Anticancer activity evaluation of kuanoniamines A and C isolated from the marine sponge Oceanapia sagittaria, collected from the Gulf of Thailand   总被引：1，自引：0，他引：1       下载免费PDF全文

Kijjoa A  Wattanadilok R  Campos N  Nascimento MS  Pinto M  Herz W 《Marine drugs》2007,5(2):6-22

The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24 α-methylcholestanol, p-hydroxybenzaldehyde, p-hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge Oceanapia sagittaria (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were evaluated for their effect on the growth of five human tumour and a non-tumour cell lines, as well as on the proliferation of human lymphocytes. Kuanoniamine A was found to be a potent growth inhibitor of all the tumour and a non-tumour cell lines while kuanoniamine C was less potent but showed high selectivity toward the estrogen dependent (ER+) breast cancer cell line. Kuanoniamine A has shown to be a more potent inhibitor of DNA synthesis than kuanoniamine C. Kuanoniamine A was also found to cause an extensive reduction of the MCF-7 cells in G2/M phase as well as an increase in the apoptotic cells.  相似文献   

Shrimp rearing in biofloc integrated with different mullet stocking densities     

Esmeralda Chamorro Legarda  Mateus Aranha Martins  Patriula Kaliana Moreira Pereira  Ramon Felipe Siqueira Carneiro  Isabela Claudiana Pinheiro  Walter Quadros Seiffert  Claudia Machado  Marco Antonio de Lorenzo  Felipe do Nascimento Vieira 《Aquaculture Research》2020,51(9):3571-3581

This work compared the effects of different densities of Mugil curema integrated in the rearing of Litopenaeus vannamei in a biofloc system on the yield and ecological performance of the system. For that, an experiment lasting 55 days was conducted. Four groups were evaluated as follows: (a) T0: shrimp reared without mullet, (b) T10: shrimp reared with 22 fish per tank, (c) T20: shrimp reared with 43 fish per tank, and (d) T30: shrimp reared with 65 fish per tank, each treatment with four replicates. The sludge:biomass ratio was higher in the T0 treatment, while the T10–T20 treatments were more efficient, producing more biomass and less sludge. The use of water was 17% more efficient in all treatments with mullet. Mullet survival was higher in the T10 and T20 treatments (mean: 84 ± 8%) than in the T30 (61 ± 5%) treatment. The fish final biomass and yield limits of the system were 0.37 kg and 3.7 kg/m³ respectively. Finally, there was no increase in the total nitrogen output of the system up to the T10 density. In conclusion, it is possible to integrate mullet up to 3.7 kg/m³, increasing the yield in 20% and decreasing water use.  相似文献   

Salt stress alters the morphoanatomy and primary and secondary metabolites of the leaves and rhizomes of Curcuma longa L.     

Bonacina  Cristine  Nascimento  Andressa Bezerra  Barbosa  Letícia Neris  de Souza  Silvia Graciele Hülse  Magalhães  Hélida Mara 《Journal of Crop Science and Biotechnology》2023,26(2):215-226

Journal of Crop Science and Biotechnology - During cultivation, environmental factors can cause changes in the metabolism of Curcuma longa L. that limit its development. This study evaluated the...  相似文献   

Aripuanin, a megastigmane skeleton from Ficus aripuanensis     

M. Nascimento  A. C. Arruda  M. S. P. Arruda  A. H. Müler  C. Y. Yoshioka 《Fitoterapia》1999,70(6):1512

The isolation and NMR spectra of aripuanin (1), a sesquiterpene from Ficus aripuanensis, are reported.  相似文献   

Reproductive dominance of pasture trees in a fragmented tropical forest mosaic   总被引：1，自引：0，他引：1  

PR Aldrich  JL Hamrick 《Science (New York, N.Y.)》1998,281(5373):103-105

Tropical forest fragmentation threatens biodiversity, yet basic information on population responses for major groups such as plants is lacking. Hypervariable genetic markers were used to reconstruct a population-level pedigree in fragmented tropical forest for the tree Symphonia globulifera. Though seedlings occurred only in remnant forest, the pedigree showed that most seedlings had been produced by sequentially fewer adults in pasture, creating a genetic bottleneck. The pedigree also implicated shifts in the foraging of animals that disperse pollen and seed in a secondary constriction of the bottleneck. These results suggest that tropical conservation strategies should anticipate complex, cryptic responses to fragmentation.  相似文献   

Experimental demonstration of guiding and bending of electromagnetic waves in a photonic crystal   总被引：3，自引：0，他引：3  

SY Lin  E Chow  V Hietala  PR Villeneuve  JD Joannopoulos 《Science (New York, N.Y.)》1998,282(5387):274-276

The routing and interconnection of optical signals through narrow channels and around sharp corners are important for large-scale all-optical circuit applications. A recent computational result suggests that photonic crystals may offer a novel way of achieving this goal by providing a mechanism for guiding light that is fundamentally different from traditional index guiding. Waveguiding in a photonic crystal and near 100 percent transmission of electromagnetic waves around sharp 90 degree corners were observed experimentally. Bending radii were made smaller than one wavelength.  相似文献   

Evidence for extreme climatic warmth from late cretaceous arctic vertebrates   总被引：1，自引：0，他引：1  

JA Tarduno  DB Brinkman  PR Renne  RD Cottrell  H Scher  P Castillo 《Science (New York, N.Y.)》1998,282(5397):2241-2244

A Late Cretaceous (92 to 86 million years ago) vertebrate assemblage from the high Canadian Arctic (Axel Heiberg Island) implies that polar climates were warm (mean annual temperature exceeding 14 degreesC) rather than near freezing. The assemblage includes large (2.4 meters long) champsosaurs, which are extinct crocodilelike reptiles. Magmatism at six large igneous provinces at this time suggests that volcanic carbon dioxide emissions helped cause the global warmth.  相似文献   

Autochthonous probiotic Lactobacillus sp. in the diet of bullfrog tadpoles Lithobates catesbeianus improves weight gain,feed conversion and gut microbiota          下载免费PDF全文

S.A. Pereira  G.T. Jerônimo  N. da Costa Marchiori  H.M. de Oliveira  M.S. Owatari  G.F.A. Jesus  P. Garcia  F. do Nascimento Vieira  M.L. Martins  J.L.P. Mouriño 《Aquaculture Nutrition》2017,23(5):910-916

Dietary supplementation with probiotics in animal production is an alternative to antibiotics. In frog culture, studies involving native strains of probiotic bacteria and their effects on the performance and intestinal histology of farmed animals are scarce. Therefore, this study aimed to evaluate a diet supplemented with Lactobacillus sp. in tadpoles of Lithobates catesbeianus. This randomized test was performed with two dietary treatments: non‐supplemented control diet and diet supplemented with Lactobacillus sp., with nine replications. The growth performance of Lactobacillus sp., including its bacterial enzymatic activity and stability in feed, as well as colonization and histology of the intestinal tract, was evaluated after 42 days of experimentation. Animals fed with a supplemented diet showed higher weight gain and concentration of lactic acid bacteria in the gut and lower feed conversion. No significant difference was observed in survival, total heterotrophic bacterial count or histological change in the gut between the two treatments. The Lactobacillus sp. strain was able to colonize the intestinal tract and feed and remain at a high concentration of 10⁷ and 10⁶ CFU g^?1, respectively. It produced several enzymes, which might have contributed to the greater weight gain and lower feed conversion in the supplemented animals, thus demonstrating its probiotic potential for use as a dietary supplement in bullfrog tadpoles.  相似文献   

Diversity of Meloidogyne incognita populations from cotton and aggressiveness to Gossypium spp. accessions     

C. M. L. Lopes  J. E. Cares  F. J. Perina  G. F. Nascimento  J. S. F. Mendonça  A. W. Moita  P. Castagnone-Sereno  R. M. D. G. Carneiro 《Plant pathology》2019,68(4):816-824

The root-knot nematode (RKN) Meloidogyne incognita is the main nematode causing losses to the cotton crop in Brazil. In order to implement control strategies within integrated management, an accurate identification of the nematode populations prevailing in the cotton production areas is necessary. This study aimed to assess the genetic variability and aggressiveness of RKN populations from cotton production areas in Bahia state, Brazil. All populations were characterized biochemically and molecularly and identified as M. incognita. RAPD and AFLP markers detected 44% of polymorphic fragments among the 13 populations of this species. The 10 M. incognita populations collected in Bahia presented 33.7% of diversity when compared to each other, and 25% when the population from Barreiras (the most polymorphic) was excluded. This polymorphism increased when populations from other Brazilian states were included. The aggressiveness and virulence among populations from Bahia towards different cotton accessions (susceptible/resistant) was also studied. None of the populations showed virulence against the moderately resistant (Clevewilt 6, Wild Mexican Jack Jones and LA 887) and highly resistant (CIR1348 and M-315 RNR) cultivars. Two M. incognita populations from Barreiras were the most aggressive, reaching reproduction factors of 539 and 218, respectively, in the susceptible cultivar FiberMax 966. The most aggressive population (8) was also the most genetically divergent in phylogenetic analyses. These results demonstrate that diversity of M. incognita populations from cotton farms in Bahia is not related to virulence against resistant accessions, which suggests that cultivars containing one or two resistance genes with good agronomic characteristics could be used in infested commercial areas in Bahia state, Brazil.  相似文献   

Resistance of Spodoptera frugiperda (Lepidoptera: Noctuidae) to spinetoram: inheritance and cross‐resistance to spinosad     

Ewerton C Lira  Anderson Bolzan  Antonio RB Nascimento  Fernando SA Amaral  Rubens H Kanno  Ingrid S Kaiser  Celso Omoto 《Pest management science》2020,76(8):2674-2680

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