Recurrent single oesophageal stricture treated with a self-expanding stent in a cat     

Glanemann B  Hildebrandt N  Schneider MA  Moritz A  Neiger R 《Journal of Feline Medicine and Surgery》2008,10(5):505-509

A 1-year-old, female spayed domestic shorthair cat was presented with a 4-week history of dysphagia and regurgitation soon after oral treatment with clindamycin. Fluoroscopic and endoscopic examinations confirmed the presence of a single cervical oesophageal stricture 4 cm caudal to the pharynx. A fluoroscopically and endoscopically guided balloon dilation was performed six times consecutively over a period of 3 weeks as reformation of the stricture appeared within 3-7 days. Feeding via percutaneous endoscopic gastrostomy-tube as long-term management of the condition was declined by the owner. A self-expanding metal oesophageal stent with the following dimension was subsequently implanted: fully open diameter 16 mm, length 30 mm. After stent implantation, the cat was fed on mashed canned food and did not show any clinical signs for 12 months. Twelve months post-implantation the cat was no longer able to eat even liquid food, became lethargic and the owner opted for euthanasia. On post-mortem examination the stent surfaces were overgrown by oesophageal mucosa by approximately 50%. Stent obstruction was detected and caused by swallowed hair which also seemed to have hampered mucosal integration in the distal part of the stent.  相似文献   

Prevotella copri,a potential indicator for high feed efficiency in western steers     

Charles G. Brooke  Negeen Najafi  Katherine C. Dykier  Matthias Hess 《Animal Science Journal》2019,90(5):696-701

There has been a great interest to identify a microbial marker that can be used to predict feed efficiency of beef cattle. Such a marker, specifically one that would allow an early identification of animals with high feed efficiency for future breeding efforts, would facilitate increasing the profitability of cattle operations and simultaneously render them more sustainable by reducing their methane footprint. The work presented here suggests that Prevotella copri might be an ideal microbial marker for identifying beef cattle with high feed efficiency early in their life span and in the production cycle. Developing more refined quantification techniques that allow correlation of P. copri to feed efficiency of beef cattle that can be applied by lay people in the field holds great promise to improve the economy of cattle operations while simultaneously reducing their environmental impact by mitigating methane production from enteric fermentation.  相似文献   

Chemistry and biology of novel amine fungicides: Attempts to improve the antifungal activity of fenpropimorph     

Alan Akers  Eberhard Ammermann  Ernst Buschmann  Norbert Gtz  Walter Himmele  Gisela Lorenz  Ernst-Heinrich Pommer  Costin Rentzea  Franz Rhl  Hardo Siegel  Bernhard Zipperer  Hubert Sauter  Matthias Zipplies 《Pest management science》1991,31(4):521-538

In spite of considerable efforts by many workers, there has been a lack of progress in the area of amine fungicides since fenpropimorph. Random synthesis of a large variety of different amine compounds, as well as intelligent structural modification of the lead structure fenpropimorph (well over 15 000 amines have been screened at BASF alone) have not led to a new market product so far. Further work has been focused on the reported mode of action of fenpropimorph, notably on the inhibition of the sterol Δ¹⁴-reductase. Although some doubt has to be cast on the hypothesis that fenpropimorph behaves as a sterol mimic, the concept of ‘high energy intermediate’ inhibitors has been employed successfully. Rational drug design of azasterol mimics has led to a number of very potent inhibitors of the sterol Δ¹⁴-reductase which also displayed high fungicidal activity in the greenhouse. Although many of these compounds are more powerful reductase inhibitors than fenpropimorph, under field conditions none showed significant advantages over this established fungicide. Most likely, fenpropimorph already exhibits the maximum fungicidal activity which can be attained by blocking the sterol Δ¹⁴-reductase. This would mean that, with the development of the ‘second generation’ amine fungicide fenpropimorph, this class of compounds has already virtually been optimized.  相似文献   

Serum Levels of Cardiac Markers NT‐proANP and NT‐proBNP in Brachycephalic bitches at Different Gestational Stages          下载免费PDF全文

MAR Feliciano  RR Uscategui  GS Maciel  VT de Almeida  MF Silveira  GAC de Oliveira  WRR Vicente 《Reproduction in domestic animals》2016,51(3):346-350

The aim of this study was to determine serum levels of natriuretic peptide precursors (NT‐proANP and NT‐proBNP) during pregnancy in brachycephalic bitches. Fifteen healthy multiparous bitches were selected for this prospective study. Serum levels of NT‐proANP and NT‐proBNP were measured during anoestrous and at 14, 35, 42, 49 and 56 days (2nd, 5th, 6th, 7th and 8th weeks) of pregnancy. Fourteen animals had normal gestations, and one bitch developed single foetus syndrome. The natriuretic peptide levels of this animal were not included in this study; however, it is important to report that its NT‐proANP levels were four times greater than those of normal patients. There was no significant difference (p = 0.072) in NT‐proBNP levels between anoestrous (0.20 ± 0.10 ng/ml) and the different pregnancy weeks (0.27 ± 0.12 ng/ml). There was a positive correlation (p < 0.0001) between NT‐proANP and gestational age, and the levels of this marker increased significantly (p < 0.0001) during the 6th (0.26 ± 0.06 ng/ml), 7th (0.28 ± 0.04 ng/ml) and 8th weeks (0.29 ± 0.05 ng/ml) when compared to anoestrous (0.18 ± 0.02 ng/ml). NT‐proANP serum levels are correlated with gestational development and may be indicative of cardiovascular adaptation in canine brachycephalic pregnancy.  相似文献   

Effect of dietary iodine on growth and iodine status of growing fattening bulls     

Ulrich Meyer  Kristin Weigel  Friedrich Schne  Matthias Leiterer  Gerhard Flachowsky 《Livestock Science》2008,115(2-3):219-225

The aim of the present study was to assess the influence of different levels of iodine supplementation on animal growth and the iodine content of food from beef cattle. In a dose–response experiment with 34 growing fattening bulls of the “German Holstein” breed, in the range from 223 to 550 kg body weight, three iodine dosages were tested. The animals were fed a corn silage/concentrate ration. Iodine concentration in the diet amounted to 0.79 (Group 1), 3.52 (Group 2) and 8.31(Group 3) mg I per kg dry matter (DM). After slaughtering, I was determined in blood, serum, plasma, thyroid, liver, kidneys and meat (M. longissimus dorsi, M. glutaeus medius) by ICP-MS. I-supplementation did not significantly influence DM intake, daily weight gain (1453 (1), 1419 (2) and 1343 (3) g; p > 0.05) or slaughtering performance, but the weight of the thyroid gland increased significantly with the highest I dosage (32 (1), 26 (2) and 42 (3) g animal^− 1, p < 0.05). I-supplementation significantly increased I-concentration in muscle, liver, kidney and thyroid gland (p < 0.05). The contribution of beef food to I-intake of humans is relatively low, therefore there is no need to reduce the EU-upper limit (10 mg kg^− 1 feed) for growing fattening cattle from the view of consumer safety. In view of animal health and performance more dose–response studies seem to be necessary.  相似文献   

Evaluation of benazepril in cats with heart disease in a prospective,randomized, blinded,placebo‐controlled clinical trial     

Jonathan N. King  Mike Martin  Valrie Chetboul  Luca Ferasin  Anne T. French  Günther Strehlau  Wolfgang Seewald  Sarah G. W. Smith  Simon T. Swift  Susan L. Roberts  Andrea M. Harvey  Christopher J. L. Little  Sarah M. A. Caney  Kerry E. Simpson  Andrew H. Sparkes  Eleanor J. Mardell  Eric Bomassi  Claude Muller  John P. Sauvage  Armelle Diqulou  Matthias A. Schneider  Laurence J. Brown  David D. Clarke  Jean‐Francois Rousselot 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(6):2559-2571

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Biosynthesis of monoterpenes and norisoprenoids in raspberry fruits (Rubus idaeus L.): the role of cytosolic mevalonate and plastidial methylerythritol phosphate pathway     

Hampel D  Swatski A  Mosandl A  Wüst M 《Journal of agricultural and food chemistry》2007,55(22):9296-9304

The biosynthesis of the monoterpenes (-)-alpha-pinene, linalool, and the norisoprenoids alpha- and beta-ionone in raspberry fruits (rubus idaeus L.) was investigated by in vivo feeding experiments with [5,5-(2)H2]-mevalonic acid lactone and [5,5-(2)H2]-1-deoxy-D-xylulose. The volatile compounds were extracted by stirbar sorptive extraction and analyzed using thermal desorption-multidimensional gas chromatography-mass spectrometry (TD-enantio-MDGC-MS). The feeding experiments demonstrate that (-)-alpha-pinene and (S)-linalool are exclusively synthesized via the cytosolic mevalonic acid pathway. In contrast, (2)H-labeled (R)-(E)-alpha-ionone and (2)H-labeled (E)-beta-ionone are detectable after application of d2-1-deoxy-D-xylulose and d2-mevalonic acid lactone, respectively. However, (R)-linalool reveals no incorporation of either one of the fed precursors, even though this enantiomer is detectable in the fruit tissue.  相似文献   

Perfused non-pregnant swine uteri: a model for evaluating transport mechanisms to the side bearing the dominant follicle in humans     

Mueller A  Siemer J  Renner S  Hoffmann I  Maltaris T  Binder H  Beckmann MW  Dittrich R 《The Journal of reproduction and development》2006,52(5):617-624

Adequate uterine contractility and periovulatory peristalsis, interpreted as "rapid sperm transport" to the side bearing the dominant follicle, may be a precondition for successful reproduction in humans. Estrogen and progesterone fluctuate characteristically during the menstrual cycle, and their source is the dominant follicle and corpus luteum. The question is, how is the direction to the left or right side of transport mechanisms influenced? An extracorporeal perfusion model of the swine uterus was used that maintained the uterus in a functional condition and that was suitable for the study of physiological questions. The effects of side-dependent estrogen, progesterone, and estrogen plus progesterone perfusion on oxytocin-induced uterine peristalsis were assessed using two intrauterine microcatheters placed in each horn of the swine uterus. Estrogen perfusion was associated with an increase in intrauterine pressure (IUP) in a dose-dependent manner only in the estrogen-perfused horn of the swine uterus. There was a significant difference between the IUP increase measured in the estrogen-perfused horn and that in the non estrogen-perfused horn of the swine uterus. Progesterone perfusion showed no effect in general. Furthermore, progesterone antagonized the estrogen effects. This study demonstrates that side-dependent estrogen perfusion resulted in side-dependent contractility in the swine uterus perfusion system used. These observations show that estrogen stimulates uterine contractility in the estrogen-perfused uterine horn and that estrogens may be the "trigger" for the transport mechanisms to the side bearing the dominant follicle during the periovulatory phase through their locally increased concentration and distribution via the utero-ovarian counter-current system in humans.  相似文献   

Coherent state evolution in a superconducting qubit from partial-collapse measurement     

Katz N  Ansmann M  Bialczak RC  Lucero E  McDermott R  Neeley M  Steffen M  Weig EM  Cleland AN  Martinis JM  Korotkov AN 《Science (New York, N.Y.)》2006,312(5779):1498-1500

Measurement is one of the fundamental building blocks of quantum-information processing systems. Partial measurement, where full wavefunction collapse is not the only outcome, provides a detailed test of the measurement process. We introduce quantum-state tomography in a superconducting qubit that exhibits high-fidelity single-shot measurement. For the two probabilistic outcomes of partial measurement, we find either a full collapse or a coherent yet nonunitary evolution of the state. This latter behavior explicitly confirms modern quantum-measurement theory and may prove important for error-correction algorithms in quantum computation.  相似文献   

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host     

Meyer-Luehmann M  Coomaraswamy J  Bolmont T  Kaeser S  Schaefer C  Kilger E  Neuenschwander A  Abramowski D  Frey P  Jaton AL  Vigouret JM  Paganetti P  Walsh DM  Mathews PM  Ghiso J  Staufenbiel M  Walker LC  Jucker M 《Science (New York, N.Y.)》2006,313(5794):1781-1784

Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-beta (Abeta)-containing brain extracts from humans with Alzheimer's disease or beta-amyloid precursor protein (APP) transgenic mice induced cerebral beta-amyloidosis and associated pathology in APP transgenic mice in a time- and concentration-dependent manner. The seeding activity of brain extracts was reduced or abolished by Abeta immunodepletion, protein denaturation, or by Abeta immunization of the host. The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic Abeta strains with varying biological activities reminiscent of prion strains.  相似文献