Genetic regulation of meat production by embryonic muscle formation - a review     

Pas MF  Visscher AH 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》1994,111(1-6):404-412

SUMMARY: The biological basis for meat production in livestock animals is localized in the muscles, where lean meat production is under the genetic control of tissue-specific and more ubiquitously operating genes. The muscle tissue-specific MyoD gene family is at the centre of the genetic regulation of myoblast proliferation and differentiation into myofibres. The regulation of embryonic muscle tissue formation (development) by the MyoD genes is duscussed in the context of livestock animals used in meat production. The possibility that the MyoD genes could be useful candidate genes for breeding is discussed. It is concluded that marker assisted selection (MAS) using markers in functional genes is advantageous over MAS using associated markers. ZUSAMMENFASSUNG: Genetische Regulierung der Fleischproduktion bei der embryonalen Muskelbildung - Ein Literaturüberblick Die biologische Grundlage für Fleischproduktion, lokalisiert in den Muskeln, steht unter genetischer Kontrolle durch gewebsspezifische una mehr ubiquit?r arbeitende Gene. Die gewebsspezifische MyoD Genfamilie in den Muskeln befindet sich im Zentrum der genetischen Regulierung des Prozesses der Myoblastteilung und Differenzierung zu Myofasern. Die Ubersicht betrifft Regulierung der Bildung des embryonalen Muskelgewebes (Entwicklung) mit Hilfe der MyoD Gene. Die M?glichkeit, da? MyoD Gene erfolgreiche Kandidatengene für Tierzüchtung sein k?nnen, wird besprochen. 'Marker-assisted selection' (MAS) mit Hilfe von Markern funktioneller Gene sollte vorteilhafter sein als MAS mit gekoppelten DNA-Sequenzen. RéSUMé: Régulation génétique de la production de viande par la formation embryologique des muscles - un résumé La base biologique de la production de viande dans les animaux d'élevage se situe dans les muscles, là où la production de viande maigre est sous contr?le génétique de gènes générals et tissu-spécifiques. La famille des gènes muscle-spécifiques MyoD forme le centre de la régulation des procès de prolifération des myoblastes et de différenciation vers les myofibres. Le but de cet article rétrospectif est de situer la discussion sur la régulation de la formation embryologique des muscles par les gènes MyoD dans le cadre de l'élevage. La possibilité que les gènes MyoD soient des gènes candidats utiles pour l'élevage sera discutée. La conclusion faite est que 'marker assisted selection' (MAS) en employant des marquers situés dans des gènes fonctionnels a plus d'avantages que MAS avec des marquers associés.  相似文献   

Biochemical polymorphisms in Spanish Avileña-Negra Iberica cattle     

Arranz JJ  Bayón Y  Medjugorac I  Primitivo F 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》1994,111(1-6):413-417

SUMMARY: Thirteen biochemical blood polymorphisms were analysed in a population of 149 Spanish Avile?a-Negra Ibérica cattle. The study revealed variation at the following nine loci: HBB, CA, NP, CP, AMY1, ALB, GC, TF and PTF2. The following systems were monomorphic: CAT, DIA1, MDH1 and ME1. Using polyacrylamide-gel electrophoresis, a slow, migrating pair of bands was found in the GC protein system. This pattern is probably controlled by the GC(C) allele, described in only a few cases in cattle. Furthermore, starch-gel electrophoresis allowed the detection of a variant with intermediate mobility between the ALB(A) and the ALB(B) alleles at the albumin locus. A variant with a similar electrophoretic pattern has occasionally been reported in cattle. However, utilizing IEF under denaturing conditions, such a variant could not be differentiated from the ALB(A) allele and thus its significance is not clear. ZUSAMMENFASSUNG: Biochemischer Polymorphismus in spanischen Avile?a-Negra Iberica Rindern Insgesamt 13 biochemische Systeme wurden in einer Population von 149 spanischen Avilena-Negra-Iberika-Rindern hinsichtlich Polymorphismus analysiert. Es zeigten sich Varianten bei folgenden Loci: HBB, CA, NP, CP, AMY1, ANB, GC, TF und BTF2, w?hrend CAT, DEA, MDH1 und ME1 monomorph sind. Bei st?rke Gel-Elektrophorese wurde im Albumin-Locus eine Variante mit intermedi?rer Mobilit?t zwischen ALB(A) und ?LB(B) Allel entdeckt. Eine solche Variante wurde bisher nur sehr selten bei Rindern beobachtet. Darüber hinaus wurde bei Polyacrylamid-Gel-Elektrophorese ein langsam wanderndes Paar von B?ndern im GC-Proteinsystem gefunden. Dieses Muster ist wahrscheinlich von dem selten vorkommenden GC(C) -Allel verursacht. RESUMEN: Se analizaron trece polimorfismos bioquímicos sanguíneos en una población de 149 animales de la raza Avile?a-Negra Ibérica de ganado vacuno. El estudio reveló la existencia de variación en los nueve loci siguientes: HBB, CA, NP, CP, AMY1, ALB, GC, TF y PTF2. Fueron monomórficos los sistemas siguientes: CAT, DIA1, MDH1 y ME1. Utilizando eletroforesis en gel de poliacrilamida se encontró un par de bandas de migración lenta en el sistema de la proteína GC. Este patrón probablemente está controlado por el infrecuente alelo GC(C) , descrito en unos pocos casos en el ganado vacuno. Además, la electroforesis en gel de almidón permitió detectar en el locus de la albúmina una banda con movilidad intermedia entre los alelos ALB(A) y ALB(B) . Una variante con un patrón electroforético similar ha sido descrita en muy pocas ocasiones en el ganado vacuno. Sin embargo, la utilización de IEF en condiciones desnaturalizantes no permitió diferenciar esta variante del alelo ALB(A) y, por lo tanto, el significado de la misma no está claro.  相似文献   

Correct equations for comparing models in diallel analysis     

Wolf J  Vítek M  Herrendörfer G  Sumpf D 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》1994,111(1-6):209-212

SUMMARY: Correct equations are given to express the parameter estimates of four models for complete diallels as a function of the parameter estimates in the model of Eisen et al. (1983). In recent literature these equations have been partly incorrect. ZUSAMMENFASSUNG: Korrekte Gleichungen für den Vergleich von Modellen in der Diallelanalyse Für die Darstellung der Parametersch?tzwerte von vier Modellen für vollst?ndige Diallele als Funktion der Parametersch?tzwerte des Modells von Eisen et al. (1983), die in der Literatur teilweise fehlerhaft erfolgte, werden korrekte Formeln angegeben.  相似文献   

Utilizing the accuracy of estimated breeding values to improve selection response     

Macbeth GM 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》1994,111(1-6):189-198

SUMMARY: Stochastic simulation was used to evaluate the increase in selection response by incorporating accuracies of estimated breeding values (ebvs) in an index to form indexed breeding values (ibvs). Simulations were made using a standard population with a selected proportion of 5%, with 10 000 selection candidates and an average accuracy of breeding value determination, r? = 0.4 with variance, σ(r) (2) = 0.075(2) . In the standard population, candidates selected on ibvs showed an 8.4 % increase in average true breeding values (tbvs) compared to selection using ebvs. Using the same standard population, but changing the proportion selected to 1.0 % and 10 %, the relative increase in the average tbvs from ibv selection was 13.5 % and 5.5 % respectively. Similarly, changing r? to 0.22, 0.32 and 0.55, the relative increase from ibv selection was 48 %, 19 % and 1.3 % respectively. As σ(r) was changed to 0.025 and 0.125, the relative increase from ibv selection was 0.6 % and 24 % respectively. In general, the average accuracy in candidates chosen for selection using ibvs was lower than that from selection using ebvs. In the standard population the accuracy was 0.38 from ibv selection and 0.43 from ebv selection. As a result the increase in inbreeding will be lower with ibv than with ebv selection. ZUSAMMENFASSUNG: Verwendung von Genauigkeiten gesch?tzter Zuchtwerte zur Verbesserung des Selektionserfolges Durch stochastische Simulation wurde Steigerung des Selektionserfolges durch Einschlu? von Genauigkeiten gesch?tzter Zuchtwerte (ebvs) in einen Index indizierter Zuchtwerte (ibvs) untersucht. Simulationen wurden mit einer Standardpopulation 5% selektierter von 10 000 Kandidaten und einer durchschnittlichen Genauigkeit der Zuchtwertsch?tzung r = 0.4; σ(r) (2) = 0.075(2) durchgeführt. In der Standardpopulation hatten Kandidaten, mit ibvs selektiert, eine Steigerung des durchschnittlichen wahren Zuchtwertes (tbvs) von 8.4 % verglichen mit Selektion auf ebvs-Basis. Bei Verwendung derselben Standardpopulation, aber Remontierung von 1 % bzw. 10 %, war der relative Zuwachs im durchschnittlichen tbvs bei ibvs-Selektion 13.5 und 5.5%. Die relative Zunahme von der ibvs-Selektion, mit r von 0.22, 0.32 oder 0.55, war 48 %, 19 % und 1.3 %. Bei Ver?nderungen von σ(r) auf 0.25 und 0.125 betrug die relative Zunahme 0.6 und 24 %. Im allgemeinen waren die durchschnittlichen Genauigkeiten bei Selektionskandidaten auf der Basis von ibvs geringer als bei Verwendung von ebvs. In der Standardpopulation waren diese Genauigkeiten 0.38 bei ibvs und 0.43 bei ebvs. Daher sollte die Zunahme der Inzucht mit ibvs geringer sein als mit ebvs.  相似文献   

Accuracies of measures of growth rate in growing meat animals     

Liu MF 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》1994,111(1-6):167-168

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Characterisation of a maize-infecting potyvirus from Spain     

M. Angeles Achon  Vicente Medina  Michael Shanks  Peter Markham  George P. Lomonossoff 《European journal of plant pathology / European Foundation for Plant Pathology》1994,100(2):157-165

In order to characterise and classify an unknown maize-infecting potyvirus isolated from fields in northeast Spain, the entire coat protein gene and the C-terminal twothirds of the large nuclear inclusion protein (NIb) gene were cloned and sequenced. Protein sequencing enabled the cleavage site between the two proteins to be deduced and also revealed that on storage the viral coat protein undergoes a specific degradation in which the N-terminal 39 amino acids are removed. Comparison of the nucleotide sequence of the 3 non-coding region of the viral RNA and the predicted amino acid sequence of the coat protein with the equivalent regions of other members of the potyvirus group revealed that the Spanish virus is closely related to maize dwarf mosaic virus strain A.  相似文献   

Prevalence and spatial distribution of bovine tuberculosis in brushtail possums on a forest-scrub margin     

Coleman JD  Jackson R  Cooke MM  Grueber L 《New Zealand veterinary journal》1994,42(4):128-132

Tuberculosis caused by Mycobacterium bovis was diagnosed in 36 of 68 (53%) brushtail possums (Trichosurus vulpecula) trapped in August 1992 from a population of exceptionally low density (trap catch <3%) on a forest-scrub margin in Westland, New Zealand. The prevalence of tuberculosis in possums, based solely on gross lesions, was at least twice that previously recorded in New Zealand, and was about seven times that recorded from the same population in 1980. More male (66%) than female (33%) possums had grossly visible tuberculous lesions. The distribution of infection appeared continuous along the forest-scrub margin. Both stoats (Mustela erminea) and one of six hares (Lepus europaeus occidentalis) trapped were also infected with M. bovis.  相似文献   

Observations on three outbreaks of Leptospira interrogans serovar pomona infection in lambs     

Vermunt JJ  West DM  Cooke MM  Alley MR  Collins-Emerson J 《New Zealand veterinary journal》1994,42(4):133-136

Sickness and deaths associated with leptospirosis were reported in three lamb flocks in the Manawatu region. The clinical, pathological and serological features of Leptospiru interrogans serovar pomona infection are described. The mucous membranes of affected animals were pale and jaundiced. Haemoglobinuria, haemoglobinaemia and centrilobular hepatocellular necrosis were also consistent findings. All clinically sick lambs had very high titres in the microscopic agglutination test for L. pomona. Circumstantial evidence of pigs being the source of infection was found in one of the three cases.  相似文献   

Persistent infection with multiple anthelmintic-resistant gastrointestinal nematodes in cashmere goats     

J. Praslička  M. Várady  J. Čorba 《Veterinary research communications》1994,18(6):443-446

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A formal method of determining the dietary amino acid requirements of laying‐type pullets during their growing period     

Patricia A. Martin  Gail D. Bradford  R. M. Gous 《British poultry science》1994,35(5):709-724

1. The amino acid requirements of laying type pullets during the growing period can be estimated by measuring the growth of different components of the body and making use of nutritional constants that define the amount of each amino acid that is required for the production of the tissues being formed.

2. In this experiment, carcase analyses of each of three breeds of pullets were conducted at weekly intervals throughout the growth of the pullets, to 18 weeks of age. Measurements were made of body weight, gut‐fill and feather weight, and chemical analyses consisted of water, protein, lipid and ash measurements of both the body and the feathers. Each age group comprised 10 birds of each breed.

3. Gompertz functions accurately estimated the growth of both body protein and feather protein, to 18 weeks of age, from which the rate of growth of these two components of the body could be estimated. The mature weight of pullets was overestimated by the Gompertz growth curve, which may indicate that a pullet ceases to increase in body protein content once sexual maturity has been reached.

4. Using allometric relationships between the chemical components of the body and of feathers, all the components of growth could be estimated from the growth of body protein and feather protein. These components were then added together to determine the growth rate of the body as a whole.

5. The daily amino acid requirements for 4 functions were calculated, namely, those for the maintenance of body protein and feather protein, and for the gain in body protein and feather protein. These requirements were then summed to determine the requirement of pullets on each day of the growing period.

6. Using the ‘effective energy’ system, the amount of energy required by these pullets was calculated for each day of the growing period, from which the desired daily food intake of the pullets could be predicted. By dividing the amino acid requirement by this daily food intake it was possible to determine the concentration of amino acids that would be needed in the diet in order to meet the requirements of a pullet.

7. The results indicate that the ratio between the requirement for lysine and for methionine and cysteine changes dramatically during the growing period, negating the concept of a fixed ratio between all the amino acids during growth.

8. The above process is the first step in determining the optimal feeding programme for a population of pullets of a given genotype. The constraining effects, of the diet being offered and of the environment in which the pullets are housed, on the food intake and growth rate of each pullet have to be estimated, and such a theory can then be expanded to include all the individuals in the population. Only by the use: of simulation models can all these constraining effects be considered simultaneously.  相似文献