Clostridium septicum myositis in a western lowland gorilla (Gorilla gorilla gorilla).     

Deidre K Fontenot  Scott P Terrell  Michele Miller  Patricia K Robbins  Mark Stetter  Martha Weber 《Journal of zoo and wildlife medicine》2005,36(3):509-511

A 10-yr-old male gorilla (Gorilla gorilla gorilla) with a history of conspecific bite wounds was evaluated for acute onset of depression, anorexia, and right hemiparesis. The animal was immobilized for diagnostic examination and treatment for suspected toxic shock from a necrotizing, emphysematous wound infection, but was euthanized due to complications during recovery. Gross and histopathologic examination revealed acute necrotizing myositis, fasciitis, cellulitis, and emphysema in the affected wound area, with large numbers of large Gram-positive rods among necrotic muscle fibers. Severe pulmonary edema with airways containing fibrin, acute hemorrhage in multiple body sites, thrombosis in blood vessels in the skeletal muscle, liver, and lung, and lymph node hyperplasia with lymphoid necrosis and hemorrhage. Immunohistochemical fluorescent antibody staining of muscle from the wound site was positive for  相似文献   

Quantifying patch distribution at multiple spatial scales: Applications to wildlife-habitat models     

Chris J. Johnson  Mark S. Boyce  Robert Mulders  Anne Gunn  Rob J. Gau  H. Dean Cluff  Ray L. Case 《Landscape Ecology》2005,19(8):869-882

Multiscale analyses are widely employed for wildlife-habitat studies. In most cases, however, each scale is considered discrete and little emphasis is placed on incorporating or measuring the responses of wildlife to resources across multiple scales. We modeled the responses of three Arctic wildlife species to vegetative resources distributed at two spatial scales: patches and collections of patches aggregated across a regional area. We defined a patch as a single or homogeneous collection of pixels representing 1 of 10 unique vegetation types. We employed a spatial pattern technique, three-term local quadrat variance, to quantify the distribution of patches at a larger regional scale. We used the distance at which the variance for each of 10 vegetation types peaked to define a moving window for calculating the density of patches. When measures of vegetation patch and density were applied to resource selection functions, the most parsimonious models for wolves and grizzly bears included covariates recorded at both scales. Seasonal resource selection by caribou was best described using a model consisting of only regional scale covariates. Our results suggest that for some species and environments simple patch-scale models may not capture the full range of spatial variation in resources to which wildlife may respond. For mobile animals that range across heterogeneous areas we recommend selection models that integrate resources occurring at a number of spatial scales. Patch density is a simple technique for representing such higher-order spatial patterns.  相似文献   

Heinz Body Formation Associated With Ketoacidosis in Diabetic Cats     

Mary M. Christopher  John D. Broussard  Mark E. Peterson 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1995,9(1):24-31

Oxidative damage plays an important role in the pathophysiology of diabetes and diabetic complications. Feline hemoglobin is uniquely susceptible to oxidative denaturation; therefore, Heinz body formation is a highly sensitive indicator of in vivo oxidative stress in this species. Heinz bodies also contribute to anemia. We investigated hematological and clinical biochemical changes in 30 cats with spontaneous diabetes mellitus (as compared to 15 healthy control cats) and evaluated the relationship of these changes to erythrocyte oxidative damage. Cats were categorized as ketoacidotic or nonketoacidotic based on their clinical presentation and the presence of urine ketones. Ketoacidotic cats had significantly ( P = .0009) more Heinz bodies (28.3% ± 9.1 %) than nonketotic diabetic cats (6.5% ± 1.60%) and healthy control cats (0.6% ± 0.2%). Percent Heinz bodies in diabetic cats directly correlated with plasma β-hydroxy-butyrate concentration ( r = .622; P = .0002), as well as with serum chloride concentration ( r = -0.576; P = 0.0009) and the number of monocytes ( r = .536; P = .0023). Percent Heinz bodies were negatively correlated with erythrocyte glutathione concentrations. Erythrocyte membrane lipid peroxidation was slightly but not significantly increased in diabetic cats. There were no significant associations between percent Heinz bodies and degree of anemia, hyperglycemia, or glycohemoglobin. These data indicate that ketones are associated with oxidative hemoglobin damage in cats, and suggest that ketone metabolism, ie by cytochrome P450 2E1, may be a potential source of in vivo oxygen radical generation in animals with ketosis.  相似文献   

Some Observations on the Diagnosis and Epidemiology of Leptospirosis in Swine   总被引：2，自引：0，他引：2       下载免费PDF全文

D. Mitchell  A. Robertson  A. H. Corner    P. Boulanger 《Canadian journal of veterinary research》1966,30(8):211-217

The results of combined epidemiological, clinical, serological, bacteriological and histopathological studies following an outbreak of disease caused by L. pomona on a farm stocked with cattle, sheep, pigs, goats and horses maintained for experimental purposes, are reported.

The incidence of infection was high in horses, cattle and pigs. A few low titres were seen in sheep. The goats were not infected. Apart from a single bovine abortion all the clinical symptoms observed occurred in pregnant sows. Seven of these aborted or gave birth to stillborn pigs within a six week period.

Fifteen species of wildlife were trapped or shot on the farm during the year following the outbreak. L. pomona was isolated from four skunks and a porcupine. Epidemiological studies indicated that wildlife reservoir hosts were the primary source of infection for the domestic livestock.

Leptospiruria and the serological response were studied in a group of eight infected sows. Microscopic agglutination titres of 10² or less could not be associated with leptospiruria and the duration of leptospiruria was found to range from a few weeks to over two years in individual sows. Direct dark-field examination of urine proved superior to guinea-pig inoculation as a method of detecting leptospiruria and it is suggested that the former technique could be adopted with advantage as a routine aid to diagnosis.

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Erythrokinetics in normal cats     

D B Gillis  R A Mitchell 《American journal of veterinary research》1974,35(1):31-33

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The place of clinical instruction in veterinary education     

B Mitchell 《The Veterinary record》1970,86(19):566-569

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Animal Health and Housing          下载免费PDF全文

W. R. Mitchell 《The Canadian veterinary journal. La revue veterinaire canadienne》1968,9(5):125

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Cultivation In Tissue Culture Of An Infectious Agent From Coital Exanthema Of Cattle. A Preliminary Report   总被引：5，自引：3，他引：2       下载免费PDF全文

A. S. Greig  G. L. Bannister  D. Mitchell    C. A. V. Barker 《Canadian journal of veterinary research》1958,22(4):119-122

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Evaluation of the complement fixation test for the diagnosis of pleuropneumonia of swine caused by Haemophilus pleuropneumoniae.   总被引：10，自引：6，他引：4       下载免费PDF全文

L H Lombin  S Rosendal    W R Mitchell 《Canadian journal of veterinary research》1982,46(2):109-114

Evaluation of diagnostic sensitivity and specificity was based on test results of 346 sera from pigs known to be infected and 139 sera from pigs known not to be infected. All sera were tested with a monospecific antigen (serotype 1) and a polyspecific antigen (serotypes 1-5). The sensitivity of the polyspecific antigen was approximately 85% at serum dilution 1:2 and was significantly higher than the monospecific antigen at all serum dilution levels. The specificity of the two antigen preparations was not significantly different at any dilution and increased from approximately 78% to 1:2 to 100% at 1:128. When pigs from herds with unknown incidence of infection were studied, it was found that a high proportion seroconverted, presumably as a response to subclinical infection. However, the antibody titres waned rapidly. This indicated that seroreaction expresses current or recent infection. Thus, the complement fixation test provides a reliable means of diagnosing pleuropneumonia of pigs and might be useful as a tool to control this disease.  相似文献   

Effects of propranolol on thyroid function in the dog   总被引：1，自引：0，他引：1  

S A Center  J Mitchell  R F Nachreiner  P W Concannon  T J Reimers 《American journal of veterinary research》1984,45(1):109-111

The effect of propranolol on thyroid function was evaluated in 6 mature euthyroid Beagles. Propranolol was administered orally in doses of 20 mg given 3 times daily for 2 weeks and then increased to 40 mg given 3 times daily for an additional 2 weeks. Six age- and sex-matched, euthyroid Beagles served as controls. Serum base-line concentrations of tetraiodothyronine (T4), triiodothyronine (T3), and reverse triiodothyronine (rT3) were measured before propranolol administration and at weekly intervals thereafter. Thyroid response to 5 IU of aqueous thyroid stimulating hormone administered IV was monitored before propranolol administration and at the 2- and 4-week treatment intervals. The T4, T3, and rT3 concentrations were measured by radioimmunoassay. There were no significant differences in base-line or postthyroid stimulating hormone serum concentrations of T4, T3, or rT3 in any individual or between the treatment or control groups at any treatment interval (P greater than 0.05). Seemingly, the therapeutic use of propranolol in euthyroid dogs should not alter thyroid hormone metabolism.  相似文献