Comparison of azaperone–detomidine–butorphanol–ketamine and azaperone–tiletamine–zolazepam for anaesthesia in piglets     

Mari L Heinonen DVM  PhD  Marja R Raekallio DVM  PhD  Claudio Oliviero DVM  Sanna Ahokas DVM  Olli AT Peltoniemi DVM  PhD 《Veterinary anaesthesia and analgesia》2009,36(2):151-157

ObjectiveTo investigate a combination of azaperone, detomidine, butorphanol and ketamine (DBK) in pigs and to compare it with the combination of azaperone, tiletamine and zolazepam (TZ).Study designProspective, randomized, blinded, cross–over study.AnimalsTwelve clinically healthy crossbred pigs aged about 2 months and weighing 16–25 kg.MethodsPigs were pre–medicated with azaperone (4 mg kg^?1). Ten minutes later anaesthesia was induced with intramuscular DBK (detomidine 0.08 mg kg^?1, butorphanol 0.2 mg kg^?1, ketamine 10 mg kg^?1) or TZ (tiletamine and zolazepam 5 mg kg^?1). The pigs were positioned in dorsal recumbency. Heart and respiratory rates, posture, anaesthesia score, PaO₂, PaCO₂, pH and bicarbonate concentration were measured. t–test was used to compare the areas under time–anaesthesia index curve (AUC_anindex) between treatments. Data concerning heart and respiratory rates, PaO₂, PaCO₂ and anaesthesia score were analysed with anova for repeated measurements. Wilcoxon signed rank test was used for the data concerning the duration of sedation and anaesthesia.ResultsThe sedation, analgesia and anaesthesia lasted longer after DBK than TZ. The AUC_anscore were 863 ± 423 and 452 ± 274 for DBK and TZ, respectively (p = 0.002). The duration of surgical anaesthesia lasted a median of 35 minutes (0–105 minutes) after DBK and a median of 15 minutes (0–35 minutes) after TZ (p = 0.05). Four pigs after DBK and six after TZ did not achieve the plane of surgical anaesthesia. The heart rate was lower after DBK than after TZ. Both treatments had similar effects on the other parameters measured.ConclusionsAt the doses used DBK was more effective than TZ for anaesthesia in pigs under field conditions.Clinical relevanceThe combinations can be used for sedation and minor field surgery in pigs. The doses and drugs chosen were insufficient to produce a reliable surgical plane of anaesthesia in these young pigs.  相似文献   

First report of raspberry yellows disease caused by raspberry bushy dwarf virus in Japan     

Masamichi Isogai  Mari Yoshida  Hiroyuki Imanishi  Nobuyuki Yoshikawa 《Journal of General Plant Pathology》2012,78(5):360-363

Severe yellowing of leaves was observed on red raspberry in Akita Prefecture. When inoculated with sap from symptomatic raspberry leaves, Chenopodium quinoa plants developed chlorotic ringspot and mottling that are typical of raspberry bushy dwarf virus (RBDV) infection. In western blot analysis, an antibody to the coat protein (CP) of RBDV reacted against ca. 30-kDa protein specific to the diseased trees. In RT-PCR testing for RBDV, single DNA fragments were amplified from total RNA samples of the diseased trees. The nucleotide sequences of the DNA fragments covering the entire CP region revealed 87–97?% identities with those of RBDV isolates.  相似文献   

Investigation of a simplified artificial lighting programme to improve the fertility of sows in commercial piggeries     

Tast A  Hälli O  Virolainen JV  Oravainen J  Heinonen M  Peltoniemi OA 《The Veterinary record》2005,156(22):702-705

Two artificial lighting regimens were studied in a commercial unit of 800 sows. The aim was to develop a simplified lighting regimen to overdrive the effects of season on reproduction. A long-day group had a constant 16 hours light and eight hours dark photoperiod in all units during a production cycle. A short-day group had eight hours of light and 16 hours darkness in a farrowing unit for four weeks and in a mating unit for four weeks. After one month of pregnancy the short-day group was transferred to 16 hours light and eight hours dark for the rest of the dry-sow period. Production data were collected for eight months, and the farrowing rate, weaning to oestrus interval, culling rate for fertility problems and the number of live-born piglets were analysed. Seasonal infertility, which had previously affected the herd, was not detected in either group during the follow-up period. The farrowing rate was 90 per cent for both groups. The median weaning to oestrus interval was five days in both lighting regimens with ranges from four to 74 days in the short-day group and three to 55 days in the long-day group. The long-day programme had a positive effect on the weaning to oestrus interval. When the sows were classified as either "normal", with a weaning to oestrus interval of up to 10 days, or "problem" animals, with a weaning to oestrus interval of over 10 days, the short-day programme also had a positive effect. The culling rate for fertility problems was 2.4 per cent for the short-day group and 3.2 per cent for the long-day group (P=0.027). The only significant predictor for the number of live-born piglets was parity (P=0.027).  相似文献   

Risk factors for stillbirth and foetal mummification in four Brazilian swine herds   总被引：3，自引：0，他引：3  

Borges VF  Bernardi ML  Bortolozzo FP  Wentz I 《Preventive veterinary medicine》2005,70(3-4):165-176

The objective of this study was to identify the risk factors of stillbirth and foetal mummification in 565 farrowings of four commercial pig farms in Brazil. Stillborn piglets were observed in 31.3% of the litters and the stillborn risk was 5.6%. Mummified foetuses occurred in 42.1% of the litters and the mummification risk was 3.4%. The potential risk factors were included in multivariable logistic regression models as categories: herd (1–4); parity (1, 2–5 and >5); litter size (<10, 10–12 and >12 piglets); farrowing length (≤3 or >3 h); presence of mummified foetuses (yes or no); farrowing induction (yes or no); use of oxytocin (yes or no); use of vaginal palpation (yes or no); body condition score (<3, 3 and ≥4), and placental production index (PPI) (≤5 or >5) which was measured as the ratio of total foetal weight to total placental weight. Duration of farrowing and use of farrowing induction, oxytocin or vaginal palpation were not included in the model that investigated the risk factors of foetal mummification. Two models were used to investigate the risk factors of stillbirth, one with and the other without the inclusion of farrowing length. When compared to sows of parity 2–5, sows of parity >5 had 1.7- and 1.6-times higher odds (P < 0.05) for stillbirth in the models with and without the inclusion of farrowing length, respectively. In both models, sows with more than 12 piglets/litter had 3.6-times higher odds of stillbirth occurrence compared to sows with less than 10 piglets (P < 0.05). Sows with prolonged farrowing (>3 h) had 2.0-times higher odds of stillbirth occurrence than sows with short farrowing (P < 0.05). Sows with more than 12 piglets/litter had 14.5-times higher odds of mummification compared to sows with less than 10 piglets (P < 0.05). Sows of parities 1 and >5 had 3.5- and 2.0-times, respectively, higher odds of mummification in comparison to sows of parity 2–5 (P < 0.05). Sows with low PPI had 1.7-times higher odds of mummification compared to those with high PPI (P < 0.05). A large litter, a high-parity and a prolonged farrowing increased the risk of stillbirth. The probability of having a mummified foetus was increased in very young and older sows, when having a large litter and a litter with a less efficient placenta.  相似文献   

Efficacy of intramammary treatment with procaine penicillin G vs. procaine penicillin G plus neomycin in bovine clinical mastitis caused by penicillin-susceptible,gram-positive bacteria--a double blind field study     

Taponen S  Dredge K  Henriksson B  Pyyhtiä AM  Suojala L  Junni R  Heinonen K  Pyörälä S 《Journal of veterinary pharmacology and therapeutics》2003,26(3):193-198

The efficacy of intramammary treatments containing procaine penicillin G alone (treatment A) or a combination of procaine penicillin G and neomycin (treatment B) was compared in treating clinical bovine mastitis caused by gram-positive bacteria susceptible in vitro to penicillin G. Both treatments were supplemented with a single intramuscular injection of procaine penicillin G on the first day of treatment. The study was carried out using a double blind design on commercial dairy farms in Southern Finland. A total of 56 quarters were treated with treatment A and 61 with treatment B. The cure rates for both treatments were equal, which suggests that the use of the penicillin G-aminoglycoside combination does not increase the efficacy of the treatment over that achieved by using penicillin G alone in bovine clinical mastitis caused by penicillin-susceptible, gram-positive bacteria.  相似文献   

A comparative pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs     

Suzuki M  Uchida K  Morozumi M  Yanai T  Nakayama H  Yamaguchi R  Tateyama S 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2003,65(12):1319-1324

Histiocytic proliferative disorders in canine central nervous system (CNS) including granulomatous meningoencephalomyelitis (GME) and malignant histiocytosis were compared pathologically. Lesions of GME mainly existed in the white matter of the cerebrum, brainstem and cerebellum and consisted of characteristic perivascular cuffing, parenchymal granuloma and leptomeningeal infiltrates of mononuclear cells. In malignant histiocytosis, there were two histological patterns, diffuse proliferation of neoplastic histiocytes through the leptomeninges and neoplastic nodule formation in the parenchyma. Neoplastic histiocytes exhibited mild to severe cellular atypia and high ability of invasion into the brain parenchyma. Mitotic and phagocytic figures were also observed. Several histiocytic markers, including lysozyme, alpha1-antitrypsin and lectin RCA-1, revealed histiocytic origin of both inflammatory and neoplastic cells, however, those were not determinative for the discrimination between GME and malignant histiocytosis. CD3- and PCNA-positive cells existed in the lesions of both diseases. The number of CD3-positive cells in GME tended to be greater than in malignant histiocytosis, while the difference was not statistically significant.  相似文献   

Pain alleviation in animals: attitudes and practices of Finnish veterinarians     

Raekallio M  Heinonen KM  Kuussaari J  Vainio O 《Veterinary journal (London, England : 1997)》2003,165(2):131-135

A questionnaire was sent to 911 Finnish veterinarians to assess their attitudes and practices to pain relief in animals. Responses to statements about recognition and treatment of pain were either to agree or to disagree. The pain caused by specified surgical and clinical conditions was rated. Inquiries were also posed about the number of analgesics available and their use in specific surgical procedures and clinical situations. The questionnaires were returned by 441 respondents. Women and younger veterinarians generally rated pain higher and treated it more frequently than men and older colleagues. Younger veterinarians and those in larger practices also had more analgesics available than older veterinarians and those in smaller practices. Respondents agreed with the statement that relieving pain is beneficial for animals. However, large differences were present in the frequency of use of pain alleviation between different animal species undergoing similar operations and between clinical conditions scored equally in the numerical rating of pain. The severity and clinical relevance of feline pain is probably often underestimated, as cats were less likely to receive analgesics than dogs after similar operations.  相似文献   

Reduction of Twin Pregnancy in the Mare by Transvaginal Ultrasound-Guided Aspiration     

G Mari  E Iacono  B Merlo  C Castagnetti 《Reproduction in domestic animals》2004,39(6):434-437

Diagnosis and management of twin pregnancies in the mare are an ongoing challenge in equine reproduction. Early detection of twin and manual crush of one vesicle are the main steps in the management of twins. Few studies were carried out about the use of transvaginal ultrasound-guided aspiration (TUGA) for reduction of twins in the mare. In this study, the efficiency of TUGA for management of twin pregnancies was investigated. Reduction of unicornuate twins between 16 and 25 days of gestation gave a success rate of 70.0% (14 viable foals/20 twin pregnancies); when reduction was performed after day 40 of gestation, all mares (one unicornuate; three bicornuate) lost both. For those cases in which the window for early crush of a twin vesicle has been missed, TUGA can be successfully used to reduce twin pregnancy between 16 and 25 days of gestation.  相似文献   

High Porcine Parvovirus Antibodies in Sow Herds: Prevalence and Associated Factors     

J Oravainen  M Heinonen  A Tast  JV Virolainen  OAT Peltoniemi 《Reproduction in domestic animals》2005,40(1):57-61

Porcine parvovirus (PPV) is widespread among swine. Our objective was to determine the prevalence of loosely housed sow herds in Finland with at least one animal with high (infection level) PPV antibodies and to gather basic knowledge about vaccination practices. In addition, selected factors associated with high antibody levels found in sows were examined. Altogether, 247 animals were sampled in 21 randomly chosen loosely housed sow herds. Samples were analysed with the haemagglutination inhibition (HI) test. PPV proved to be common; in 17 farms (81%) at least one animal had a high titre (>1 : 512), and 44% of all animals sampled had a high titre. The vaccination programmes had many shortcomings. In the generalised estimation equations (GEE) population-averaged model developed, the factors found to have a significant (p < or = 0.05) effect on HI titres were herd size, parity of two or greater and storage of the vaccine vial after use. Non-returning rate, re-breeding interval and litter size did not differ between herds with no high HI titres (n = 4) and those with at least one high HI titre (n = 17).  相似文献   

Control of Penicillium expansum by plant volatile compounds   总被引：1，自引：0，他引：1  

F. Neri  M. Mari  S. Brigati 《Plant pathology》2006,55(1):100-105

Nine plant volatiles were tested for their activity in vitro and in vivo against Penicillium expansum , the cause of blue mould of pear. In vitro spore germination and mycelial growth assay showed a consistent fungicidal activity by trans -2-hexenal, carvacrol, trans -cinnamaldehyde and citral, while hexanal (-)- carvone, p -anisaldehyde, eugenol and 2-nonanone exhibited a progressively lower inhibition. trans -2-Hexenal was the best inhibitor of conidial germination [MIC (minimum inhibitory concentration) = 24·6  µ L L⁻¹; ED₅₀ = 10·2  µ L L⁻¹], while carvacrol was the best inhibitor of mycelial growth (MIC = 24·6  µ L L⁻¹; ED₅₀ = 9  µ L L⁻¹). The four most active compounds in in vitro studies were tested in vivo as fumigants against blue mould on pear cv. Conference. Best control was achieved by trans -2-hexenal vapour treatments (12·5  µ L L⁻¹) when applied over a 24-h period, beginning 24 h after inoculation. In contrast, carvacrol (12·5–200  µ L L⁻¹), and trans -cinnamaldehyde (50–400  µ L L⁻¹) were ineffective and citral (200  µ L L⁻¹) showed only slight effect.  相似文献