Endogenous Benzodiazepine Activity in the Peripheral and Portal Blood of Dogs With Congenital Portosystemic Shunts     

LILLIAN R. ARONSON VMD    REYNALDO C. GACAD MD    KRISTINE KAMINSKY-RUSS MS    CLARE R. GREGORY DVM  Dipiomate ACVS  KEVIN D. MULLEN MB  FRCPI 《Veterinary surgery : VS》1997,26(3):189-194

Objective- The purpose of this study was to determine whether an endogenous benzodiazepine receptor ligand (EBZ) was present in the arterial and portal blood of dogs with congenital portosystemic shunts (CPSS).
Study Design- The presence or absence of an EBZ was determined by the collection of systemic and portal blood from dogs with CPSS.
Animals- Fifteen client-owned dogs with a confirmed CPSS. All dogs had historical signs compatible with hepatic encephalopathy. Eight healthy dogs were used as controls.
Methods- In all dogs, systemic blood samples were collected after they were anesthetized. Portal blood samples were collected intraoperatively. EBZ was measured by radioreceptor assay.
Results- In 10 of 15 dogs, the portal blood concentration of EBZ was significantly elevated compared with normal dogs (mean, 13.2 ±18.55 ng/mL). Five dogs had elevated systemic blood EBZ levels (mean, 8.2 ±16.08 ng/mL). Eleven of 15 dogs had a higher portal than systemic blood concentration of EBZ. In contrast, control dogs had extremely low EBZ concentrations detected in their portal blood (mean, 0.16 ±0.3 ng/mL) and systemic blood (0 ng/mL). The mean portal and systemic blood concentrations in dogs with CPSS were significantly greater than in control dogs ( P <.05).
Conclusions- Elevated blood levels of EBZ were found in dogs with CPSS. The portosystemic gradient noted in 11 dogs suggests the gastrointestinal tract as a possible source for the endogenous ligand.
Clinical Relevance- Generalized motor seizures have been reported in dogs after surgical correction of CPSS. If the presence of a CPSS results in stimulation of brain receptors for benzodiazepines, post-CPSS ligation seizures may result from a withdrawal of EBZ after ligation of the portosystemic shunt.  相似文献   

TRUE DIAPHRAGMATIC HERNIA IN A CAT     

Andra K.  Voges  DVM  Scott  Bertrand  DVM  Richard C.  Hill  MA Vet MB  PhD  Lisa  Neuwirth  DVM  MS  Michael  Schaer  DVM 《Veterinary radiology & ultrasound》1997,38(2):116-119

A report of a cat with a true diaphragmatic hernia in which only falciform fat had herniated is pressented. The lession was misinterpreted as a pulmonary mass. Additional radiographic studies which may have been of diagnostic benefit are briefly discussed.  相似文献   

Normal and abnormal sex, chromosomes and H-Y antigen     

C.R.E. Hainan MA VET. MB  PhD  FRCVS 《Journal of Equine Veterinary Science》1985,5(1):38-39

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Modelling the potential impact of exotic diseases on regional Australia     

MG GARNER  MB LACK 《Australian veterinary journal》1995,72(3):81-87

SUMMARY: Recent international initiatives for disease control suggest that, in the future, the consequences for trade of an exotic disease outbreak may not be as severe as estimated in the past. If zoning were to be accepted by Australia's trading partners, then the major effects may be felt at the regional rather than the national level. A study, using an integrated epidemiological/economic model, was undertaken to compare the impacts of 3 important exotic diseases (foot-and-mouth disease, classical swine fever and sheep pox) in 3 different regions of Australia. The study demonstrated that there are significant differences between the size and effect of different disease outbreaks. Regional factors influence not only the way that the disease will spread and manifest itself, but also the effects on local communities. Foot-and-mouth disease caused more economic losses than sheep pox or classical swine fever. The major determinant of differences in the effects of the diseases between regions was the nature of the regional economies. The less diversified the economy, the greater the effect of an exotic disease outbreak in relation to the size of that economy.  相似文献   

Cryptococcal meningitis in an alpaca   总被引：1，自引：0，他引：1  

LM GOODCHILD  AJ DART  MB COLLINS  CM DART  JL HODGSON  DR HODGSON 《Australian veterinary journal》1996,74(6):428-430

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Biomechanical Comparison Between Bicortical Pin and Monocortical Screw/Polymethylmethacrylate Constructs in the Cadaveric Canine Cervical Vertebral Column     

Bianca F. Hettlich Dr. med vet  Diplomate ACVS  Matthew J. Allen Vet MB  PhD  Daniel Pascetta BS  Geoffrey T. Fosgate DVM  PhD  Diplomate ACVPM  Alan S. Litsky MD  Sc.D. 《Veterinary surgery : VS》2013,42(6):693-700

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Clinical management of Brucella suis infection in dogs and implications for public health          下载免费PDF全文

DR James  G Golovsky  JM Thornton  L Goodchild  M Havlicek  P Martin  MB Krockenberger  DJE Marriott  V Ahuja  R Malik  SM Mor 《Australian veterinary journal》2017,95(1-2):19-25

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Use of carbon dioxide laser for onychectomy in cats     

Mison MB  Bohart GH  Walshaw R  Winters CA  Hauptman JG 《Journal of the American Veterinary Medical Association》2002,221(5):651-653

OBJECTIVE: To compare postoperative signs of discomfort and complications associated with use of CO2 laser for onychectomy with those of the scalpel technique in cats. DESIGN: Prospective, randomized, masked clinical trial. ANIMALS: 20 client-owned cats. PROCEDURE: Forelimb feet (right, left) were randomly assigned to laser and scalpel treatment groups. Signs of discomfort (lameness and signs of pain) and complications (hemorrhage, swelling, and discharge) were assessed on days 0, 1, and 7. Surgeries were performed by 1 experienced surgeon. Evaluations were performed by 2 individuals without knowledge of treatment group. Signs of discomfort and complications were scored on scales of 0 to 8 and 0 to 9, respectively. RESULTS: Onychectomy did not result in high discomfort or complication scores 1 day after surgery, regardless of technique used, although the laser-treated group had significantly lower scores for signs of discomfort and complications. Seven days after surgery, significant differences were not detected between groups for signs of discomfort or complications. CONCLUSIONS AND CLINICAL RELEVANCE: The CO2 laser can be an excellent tool for onychectomy in cats, with excellent hemostasis and minimal postoperative discomfort and complications. Differences in discomfort and complications between groups treated via scalpel versus CO2 laser were not clinically relevant and were only observed 1 day after surgery.  相似文献   

Comparison of Two Methods for Presurgical Disinfection of the Equine Hoof     

Gayle E. Hennig  DVM    Bonnie Hay Kraus  DVM  Diplomate ACVS    Richard Fister  PhD    Vickie L. King  PhD    Robert R. Steckel  DVM  MS  Diplomate ACVS    Carl A. Kirker-head  MA  Vet MB  MRCVS  Diplomate ACVS  Diplomate ECVS 《Veterinary surgery : VS》2001,30(4):366-373

OBJECTIVES: To determine for equine hooves the normal resident aerobic bacterial population and the efficacy of 2 methods of disinfection. Study Design-Measurement of total bacterial, gram-positive bacterial, and gram-negative bacterial surface populations from the frog, sole, and hoof wall after each step of 2 different preoperative surgical disinfection techniques. ANIMALS: Six adult horses. METHODS: Hoof wall, sole, and frog samples were collected for quantitative bacteriology before, during, and after 2 multistep antiseptic preparation techniques: Method A-6-minute scrub with povidone-iodine soap, followed by 24-hour submersion in povidone-iodine solution-soaked cotton; and Method B-initial removal of superficial layer of hoof capsule before completing Method A disinfection procedures. RESULTS: Removal of the superficial hoof layer, application of the povidone iodine scrub, and completion of the povidone-iodine soak all significantly (P < .0008) decreased total bacterial numbers. Method B had significantly lower bacterial counts than method A at each consecutive step. Final total bacterial counts remained greater than 10(5) bacteria per gram of tissue regardless of preparation method. CONCLUSIONS: The hoof surface hosts a broad spectrum of aerobic gram-positive and -negative bacteria, many of which are potential pathogens. Bacterial numbers can be significantly reduced by removal of the superficial hoof surface, by application of a povidone-iodine scrub, and by use of a 24-hour povidone-iodine soak. However, bacterial populations >10(5) g per tissue persist after these disinfection procedures. CLINICAL RELEVANCE: Regardless of the preparation methods used in this study, bacterial populations capable of inducing wound infection remain on the hoof capsule.  相似文献   

THE ROLE OF ULTRASOUND IN THE ASSESSMENT OF LARYNGEAL PARALYSIS IN THE DOG     

Heike  Rudorf  DMV  Frances J.  Barr  MB  PhD  J. Geoffrey  Lane  BVM 《Veterinary radiology & ultrasound》2001,42(4):338-343

Forty dogs with clinical signs suggestive of upper respiratory tract disease underwent echolaryngography and laryngoscopy. Laryngoscopy was used as the definitive technique to diagnose laryngeal paralysis. The ultrasound investigation accurately indicated the presence of the paralysis and confirmed the uni- or bilateral nature of the disorder. Findings indicative of laryngeal paralysis included asymmetry or absence of motion of the cuneiform processes (30/30), abnormal arytenoid movement (16/30), paradoxical movement (9/30), caudal displacement of the larynx (2/30) and laryngeal collapse (1/30). Thirty dogs were found to be afflicted with laryngeal paralysis and ten had normal laryngeal motility.  相似文献