排序方式： 共有36条查询结果，搜索用时 203 毫秒
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C.L. Stoltenow DVM Diplomate ACVPM M. Mostrom DVM PhD Diplomate ACVT L.R. Stoltenow DVM T.E. Matz DVM 《Journal of Equine Veterinary Science》2002,22(11)
Six mixed breed horses of varying ages accidentally consumed strychnine-laced barley. Onset and severity of clinical signs were associated with age and sex of the horse. Of the 6 horses, 5 exhibited clinical signs and 2 died. Under field conditions xylazine proved to be beneficial in treating strychnine poisoning. Two horses were treated with a combination of pentobarbital, diazepam, and xylazine to maintain complete anesthesia. Activated charcoal and mineral oil were used effectively to decrease the amount of strychnine available in the alimentary tract of the horses. 相似文献
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K G Braund J R Mehta M Toivio-Kinnucan K A Amling L G Shell M E Matz 《Veterinary pathology》1989,26(3):202-208
Serial peripheral nerve biopsies from two golden retriever littermates with chronic neurologic disease were taken for morphologic and morphometric evaluation. Teased nerve preparations were difficult to interpret due to the lightness of myelin staining. Light and electron microscopic findings were characterized by the following: reduced number of myelinated axons, presence of myelinated sheaths inappropriately thin for the caliber of the fiber, poor myelin compaction, increased numbers of Schwann cell nuclei, increased concentration of neurofilaments in myelinated axons, many Schwann cells with voluminous cytoplasm, and increased perineurial collagen. Onion bulb formation was not seen. In contrast to control data, a poor correlation was seen between numbers of myelin lamellae (ML) and axonal circumference (AC). The frequency distribution of ML ranged from 5 to 55 lamellae in affected animals (mean, 28 lamellae) compared to 20 to 140 lamellae in controls (mean, 66 lamellae). The ML/AC ratio was significantly reduced (P less than 0.001) in nerves of affected dogs. Morphometric results indicated that fibers of all calibers were hypomyelinated. 相似文献
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In proteins homologous to the green fluorescent protein (GFP), formation of red fluorescence requires three autocatalytic steps, whereas only two are needed for green fluorescence. Multiple red/green color diversification events in the GFP superfamily may reflect convergent evolution of the more complex three-step pathway. In the great star coral Montastraea cavernosa, a recreated common ancestor of green and red proteins turned out to be green, indicating that in this case red proteins evolved their color independently from most other homologous red proteins. Furthermore, red color appears to have evolved gradually by small incremental transitions. 相似文献
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"Fluorescent timer": protein that changes color with time 总被引：1，自引：0，他引：1
Terskikh A Fradkov A Ermakova G Zaraisky A Tan P Kajava AV Zhao X Lukyanov S Matz M Kim S Weissman I Siebert P 《Science (New York, N.Y.)》2000,290(5496):1585-1588
We generated a mutant of the red fluorescent protein drFP583. The mutant (E5) changes its fluorescence from green to red over time. The rate of color conversion is independent of protein concentration and therefore can be used to trace time-dependent expression. We used in vivo labeling with E5 to measure expression from the heat shock-dependent promoter in Caenorhabditis elegans and from the Otx-2 promoter in developing Xenopus embryos. Thus, E5 is a "fluorescent timer" that can be used to monitor both activation and down-regulation of target promoters on the whole-organism scale. 相似文献