Metronidazole treatment of acute diarrhea in dogs: A randomized double blinded placebo-controlled clinical trial     

Daniel K. Langlois  Amy M. Koenigshof  Rinosh Mani 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(1):98-104

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LRP6 mutation in a family with early coronary disease and metabolic risk factors     

Mani A  Radhakrishnan J  Wang H  Mani A  Mani MA  Nelson-Williams C  Carew KS  Mane S  Najmabadi H  Wu D  Lifton RP 《Science (New York, N.Y.)》2007,315(5816):1278-1282

Coronary artery disease (CAD) is the leading cause of death worldwide and is commonly caused by a constellation of risk factors called the metabolic syndrome. We characterized a family with autosomal dominant early CAD, features of the metabolic syndrome (hyperlipidemia, hypertension, and diabetes), and osteoporosis. These traits showed genetic linkage to a short segment of chromosome 12p, in which we identified a missense mutation in LRP6, which encodes a co-receptor in the Wnt signaling pathway. The mutation, which substitutes cysteine for arginine at a highly conserved residue of an epidermal growth factor-like domain, impairs Wnt signaling in vitro. These results link a single gene defect in Wnt signaling to CAD and multiple cardiovascular risk factors.  相似文献   

Evaluation of multi-satellite precipitation products for soil loss and sediment export modeling over eastern regions of the Koshi River Basin,Nepal     

Yigez  Belayneh  Xiong  Donghong  Belete  Marye  Zhang  Baojun  Azene  Belayneh  Baig  Muhammad Aslam  Min  Qin Xiao  Rai  Dil Kumar  Dahal  Nirmal Mani  Wu  Yanhong  Wenduo  Zhang 《Journal of Soils and Sediments》2022,22(10):2731-2749

Journal of Soils and Sediments - Precipitation data are an important input variable for soil loss (SL) and sediment export (SE) modeling, although they are rarely available at fine spatial and...  相似文献   

A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations     

Fan W  Waymire KG  Narula N  Li P  Rocher C  Coskun PE  Vannan MA  Narula J  Macgregor GR  Wallace DC 《Science (New York, N.Y.)》2008,319(5865):958-962

The majority of mitochondrial DNA (mtDNA) mutations that cause human disease are mild to moderately deleterious, yet many random mtDNA mutations would be expected to be severe. To determine the fate of the more severe mtDNA mutations, we introduced mtDNAs containing two mutations that affect oxidative phosphorylation into the female mouse germ line. The severe ND6 mutation was selectively eliminated during oogenesis within four generations, whereas the milder COI mutation was retained throughout multiple generations even though the offspring consistently developed mitochondrial myopathy and cardiomyopathy. Thus, severe mtDNA mutations appear to be selectively eliminated from the female germ line, thereby minimizing their impact on population fitness.  相似文献   

Effects of a tristearate-containing lipid and canola oil on plasma and tissue lipids in rats     

P. Mani  M. Liebman  D. C. Rule 《Plant foods for human nutrition (Dordrecht, Netherlands)》1994,45(3):203-212

Male Sprague-Dawley rats were fed semipurified diets containing 12% fat and 0.4% cholesterol for 4 wk. The fats were palm oil, a high-stearate fat and canola oil; each of the latter two fat sources was substituted for palm oil in 4% (w/w) increments (i.e, 4, 8 and 12%) thus yielding 3 stearate-containing, 3 canola-containing, and a 12% palm oil diet. Stearate-fed animals exhibited significantly decreased food efficiency ratios, plasma total cholesterol, and liver cholesterol whereas the substitution of canola for palm oil did not consistently alter these parameters. Liver fatty acids generally reflected the composition of the dietary fat sources with the exception of significantly higher arachidonate observed in the stearate-fed rats.  相似文献   

Association between line per se and hybrid performance under excessive soil moisture stress in tropical maize (Zea mays L.)     

P.H. Zaidi  P. Mani Selvan  Rafat Sultana  Ashish Srivastava  Anup K. Singh  G. Srinivasan  R.P. Singh  P.P. Singh 《Field Crops Research》2007

Excessive moisture (EM) stress during the summer–rainy season is one of the major production constraints for maize (Zea mays L.) in large areas of South and South-East Asia. A key question in breeding for tolerance to excessive moisture is the extent to which the performance of maize hybrids can be predicted on the basis of per se performance of inbred lines under excessive moisture. We attempted to identify the relationship between morpho-physiological traits and grain yield measured on inbred parents and their single cross progenies under EM stress. Responses of various morpho-physiological traits, except days to 50% anthesis, differ significantly under normal versus EM stress. Superiority of hybrid progenies over parental inbred lines increased under EM stress, suggesting that hybrids were comparatively more tolerant to EM stress than inbred progenies. Across moisture regimes, all morpho-physiological traits of hybrids, except lodging and root porosity under normal moisture, were found to be positively and significantly correlated with mid-parent traits. Our data suggest that per se performance of lines was a relatively more important factor in determining hybrid performance under EM stress, while under optimum soil moisture conditions mid-parent heterosis was relatively more important than per se performance of mid-parent. Phenotypic correlation between hybrid and mid-parent yields showed a strong relationship under EM stress (r = 0.66^**). The relationship was statistically significant under normal moisture as well, though it was comparatively weak (r = 0.41^*). Our findings suggest that performance of hybrid progenies under excessive moisture can be predicted and improved to some extent on the basis of their inbred parents that have been systematically selected and improved for EM stress.  相似文献   

Analysis of ATPase and succinic dehydrogenase in F1 hybrids of rice (Oryza sativa L.)     

Jag Paul Sharma  S. C. Mani 《Euphytica》1990,48(2):91-95

Summary Activities of ATPase and succinic dehydrogenase were assessed in three F₁ hybrids of rice and their parental lines during boot leaf stage, flowering, on 10th and 20th days after flowering. ATPase activity showed increase at the flowering and on 20th day after flowering. Succinic dehydrogenase activity continued to rise till 10th day after flowering and declined on 20th day after flowering. Hybrids with high yield were generally endowed with more positive heterosis for these two enzymes. Correlation coefficient of grain yield per panicle was significantly positive with ATPase activity at all the stages studied. Heterosis for ATPase activity might serve a reliable criterion for the selection of efficient F₁ combinations.  相似文献   

Introduction: Infectious Diseases in Clinical Practice     

Indu Mani 《Topics in companion animal medicine》2009,24(4):163

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Determining critical limit of boron in soil for wheat (Triticum aestivum L.)     

Aritra Saha  Pabitra K. Mani  Gora Chand Hazra  Arup Dey  Shubhadip Dasgupta 《Journal of plant nutrition》2013,36(16):2091-2102

Abstract

Critical values of boron (B) for wheat nutrition in soil and plant were determined through a pot experiment with twenty-one surface soils of Alluvial flood plain and Red-latertic belt comprising three major soil orders (Entisols, Alfisols, Inceptisols) with four levels of boron. Application of boron significantly increased the dry matter yield as well as uptake of B by plants. Critical concentration of hot calcium chloride (CaCl₂) extractable B in soil for wheat was found to be 0.53?mg?kg^?1. The critical plant B concentration varied with growth stages and values were 7.4?mg?kg^?1 at panicle initiation and 4.18?mg?kg^?1 at maturity, respectively. The findings of this investigation also recommend the application of 2?kg?B^?1?ha^?1 for ensuring B sufficiency to wheat in Indo-gangetic alluvial and Red-Lateritic soils.  相似文献   

The effective dominance of resistance genes in relation to the evolution of resistance     

Roger J. Wood  Gopalakrishnan S. Mani 《Pest management science》1981,12(5):573-581

Field selection for a rare insecticide resistance (R) gene can be substantially delayed if R is rendered effectively recessive [if all or most heterozygotes ( R + ) are killed by the field dosages] and if a representative sample (+ +, R +, RR) of the population is permitted to escape exposure. The relationship between heterozygote mortality and escape in influencing selection rates has been considered at various frequencies of R. The cases when mating precedes selection, and when selection precedes mating, have been calculated using computer simulations. It is concluded that when R genes are rare it is advantageous (a) to apply the highest possible doses of insecticide in such a form that all exposed insects pick up an amount sufficient to kill all or most heterozygotes, (b) to apply the insecticide to adults after they have mated, rather than to younger adults or to larvae, and (c) to ensure that the proportion of insects given the opportunity to escape contact is as high as practical considerations allow. Once resistance is obvious (when samples are brought into the laboratory for tests), the R gene frequency will have risen to a level which makes the suggested strategy no longer valuable. Alternative strategies are briefly discussed.  相似文献