Nader: from auto safety to a permanent crusade     

Mueller M 《Science (New York, N.Y.)》1969,166(3908):979-983

  相似文献   

Sympathoadrenal Neurochemistry and early weaning of swine.     

H C Stanton  R L Mueller 《American journal of veterinary research》1976,37(7):779-783

Three litters of pigs were weaned at 21 days of age, and 3 others were left with the sow. Pigs were killed at 21, 23, 28, or 39 days of age. Weaned pigs exhibited anxiety, gastrointestinal dysfunction, and decreased rate of body weight gain. Plasma glucose or liver glycogen concentrations were not decreased by weaning. Adrenal gland weights and tyrosine hydroxylase (EC 1.14.3a), dopamine beta-hydroxylase (EC 1.14.2.1), phenethanolamine-N-methyl transferase (EC 2.1.1), and monoamine oxidase (EC 1.4.3.4) activities were increased after weaning. Adrenal catecholamine and cortisol levels and dopa decarboxylase (EC 4.1.1.26) and catechol-o-methyl transferase (EC 2.1.1.6) activities were not significantly altered, although some increases were indicated. Cranial cervical ganglionic choline acetyltransferase (EC 2.3.1.6) and tyrosine hydroxylase activities were increased after weaning. Weaning of swine at 21 days of age is a stressful experience, and many effects persist for at least 18 days; however, growth was no longer impaired 18 days after weaning.  相似文献   

Methodic studies on the determination of antibiotic resistance of mastitis-causing organisms]     

R Mueller  M Berchtold 《Zentralblatt für Veterin?rmedizin. Reihe B. Journal of veterinary medicine. Series B》1977,24(4):325-330

  相似文献   

Use of a hyaluronate membrane for jejunal anastomosis in horses   总被引：1，自引：0，他引：1  

Eggleston RB  Mueller E  Quandt JE  Neuwirth L  Harmon BG  Waguespack WR  Rainbow ME 《American journal of veterinary research》2001,62(8):1314-1319

OBJECTIVE: To compare the outcomes of double-layer inverting anastomosis (DIA), single-layer anastomosis (SLA), and single-layer anastomosis combined with a hyaluronate membrane (SLA+HA-membrane) with respect to stomal diameter, adhesion formation, surgery time, and anastomotic healing in horses. ANIMALS: 18 adult horses. PROCEDURE: Midline celiotomy and end-to-end anastomoses were performed. In control horses (n = 6), DIA was performed; in treated horses, SLA was performed (6) or SLA+HA-membrane was performed (6). Horses were euthanatized 21 days after surgery. Abdominal adhesions were evaluated grossly and histologically. Stomal diameters were measured ultrasonographically and compared with adjacent luminal diameters. Anastomotic healing was evaluated histologically for fibrosis and inflammation, tissue alignment, and inversion. Surgery times were recorded for the anastomotic procedure and compared among groups. RESULTS: There were significantly more adhesions in the SLA group, compared with the DIA and SLA+HA-membrane groups. Reduction in stomal diameters in the DIA group was significantly greater than the SLA and SLA+HA-membrane groups. Surgery times for the DIA group were significantly greater than the SLA and SLA+HA-membrane groups. Histologic findings of fibrosis, inflammation, and mucosal healing were similar among groups. There was significant tissue inversion in the DIA group, compared with the 2 treatment groups. Tissue alignment was not different among groups. CONCLUSIONS AND CLINICAL RELEVANCE: Use of a SLA+HA-membrane was an effective small intestinal anastomotic technique. This technique was faster to perform and resulted in a larger stomal diameter, compared with the DIA technique and significantly fewer perianastomotic adhesions, compared with the SLA technique.  相似文献   

Effect of omega-3 fatty acids on canine atopic dermatitis     

Mueller RS  Fieseler KV  Fettman MJ  Zabel S  Rosychuk RA  Ogilvie GK  Greenwalt TL 《The Journal of small animal practice》2004,45(6):293-297

Twenty-nine dogs were included in a double-blinded, placebo-controlled, randomised trial and were orally supplemented for 10 weeks with either flax oil (200 mg/kg/day), eicosapentaenoic acid (50 mg/kg/day) and docosahexaenoic acid (35 mg/kg/day) in a commercial preparation, or mineral oil as a placebo. For each dog, clinical scores were determined based on a scoring system developed prior to the trial. Total omega-6 and omega-3 intake and the ratio of omega-6:omega-3 (omega-6:3) were calculated before and after the trial. The dogs' clinical scores improved in those supplemented with flax oil and the commercial preparation, but not in the placebo group. No correlation was identified between total fatty acid intake or omega-6:3 ratio and clinical scores. Based on the results of this study, the total intake of fatty acids or the omega-6:3 ratio do not seem to be the main factors in determining the clinical response.  相似文献   

Immunohistochemical evaluation of mononuclear infiltrates in canine lupoid onychodystrophy     

Mueller RS  West K  Bettenay SV 《Veterinary pathology》2004,41(1):37-43

Claw biopsy samples of 11 dogs with lupoid onychodystrophy were evaluated. They were stained with hematoxylin and eosin and with antibodies against CD 3 as a T-cell marker, BLA 36 and HM 57 (CD 79alpha) as B-cell markers, and lysozyme, Mac 387, and major histocompatibility complex (MHC) class II as a marker for histiocytes using an immunoperoxidase and avidin-biotin technique. Inflammatory cells were counted in five high-power fields. The inflammatory infiltrate comprised predominantly B cells and T cells. Macrophages were typically only present in small numbers. CD 3, BLA 36, lysozyme, and MHC class II preserved significant antigenicity during formalin fixation and short decalcification for 24-48 hours, whereas CD 79alpha and particularly Mac 387 seemed to be more susceptible to denaturation by the decalcification process.  相似文献   

Treatment protocols for demodicosis: an evidence-based review   总被引：4，自引：3，他引：1  

Mueller RS 《Veterinary dermatology》2004,15(2):75-89

Publications discussing the treatment of demodicosis in the dog and cat are reviewed. Based on the evidence in the literature, amitraz rinses at 0.025-0.06% every 7-14 days, and oral daily ivermectin at 300 micro g kg(-1), milbemycin at 2 mg kg(-1) and moxidectin at 400 micro g kg(-1), respectively, can all be recommended for the treatment of generalized canine demodicosis. Ivermectin and moxidectin should be initiated at lower doses and patients monitored for possible adverse effects during therapy. In cats, 2% lime sulfur dips and amitraz rinses at 0.0125-0.025% have been used successfully.  相似文献   

Use of an external ring fixator for correction of an acquired angular limb deformity in a donkey     

Eggleston RB  Mueller PO  Chambers JN  Bentley A 《Journal of the American Veterinary Medical Association》2000,217(8):1186-1190

Numerous techniques for surgical correction of angular limb deformities in horses involving an osteotomy of the affected bone and stabilization with an internal fixation device have been described. However, because the osteotomy typically has to be performed at the level of the physis, leaving little bone between the physis and the nearest joint, stabilizing the osteotomy by use of internal fixation devices may be difficult. In horses with severe chronic angular limb deformities, the amount of soft-tissue contracture may make it impossible to correct the deformity during a single procedure without causing stretch injuries to the adjacent tendons and neurovascular structures. Adjustable external ring fixators incorporating hinged rods on 1 side of the limb and an angular motor assembly on the other may be useful for treatment of severe chronic angular limb deformities in younger equids, because they allow for gradual correction of the deformity.  相似文献   

An undescribed Demodex sp. and demodicosis in a captive koala (Phascolarctos cinereus).     

L J Vogelnest  L Vogelnest  R S Mueller 《Journal of zoo and wildlife medicine》2000,31(1):100-106

A 12-yr-old male koala (Phascolarctos cinereus) in a zoo collection developed bilateral, noninflammatory, periocular alopecia. Deep periocular skin scrapings yielded multiple adult, nymphal, and larval mites of a previously undescribed Demodex species. Skin biopsies from affected areas revealed multiple mites in superficial keratin and within hair follicles, associated with a mild intramural lymphocytic folliculitis. Treatment with daily oral ivermectin was safe and effective. Although Demodex sp. are previously reported from skin scrapings in another koala with periocular alopecia, this is the first confirmed case of koala demodicosis.  相似文献   

Diagnosis of canine claw disease – a prospective study of 24 dogs     

Ralf S. Mueller  Sue Friend  Michael A. Shipstone  & Greg Burton 《Veterinary dermatology》2000,11(2):133-141

The aetiology of claw disease in 24 dogs exhibiting only claw disease was investigated with cytologic examination of claw exudate, complete blood count (CBC), serum biochemistry panel, urinalysis, total thyroxine (tT4) concentration, antinuclear antibody (ANA) titre, bacterial culture and sensitivity testing, fungal culture, histopathology of claw biopsy samples and elimination diet. Abnormalities on the CBC, serum biochemistry panel and urinalysis were minor and nonspecific. Total T4 concentrations were within the normal laboratory reference range. Fungal cultures and ANA titres were negative in all dogs. A bacterial infection was present in approximately half of the dogs. On histological examination of claw tissue, a cell-poor or cell-rich interface onychitis was seen in all but one dog. Evidence for an adverse reaction to food was present in four dogs. One dog responded completely to antibiotic therapy. Interface onychitis seems to be a histological reaction pattern of the claw matrix in the dog with various possible underlying aetiologies. In dogs with claw disease as the only clinical sign, the recommended initial diagnostic evaluation includes cytologic examination, bacterial culture and sensitivity, claw biopsy and an elimination diet.  相似文献