Bioavailability of ketoprofen in horses after rectal administration     

S. CORVELEYN  P. DEPREZ†  G. VAN DER WEKEN‡  W. BAEYENS‡  J. P. REMON 《Journal of veterinary pharmacology and therapeutics》1996,19(5):359-363

Six healthy mares ranging in age from 6 to 12 years and weighing from 415 to 540 kg were used to determine the rectal bioavailability of ketoprofen. For the rectal administration, three different formulations, each containing 1 g of ketoprofen, were administered in a fatty and a hydrophilic suppository base and as a liquid suspension. An average elimination half-life of 1.3 h (±1.2) was found. The average value for the total plasma clearance ( Cl _T) was 131.9 mL/min.kg (range 95-183.5). The volume of distribution V _d(area) was 255 mL/kg and the mean residence time (MRT)P = 0.05; Friedman test). Despite the low rectal bioavailability obtained in this study, there was some evidence for the clinical effectiveness of the rectal formulations.  相似文献   

Mechanical Properties of Four Suture Patterns for Transected Equine Tendon Repair     

K. J. EASLEY DVM  MS    T. S. STASHAK DVM  MS  DiplomateACVS    F. W. SMITH PhD  G. VAN SLYKE BVSC 《Veterinary surgery : VS》1990,19(2):102-106

Thirty-six superficial digital flexor tendons from nine fresh equine cadavers were transected and sutured with size 2 monofilament nylon. Nine tendons were repaired with each of four suture patterns: single-locking loop, double-locking loop, triple-locking loop, or three-loop pulley. The times required for application, tensile strengths, resistance to distraction (gap), and modes of failure were analyzed. The mean times required were: single-locking loop, 3 mins, 15 secs; double-locking loop, 4 mins, 15 secs; triple-locking loop, 10 mins, 50 secs; and three-loop pulley, 4 mins. The double-locking loop, triple-locking loop, and three-loop pulley suture patterns were stronger than the single-locking loop. The triple-locking loop and three-loop pulley patterns were close in strength and only the triple-locking loop was stronger than the double-locking loop. The three-loop pulley had the greatest resistance to gap formation and its mode of failure was different from the others. The three-locking loop suture patterns failed by suture breakage but the three-loop pulley failed first by suture pull-out and then by suture breakage.  相似文献   

Heat Transfer Performance of Ethanol Tree-Dimensional Inner Micro-Fin Heat Pipe     

DE Jun  XIN Ming dao 《保鲜与加工》2003,(4):115-117

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Use of Spinach, Radish, and Perennial Ryegrass to Assess the Availability of Metals in Waste Foundry Sands     

Robert S. Dungan  Nikki H. Dees 《Water, air, and soil pollution》2007,180(1-4):213-223

Opencast coalmine effluent contains higher concentrations of Cd, Cr, Co, Ni and Pb. Biofiltration of these metals has been demonstrated successfully with the help of aquatic macrophytes i.e., E. crassipes, L. minor and A. pinnata. Experiments revealed E. crassipes reduced highest concentration of heavy metals followed by L. minor and A. pinnata on 20th days retention period. Plant tissue analysis revealed higher accumulation of metals in roots than leaves. Highly significant correlations have been noted between removal of heavy metals in effluent and their accumulation in roots and leaves of the experimental sets. Translocation factor also revealed lower transportation of metals from root to leaves. Reduction in chlorophyll and protein content was noted with the accumulation of heavy metals. N, P and K analysis in plant tissues indicated continuous decrease in their concentration with increasing metal concentration. Negative and significant correlations between metal accumulation and N, P and K concentrations in plant tissues showed adverse effects of heavy metals. Analysis of variance (Dunnett t-test) showed significant results (p?<?0.001) for all the metals in different durations.  相似文献   

SOIL STRUCTURE IN VERTISOLS OF THE BLUE NILE CLAY PLAINS, SUDAN     

J. H. DE  VOS t. N. C. K. J. VIRGO 《European Journal of Soil Science》1969,20(1):189-206

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Floras and oxygen     

VAN Valen L 《Science (New York, N.Y.)》1979,205(4412):1302

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Carotenoids function in photoperiodic induction of diapause in a predacious mite     

VAN Zon AQ  Overmeer WP  Veerman A 《Science (New York, N.Y.)》1981,213(4512):1131-1133

Predacious mites fed for two generations solely on the eggs of wild-type spider mites responded normally to short day lengths by entering diapause. However, predacious mites fedfor two generations on eggs of albino spider mites, which are completely devoid of carotenoids, did not respond to short-day photoperiods. Apparently carotenoids are essential for photoperiodic induction; possibly a carotenoid or carotenoid derivative functions as the photopigment concerned in photoperiodic light reception in these mites.  相似文献   

A.J. Kluyver,microbiologist     

VAN NIEL CB 《Science (New York, N.Y.)》1956,124(3216):308

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Photosynthesis-associated gene families: differences in response to tissue-specific and environmental factors     

Simpson J  VAN Montagu M  Herrera-Estrella L 《Science (New York, N.Y.)》1986,233(4759):34-38

The endogenous small subunit of the ribulose-1,5-bisphosphate carboxylase gene rbcS and the light-harvesting chlorophyll a/b-binding protein gene (LHCP) of pea are expressed in a light-inducible manner and are active mainly in green chloroplast-containing tissue. Chimeric genes under control of the 5'-flanking sequences of the rbcS ss3.6 or LHCP AB80 genes from pea were used to study the factors relating to the issue-specific and lightinducible expression of these nuclear-encoded genes in transgenic tobacco plants. The results show that plastid development plays a crucial role in the activation of expression of these chimeric genes. Particular members of each of the above gene families respond differently to tissue-specific and environmental factors. Furthermore, the light-inducible expression directed by the 5'-flanking sequence of ss3.6 rbcSgene is not exclusively mediated by phytochrome, but probably is controlledin large part by another photoreceptor.  相似文献   

Comparative Earth History and Late Permian Mass Extinction   总被引：6，自引：0，他引：6  

AH Knoll  RK Bambach  DE Canfield  JP Grotzinger 《Science (New York, N.Y.)》1996,273(5274):452-457

The repeated association during the late Neoproterozoic Era of large carbon-isotopic excursions, continental glaciation, and stratigraphically anomalous carbonate precipitation provides a framework for interpreting the reprise of these conditions on the Late Permian Earth. A paleoceanographic model that was developed to explain these stratigraphically linked phenomena suggests that the overturn of anoxic deep oceans during the Late Permian introduced high concentrations of carbon dioxide into surficial environments. The predicted physiological and climatic consequences for marine and terrestrial organisms are in good accord with the observed timing and selectivity of Late Permian mass extinction.  相似文献