IFN-gamma diagnostic tests in the context of bovine mycobacterial infections in Belgium     

Walravens K  Marché S  Rosseels V  Wellemans V  Boelaert F  Huygen K  Godfroid J 《Veterinary immunology and immunopathology》2002,87(3-4):401-406

In countries where cattle tuberculosis caused by Mycobacterium bovis (Mbov) and paratuberculosis caused by Mycobacterium avium subsp. paratuberculosis (Mptb) are present, testing strategies for the Mbov eradication have to discriminate between these two infections. Present indirect tests are based on the analysis of the specific cellular immune response (DTH, IFN-gamma) against crude mycobacterial antigens (avian and bovine PPD). In this study, we compared the evolution of the IFN-gamma responses of animals experimentally infected with Mbov, Mptb, or inoculated with Mycobacterium phlei. Mbov inoculation induced a strong IFN-gamma response that allows rapid classification of the status of the animals following interpretation criteria set up by us. Experimental inoculation with M. phlei induced sensitisation to mycobacterial antigens as detected by the IFN-gamma test but these reactions were of short duration, therefore, repeated testing allows us to define these animals as aspecific reactors. IFN-gamma response induced after oral inoculation of calves with Mptb was of low intensity and ratio of responses measured against avian versus bovine PPD did not allow a clear diagnostic at least for the six first month of infection.  相似文献   

Comparison of the virulence of European and African isolates of Mycoplasma mycoides subspecies mycoides small colony type     

March JB  Brodlie M 《The Veterinary record》2000,147(1):20-21

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Acute bilateral trigeminal neuropathy associated with nervous system lymphosarcoma in a dog     

Pfaff AM  March PA  Fishman C 《Journal of the American Animal Hospital Association》2000,36(1):57-61

A nine-year-old dog presented with clinical signs consistent with bilateral trigeminal neuropathy. Multicentric lymphoma was diagnosed, and neoplastic lymphocytes were identified in the cerebrospinal fluid. Electromyography revealed spontaneous activity in temporal and masseter muscles. Histopathological examination demonstrated neoplastic cell invasion of temporal and masseter myofibers and of multiple peripheral nerves, including the trigeminal nerve. Central nervous system pathology consisted primarily of spinal root and leptomeningeal lymphoid cell infiltration with relative sparing of spinal cord and brain parenchyma.  相似文献   

Prevalence of resistance in sheep nematode populations to benzimidazole and levamisole anthelmintics in the high rainfall areas of South Australia     

I. BEVERIDGE  NJS ELLIS  MJ RILEY  TH BROWN 《Australian veterinary journal》1990,67(11):413-415

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Delayed acute toxicity of O,S,S-trimethyl phosphorodithioate and O,O,S-trimethyl phosphorothioate to the rat     

Philip S. Hammond  Salema M.A. Badawy  Ralph B. March  T.R. Fukuto 《Pesticide biochemistry and physiology》1982,18(1):90-100

The toxicity and LD₅₀ of O,S,S-trimethyl phosphorodithioate were reexamined in the rat. Animals treated orally (single dose) with this compound exhibited early cholinergic signs followed at approximately 5 hr by delayed toxic signs, with an LD₅₀ of 43 mg/kg. Contamination of O,S,S-trimethyl phosphorodithioate by as much as 5% (w/w) O,O,O-trimethyl phosphorothioate provided only limited antagonism to the dithioate's toxicity. In contrast, the addition of 5% O,O,S-trimethyl phosphorodithioate to O,O,S-trimethyl phosphorothioate gave protection against the toxic effects of the latter compound up to 80 mg/kg of toxicant. Pretreatment of rats with as little as 5% O,O,O-trimethyl phosphorothioate, 24 hr prior to treatment with 200 mg/kg O,O,S-trimethyl phosphorothioate, gave complete protection against the toxic effects of this compound. Conversely, administration of 10% (w/w) O,O,O-trimethyl phosphorothioate 4 or 24 hr after treatment with 60 or 80 mg/kg of O,O,S-trimethyl phosphorothioate provided only partial protection at 4 hr and no protection from the effects of the toxicant at 24 hr. The ability of O,O,O-trimethyl phosphorothioate to antagonize the toxicity of this compound depended markedly on the route of administration (oral, intravenous, or intraperitoneal). At 4 hr past treatment with toxicant, only oral administration of the antagonist provided full protection. Intraperitoneal and intravenous administration of antagonist 4 hr after treatment with toxicant were partially effective and completely ineffective, respectively, in halting the toxic effects of this compound.  相似文献   

Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs     

Byron JK  March PA  Chew DJ  DiBartola SP 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(1):47-53

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Spectral Properties of Near-Earth Asteroids: Evidence for Sources of Ordinary Chondrite Meteorites     

RP Binzel  SJ Bus  TH Burbine  JM Sunshine 《Science (New York, N.Y.)》1996,273(5277):946-948

Although ordinary chondrite (OC) meteorites dominate observed falls, the identification of near-Earth and main-belt asteroid sources has remained elusive. Telescopic measurements of 35 near-Earth asteroids ( approximately3 kilometers in diameter) revealed six that have visible wavelength spectra similar to laboratory spectra of OC meteorites. Near-Earth asteroids were found to have spectral properties that span the range between the previously separated domains of OC meteorites and the most common (S class) asteroids, suggesting a link. This range of spectral properties could arise through a diversity of mineralogies and regolith particle sizes, as well as through a time-dependent surface weathering process.  相似文献   

The use of echocardiography as a health assessment tool in green sea turtles (Chelonia mydas)     

DT March  K Marshall  G Swan  T Gerlach  H Smith  D Blyde  E Ariel  L Christidis  BP Kelaher 《Australian veterinary journal》2021,99(1-2):46-54

There are limited techniques available to assess the health of sea turtles as physical examination has little correlation to clinical findings, and blood reference intervals are broad and provide limited prognostic significance. Advances in the portability of ultrasound machines allow echocardiography to be increasingly used in the health assessments of wild animals. This study performed blood analysis and echocardiograms on 11 green sea turtles upon admission to a rehabilitation clinic and six animals before release. Significant differences were seen between groups, with admission animals having significantly smaller diameters of the cavum arteriosum at systole and diastole, smaller E‐waves and an increased fractional shortening. Pre‐release animals displayed significant increases in the maximum blood velocities of both the pulmonary artery and the left aorta. Significant negative correlations were seen between fractional shortening and uric acid and between the velocity time integral of the pulmonary artery and urea. The pulmonary artery velocity time integral was also significantly correlated to the E wave. Furthermore, there was asynchrony between the cavum arteriosum and the cavum pulmonale and the detection of a parasitic granuloma in the ventricular outflow tract of one animal. Overall, the results suggest that cardiac function in stranded green sea turtles is significantly impaired and that echocardiography has applications in the health assessments of green sea turtles.  相似文献   

cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily   总被引：65，自引：0，他引：65  

J E Sims  C J March  D Cosman  M B Widmer  H R MacDonald  C J McMahan  C E Grubin  J M Wignall  J L Jackson  S M Call 《Science (New York, N.Y.)》1988,241(4865):585-589

Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.  相似文献   

Chemical composition of cover crops and soil organic matter pools in no-tillage systems in the Cerrado     

Arminda Moreira de Carvalho  Luana Ramos Passos Ribeiro  Robélio Leandro Marchão  Alexsandra Duarte de Oliveira  Karina Pulrolnik  Cícero Célio de Figueiredo 《Soil Use and Management》2022,38(1):940-952

In no-tillage systems (NTS), cover crops are recommended to increase the productivity of agricultural systems. Furthermore, a greater diversity of cover crops in NTS favours an increase in soil carbon (C) stocks. However, there are scarce published data on the relationship between the chemical composition of cover crops and the accumulation of labile and stable fractions of SOM. We evaluated the relationship between the chemical composition of cover crops and SOM fractions, C stocks and maize yield. Hemicellulose, cellulose and lignin contents were determined for Urochloa ruziziensis, Canavalia brasiliensis, Cajanus cajan and Sorghum bicolor, cultivated in the off-season of maize. Canavalia brasiliensis had high N (20.96 g kg⁻¹) and hemicellulose (185.67 g kg⁻¹) contents, lower lignin content (39.50 g kg⁻¹) and high dry matter yield (3,251 kg ha⁻¹). All these characteristics resulted in a better SOM quality. Urochloa ruziziensis, with higher hemicellulose and lower lignin contents, and low lignin/N ratio, was associated with accumulation of TOC (19.95 and 18.33 g kg⁻¹ in 0- to 10-cm and 10- to 20-cm layers, respectively) and mineral-associated organic C (on average, 16.68 g kg⁻¹) in the soil. Cover plants with N:lignin ratio lower than 2.0 are fundamental for soil C sequestration. In conclusion, it is recommended the adoption of Urochloa ruziziensis and Canavalia brasiliensis as cover plants improve maize production, soil organic matter quality and C sequestration in the Cerrado region.  相似文献