     

WK JORGENSEN  RE BOCK  TG KINGSTON  AJ DE VOS  SJ WALDRON 《Australian veterinary journal》1993,70(1):35-36

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Lack of oxidative pathways in the metabolism of sulphisomidine by the turtle Pseudemys scripta elegans     

T. B. VREE †  J. B. VREE‡  P. A. M. DE JONGE  M.J. M. PLAUM  C. P. W. G. M. VERWEY  Y. A. HEKSTER  M. SHIMODA§  J. F. M. NOUWS¶ 《Journal of veterinary pharmacology and therapeutics》1989,12(4):459-462

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Dorsal Approach to the Caudal Pelvic Canal and Rectum Effect on Normal Dogs     

D. B. McKEOWN DVM    J. R. COCKSHUTT DVM    G. D. PARTLOW PhD  V. S. DE KLEER DVM 《Veterinary surgery : VS》1984,13(3):181-184

A dorsal surgical approach to the perineal area and rectum was made on 10 healthy, adult dogs. The rectococcygeal muscle was incised and the levator ani and external sphincter muscles were separated to the level of the caudal rectal nerve. All dogs were clinically normal throughout a 3 week postoperative observation period.  相似文献   

CHEMICAL WEED CONTROL IN BROADCAST-SEEDED FLOODED TROPICAL RICE     

S. K. DE  DATTA P. C. BERNASOR 《Weed Research》1973,13(4):351-354

Summary. Several new herbicides were tested for control of weeds in broadcast-seeded flooded tropical rice. Among the new herbicides, S-(2-methyl-l-piperidylcarbonyl-methyl)- O,O -di- n -propyl dithiophosphate (C-19490), S-(2-methyl-l-piperidylcarbonyl-methyl)- O,O -di- n -propyl dithiophosphate combined with 2-(1',2'-dimethylpropylamino)-4-ethylamino-6-methylmercapto- s -triazine [C-19490/C-18898 (C-288)], and N -secondary-butyl-4-tertiary-butyl-2,6-dinitroaniline (A-820) were highly selective in controlling Echinochloa crus-galli (barnyard grass) and other annual weeds under tropical conditions. S-(4-chlorobenzyl)- N,N -diethylthiol carbamate (benthiocarb) and N -(butoxymethyl)-2-chloro-2',6'-diethylacetanilide (butachlor) continued to look promising in our experiments. Only butachlor is widely used in Asia.
Désherbage chimique des cultures tropicales de riz inorndé, seméà la volée  相似文献   

Plant materials used by primitive peoples to affect fertility     

DE LASZLO H  HENSHAW PS 《Science (New York, N.Y.)》1954,119(3097):626-631

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Some techniques used in clinical investigation of cardiovascular function in the dog     

A. L. DELAUNOIS  A. DE  RICK D. MATTHEEUWS 《The Journal of small animal practice》1976,17(4):219-230

Five methods are described, which have proved to be useful in closed chest experimental and clinical cardiovascular research in small animals.  相似文献