CT features of subcutaneous,intermuscular, and intramuscular mast cell tumors in dogs     

Rebecca J M Farmer  Valerie J Poirier  Stephanie Nykamp  Monica Jensen  Robert A Foster  Michelle Oblak  Ryan Appleby 《Veterinary radiology & ultrasound》2023,64(1):53-60

Surgical removal is the treatment of choice for subcutaneous (SC), intermuscular (InterM), and intramuscular (IntraM) mast cell tumors (MCTs). Advanced imaging (CT or MRI) is frequently used for presurgical planning, but InterM and IntraM MCTs can be difficult to identify and delineate on CT. Aims of the current retrospective, diagnostic accuracy, observer agreement study were to describe the imaging features of SC, InterM, and IntraM MCTs on CT and to assess the limitation of CT to identify the full local extent of the MCT. Inclusion criteria for the study were dogs with a cytologically or histologically diagnosed MCTs determined to be SC, InterM, or IntraM MCT based on histology and/or a CT scan performed in the gross disease setting. Two board-certified veterinary radiologists reviewed the CT images and recorded location, contrast enhancement pattern, and delineation between the normal and abnormal tissue. Sensitivity and specificity of CT for determining location (SC/InterM versus IntraM) was 85.71% and 55.56%, respectively, when compared to consensus location based on surgical pathology report/CT/MRI review. There was a low inter-rater agreement for delineation (kappa: 0.150 (−0.070 to 0.370) and measurement had a low/moderate correlation (rho: 0.4667 to 0.5792). Upon review by a surgical oncologist, CT findings were deemed insufficient for curative surgical planning in 13 of 16 due to inadequate definition of tumor depth, compartment boundary (fascial plane) or MCT margins. The use of CT for presurgical planning of SC/InterM/IntraM MCT dogs has limitations, especially when differentiating MCT from the adjacent muscle.  相似文献   

In vitro antiprotozoal activity of the leaves of Artemisia ludoviciana     

Said Fernández S  Ramos Guerra MC  Mata Cárdenas BD  Vargas Villarreal J  Villarreal Treviño L 《Fitoterapia》2005,76(5):466-468

The inhabitants of Northeast of Mexico use an infusion of leaves from Artemisia ludoviciana as an antidiarrheal remedy. The aqueous, methanol, acetone and hexane leaf extracts from mature plants were found to be active in vitro against the parasitic protozoa Entamoeba histolytica and Giardia lamblia.  相似文献   

Crown condition as a function of soil,site and tree characteristics     

Monica Musio  Klaus von Wilpert  Nicole H. Augustin 《European Journal of Forest Research》2007,126(1):91-100

One of the aims of this work is to describe how the target variable “tree vitality” in terms of needle loss is affected by other explanatory variables. To describe such a relationship in a realistic way, we use generalized additive mixed models (GAMMs) which allow to take spatial correlation of the data into account and in addition allow the inclusion of explanatory variables as predictors with the possibility of having non-linear effects. The GAMMs are fitted in a Bayesian framework using Markov chain Monte Carlo techniques. Data are available for two years 1988 and 1994. We select a set of best explanatory variables from a large set of variables including tree-specific variables, such as species, age, nutrients in the needles and site-specific variables such as altitude, relief type, soil depth and content of different nutrients in the top soil. In the two models for 1988 and 1994, different sets of explanatory variables were selected as best predictors. In both models, the effects of explanatory variables allowed a plausible interpretation. For example, the site-specific variables such as relief and soil depth were significant predictors, since these factors determine how well water and nutrient supply is balanced at a specific site. The selected sets of explanatory variables differed between 1988 and 1994, giving an indication of a possible change in the main causes of forest deterioration between 1988 and 1994. From the set of nutrient variables measured in the soil and in the needles, in 1988 altitude a.s.l. and magnesium supply were among the explanatory variables, in 1994 a combination of Al in the soil and the N/K-ratio (in the needles) was selected in the model. In 1988 altitude a.s.l. was among the most important predictors in the model. This is in contrast to 1994 where altitude was not selected. This may have to do with the fact that in the early phase of forest health monitoring (1988) one of the main causes of forest deterioration was magnesium deficiency. Later on this may have changed to a combination of soil acidification and nitrogen eutrophication. Thus by using an adequate model such as the GAMM, sets of explanatory variables for needle loss may be identified. By fitting two GAMMs, with different sets of “best” predictors, at two time points 1988 and 1994, we can detect changes in these sets of “best” predictors over time. This allows us to use the monitoring data with the tree vitality indicator crown condition/needle loss as a tool for forest health management, which may involve decisions about concrete counter measures like e.g. forest liming.  相似文献   

Genetic diversity in bread wheat, as revealed by coefficient of parentage and molecular markers, and its relationship to hybrid performance   总被引：2，自引：0，他引：2  

Maria Corbellini  Maurizio Perenzin  Monica Accerbi  Patrizia Vaccino  Basilio Borghi 《Euphytica》2002,123(2):273-285

Variable results have been obtained in different crop species using geneticsimilarity (GS) estimates based on molecular markers and coefficient ofparentage (COP) to predict heterosis.This study was designed: i) to assess the level of GS among 40 breadwheat (Triticum aestivum L.) cultivars selected in Central and SouthEurope; ii) to compare GS with COP; iii) to correlate the estimates ofparental diversity with the heterotic effects detected on 149 F₁hybrids obtained by crossing the 40 cultivars according to three matingdesigns.The parental cultivars and the F₁ hybrids were grown in severallocations at normal seed density. Significant heterotic effects were detectedfor grain yield and other traits including quality attributes. The parentalcultivars were assayed for DNA polymorphisms using two classes ofmarkers: 338 RFLP and 200 AFLP^® bands were scored. GS estimates werecomputed considering each molecular marker set separately (GS_RFLP,GS_AFLP) and together (GS_TOT). Ample differentiation amongthe parental cultivars was detected with the two marker sets. Although theaverage GS_TOT (0.43) was higher than COP (0.10), the twomeasurements were significantly correlated (r = 0.36, p < 0.01).Correlations between the different estimates of genetic diversity andF₁ performance or mid parent heterosis for grain yield and otherrelated traits were in general low although statistically significant.A more detailed analysis was conducted on 28 F₁ hybridsproduced in a half diallel cross of eight parental cultivars characterized byhigh heterotic effects for grain yield. The GS estimates based on RFLP,AFLP^® markers and also on RAPD were partitioned into general andspecific components. Correlations with general and specific combiningability effects for the measured traits were in several cases statisticallysignificant but too low to be predictive and therefore exploitable in practicalbreeding.  相似文献   

Anti-inflammatory properties of clovamide and Theobroma cacao phenolic extracts in human monocytes: evaluation of respiratory burst, cytokine release, NF-κB activation, and PPARγ modulation     

Zeng H  Locatelli M  Bardelli C  Amoruso A  Coisson JD  Travaglia F  Arlorio M  Brunelleschi S 《Journal of agricultural and food chemistry》2011,59(10):5342-5350

There is a great interest in the potential health benefits of biologically active phenolic compounds in cocoa (Theobroma cacao) and dark chocolate. We investigated the anti-inflammatory potential of clovamide (a N-phenylpropenoyl-L-amino acid amide present in cocoa beans) and two phenolic extracts from unroasted and roasted cocoa beans, by evaluating superoxide anion (O(2)(-)) production, cytokine release, and NF-κB activation in human monocytes stimulated by phorbol 12-myristate 13-acetate (PMA). The effects of rosmarinic acid are shown for comparison. Clovamide and rosmarinic acid inhibited PMA-induced O(2)(-) production and cytokine release (with a bell-shaped curve and maximal inhibition at 10-100 nM), as well as PMA-induced NF-κB activation; the two cocoa extracts were less effective. In all tests, clovamide was the most potent compound and also enhanced peroxisome proliferator-activated receptor-γ (PPARγ) activity, which may exert anti-inflammatory effects. These findings indicate clovamide as a possible bioactive compound with anti-inflammatory activity in human cells.  相似文献   

Computed tomographic findings in the pituitary gland and brain of horses with pituitary pars intermedia dysfunction     

Pease AP  Schott HC  Howey EB  Patterson JS 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2011,25(5):1144-1151

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Miscellaneous Neurologic or Neuromuscular Disorders in Horses     

Monica Aleman 《Veterinary Clinics of North America: Equine Practice》2011,27(3):481-506

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Serum insulin-like growth factor-1 measurements in dogs: performance characteristics of an automated assay and study of some sources of variation     

Tvarijonaviciute A  Tecles F  Carillo JM  Rubio M  Ceron JJ 《Canadian journal of veterinary research》2011,75(4):312-316

The aim of this study was to evaluate the performance characteristics of an automated immunoassay for canine insulin-like growth factor 1 (IGF-1) measurement and to investigate the possible effects of some sources of variation, such as diurnal variations, feeding/fasting cycles, and glucocorticoid administration, in dogs. The immunoassay evaluated had an adequate analytical performance with intra- and inter-assay coefficients of variation (CVs) lower than 10%, linear regression equations with correlation coefficients of 0.9993 and 0.9988 after serial dilutions, and a limit of quantification of 7.1 ng/mL that was even lower than that reported by the manufacturer. The assay was significantly affected by hemolysis and lipemia producing a significant decrease in IGF-1 concentrations, but not by bilirubinemia.Serum IGF-1 concentrations did not show significant diurnal changes in fed or fasted dogs and were not affected by glucocorticoid administration.  相似文献   

Usutu virus in Italy: an emergence or a silent infection?     

Savini G  Monaco F  Terregino C  Di Gennaro A  Bano L  Pinoni C  De Nardi R  Bonilauri P  Pecorari M  Di Gialleonardo L  Bonfanti L  Polci A  Calistri P  Lelli R 《Veterinary microbiology》2011,151(3-4):264-274

A two year study (2008-2009) was carried out to monitor the Usutu virus (USUV) circulation in Italy. Sentinel horses and chickens, wild birds and mosquitoes were sampled and tested for the presence of USUV and USUV antibodies within the WND National Surveillance plan. Seroconversion evidenced in sentinel animals proved that in these two years the virus has circulated in Tuscany, Emilia Romagna, Veneto and Friuli Venezia Giulia regions. In Veneto USUV caused a severe blackbird die-off disease involving at least a thousand birds. Eleven viral strains were detected in organs of 9 blackbirds (52.9%) and two magpies (0.5%) originating from Veneto and Emilia Romagna regions. USUV was also detected in a pool of Culex pipiens caught in Tuscany. According to the alignment of the NS5 partial sequences, no differences between the Italian USUV strains isolated from Veneto, Friuli and Emilia Romagna regions were observed. The Italian North Eastern strain sequences were identical to those of the strain detected in the brain of a human patient and shared a high similarity with the isolates from Vienna and Budapest. Conversely, there were few differences between the Italian strains which circulated in the North Eastern regions and the USUV strain detected in a pool of C. pipiens caught in Tuscany. A high degree of similarity at both nucleotide and amino acid level was also found when the full genome sequence of the Italian North Eastern isolate was compared with that of the strains circulating in Europe. The North Eastern Italian strain sequence exhibited 97% identity to the South African reference strain SAAR-1776. The deduced amino acid sequences of the Italian strain differed by 10 and 11 amino-acids from the Budapest and Vienna strains, respectively, and by 28 from the SAAR-1776 strain. According to this study two strains of USUVs are likely to have circulated in Italy between 2008 and 2009. They have developed strategies of adaptation and evolution to spread into new areas and to become established.  相似文献   

Effect of Age on Digestibility of Various Feedstuffs in Horses     

S. Elzinga  B. Nielsen  H. Schott  J. Rapson  C. Robison  J. McCutcheon  P. Harris  R. Geor 《Journal of Equine Veterinary Science》2011,31(5-6):268-269

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