排序方式： 共有72条查询结果，搜索用时 15 毫秒
61.
Ataru NAKANISHI Tadahisa MASHITA Kyoko AKIYAMA Wakana NAKANISHI Takashi MORI Masaki YANO Tetsuo ASAI Rui KANO Syunsuke SHIMAMURA Jun YASUDA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(5):597-599
A 9-year-old spayed female cat was examined for cheek skin drainage. The skin
lesion did not respond to medical therapy; thereafter, facial deformity developed. A
computed tomography revealed an intranasal mass and maxillary osteolysis. The mass was
histopathologically diagnosed as suppurative granulomatous inflammation caused by
filamentous bacteria. The lesion responded well to radiation therapy. Although
actinomycosis was suspected histopathologically, no actinomycetes were detected in the
nasal lesion by a bacterial culture conducted at a commercial laboratory. The
submandibular lymph node and subcutaneous tissue exhibited swelling. Microbiological
examination and genetic analysis based on 16S rDNA gene sequence revealed that
Nocardia spp. were isolated from both lesions. 相似文献
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Funamoto M Nibe K Morozumi M Edamura K Uchida K 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2007,69(12):1247-1253
Canine ganglioradiculitis (sensory neuropathy) was examined pathologically in two dogs (dog Nos. 1 and 2). The affected dogs had 1 and 2 years clinical courses from the onset, respectively. As common clinical signs, both cases showed progressive ataxia, difficulty in prehending food, visual deficit, and several sensory abnormalities. Gross observation after tissue fixation revealed whitish discoloration in the dorsal column of the spinal cords. The histological lesions were mainly distributed in the spinal dorsal roots, ganglions, and dorsal columns. In the spinal dorsal roots and ganglions, there were striking myelin loss, mild infiltration of mononuclear cells, and proliferation of small spindle cells. In the dorsal funiculus, there were moderate to severe diffuse myelin-loss and axonal degeneration. Immunohistochemistry for substance P (SP) revealed marked reduction of SP-immunopositive granules in the spinal substantia gelatinosa of affected dogs. By immunohistochemistry, CD3-positive cells were observed in the dorsal roots of dog No. 2, while CD3-positive cells were rare in those of dog No. 1. In the spinal ganglion of dog No. 1 there were many CD3- and MHC class II-positive cells. By indirect immunofluorescence assay using sera from affected dogs, no autoantibodies against canine nerve tissues were detected. The clinicopathological features of the present cases are almost consistent with those in previous reports of canine sensory neuropathies, while the etiology remains unclear. 相似文献
64.
The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine 总被引：1，自引：0，他引：1
Vaishnava S Yamamoto M Severson KM Ruhn KA Yu X Koren O Ley R Wakeland EK Hooper LV 《Science (New York, N.Y.)》2011,334(6053):255-258
The mammalian intestine is home to ~100 trillion bacteria that perform important metabolic functions for their hosts. The proximity of vast numbers of bacteria to host intestinal tissues raises the question of how symbiotic host-bacterial relationships are maintained without eliciting potentially harmful immune responses. Here, we show that RegIIIγ, a secreted antibacterial lectin, is essential for maintaining a ~50-micrometer zone that physically separates the microbiota from the small intestinal epithelial surface. Loss of host-bacterial segregation in RegIIIγ(-/-) mice was coupled to increased bacterial colonization of the intestinal epithelial surface and enhanced activation of intestinal adaptive immune responses by the microbiota. Together, our findings reveal that RegIIIγ is a fundamental immune mechanism that promotes host-bacterial mutualism by regulating the spatial relationships between microbiota and host. 相似文献
65.
AIM: To study the inhibitory effect of CoQ10 on the apoptosis of microvascular endothelial cells and it's probable mechanism. METHODS: Using serum pharmacology method and cytoflowmetery, the effects of CoQ10 at different concentrations on apoptosis and proliferation in cultured mouse brain microvascular endothelial cells (bEnd.3) were investigated. The expression of Fas protein and Bcl-2 protein were observed with immunocytochemical method (ABC). RESULTS: The cell apoptosis was inhibited significantly in CoQ10 groups (50 μL and 25 μL) in cultured bEnd.3 cells. The results of immunocytochemical staining showed that the expressions of Fas protein was inhibited and Bcl-2 protein was stimulated significantly in CoQ10 group with above concentration. But there was no significant change in cell proliferation. CONCLUSIONS: CoQ10 may inhibit apoptosis of microvascular endothelial cells (bEnd.3) via up-regulation of Bcl-2 and down-regulation of Fas. Authors suggest that this is one of the protection mechanisms of CoQ10 from dysfunction of microvascular endothelial cells. 相似文献
66.
Yamato SAJIKI Satoru KONNAI Reiko NAGATA Satoko KAWAJI Hayato NAKAMURA Sotaro FUJISAWA Tomohiro OKAGAWA Naoya MAEKAWA Yukinari KATO Yasuhiko SUZUKI Shiro MURATA Yasuyuki MORI Kazuhiko OHASHI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(2):162
Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic enteritis of ruminants. Previous studies have shown that programmed death-ligand 1 (PD-L1) is associated with the disease progression, and PD-L1 blockade activates MAP-specific Th1 responses in vitro. Here, we performed anti-PD-L1 antibody administration using 2 MAP-infected cattle at the late subclinical stage of infection. After administration, bacterial shedding was reduced or maintained at a low level. Additionally, MAP-specific Th1 cytokine production was upregulated, and CD69 expression was increased in T cells. Collectively, the treatment has a potential as a novel control method against Johne’s disease. 相似文献
67.
Abstract. Carotenoid distribution was examined in muscle, ovary, integument and serum from red- and white-fleshed chinook salmon, Oncorhynchus tshawytscha (Walbaum), along with their muscle proximate compositions. There were no significant differences in muscle compositions of moisture, protein and lipid except for the carotenoid levels between red- and white-fleshed salmon. Similar carotenoid levels of ovaries were found between red- and white-fleshed chinook salmon, although the muscle carotenoid level of white-fleshed salmon was apparently low compared to red-fleshed salmon. This suggests that white-fleshed chinook salmon have the ability to accumulate the carotenoids in their ovaries but not muscle. The white-fleshed chinook salmon may be devoid of carotenoid receptors in their muscle and this seems to be the reason for the failure to accumulate the carotenoids in their muscle. 相似文献
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Yoshihiro WAKABAYASHI Takashi YAMAMURA Kohei SAKAMOTO Yuji MORI Hiroaki OKAMURA 《The Journal of reproduction and development》2013,59(1):40-48
Neurons in the arcuate nucleus (ARC) that concomitantly express kisspeptin, neurokinin B
(NKB) and dynorphin A are termed KNDy neurons and are likely candidates for the intrinsic
gonadotropin-releasing hormone (GnRH) pulse generator. Our hypothesis is that KNDy neurons
are functionally and anatomically interconnected to generate discrete neural signals that
govern pulsatile GnRH secretion. Our goal was to address this hypothesis using
electrophysiological and anatomical experiments in goats. Bilateral electrodes targeting
KNDy neurons were implanted into ovariectomized goats, and GnRH pulse generator activity,
represented by characteristic increases in multiple-unit activity (MUA volleys), was
measured. Spontaneous and pheromone- or senktide (an NKB receptor agonist)-induced MUA
volleys were simultaneously recorded from both sides of the ARC. An anterograde tracer,
biotinylated dextran amine (BDA), was also injected unilaterally into the ARC of castrated
male goats, and the distribution of fibers containing both BDA and NKB was examined using
dual-labeling histochemistry. The results showed that MUA volleys, regardless of origin
(spontaneous or experimentally induced), occur simultaneously between the right and left
sides of the ARC. Tract tracing indicated that axons projecting from NKB neurons in the
ARC were directly apposed to other NKB neuronal cells located bilaterally in the ARC.
These results demonstrate that GnRH pulse generator activity occurs synchronously between
both sides of the ARC in goats and that KNDy neurons are bilaterally interconnected in the
ARC via NKB-containing fibers. Taken together, the results suggest that KNDy neurons form
a neuronal circuit to synchronize burst activity among KNDy neurons and thereby generate
discrete neural signals that govern pulsatile GnRH secretion. 相似文献
70.
Horizontal distribution patterns of jack mackerel (Trachurus japonicus) larvae and juveniles were investigated in the East China Sea between 4 February and 30 April 2001. A total of 1549 larvae and juveniles were collected by bongo and neuston nets at 357 stations. The larvae were concentrated in the frontal area between the Kuroshio Current and shelf waters in the upstream region of the Kuroshio. The abundance of small larvae (<3 mm notochord length) was highest in the southern East China Sea (SECS) south of 28°N, suggesting that the principal spawning ground is formed in the SECS from late winter to spring. Jack mackerel also spawned in the northern and central East China Sea (NECS and CECS, respectively), as some small larvae were also collected in these areas. In the SECS, the abundance of small larvae was highest in February and gradually decreased from March to April. The habitat temperature of small larvae in the SECS and CECS (20–26°C) was higher than that in the NECS (15–21°C), suggesting higher growth rates in the SECS and CECS than in the NECS. The juveniles (10‐ to 30‐mm standard length) became abundant in the NECS off the west coast of Kyushu Island and CECS in April and were collected in association with scyphozoans typical of the Kuroshio waters. However, juveniles were rarely collected in the SECS, where the small larvae were concentrated. Considering the current systems in the study area, a large number of the eggs and larvae spawned and hatched in the SECS would be transported northeastward by the Kuroshio and its branches into the jack mackerels’ nursery grounds, such as the shallow waters off the west coast of Kyushu and the Pacific coast of southern Japan. 相似文献