High levels of serum matrix metalloproteinases in dogs with natural visceral leishmaniosis: A preliminary report     

Guilherme D. Melo  Natalia R. Marangoni  Mary Marcondes  Valria M.F. Lima  Gisele F. Machado 《Veterinary journal (London, England : 1997)》2011,188(2):330

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<Emphasis Type="Italic">Bemisia tabaci</Emphasis> Biotype Q is present in Costa Rica     

Jose Andres Guevara-Coto  Natalia Barboza-Vargas  Eduardo Hernandez-Jimenez  Rosemarie W. Hammond  Pilar Ramirez-Fonseca 《European journal of plant pathology / European Foundation for Plant Pathology》2011,131(2):167-170

Whiteflies are an insect group that comprises multiple species and biotypes, capable of affecting crops by phloem feeding, virus transmission and promotion of fungal colonization. The distribution of these pests is worldwide. In Costa Rica, a country located in the tropics, the most problematic whiteflies are Bemisia tabaci biotype B and Trialeurodes vaporariorum. In September 2009, two greenhouses in the Alfaro Ruiz region, northwest of the country’s capital, San Jose, were surveyed as part of a larger effort to determine the occurrence of species and races of whiteflies in this agronomically important region. In addition, the insect samples were analyzed to determine the presence of Tomato chlorosis virus (ToCV), a yield-affecting crinivirus transmitted by whiteflies. The results revealed the presence of the Q biotype of B. tabaci, and important invasive species, as well as the expected T. vaporariorum. Viral detection assays identified potentially viruliferous individuals for Tomato chlorosis virus. These results identified a new pest capable of harbouring plant viruses has been identified, as well as a viral agent (ToCV) in a region where it was not reported, and which might cause significant yield losses.  相似文献   

How much do soil and water contribute to the composition of meat? A case study: meat from three areas of Argentina     

Baroni MV  Podio NS  Badini RG  Inga M  Ostera HA  Cagnoni M  Gallegos E  Gautier E  Peral-García P  Hoogewerff J  Wunderlin DA 《Journal of agricultural and food chemistry》2011,59(20):11117-11128

The main goal of this study was to propose a reliable method to verify the geographical origin of meat, establishing the influence of soil and water on its isotopic and elemental composition. Thus, beef meat, soil, and water samples were collected from three major cattle-producing regions of Argentina (Buenos Aires, Córdoba, and Entre Ríos). Multielemental composition was determined on these three matrices by inductively coupled plasma mass spectrometry (ICP-MS), δ(13)C and δ(15)N by isotope-ratio mass spectrometry (IRMS), and the (87)Sr/(86)Sr ratio by thermal ionization mass spectrometry (TIMS). Soil and drinking water samples could be characterized and clearly differentiated by combining the isotopic ratios and elements, demonstrating differences in geology and climatic conditions of three regions. Similarly, meat originating at each sampling area was characterized and differentiated using only five key variables (Rb, Ca/Sr, δ(13)C, δ(15)N, and (87)Sr/(86)Sr). Generalized procrustes analysis (GPA), using the three studied matrices (soil, water, and meat) shows consensus between them and clear differences between studied areas. Furthermore, canonical correlation analysis (CCA) demonstrates significant correlation between the chemical-isotopic profile of meat with those corresponding to both soil and water (r(2) = 0.93, p < 0.001; and r(2) = 0.83, p < 0.001, respectively). So far, there are clear coincidences between the meat fingerprint and those from soil/water where cattle grew, presenting a good method to establish beef provenance. To the authors' knowledge this is the first report linking the influence of soil and water all together on the composition of beef, presenting the basis for the authentication of Argentinean beef, which could be extended to meat from different provenances.  相似文献   

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome   总被引：1，自引：0，他引：1  

Mural RJ  Adams MD  Myers EW  Smith HO  Miklos GL  Wides R  Halpern A  Li PW  Sutton GG  Nadeau J  Salzberg SL  Holt RA  Kodira CD  Lu F  Chen L  Deng Z  Evangelista CC  Gan W  Heiman TJ  Li J  Li Z  Merkulov GV  Milshina NV  Naik AK  Qi R  Shue BC  Wang A  Wang J  Wang X  Yan X  Ye J  Yooseph S  Zhao Q  Zheng L  Zhu SC  Biddick K  Bolanos R  Delcher AL  Dew IM  Fasulo D  Flanigan MJ  Huson DH  Kravitz SA  Miller JR  Mobarry CM  Reinert K  Remington KA  Zhang Q  Zheng XH  Nusskern DR  Lai Z  Lei Y  Zhong W  Yao A  Guan P  Ji RR  Gu Z  Wang ZY  Zhong F 《Science (New York, N.Y.)》2002,296(5573):1661-1671

The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.  相似文献   

Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives     

Chamberlain SR  Menzies L  Hampshire A  Suckling J  Fineberg NA  del Campo N  Aitken M  Craig K  Owen AM  Bullmore ET  Robbins TW  Sahakian BJ 《Science (New York, N.Y.)》2008,321(5887):421-422

Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.  相似文献   

Isolation of two seven-membered ring C58 fullerene derivatives: C58F17CF3 and C58F18     

Troshin PA  Avent AG  Darwish AD  Martsinovich N  Abdul-Sada AK  Street JM  Taylor R 《Science (New York, N.Y.)》2005,309(5732):278-281

Fluorination of C60 at 550 degrees C leads to milligram quantities of two stable fullerene derivatives with 58-carbon cage structures: C58F18 and C58F17CF3. The compounds were characterized by mass spectrometry and fluorine nuclear magnetic resonance spectroscopy, and the data support a heptagonal ring in the framework. The resulting strain, which has hindered past attempts to prepare these smaller quasi-fullerenes, is mitigated here by hybridization change of some of the carbons in the pentagons from sp2 to sp3 because of fluorine addition. The loss of carbon from C60 is believed to occur via sequential fluorine addition to a CC single bond and an adjacent CC bond, followed by loss of a:CF2 carbene.  相似文献   

IMPACT OF CHINESE IMPORTS IN COLOMBIA’S JOB LOSSES INTHE TEXTILE INDUSTRY     

Natalia Gomez 《山东饲料》2014,(5):215-216

China's growing participation in Latin American countries has been seen as a massive threat on the region 's manufacturing sector. Is it really this significant when it comes to its impact on manufacturing employment?With this project I pretend to examine the relationship between the bilateral commerce from China and Colombia in the textile a sector between the years 2000-2012. By examining the data I want to find out what is the correlation between jobs losses in Colombia's textile industry and the imports from China in the same industry.Analyzing the sector of textile is very significant to the country.It represents employment and production of added value products in an industry that has not only social impact but also historical meaning for the country.  相似文献   

SUMO modification of Huntingtin and Huntington's disease pathology     

Steffan JS  Agrawal N  Pallos J  Rockabrand E  Trotman LC  Slepko N  Illes K  Lukacsovich T  Zhu YZ  Cattaneo E  Pandolfi PP  Thompson LM  Marsh JL 《Science (New York, N.Y.)》2004,304(5667):100-104

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Probabilistic Model of the Brown Rat Control     

Valentin Andreevich Rylnikov  Natalia Pavlovna Tuchkova 《农业科学与技术》2013,(9):745-756

We represent assessment of the rats control operator＇s actions, starting from the placement of rat control means （chemical, mechanical and others） in the object territory until the full its elimination and followed by assessment of the probability of rat population recovery. The probability of success is evaluated when using a combination of rat control means. We took into account changes in rat population occurring in different calendar periods of the year. The proposed calculation method can be used in training programs, as well as for the local forecast of releasing objects from rats and rats＇ re-settling.  相似文献   

Polypeptide Modulators of TRPV1 Produce Analgesia without Hyperthermia     

Yaroslav A. Andreev  Sergey A. Kozlov  Yuliya V. Korolkova  Igor A. Dyachenko  Dmitrii A. Bondarenko  Denis I. Skobtsov  Arkadii N. Murashev  Polina D. Kotova  Olga A. Rogachevskaja  Natalia V. Kabanova  Stanislav S. Kolesnikov  Eugene V. Grishin 《Marine drugs》2013,11(12):5100-5115

Transient receptor potential vanilloid 1 receptors (TRPV1) play a significant physiological role. The study of novel TRPV1 agonists and antagonists is essential. Here, we report on the characterization of polypeptide antagonists of TRPV1 based on in vitro and in vivo experiments. We evaluated the ability of APHC1 and APHC3 to inhibit TRPV1 using the whole-cell patch clamp approach and single cell Ca²⁺ imaging. In vivo tests were performed to assess the biological effects of APHC1 and APHC3 on temperature sensation, inflammation and core body temperature. In the electrophysiological study, both polypeptides partially blocked the capsaicin-induced response of TRPV1, but only APHC3 inhibited acid-induced (pH 5.5) activation of the receptor. APHC1 and APHC3 showed significant antinociceptive and analgesic activity in vivo at reasonable doses (0.01–0.1 mg/kg) and did not cause hyperthermia. Intravenous administration of these polypeptides prolonged hot-plate latency, blocked capsaicin- and formalin-induced behavior, reversed CFA-induced hyperalgesia and produced hypothermia. Notably, APHC3’s ability to inhibit the low pH-induced activation of TRPV1 resulted in a reduced behavioural response in the acetic acid-induced writhing test, whereas APHC1 was much less effective. The polypeptides APHC1 and APHC3 could be referred to as a new class of TRPV1 modulators that produce a significant analgesic effect without hyperthermia.  相似文献