Tumor necrosis factor activity in serum from neonatal foals with presumed septicemia.     

D D Morris  J N Moore 《Journal of the American Veterinary Medical Association》1991,199(11):1584-1589

A study was performed to determine prevalence of tumor necrosis factor (TNF) activity in serum of equine neonates with presumed sepsis and to determine correlation between serum TNF activity and severity and outcome of disease. Twenty foals less than 21 days old were considered suitable for inclusion in this study by satisfying clinical and laboratory criteria suggestive of septicemia. At admission, blood samples were collected from all foals for determination of serum TNF activity, then clinical course and outcome of disease were recorded. Thirty-one clinically normal foals less than 21 days old served as controls for serum TNF activity. Serum TNF activity was estimated by use of an in vitro cytotoxicity bioassay and WEHI 164 clone-13 murine fibrosarcoma cells. Of the 20 foals with presumed sepsis, 5 had high serum TNF activity. Mean heart rate (P less than 0.005), mucosal petechial hemorrhages (P = 0.06), and death rate (P = 0.06) were greater in the group of foals with high serum TNF activity. These foals also had a lower mean neutrophil count (P less than 0.001), greater band-to-segmented neutrophil ratio (P less than 0.0001), and more prevalent neutrophil toxic changes (P = 0.07) than did foals without serum TNF activity (P = 0.02). Joint swelling was more prevalent in foals without serum TNF activity. Results of the study indicate that serum TNF activity is correlated with clinical criteria of sepsis in equine neonates. An association was apparent between disease severity and serum TNF activity in this group of foals with presumed septicemia.  相似文献   

ECTRODACTYLY (SPLIT-HAND DEFORMITY) IN THE DOG     

ColinB.  Carrig  BVSc  PhD  JeffreyA.  Wortman  DVM  PhD†  EarlL.  Morris  DVM‡  WilliamE.  Blevins  DVM  MS§ CharlesR.  Root DVM  MS&#;  GriseldaF.  Hanlon  DVM¶ PeterF.  Suter  Dr med vet 《Veterinary radiology & ultrasound》1981,22(3):123-144

Radiographs of 14 dogs with ectrodactyly of the forelimb were evaluated and the defect classified according to the site of division of the longitudinal axis of the paw. The majority of separations occurred between metacarpal bones one and two, although separations were also noted between metacarpal bones two and three, two and four, and three and four. Other lesions noted in affected limbs included digit contracture, digit aplasia, metacarpal hypoplasia and metacarpal fusions. Bilateral involvement was noted in only one of 14 cases. No breed or sex predisposition was found and there was equal involvement of the left and right limbs.  相似文献   

Immunoglobulins Detected by the Serum Agglutination Test for Salmonella dublin Infection of Cattle     

C. Wray  J. A. Morris  W. J. Sojka 《Zoonoses and public health》1979,26(4):340-343

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THE EFFECT OF PRIOR INFECTION WITH FASCIOLA HEPATICA ON THE RESISTANCE OF SHEEP TO THE SAME PARASITE     

A.H. Meek  R.S. Morris † 《Australian veterinary journal》1979,55(2):61-64

The development of flukes that resulted from a challenge dose of 175 F. hepatica metacercariae was compared in 4 groups of sheep that were maintained under grazing conditions on fluke-free pasture. One group had been previously uninfected and all subgroups of each of the other 3 groups had been exposed to one of a range of previous doses of metacercariae. The preliminary infections of 2 of the 3 groups had been terminated respectively after 7 and 14 weeks. The third previously infected group had received its preliminary infection as 2 doses of metacercariae, 7 weeks apart. The latter infection had been terminated after 14 weeks. No appreciable differences in the mean numbers, length, prepatent period or fecundity of flukes, established as a result of the challenge dose of metacercariae, were detected between the control group and the 3 previously infected groups. It was concluded that under the conditions of the present experiment no evidence was detected that would suggest that previous infection with F. hepatica conferred any significant resistance to a future challenge.  相似文献   

Effect of salicylates on intestinal secretion in calves given (intestinal loops) Escherichia coli heat-stable enterotoxin     

C M Wise  A P Knight  M J Lucas  C J Morris  R P Ellis  R W Phillips 《American journal of veterinary research》1983,44(12):2221-2225

The inhibitory effect of salicylates on intestinal secretion in 1- to 5-day-old calves given Escherichia coli heat-stable enterotoxin (ST)-induced intestinal fluid response was investigated. Purified ST was diluted in isotonic saline solution to obtain 1:10, 1:25, 1:50, 1:75, and 1:100 dilutions. Each dilution (1 ml) was inoculated into ligated loops in the distal part of the jejunum of each calf. Acetylsalicylic acid (aspirin) given orally (100 mg/kg) at 4 hours before ST was inoculated did not substantially alter the intestinal fluid response to ST. Sodium salicylate (IV) infusion, begun simultaneously when, or at 1 hour after, ST was inoculated, significantly (P less than 0.05) decreased fluid accumulation in those loops inoculated with ST dilutions of 1:25 or greater. The sodium and potassium concentrations of the accumulated fluid did not differ significantly between or within treatment groups. These results indicate that sodium salicylate infusion may be beneficial in treating enterotoxic colibacillosis in calves. Aspirin given orally at the dose used in the present study, would not have any beneficial effect.  相似文献   

Inhibition of interleukin 1-mediated proteoglycan degradation in bovine articular cartilage explants by addition of sodium hyaluronate.     

E A Morris  S Wilcon  B V Treadwell 《American journal of veterinary research》1992,53(11):1977-1982

The effect of exogenous hyaluronate on normal cartilage metabolism and interleukin-1 (IL-1)-induced cartilage matrix degradation was investigated in a bovine cartilage explant culture system. Addition of hyaluronate at a concentration of 1.5 mg/ml to cartilage culture explants consistently decreased normal proteoglycan release from the matrix to a value less than that found in control cultures. Addition of 1.5 mg of hyaluronate/ml to IL-1 stimulated cartilage culture systems reduced proteoglycan release from the matrix by 83 to 113%. The reduction in control and IL-1-stimulated proteoglycan degradation by hyaluronate had a concentration-dependent trend. Evaluation of alterations in protein (enzyme) release by IL-1-stimulated chondrocytes after introduction of hyaluronate was evaluated by use of sodium dodecyl sulfate agar gel electrophoresis of cartilage-conditioned media. The quantity or the molecular weight profile of IL-1-induced proteins did not differ after introduction of hyaluronate into the culture system. Results indicate that introduction of high molecular weight hyaluronate into cartilage culture systems results in a decrease in proteoglycan release from the matrix in control systems, as well as in cultures incubated with IL-1. Because IL-1-stimulated protein synthesis by chondrocytes remains unchanged after addition of exogenous hyaluronate, the mechanism of inhibition of matrix degradation does not appear to be interference with binding of IL-1 to chondrocytes or to be inhibition of the production of neutral metalloproteases, including stromelysin.  相似文献   

AGENESIS OF THE DISTAL PHALANX IN A MULE     

T.S. Taylor  DVM  MS  E. L. Morris  DVM  MS 《Veterinary radiology & ultrasound》1983,24(2):63-65

Agenesis of the distal phalanx of a mule foal is documented. The condition was identified when the foal was 14 days old and supported by follow-up radiographs obtained at four months of age.  相似文献   

Laryngotracheitis outbreak limited to a part of a chicken flock exposed to smoke and chemicals     

M P Morris  S A Davison  R J Eckroade 《Avian diseases》1986,30(4):843-846

Laryngotracheitis was diagnosed in a flock of molted, caged table-egg-layers. Morbidity was restricted to an area of the house in which the birds had been exposed to smoke from a fire in the house and to a powdered chemical fire-extinguisher used on the fire. Mortality in this group began to rise 6 days after the fire and continued to be above normal for about 3 weeks. Feed consumption dropped for about 1 1/2 weeks after the fire but was normal or above normal during the rest of the disease outbreak. Egg production dropped slightly for 1 week after the fire, then returned to normal. Microscopic tracheitis in the exposed birds continued for 11 weeks after the fire. Hens outside of the smoke-affected area did not show histopathological changes or shed laryngotracheitis virus.  相似文献   

Pancytopenia caused by bone marrow aplasia in a horse   总被引：1，自引：0，他引：1  

J P Lavoie  D D Morris  J G Zinkl  K Lloyd  T J Divers 《Journal of the American Veterinary Medical Association》1987,191(11):1462-1464

Pancytopenia was evaluated in a mature Quarter Horse gelding. A diagnosis of bone marrow aplasia was made on the basis of bone marrow hypocellularity. History of drugs administered included penicillin, oxytetracycline, trimethoprim-sulfadiazine, phenylbutazone, dipyrone, flunixin meglumine, and isoxsuprine. Clinical remission was observed after treatment with glucocorticoids, androgens, and broad-spectrum antimicrobials.  相似文献   

Effects of dietary protein concentration on the response of growing chicks to methionine.     

T R Morris  R M Gous  S Abebe 《British poultry science》1992,33(4):795-803

1. Experiments were conducted independently at two stations to measure the requirement for methionine in chick diets with crude protein (CP) varying in 8 steps from 140 to 280 g/kg diet (experiment 1) or from 90 to 300 g/kg (experiment 2). 2. Protein composition was the same at all protein concentrations within a trial. The diet was designed to be first-limiting in methionine and DL-methionine was added to provide 5 ratios of methionine to CP at each protein concentration. 3. Methionine required for maximum growth rate or maximum efficiency of food utilisation was estimated at each protein concentration by fitting a quadratic regression equation to the relevant data. The requirement was also estimated by fitting the Reading model to data for growth rate and methionine intake. 4. In both trials and by all three methods of estimation, the methionine requirement (g/kg diet) for maximum performance increased as a linear function of dietary CP concentration and nearly in direct proportion to CP. 5. It is concluded that diets which contain surplus protein, beyond that needed to maximise growth rate or food efficiency, need supplementation with methionine beyond that required when dietary protein is just adequate. A suitable rule for practical formulation is that methionine concentration in chick diets should be not less than 0.025 times the dietary CP concentration.  相似文献