Tumour angiogenesis,anti‐angiogenic therapy and chemotherapeutic resistance          下载免费PDF全文

KA Mander  JW Finnie 《Australian veterinary journal》2018,96(10):371-378

In order for a tumour to continue to grow and disseminate, it must acquire a new blood supply. Neovascularisation can be enacted by a number of different mechanisms. This dependence of tumour progression on an augmented vascular supply has been exploited by the development of anti‐angiogenic drugs, which are designed to inhibit new blood vessel formation or disrupt existing tumour‐associated vasculature, both leading to ischaemic–hypoxic tumour cell death. However, the clinical benefits of these therapeutic approaches are frequently variable and often transient, the neoplasm sometimes being able to use other neovascularisation mechanisms to maintain its blood supply and thus evade the current anti‐angiogenic therapy. Tumours may also develop a more malignant phenotype following this treatment. Clinical outcomes may be improved by simultaneously inhibiting different angiogenic pathways, abetted by more effective drug delivery regimens such as metronomic chemotherapy and the concurrent use of other antitumour modalities.  相似文献   

In ovo feeding of carbohydrates for broilers—a systematic review          下载免费PDF全文

P. L. Retes  A. H. S. Clemente  D. G. Neves  M. Espósito  L. Makiyama  R. R. Alvarenga  L. J. Pereira  M. G. Zangeronimo 《Journal of animal physiology and animal nutrition》2018,102(2):361-369

The purpose of this systematic review was to evaluate the evidence that the injection of carbohydrate‐based solutions into embryonated eggs improves broiler performance. A literature search was conducted in April 2017 using the keywords broiler, carbohydrate, in ovo, nutrition and poultry. Only papers that involved in ovo carbohydrate injections in poultry were used in this study. After specific selection criteria, 17 papers were selected. The quality scoring system of the selected studies was based on the injection methodology, use of control groups, type of solution injected, period of injection, egg and hens characteristics, number of variables analysed and the statistical design. Among papers, there was no standardised procedure in to inoculate the solutions. Nevertheless, in general, in ovo feeding of carbohydrates decreases the hatch rate, improves the hatch weight, but it does not seem to influence the post‐hatch performance of broilers. The inoculation of 75 mg of glucose in the albumen seems to bring better results. Further studies are needed to improve the technical methodology of in ovo injections for commercial use.  相似文献   

The impact of bisphenol S on bovine granulosa and theca cells          下载免费PDF全文

KA Campen  M Lavallee  CMH Combelles 《Reproduction in domestic animals》2018,53(2):450-457

Bisphenol S (BPS) is an endocrine‐disrupting chemical with multiple potential mechanisms of action, including as an oestrogen receptor agonist. BPS is increasingly used in plastics and thermal receipts as a substitute for bisphenol A, which has been phased out due to concerns about human health implications. The ability of BPS to alter female reproductive function in mammals has not been widely studied, despite the importance of normal hormone signalling for female reproduction. The aim of this study was to investigate how BPS (in a wide range of doses, including very low doses) affects granulosa cell and theca cell steroid hormone production and cell viability in the bovine. Granulosa cell oestradiol production was stimulated when cells were exposed to 100 μM BPS under basal conditions, but there was no effect of BPS when cells were stimulated with follicle‐stimulating hormone (FSH). Additionally, there was no effect of BPS on granulosa cell progesterone production or cell viability under basal or FSH‐stimulated conditions. BPS did not affect theca cell androstenedione or progesterone production, or theca cell viability under basal or luteinizing hormone‐stimulated conditions. This study suggests for the first time that BPS may alter oestradiol production by bovine granulosa cells, albeit at a concentration that is unlikely to be physiologically relevant. Further studies are needed to determine the effects of BPS on the bovine oocyte and on other functions of follicular cells.  相似文献   

Detection and genetic characterization of diverse Bartonella genotypes in the small mammals of Singapore          下载免费PDF全文

E. S. Neves  I. H. Mendenhall  S. A. Borthwick  Y. C. F. Su  G. J. D. Smith 《Zoonoses and public health》2018,65(1):e207-e215

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Dynamics of soil chemical properties in shifting cultivation systems in the tropics: a meta‐analysis          下载免费PDF全文

A. A. Ribeiro Filho  C. Adams  S. Manfredini  R. Aguilar  W. A. Neves 《Soil Use and Management》2015,31(4):474-482

The forest cultivation system (slash‐and‐burn or shifting cultivation) has contributed to the transformation of social systems since the early Neolithic period. Despite being considered by conservationists and public policymakers as a system of low productivity that generates environmental degradation and contributes to the maintenance of rural poverty, the shifting cultivation system (SCS) is being declared a practice that is highly ecologically and economically efficient. Such dichotomy of opinions is the consequence of the disparate results of studies assessing the effects of SCS on soil properties of rainforests throughout the last three decades. To circumvent this apparent inconsistency, we used a systematic quantitative review method (meta‐analysis), with the objective of integrating and synthesizing the data published in the literature to assess the overall effects of SCS on soil chemical properties. Four variables traditionally assessed in primary studies were chosen for the meta‐analyses: pH, cation exchange capacity (CEC), total carbon (Total C) and total nitrogen (Total N). Our results show that pH values increase under SCS conditions, while Total N and C content are significantly reduced under SCS. No significant impacts are observed on CEC. Our results on pH and CEC support the position from researchers who argue for the sustainability of SCS and highlight the importance of evaluating the soil system as a soil/vegetation complex. Also, our results indicate that soil chemical properties under SCS scenarios are better conserved and more readily recoverable, provided there is a rather longer fallow period than has been traditionally employed.  相似文献   

南疆灌区冬小麦/夏玉米改良模式增产潜力与机理分析     

章建新  赵明  图尔贡  卡地尔亚 《干旱地区农业研究》2013,31(6):15-21

田间试验系统地比较了新冬20/沈玉2002不同套种模式（“522模式”与“952模式”）及“521模式”下保麦10号/蠡玉35、保麦10号/登海3672、新冬20/蠡玉35的产量、叶面积指数、光合势及干物质积累等性状的差异。结果表明,“522模式”新冬20/沈玉2002周年产量（17 838.2 kg·hm^-2）较“952模式”(16 550.9 kg·hm^-2)增产7.8%,其中,冬小麦增产18.4%。“521模式”保麦10号/蠡玉35、保麦10号/登海3672、新冬20/蠡玉35周年产量为19 905.0～20 751.0 kg·hm^-2,其中,冬小麦产量为9 740～10 275 kg·hm^-2、夏玉米产量为9 630～10 211.0 kg·hm^-2;冬小麦孕穗期和开花期叶面积指数分别为6.0、5.0左右,返青至成熟的总光合势290.2～324.3×10⁴·m²·d·hm^-2;夏玉米生育期111 d,大喇叭口期至吐丝后20 d的叶面积指数均保持在4左右,生育期间总光合势233.1～257.5×10⁴·m²·d·hm^-2,冬小麦和玉米总光合势为523.3～581.8×10⁴·m²·d·hm^-2;总干物质量38 569.1～40 487.0 kg·hm^-2;冬小麦产量的边际效应为85.7%～112.9%。“521模式”比“952模式”大幅度增产,是小麦行数和边行数及边际产量增大的结果,并将夏玉米播期提至麦收前15 d左右,延长玉米生育期（达110 d左右）,优化株行配置使玉米增产显著,实现全年超高产。“521模式”同时充分利用了冬小麦边际补偿效应和玉米时间补偿效应,较“952模式”易获得周年超高产。并对超高产栽培技术进行了讨论。  相似文献   

Folliculogenesis in mares: gene expression and immunohistochemical staining of LH receptors     

H.B.A. Bastos  N.A. Kretzmann  G.O. Santos  A.T. Esmeraldino  C.A. Wolf  S. Fiala Rechsteiner  R.C. Mattos  A.P. Neves 《Journal of Equine Veterinary Science》2014

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Preliminary Studies on Cryopreservation of Common Tench (Tinca tinca) Embryos (Work in Progress)     

KA El-Battawy  O Linhart 《Reproduction in domestic animals》2009,44(4):718-723

Vitrification could provide a promising tool for the cryopreservation of fish embryos. However, to achieve cryopreservation using vitrification, chilling sensitivity and cryoprotectants toxicity were determined using tench embryos at four developmental stages (11, 17, 23 and 29 h). Embryos treated with alcalase (2 ml/998 ml, 2 min at 22°C) were exposed to chilling with/without warming. Other embryos were exposed to methanol and glycerol at the concentration of 10% and 20% for periods of 20 min. At last, embryos were incubated at special incubator cages where hatching rates were counted. Regarding chilling sensitivity and exposure to chilling followed by warming, the hatching rates of embryos decreased significantly (p < 0.001) after exposure to 0°C at all developmental stages except the 29-h stage compared with the controls. The embryo stage most sensitive to chilling was 11-h stage. The 29-h stage exhibited the least sensitivity to low temperature while 17-h and 23-h stages were intermediate in their sensitivity to chilling. The toxicity of methanol increased significantly (p < 0.001) with developmental stage for 11, 17 and 23-h stages. The highest hatching rates of tench embryos were obtained with 29-h embryos using various concentrations of methanol. The hatching rates of tench embryos exposed to glycerol concentrations were approximately similar to those embryos exposed to methanol concentrations except for 11-h embryos that showed no hatching. Unfortunately, we could not obtain living embryos in any of the conditions examined after vitrification. In conclusion, it was quite difficult to vitrify the tench embryos during this study using various vitrifying solutions and the method reported by Chen & Tian (2005) and further studies are needed to achieve successful cryopreservation.  相似文献   

Contribution of biological nitrogen fixation to cowpea: a strategy for improving grain yield in the semi-arid region of Brazil     

L.?M.?V.?Martins  G.?R.?Xavier  F.?W.?Rangel  J.?R.?A.?Ribeiro  M.?C.?P.?Neves  L.?B.?Morgado  N.?G.?RumjanekEmail author 《Biology and Fertility of Soils》2003,38(6):333-339

Nodulating bacteria from the family Rhizobiaceae are common in the semi-arid tropics around the world. The Brazilian semi-arid region extends over 95 million hectares of which only 3% is suitable for irrigation, therefore leaving an immense dryland area to be exploited by peasant farmers, who often lack appropriate technologies for sustainable management. Cowpea is an important crop in this area, representing the staple protein source for human nutrition. This work aimed to identify rhizobial strains capable of guaranteeing sufficient nitrogen derived from biological fixation for cowpea cultivated in dryland areas, evaluating not just efficiency but also the ecological parameters of competitiveness and survival in the soil. Grain yield and nodulation parameters showed that strain BR 3267 is capable of establishing efficient nodulation, improving both yield and total N accumulated in grain. Cowpea inoculated with strain BR 3267 showed grain productivity similar to plants receiving 50 kg of N per hectare, which is the amount of fertilizer commonly used in the north-east region. These characteristics associated with previously determined ecological properties makes strain BR 3267 an important resource for the optimization of biological nitrogen fixation in cowpea in the dryland areas of the semi-arid tropics. Data on the dynamics of rhizobial populations in such areas have shown that (1) the naturalized rhizobium population is very small and, by themselves, do not promote proper nodulation and, (2) the inoculant rhizobia do not persist between crops. Such characteristics represent an opportunity for the introduction of superior rhizobia strains, such as BR 3267, during the cowpea crop.  相似文献   

Antioxidant properties of prepared blueberry (Vaccinium myrtillus) extracts   总被引：3，自引：0，他引：3  

Faria A  Oliveira J  Neves P  Gameiro P  Santos-Buelga C  de Freitas V  Mateus N 《Journal of agricultural and food chemistry》2005,53(17):6896-6902

A blueberry extract (A) and two anthocyanin-derived extracts (B and C) were prepared. The contents of polyphenols, flavonoids, anthocyanins, and anthocyanin-derived pigments of the extracts were determined for the first time. The pigment profile of blueberry extract A corresponded to 15 anthocyanins, whereas extract B was mainly composed of anthocyanin-pyruvic acid adducts of the blueberry original anthocyanins and extract C was mainly composed of the respective vinylpyranoanthocyanin-catechins (portisins). The extracts' abilities to inhibit lipid peroxidation, induced by 2,2'-azobis(2-methyl-propanimidamide) dihydrochloride in a liposomal membrane system were examined. The antioxidant capacities of the extracts were evaluated through monitoring oxygen consumption and by measuring the formation of conjugated dienes. All of the extracts provided protection of membranes against peroxyl radicals by increasing the induction time of oxidation. This effect increased with the polyphenol content and with the structural complexity of the anthocyanin-derived pigments of the extracts. The pigments present in extract C seemed to induce a higher protection of the liposome membranes toward oxidation. In addition, the antiradical properties and the reducing power of the extracts were determined by using DPPH and FRAP methods, respectively. The results from these assays were in agreement with those obtained with the liposome membranes.  相似文献