Differences in the efficacy of carboxylic acid amide fungicides against less sensitive strains of Plasmopara viticola          下载免费PDF全文

Irene Maja Nanni  Alessandro Pirondi  Daniela Mancini  Gerd Stammler  Randall Gold  Ilaria Ferri  Agostino Brunelli  Marina Collina 《Pest management science》2016,72(8):1537-1539

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Reviewing and updating the detected locations of beautiful vavilovia (Vavilovia formosa) on the Caucasus sensu stricto     

Margarita Vishnyakova  Marina Burlyaeva  Janna Akopian  Ramazan Murtazaliev  Aleksandar Mikić 《Genetic Resources and Crop Evolution》2016,63(7):1085-1102

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Weak effects of habitat type on susceptibility to invasive freshwater species: an Italian case study          下载免费PDF全文

Angela Boggero  Alberto Basset  Martina Austoni  Enrico Barbone  Luca Bartolozzi  Isabella Bertani  Alessandro Campanaro  Antonella Cattaneo  Fabio Cianferoni  Giuseppe Corriero  Ambrosius Martin Dörr  A. Concetta Elia  Gentile Francesco Ficetola  Lyudmila Kamburska  Gianandrea La Porta  Sara Lauceri  Alessandro Ludovisi  Elda Gaino  Enzo Goretti  Massimo Lorenzoni  Marina Manca  Aldo Marchetto  Giuseppe Morabito  Francesco Nonnis Marzano  Alessandro Oggioni  Cataldo Pierri  Nicoletta Riccardi  Giampaolo Rossetti  Nicola Ungaro  Pietro Volta  Silvia Zaupa  Diego Fontaneto 《水产资源保护:海洋与淡水生态系统》2014,24(6):841-852

Differences in phagocytosis susceptibility in Haemophilus parasuis strains     

Alexandre Olvera  Maria Ballester  Miquel Nofrar��as  Marina Sibila    Virginia Aragon 《Veterinary research》2009,40(3)

Haemophilus parasuis is a colonizer of the upper respiratory tract of healthy pigs, but virulent strains can cause a systemic infection characterized by fibrinous polyserositis, commonly known as Glässer’s disease. The variability in virulence that is observed among H. parasuis strains is not completely understood, since the virulence mechanisms of H. parasuis are largely unknown. In the course of infection, H. parasuis has to survive the host pulmonary defences, which include alveolar macrophages, to produce disease. Using strains from different clinical backgrounds, we were able to detect clear differences in susceptibility to phagocytosis. Strains isolated from the nose of healthy animals were efficiently phagocytosed by porcine alveolar macrophages (PAM), while strains isolated from systemic lesions were resistant to this interaction. Phagocytosis of susceptible strains proceeded through mechanisms independent of a specific receptor, which involved actin filaments and microtubules. In all the systemic strains tested in this study, we observed a distinct capsule after interaction with PAM, indicating a role of this surface structure in phagocytosis resistance. However, additional mechanisms of resistance to phagocytosis should be explored, since we detected different effects of microtubule inhibition among systemic strains.  相似文献   

Early shoot and root growth dynamics as indicators for the survival of black poplar cuttings     

Kovacevic Branislav  Roncevic Savo  Miladinovic Dragana  Ivanisevic Petar  Katanic Marina 《New Forests》2009,38(2):177-185

The relationship between early root and shoot formation at the beginning of the vegetation period and cutting survival on sandy and loamy fluvisol for 14 genotypes of black poplars was analyzed. Considerable cutting mortality was observed only within the first 80 days since planting. Intensive root formation in the first 20 days since the planting and vigorous shoot growth and development in subsequent 20 days was observed in easy-to-root genotypes. Coefficients of correlation revealed close relationship between early root and shoot growth and development and cutting survival of tested genotypes. The obtained results could be used in the breeding process, as well as for the design of cultivar-adjusted nursery and plantation establishment technology. Tested shoot characteristics, were found to be especially interesting since they could be measured rapidly, by non-destructive means.  相似文献   

An iridoid and a flavonoid from Sideritis lanata L     

Alipieva KI  Kostadinova EP  Evstatieva LN  Stefova M  Bankova VS 《Fitoterapia》2009,80(1):51-53

A new iridoid diglucoside, 10-O-(E)-p-coumaroylmelittoside (1) and a new flavone glucoside, O-(6'-O-Acetyl-)-beta-glucopyranosylchrysoeriol (2), together with four known flavone glycosides, were isolated from the aerial parts of Sideritis lanata. The structures of the new compounds were elucidated by spectroscopic methods, 2D NMR and MS.  相似文献   

Reversible changes in cell morphology due to cytoskeletal rearrangements measured in real-time by QCM-D     

N Tymchenko  E Nilebäck  MV Voinova  J Gold  B Kasemo  S Svedhem 《Biointerphases》2012,7(1-4):43

The mechanical properties and responses of cells to external stimuli (including drugs) are closely connected to important phenomena such as cell spreading, motility, activity, and potentially even differentiation. Here, reversible changes in the viscoelastic properties of surface-attached fibroblasts were induced by the cytoskeleton-perturbing agent cytochalasin D, and studied in real-time by the quartz crystal microbalance with dissipation (QCM-D) technique. QCM-D is a surface sensitive technique that measures changes in (dynamically coupled) mass and viscoelastic properties close to the sensor surface, within a distance into the cell that is usually only a fraction of its size. In this work, QCM-D was combined with light microscopy to study in situ cell attachment and spreading. Overtone-dependent changes of the QCM-D responses (frequency and dissipation shifts) were first recorded, as fibroblast cells attached to protein-coated sensors in a window equipped flow module. Then, as the cell layer had stabilised, morphological changes were induced in the cells by injecting cytochalasin D. This caused changes in the QCM-D signals that were reversible in the sense that they disappeared upon removal of cytochalasin D. These results are compared to other cell QCM-D studies. Our results stress the combination of QCM-D and light microscopy to help interpret QCM-D results obtained in cell assays and thus suggests a direction to develop the QCM-D technique as an even more useful tool for real-time cell studies.  相似文献   

Effect of prolonged photoperiod on ocular tissues of domestic turkeys          下载免费PDF全文

Marina L. Leis  Mary‐Magdalene U. Dodd  Gregory Starrak  Catherine J. Vermette  Susantha Gomis  Bianca S. Bauer  Lynne S. Sandmeyer  Karen Schwean‐Lardner  Henry L. Classen  Bruce H. Grahn 《Veterinary ophthalmology》2017,20(3):232-241

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Primary bilateral corneal nerve sheath neoplasm in a dog          下载免费PDF全文

Marina L. Leis  M. Elyse Salpeter  Bianca S. Bauer  Dale L. Godson  Bruce H. Grahn 《Veterinary ophthalmology》2017,20(4):365-371

A 15‐year‐old, neutered male, Shih Tzu cross developed progressive corneal stromal thickening and vascularization of the right eye, and 5 months later, of the left eye. Both eyes became blind due to extensive corneal opacification and were enucleated. Light microscopic examination revealed a diffuse corneal infiltrate of neoplastic mesenchymal cells, and immunohistochemistry revealed diffuse cytoplasmic vimentin immunoreactivity and variable cytoplasmic and nuclear immunoreactivity for S100 in the neoplastic cells. Transmission electron microscopy revealed desmosomes between contiguous cells, thread‐like cytoplasmic processes coated with basement membrane, extracellular bundles of collagen, and axonal degeneration consistent with features of a nerve sheath neoplasm. This is the first report of primary, bilateral corneal nerve sheath sarcoma in a canine.  相似文献   

Thermal antinociception following oral administration of tapentadol in conscious cats     

Graeme M. Doodnaught  Marina C. Evangelista  Paulo V.M. Steagall 《Veterinary anaesthesia and analgesia》2017,44(2):364-369

Objective

To evaluate the onset, magnitude and duration of thermal antinociception after oral administration of two doses of tapentadol in cats.

Study design

Prospective, randomized, blinded, experimental study.

Animals

Six healthy adult cats weighing 4.4 ± 0.4 kg.

Methods

Skin temperature (ST) and thermal threshold (TT) were evaluated using a wireless TT device up to 12 hours after treatment. Treatments included placebo (PBO, 50 mg dextrose anhydrase orally), buprenorphine (BUP, 0.02 mg kg^?1) administered intramuscularly, low-dose tapentadol (LowTAP, 25 mg orally; mean 5.7 mg kg^?1) and high-dose tapentadol (HighTAP, 50 mg orally; mean 11.4 mg kg^?1) in a blinded crossover design with 7 day intervals. Statistical analysis was performed using anova with appropriate post hoc test (p ≤ 0.05).

Results

Salivation was observed immediately following 11 out of 12 treatments with tapentadol. The ST was significantly increased at various time points in the opioid treatments. Hyperthermia (≥ 39.5 °C) was not observed. Baseline TT was 45.4 ± 1.4 °C for all treatments. Maximum TT values were 48.8 ± 4.8 °C at 1 hour in LowTAP, 48.5 ± 3.0 °C at 2 hours in HighTAP and 50.2 ± 5.3 °C at 1 hour in BUP. TT significantly increased after LowTAP at 1 hour, after HighTAP at 1–2 hours, and after BUP at 1–2 hours compared with baseline values. TTs were significantly increased in BUP at 1–2 hours compared with PBO.

Conclusion and clinical relevance

Oral administration of tapentadol increased ST and TT in cats. The durations of thermal antinociception were similar between HighTAP and BUP, both of which were twice as long as that in LowTAP. Studies of different formulations may be necessary before tapentadol can be accepted into feline practice.  相似文献