Three phase elimination of oxytetracycline in veal calves; the presence of an extended terminal elimination phase     

L. A. MEIJER  K. G. F. CEYSSENS  W. TH. DEJONG  B. I.J. A. C. DE GREVE 《Journal of veterinary pharmacology and therapeutics》1993,16(2):214-222

The pharmacokinetics of oxytetracycline were studied after both intravenous (i.v.) and intramuscular (i.m.) administration to a group of five veal calves. Blood samples were taken frequently during the terminal elimination phase in order to calculate a reliable elimination rate constant. Because of the low limit of quantification of the method of analysis used, oxytetracycline plasma concentrations could be monitored over a 12-day period of time.
After the intravenous administration of oxytetracycline, data were fitted according a three-compartment model. After i.m. administration, plasma-concentration-time curves could best be described by a two-compartment model. It was demonstrated that a very slow terminal elimination phase was present both after i.v. and i.m. administration with a half-life of approximately 95 h. The data show that this phase cannot be explained by slow absorption from the injection site and that release of oxytetracycline incorporated into bone is not a likely explanation.  相似文献   

Histomorphometrische und histologische Untersuchungen zur morphokinetischen Wirkung von Furazolidon auf die Spermiogenese geschlechtsreifer Ratten     

TH. Ludewig  G. Gutte 《Anatomia, histologia, embryologia》1995,24(1):7-12

The antispermatongenic effects of furazolidone on the testes of mature Wistar rats were investigated using histological and morphometric methods. The sections showed a varying degree of depopulation of the germinal epithelium, a shrinking and a deformation of the Tubuli contorti, and an enlargement of the intertubular lymphatic sinuses. The strain led to a standstill in the spermatogenesis at the primary-spermatocyte stage. After administering furazolidone, the following results could be seen: – a weightloss of up to 42.1% and a decrease in testes volume by up to 30.2% – a decrease in the volume of the nuclei of the Leydig-cells by up to 51.6% – a reduction in the diameter, perimeter and area covered by Tubuli seminiferi contorti of up to 33.5%, 30.8%, and 53.4%, respectively – an increase in the number of Tubuli seminiferi contorti per mm2 by up to 44.8% – a decrease in the percentage of Tubuli seminiferi contorti of the total testes tissue by up to 39.1%  相似文献   

Physiological races and vegetative compatibility groups within Fusarium oxysporum f.sp. gladioli     

E. J. A. Roebroeck  J. J. Mes 《European journal of plant pathology / European Foundation for Plant Pathology》1992,98(1):57-64

The pathogenicity and vegetative compatibility of mainly Dutch isolates ofFusarium oxysporum collected from diseased gladioli and other Iridaceae were investigated. Based on their pathogenicity to two differential gladiolus cultivars, the isolates could tentatively be divided into two races. All self-compatible isolates ofFusarium oxysporum f.sp.gladioli belonged to one of three distinct vegetative compatibility groups, VCG 0340, 0341 or 0342, and were incompatible with isolates that were not pathogenic to gladiolus. Isolates of one of the two races were restricted to one VCG while isolates of the other race were present in all three VCGs.  相似文献   

Occurrence of pepper yellow vein in the Netherlands     

A. TH. B. Rast 《European journal of plant pathology / European Foundation for Plant Pathology》1988,94(6):311-313

Samenvatting Het verschijnsel van geelnervigheid bij paprika (Capsicum annuum) kon door verenting en met de schimmelOlpidium brassicae worden overgebracht. Hierdoor bleek de ziekte identiek te zijn met een eerder in Engeland gemelde ziekte. Door inoculatie met zoösporen of rustsporen vanO. brassicae werden ook symptomen verkregen inC. baccatum, C. chacoense enC. frutescens. S. villosum bleek een waardplant te zijn voor het geelnervigheidsagens, waarbij zwakke nerfchlorosen werden waargenomen.Seconded to the Glasshouse Crops Research Station, P.O. Box 8, 2670 AA Naaldwijk, the Netherlands.  相似文献   

Biological and Molecular Characterization of Fusarium oxysporum f. sp. lycopersici Divides Race 1 Isolates into Separate Virulence Groups     

Mes JJ  Weststeijn EA  Herlaar F  Lambalk JJ  Wijbrandi J  Haring MA  Cornelissen BJ 《Phytopathology》1999,89(2):156-160

ABSTRACT A collection of race 1 and race 2 isolates of Fusarium oxysporum f. sp. lycopersici was screened for vegetative compatibility and characterized by random amplified polymorphic DNA (RAPD) analysis to establish the identity and genetic diversity of the isolates. Comparison of RAPD profiles revealed two main groups that coincide with vegetative compatibility groups (VCGs). In addition, several single-member VCGs were identified that could not be grouped in one of the two main RAPD clusters. This suggests that F. oxysporum f. sp. lycopersici is a polyphyletic taxon. To assign avirulence genotypes to race 1 isolates, they were tested for their virulence on a small set of tomato lines (Lycopersicon esculentum), including line OT364. This line was selected because it shows resistance to race 2 isolates but, unlike most other race 2-resistant lines, susceptibility to race 1 isolates. To exclude the influence of other components than those related to the race-specific resistance response, we tested the virulence of race 1 isolates on a susceptible tomato that has become race 2 resistant by introduction of an I-2 transgene. The results show that both line OT364 and the transgenic line were significantly affected by four race 1 isolates, but not by seven other race 1 isolates nor by any race 2 isolates. This allowed a subdivision of race 1 isolates based on the presence or absence of an avirulence gene corresponding to the I-2 resistance gene. The data presented here support a gene-for-gene relationship for the interaction between F. oxysporum f. sp. lycopersici and its host tomato.  相似文献   

Polychlorinated biphenyl and organochlorine pesticides residues in Canadian chicken eggs     

J Mes  D E Coffin  D Campbell 《Pesticides monitoring journal》1974,8(1):8-11

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Comparative Aspects of the Endotoxin- and Cytokine-Induced Endocrine Cascade Influencing Neuroendocrine Control of Growth and Reproduction in Farm Animals     

BK Whitlock  JA Daniel  RR Wilborn  TH Elsasser  JA Carroll  JL Sartin 《Reproduction in domestic animals》2008,43(S2):317-323

Disease in animals is a well-known inhibitor of growth and reproduction. Earlier studies were initiated to determine the effects of endotoxin on pituitary hormone secretion. These studies found that in sheep, growth hormone (GH) concentration was elevated, whereas insulin-like growth factor-I (IGF-I) was inhibited, as was luteinizing hormone (LH). Examination of the site of action of endotoxin in sheep determined that somatotropes expressed the endotoxin receptor (CD14) and that both endotoxin and interleukin-Iβ activated GH secretion directly from the pituitary. In the face of elevated GH, there is a reduction of IGF-I in all species examined. As GH cannot activate IGF-I release during disease, there appears to be a downregulation of GH signalling at the liver, perhaps related to altered nitration of Janus kinase (JAK). In contrast to GH downregulation, LH release is inhibited at the level of the hypothalamus. New insights have been gained in determining the mechanisms by which disease perturbs growth and reproduction, particularly with regard to nitration of critical control pathways, with this perhaps serving as a novel mechanism central to lipopolysaccharide suppression of all signalling pathways. This pathway-based analysis is critical to the developing novel strategies to reverse the detrimental effect of disease on animal production.  相似文献   

Evaluation of effectiveness of Insegar (fenoxycarb 250 g/kg) WP against Phyllocnistis citrella Stainton (Lep., Gracillariidae) and its effect on Cales noacki How. (Hym., Aphelinidae)     

C. TH. Buchelos  M. Foudoulakis 《Anzeiger für Sch?dlingskunde》2000,43(3):19-21

Aiming to control the citrus leafminer Phyllocnistis citrella St. while at the same time protecting the biological equilibrium and mainly the beneficial insect Cales noacki, experiments have taken place in the regions of Argolis and Fthiotis, Greece in 1996 and 1997. Insegar (fenoxycarb) 2 5 WP was applied on young citrus trees. During 1996, the compound, applied every 10 days at a rate of 30 g/hI (with or without adjuvant), gave satisfactory protection from P. citrella without substantially harming C. noacki populations. No phytotoxicity symptoms were observed during the experiments.  相似文献   

Evaluation of effectiveness of Insegar (fenoxycarb 250 g/kg) WP against Phyllocnistis citrella Stainton (Lep., Gracillariidae) and its effect on Cales noacki How. (Hym., Aphelinidae)     

C. TH. Buchelos  M. Foudoulakis 《Anzeiger für Sch?dlingskunde》2000,73(1):19-21

Aiming to control the citrus leafminer Phyllocnistis citrella St. while at the same time protecting the biological equilibrium and mainly the beneficial insect Cales noacki, experiments have taken place in the regions of Argolis and Fthiotis, Greece in 1996 and 1997. Insegar (fenoxycarb) 2 5 WP was applied on young citrus trees. During 1996, the compound, applied every 10 days at a rate of 30 g/hI (with or without adjuvant), gave satisfactory protection from P. citrella without substantially harming C. noacki populations. No phytotoxicity symptoms were observed during the experiments.  相似文献   

Reptarenaviruses in apparently healthy snakes in an Australian zoological collection     

TH Hyndman  RE Marschang  M Bruce  P Clark  SD Vitali 《Australian veterinary journal》2019,97(4):93-102

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